Abstract:
BACKGROUND:We present an analysis of the first 2 years of hepatitis B virus (HBV) nucleic acid testing (NAT) of the Australian donor population. STUDY DESIGN AND METHODS:Between July 5, 2010, and July 4, 2012, all blood donations were screened for HBV DNA and hepatitis B surface antigen (HBsAg). Donors who tested HBsAg negative but HBV NAT positive were assessed as occult hepatitis B infections (OBI) if reactive for antibodies to HBV core antigen (anti-HBc). Donors who were anti-HBc reactive but with nonrepeatable or nondiscriminated NAT results were assessed as HBV inconclusive pending follow-up testing. RESULTS:During the study period a total of 2,673,521 donations were screened for HBV. Forty-two chronic OBI infections (5.55/100,000 donors) were identified compared to eight acute serologic window period infections (1.06/100,000 donors). Of the 42 OBI cases, 23 (54.8%) were detected the first time they were screened for HBV DNA while 19 (45.2%) gave one or more HBV NAT-nonreactive results before detection. Of 68 donors initially assessed as HBV inconclusive and available for follow-up, 10 later confirmed as OBI cases while 51 were NAT nonreactive but remained anti-HBc reactive and OBI could not be excluded. CONCLUSION:This study demonstrated a substantially higher prevalence of OBI compared to acute serologic window period HBV infections in Australian blood donors. Follow-up testing of OBI cases indicates that HBV DNA is often only intermittently detectable in OBI, highlighting the importance of including anti-HBc to optimize the HBV testing algorithm.
journal_name
Transfusionjournal_title
Transfusionauthors
Kiely P,Margaritis AR,Seed CR,Yang H,Australian Red Cross Blood Service NAT Study Group.doi
10.1111/trf.12556subject
Has Abstractpub_date
2014-08-01 00:00:00pages
2084-91issue
8eissn
0041-1132issn
1537-2995journal_volume
54pub_type
杂志文章相关文献
TRANSFUSION文献大全abstract:BACKGROUND:Adequate administration of Rh immune globulin requires an accurate determination of the number of D-positive cells in the circulation of D-negative women. Although several tests have been described for the detection of fetomaternal hemorrhage, there is still a need for a rapid, simple, and clinically relevan...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1998.38298193101.x
更新日期:1998-02-01 00:00:00
abstract::Alloagglutinins of M and N specificites with unique characteristics found in normal sera are described. Specific M or N agglutination by these sera occurred only when erythrocytes had been exposed to glucose-containing solutions. Conversion to the form of MN recognized by these sera required incubation of the cells in...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1981.21682085751.x
更新日期:1981-11-01 00:00:00
abstract:BACKGROUND:Serious complications of blood donation are rare. Reported here is a significant vascular event that resulted from whole-blood phlebotomy and required surgical repair. CASE REPORT:A 49-year-old woman donated whole blood without incident in November 1992, but reported ecchymosis and tenderness in the antecub...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1994.34394196625.x
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Washing of red blood cell concentrates (RCCs) is required for potassium-sensitive transfusion recipients, including neonates in need of large-volume transfusions. When open, nonsterile washing systems are used, postwash outdate time is limited to 24 hours, often leading to problems providing the component to...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.12170
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Some jurisdictions require leukoreduction of cellular blood components. The only whole blood collection set with a platelet-saving filter uses citrate-phosphate-dextrose (CPD) as storage solution. Substituting CPD with citrate-phosphate-dextrose-adenine (CPDA-1) increases shelf life from 21 to 35 days. This ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.15748
更新日期:2020-05-01 00:00:00
abstract::Currently, platelet concentrates are stored in 50 to 60 ml of plasma. A major drawback to storage in plasma is the considerable loss of platelet function which occurs during storage. A modified Tyrodes medium has been developed for storage of platelets. A comparison between platelet concentrates stored in this medium ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1985.25686071429.x
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Critically bleeding trauma patients require coordinated and efficient decision-making processes to ensure optimal management of their massive transfusion (MT) requirements. Human factors (HFs) is a discipline that investigates factors influencing work processes from the organizational, group, and individual ...
journal_title:Transfusion
pub_type: 杂志文章,评审
doi:10.1111/j.1537-2995.2012.03648.x
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Flow cytometric measurement of CD34+ events is used to ensure the quality of human progenitor cell grafts. This study was conducted to evaluate whether the spiking of routine samples from peripheral blood and apheresis products with CD34+ positive controls is feasible. STUDY DESIGN AND METHODS:A total of 42...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2011.03259.x
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Absolute counts of CD4+ T-lymphocytes are used in the management of patients with human immunodeficiency virus infection. Low absolute counts of CD3+CD4+ cells have also been observed in healthy people--a phenomenon called idiopathic CD4 lymphocytopenia. It is common practice for normal ranges for lymphocyte...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1996.36696269517.x
更新日期:1996-06-01 00:00:00
abstract::Donation willingness is generally high but registering with donor centers lags behind. We need to understand why and when during the life course which groups of individuals are motivated to donate. With this knowledge, we can design targeted recruitment and retention strategies and improve evidence-based donor managem...
