Effects of filtration and gamma radiation on the accumulation of RANTES and transforming growth factor-beta1 in apheresis platelet concentrates during storage.

Abstract:

BACKGROUND:Platelet-derived biologic response modifiers (BRMs) including RANTES and transforming growth factor (TGF)-beta1 accumulate in platelet components during storage because of platelet activation, and they may play a causative role in nonhemolytic febrile transfusion reactions. The majority of PCs with high unit values are provided by single donor apheresis in Japan. STUDY DESIGN AND METHODS:RANTES and TGF-beta1 levels in platelet units prepared from single-donor apheresis platelet concentrates (apheresis PCs) and units from whole blood (buffy coat PCs) were investigated. The effects of prestorage and poststorage filtration and gamma radiation on the levels of RANTES and TGF-beta1 in the supernatant of apheresis PCs during storage were also examined. RESULTS:The levels of RANTES and TGF-beta1 increased during storage from Day 0 to Day 5. The levels of RANTES and of TGF-beta1 correlated with the platelet concentration (p<0.01), but not with the residual white cell concentration in apheresis PCs that were not white cell reduced by filtration (p>0.05). In addition, there was a correlation between RANTES and TGF-beta1 levels (p<0.01). In white cell-reduced apheresis PCs using negatively charged filters as well as in gamma-radiated apheresis PCs, the levels of these two BRMs-did not differ at any storage time from those of untreated apheresis PCs. Filtration of apheresis PCs with negatively charged filters after 3 days of storage significantly (p<0.05) reduced the levels of RANTES, but not of TGF-beta1. There was no reduction in the levels of RANTES and TGF-beta1 levels by positively charged filters. The RANTES levels in buffy coat PCs were slightly higher than but not significantly different from those of apheresis PCs during storage, except for the level on Day 1. There were no differences in the TGF-beta1 levels in apheresis and buffy coat PCs during storage. CONCLUSION:Prestorage filtration and gamma radiation had neither preventive effects on the accumulation of RANTES and TGF-beta1 nor adverse effects on platelet activation. Negatively charged filters might be useful for the reducing the levels of RANTES in stored apheresis PCs.

journal_name

Transfusion

journal_title

Transfusion

authors

Fujihara M,Ikebuchi K,Wakamoto S,Sekiguchi S

doi

10.1046/j.1537-2995.1999.39050498.x

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

498-505

issue

5

eissn

0041-1132

issn

1537-2995

journal_volume

39

pub_type

临床试验,杂志文章
  • Creating a uniform donor medical history questionnaire.

    abstract::Blood Centers of California, Inc. (BCC) is a consortium of 19 independent blood centers that collectively draw approximately 800,000 units of whole blood each year. Over the past several years, a committee of BCC, composed primarily of medical and nursing directors at member institutions, developed a Uniform Donor Med...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31491213302.x

    authors: Kolins J,Silvergleid AJ

    更新日期:1991-05-01 00:00:00

  • A path analysis of intention to redonate among experienced blood donors: an extension of the theory of planned behavior.

    abstract:BACKGROUND:The need for blood products is constant and unremitting, yet only a small percentage of eligible individuals answer the appeal to donate. Further, most new donors never return to provide a repeat donation. The ongoing need to attract and retain new donors has led to the examination of psychosocial factors th...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01236.x

    authors: France JL,France CR,Himawan LK

    更新日期:2007-06-01 00:00:00

  • Collection and immunoselection of CD34+ cells: the impact of age, sex, and diabetes in patients with chronic heart failure.

    abstract:BACKGROUND:Mobilized peripheral blood is the most common source of CD34+ cells intended for transplantations. The collection and enrichment of CD34+ cells could be affected by various factors and there are some controversies regarding the effects of patient-related factors. The aim of this study was to assess the impac...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/trf.13646

    authors: Kresnik PK,Krasna M,Rozman P,Vrtovec B,Malicev E

    更新日期:2016-07-01 00:00:00

  • Flow cytometric studies of the D antigen of various Rh phenotypes with particular reference to Du and Del.

    abstract::Flow cytometric analysis was performed on red cells (RBCs) to compare the antigen activity of various Rh phenotypes, including the rare variants Del and Du (both high-grade and low-grade), whose genotypes were confirmed or presumed by the family study. This appears to be the first report that the Del phenotype is due ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30390194344.x

    authors: Hasekura H,Ota M,Ito S,Hasegawa Y,Ichinose A,Fukushima H,Ogata H

    更新日期:1990-03-01 00:00:00

  • Range forb lectins.

    abstract::In this study we tested the seeds of uncultivated plants for lectin activity. Extracts prepared from the seeds of 167 forb species were tested against human red cell samples. Extracts of 54 species agglutinated unmodified or enzyme-modified red cells. In nine species, the hemagglutinating lectin activity could be neut...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1983.23684074276.x

    authors: Hardman JT,Beck ML,Owensby CE

    更新日期:1983-11-01 00:00:00

  • Multicenter study to evaluate a new enumeration method for hematopoietic stem cell collection management.

    abstract:BACKGROUND:CD34 flow cytometry is the gold standard for stem cell enumeration in peripheral blood at the mobilization stage and in the final apheresis product. The new stem cell mode of the Sysmex XN Series analyzer enumerates an immature cell population in the white progenitor and pathological cell (WPC) channel, base...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/trf.14183

    authors: Grommé M,Russcher H,Braakman E,Klinkspoor JH,Dobber JA,de Greef I,de Wit NCJ

    更新日期:2017-08-01 00:00:00

  • The National Marrow Donor Program.

    abstract::As the number of successful marrow transplants has increased, the lack of HLA-identical sibling donors for 60 to 70 percent of transplant candidates has become a serious problem. Pilot studies established that marrow transplantation between phenotypically HLA-identical, unrelated individuals can be accomplished succes...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.33793325052.x

    authors: Stroncek D,Bartsch G,Perkins HA,Randall BL,Hansen JA,McCullough J

    更新日期:1993-07-01 00:00:00

  • Outliers in RhD membrane integration are explained by variant RH haplotypes.

    abstract:BACKGROUND:Variations in a multipass transmembrane protein may affect its membrane integration. To study this effect, the systematic molecular characterization of variant D antigen density is a suitable model. Unlike most other membrane proteins, the expression of the D antigen is often determined by a single allele, b...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00902.x

    authors: Yu X,Wagner FF,Witter B,Flegel WA

    更新日期:2006-08-01 00:00:00

  • First results of a ferritin-based blood donor deferral policy in the Netherlands.

    abstract:BACKGROUND:Whole blood donors are at risk of becoming iron deficient. To monitor iron stores, Sanquin implemented a new deferral policy based on ferritin levels, in addition to the traditional hemoglobin measurements. METHODS:Ferritin levels are determined in every fifth donation, as well as in all first-time donors. ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15906

    authors: Vinkenoog M,van den Hurk K,van Kraaij M,van Leeuwen M,Janssen MP

    更新日期:2020-08-01 00:00:00

  • Cost projections for implementation of safety interventions to prevent transfusion-transmitted Zika virus infection in the United States.

    abstract:BACKGROUND:In August 2016, the Food and Drug Administration advised US blood centers to screen all whole blood and apheresis donations for Zika virus (ZIKV) with an individual-donor nucleic acid test (ID-NAT) or to use approved pathogen reduction technology (PRT). The cost of implementing this guidance nationally has n...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14164

    authors: Ellingson KD,Sapiano MRP,Haass KA,Savinkina AA,Baker ML,Henry RA,Berger JJ,Kuehnert MJ,Basavaraju SV

    更新日期:2017-06-01 00:00:00

  • Safety of blood donation by individuals over age 70 and their contribution to the blood supply in five developed countries: a BEST Collaborative group study.

    abstract:BACKGROUND:Some countries impose an upper age limit on whole blood and double RBC donation while others do not. We evaluated the safety of blood donation in older individuals (≥71 years), and their contribution to the blood supply of five countries. STUDY DESIGN AND METHODS:Twelve blood center members of the Biomedica...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/trf.15132

    authors: Goldman M,Germain M,Grégoire Y,Vassallo RR,Kamel H,Bravo M,Irving DO,Di Angelantonio E,Steele WR,O'Brien SF,Biomedical Excellence for Safer Transfusion Collaborative (BEST) Investigators.

    更新日期:2019-04-01 00:00:00

  • Transfusion and blood donation on the screen.

    abstract:BACKGROUND:In the 20th century, blood transfusion has become an indispensable therapy in carrying out and improving many medical and surgical applications. Its scope of influence goes well beyond that of medicine, because blood donation, an action with high social significance, is completely connected to progress in th...

    journal_title:Transfusion

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1537-2995.2007.01634.x

    authors: Danic B,Lefrère JJ

    更新日期:2008-05-01 00:00:00

  • Hepatitis B virus nucleic acid amplification testing of Australian blood donors highlights the complexity of confirming occult hepatitis B virus infection.

    abstract:BACKGROUND:We present an analysis of the first 2 years of hepatitis B virus (HBV) nucleic acid testing (NAT) of the Australian donor population. STUDY DESIGN AND METHODS:Between July 5, 2010, and July 4, 2012, all blood donations were screened for HBV DNA and hepatitis B surface antigen (HBsAg). Donors who tested HBsA...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12556

    authors: Kiely P,Margaritis AR,Seed CR,Yang H,Australian Red Cross Blood Service NAT Study Group.