journal_title:Transfusion
pub_type: 杂志文章,评审
doi:10.1111/trf.15268
更新日期:2019-06-01 00:00:00
abstract::Prospective-concurrent audits and medical consultation were associated with a 56 percent decrease in the use of platelet concentrates at a tertiary care medical center. This study documents that mandatory pretransfusion review of component requests can alter hospital transfusion practices. ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1987.27287150198.x
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:With the emergence of e-mail as a common form of communication, it is important to understand the role and impact e-mail can have on acquiring and retaining whole-blood donors. STUDY DESIGN AND METHODS:Whole-blood donors who opted in to receive e-mail communications (n = 43,232) from the Puget Sound Blood C...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2005.00642.x
更新日期:2005-12-01 00:00:00
abstract::Japanese encephalitis virus (JEV) is endemic to tropical areas in Asia and the Western Pacific. It can cause fatal encephalitis, although most infected individuals are asymptomatic. JEV is mainly transmitted to humans through the bite of an infected mosquito, but can also be transmitted through blood transfusion. To m...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.16021
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Transfusion of plasma is a basic treatment for complex coagulopathies as well as in major blood loss. Early transfusion of plasma after trauma with major hemorrhage has been recommended by retrospective studies. However, the use of plasma is often hampered by the need to maintain a cold chain and the time ne...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.12191
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:This study evaluated the effect of routine, uncontrolled, Israeli field storage conditions on the stability and efficacy of Lyo-Plas N freeze-dried plasma (FDP). We evaluated clotting factors V, VIII, and XI; proteins S and C; fibrinogen; partial thromboplastin time (PTT); antithrombin III (ATIII); von Wille...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.15533
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Storage age of red blood cells (RBCs) has been reported to be associated with increased mortality and morbidity. During storage, RBCs undergo changes in biochemical and functional properties. Stored RBCs may also contain white blood cells (WBCs), activated platelets (PLTs), cytokines, immunoglobulin, and oth...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.12330
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Research with primary human white blood cell (WBC) subpopulations requires high quantity, quality, and functionality of peripheral blood mononuclear cells (PBMCs) as a source to further characterize cellular subpopulations such as T and B lymphocytes, monocytes, or natural killer cells. Apart from buffy coat...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.14616
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Immunoglobulin (Ig)G replacement with intravenous or subcutaneous immunoglobulins is a lifelong substitutive therapy in patients with primary antibody deficiencies (PADs). Hemolysis after immunoglobulin therapy was described in patients receiving high immunoglobulin dosages. The issue of hemolysis after immu...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.12939
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The operational and analytical performance of two automated triplex hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) nucleic acid test (NAT) systems were compared in four screening laboratories of the French Blood Service. STUDY DESIGN AND METHODS:Two laboratories eva...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2008.01965.x
更新日期:2009-02-01 00:00:00
abstract::The effects of hydroxyethyl starch (HES) on hemostasis were investigated extensively. In order to simulate acute blood loss due to surgery or trauma, one unit (450 ml) of blood was drawn from normal healthy men. This was followed by a 1-liter infusion over 60 minutes of either 6 percent HES, 5 percent albumin, or 0.9 ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1985.25485273815.x
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:Collections and transfusions of blood in the United States in 1994 were measured and compared with those in 1992. STUDY DESIGN AND METHODS:Completed survey questionnaires were returned by all 147 regional blood centers, 1340 American Association of Blood Banks (AABB) member hospitals, and 523 non-AABB hospi...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1998.38798346630.x
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Advances in the past two decades in dendritic cell (DC) biology paved the way to exploit them as a promising tool in cancer immunotherapy. The prerequisite for DC vaccine preparations is large-scale in vitro generations of homogeneous, mature, and functional DCs. Frequent improvements are being made in the e...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2010.02706.x
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:The inventory size for cord blood (CB) depends on the ethnic diversity of human leukocyte antigen (HLA) and the size estimation is important for public health in each ethnicity. STUDY DESIGN AND METHODS:We estimate the CB inventory size in Koreans with stored CB units (CBUs) and patients who underwent allog...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.12284
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Transfusion reactions to platelet concentrates prepared from buffy coats (BC-PCs) were reviewed to determine the effect of some variables of BC-PC preparation and storage: time of BC storage before BC-PC preparation (1-2 days); time of BC-PC storage before transfusion (1-5 days); no white cell reduction vers...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1997.37597293886.x
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Human parvovirus B19 is a common human pathogen that causes a variety of diseases with outcomes ranging from asymptomatic to severe, especially in immunocompromised patients. The B19 virus can be transmitted via blood and/or blood products and its resistance to common viral inactivation and/or removal method...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2011.03067.x
更新日期:2011-09-01 00:00:00
abstract::It has previously been shown that buffy coat platelet concentrates (BC-PCs) stored in a medium made up of approximately 70 percent platelet storage medium (Plasma-Lyte A, PL) and 30 percent plasma (BC-PC-P) are effective in vivo after 9 to 12 days of storage. In addition to sodium, potassium, magnesium, and chloride, ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1992.32292180145.x
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Endothelial cells (ECs) play a pivotal role in the allogeneic immune response upon transplantation. Semaphorin 3A (Sema3A) was implicated in the modulation of EC growth, but its effects on immunogenicity were not previously investigated. STUDY DESIGN AND METHODS:ECs were transduced with a lentiviral vector ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.12631
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Borrelia miyamotoi, a recently discovered relapsing fever spirochete, occurs in hard-bodied ticks wherever Lyme disease is endemic. Human infection is associated with relapsing fever and can cause meningoencephalitis in immunocompromised patients. A few cases of transfusion transmission of other relapsing fe...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.12879
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Almost 2 percent of murine blood red blood cells (RBCs) are destroyed each day and are replaced by fresh RBCs generated through the process of erythropoiesis. RBCs to be destroyed are phagocytosed by macrophages in the reticuloendothelial system, especially in the spleen. CD47 molecules on RBCs may regulate ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2007.01348.x
更新日期:2007-09-01 00:00:00
abstract::Data collected from 50 saline washed units of red blood cells shows that units washed with one liter of 0.9 per cent NaCl on an IBM cell processor have an average hematocrit of 72.2 per cent, with 84.7 per cent of the white blood cells removed, and only 0.6 per cent of the original total protein remaining. The red blo...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1976.16577039304.x
更新日期:1976-09-01 00:00:00