    更新日期:2014-08-01 00:00:00

  • Unexpected red blood cell antibody distributions in Chinese people by a systematic literature review.

    abstract:BACKGROUND:Unexpected antibodies are frequently associated with hemolytic disease of the fetus and newborn (HDFN) and hemolytic transfusion reactions (HTRs), and screening for those unexpected antibodies is critical for the safety and effectiveness of transfusion. Different populations differ in the prevalence of signi...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.13430

    authors: Chen C,Tan J,Wang L,Han B,Sun W,Zhao L,Huang C,Tan B,Qin L

    更新日期:2016-04-01 00:00:00

  • Collection of mobilized blood progenitor cells for hematopoietic rescue by large-volume leukapheresis.

    abstract:BACKGROUND:Mobilized blood progenitor cells rapidly reconstitute hematopoiesis in patients after dose-intensive chemotherapy. However, optimal timing and methods of mobilized blood progenitor cell collection have yet to be fully defined. STUDY DESIGN AND METHODS:The utility of large-volume leukapheresis (LVL; > 15 L b...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1995.35695288768.x

    authors: Comenzo RL,Vosburgh E,Weintraub LR,Tansan S,Arkin CF,Wright DG

    更新日期:1995-06-01 00:00:00

  • Blood screening nucleic acid amplification tests for human immunodeficiency virus Type 1 may require two different amplification targets.

    abstract:BACKGROUND:Five cases of human immunodeficiency virus Type 1 (HIV-1) RNA-positive blood donations are described that escaped detection by three different CE-marked nucleic acid amplification technique (NAT) screening assays. These events were associated with two HIV-1 transmissions to recipients of blood components. Th...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03281.x

    authors: Chudy M,Weber-Schehl M,Pichl L,Jork C,Kress J,Heiden M,Funk MB,Nübling CM

    更新日期:2012-02-01 00:00:00

  • Effects of blood storage age on immune, coagulation, and nitric oxide parameters in transfused patients undergoing cardiac surgery.

    abstract:BACKGROUND:Retrospective studies suggested that storage age of RBCs is associated with inflammation and thromboembolism. The Red Cell Storage Duration Study (RECESS) trial randomized subjects undergoing complex cardiac surgery to receive RBCs stored for shorter versus longer periods, and no difference was seen in the p...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/trf.15228

    authors: Spinella PC,Sniecinski RM,Trachtenberg F,Inglis HC,Ranganathan G,Heitman JW,Szlam F,Danesh A,Stone M,Keating SM,Levy JH,Assmann SF,Steiner ME,Doctor A,Norris PJ

    更新日期:2019-04-01 00:00:00

  • Assessment of cell viability, early apoptosis, and hematopoietic potential in umbilical cord blood units after storage.

    abstract:BACKGROUND:Successful hematopoietic stem cell transplantation using stored umbilical cord blood (CB) largely depends on cell dose and quality of CB units. The aim of this study was to assess the degree of early apoptosis, in addition to cell viability and hematopoietic potential, in umbilical CB units after storage. S...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13120

    authors: Kim KM,Huh JY,Hong SS,Kang MS

    更新日期:2015-08-01 00:00:00

  • Collection of white blood cell-reduced plasma by apheresis.

    abstract:BACKGROUND:WBC reduction of cellular blood components has been introduced in many countries. Owing to concerns of residual WBCs in plasma, a new method to collect WBC-reduced plasma by apheresis was studied. STUDY DESIGN AND METHODS:An apheresis machine (PCS2, Haemonetics) was used, in combination with the "high-separ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.03314.x

    authors: Vrielink H,van der Meer PF

    更新日期:2004-06-01 00:00:00

  • Patient blood management in colorectal cancer patients: a survey among Dutch gastroenterologists, surgeons, and anesthesiologists.

    abstract:INTRODUCTION:There is an increasing awareness to integrate patient blood management (PBM) within routine surgical care. Limited information about the implementation of PBM in colorectal cancer surgery is available. This is curious, as preoperative anemia, associated with increased morbidity, is highly prevalent in colo...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14807

    authors: Wilson MJ,Koopman-van Gemert AWMM,Harlaar JJ,Jeekel J,Zwaginga JJ,Schipperus M

    更新日期:2018-10-01 00:00:00

  • A rapid tube technique for fetal cell typing.

    abstract::A modification of Greendyke technique for fetal cell typing is described in which incubation time and quantities of antisera are reduced without affecting the sensitivity of the test. ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1979.19279160292.x

    authors: Bryant NJ,Shanahan LS,Sutton DM

    更新日期:1979-03-01 00:00:00

  • Safety of acoustic separation in plastic devices for extracorporeal blood processing.

    abstract:BACKGROUND:Acoustic cell separation uses ultrasound waves to separate cells from plasma to perform plasmapheresis. Although the fundamental process has been studied for decades, no acoustic cell separation has been studied in a disposable plastic format suitable for clinical applications. STUDY DESIGN AND METHODS:We d...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14158

    authors: Savage WJ,Burns JR,Fiering J

    更新日期:2017-07-01 00:00:00

  • Anti-K formation is not associated with the storage time of transfused red blood cells.

    abstract:BACKGROUND:The formation of red blood cell (RBC) antibodies could be enhanced by the presence of inflammation caused by prolonged RBC storage, as was shown in animal studies. The low occurrence (<10%) of K-antigen in most populations often enables identification of the K+ RBC unit that triggered anti-K formation and de...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12974

    authors: Hogervorst E,Middelburg R,Brand A,van de Watering L,Schonewille H

    更新日期:2015-06-01 00:00:00

  • Differentiation of autologous ABO, RHD, RHCE, KEL, JK, and FY blood group genotypes by analysis of peripheral blood samples of patients who have recently received multiple transfusions.

    abstract:BACKGROUND:After multiple transfusions, the serologic typing of autologous blood group phenotypes is difficult, because of mixed RBC populations. The genotyping of ABO, Rh, Kell, Kidd, and Duffy systems could be used to determine autologous blood group antigen status. STUDY DESIGN AND METHODS:Blood samples from patien...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40080936.x

    authors: Rozman P,Dovc T,Gassner C

    更新日期:2000-08-01 00:00:00

  • Immune hemolytic anemia associated with teicoplanin.

    abstract:BACKGROUND:Several drugs can cause immune hemolytic anemia. Here a patient who developed hemolytic anemia after treatment with teicoplanin is described. CASE REPORT:Owing to a two-vessel disease, a 68-year-old white man underwent coronary artery bypass grafting. He was readmitted for superficial sternal wound infectio...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.0041-1132.2003.00599.x

    authors: Coluccio E,Villa MA,Villa E,Morelati F,Revelli N,Paccapelo C,Garratty G,Rebulla P

    更新日期:2004-01-01 00:00:00

  • AABB Committee Report: reducing transfusion-transmitted cytomegalovirus infections.

    abstract::Transfusion-transmitted cytomegalovirus (TT-CMV) is often asymptomatic, but certain patient populations, such as very low birth weight neonates, fetuses requiring intrauterine transfusion, pregnant women, patients with primary immunodeficiencies, transplant recipients, and patients receiving chemotherapy or transplant...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.13503

    authors: AABB, Clinical Transfusion Medicine Committee.,Heddle NM,Boeckh M,Grossman B,Jacobson J,Kleinman S,Tobian AA,Webert K,Wong EC,Roback JD

    更新日期:2016-06-01 00:00:00

  • Addressing gaps in international blood availability and transfusion safety in low- and middle-income countries: a NHLBI workshop.

    abstract::In April 2017, a workshop sponsored by the National Heart, Lung, and Blood Institute, Division of Blood Diseases and Resources, and the Center for Translation Research and Implementation Science was held to discuss blood availability and transfusion safety in low- and middle-income countries (LMICs). The purpose of th...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.14598

    authors: Custer B,Zou S,Glynn SA,Makani J,Tayou Tagny C,El Ekiaby M,Sabino EC,Choudhury N,Teo D,Nelson K,Peprah E,Price L,Engelgau MM

    更新日期:2018-05-01 00:00:00

  • Predicting hemolytic disease of the newborn: a comparison of the monocyte monolayer assay and the chemiluminescence test.

    abstract::The ability of the monocyte monolayer assay (MMA) and the chemiluminescence test (CLT) to predict the clinical significance of alloantibodies associated with hemolytic disease of the newborn (HDN) was assessed by the use of 22 well-characterized antisera--predominantly anti-D--from alloimmunized pregnant women. Sevent...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.33693296810.x

    authors: Lucas GF,Hadley AG,Nance SJ,Garratty G

    更新日期:1993-06-01 00:00:00

  • Persistence of cefotetan on red blood cells.

    abstract:BACKGROUND:Cefotetan can cause severe immune hemolytic anemia that may persist long after the drug is discontinued. To study the binding of cefotetan to RBCs, patients who received cefotetan were followed and tested for the presence of antibody to cefotetan. STUDY DESIGN AND METHODS:Patients receiving cefotetan were i...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.03360.x

    authors: Davenport RD,Judd WJ,Dake LR

    更新日期:2004-06-01 00:00:00

  • Preparation and storage of platelet concentrates.

    abstract::A technique of platelet concentrate preparation and storage is presented which permits the maximum number of viable and functional platelets to be preserved for periods of 72 hours. Although the storage conditions must be followed precisely, the method is nevertheless simple to perform and does not require specialized...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1976.16176130842.x

    authors: Slichter SJ,Harker LA

    更新日期:1976-01-01 00:00:00