Factors affecting umbilical cord blood stem cell suitability for transplantation in an in utero collection program.

Abstract:

BACKGROUND:The greatest limiting factor in the use of umbilical cord blood (UCB) for transplantations is the number of stem cells available in any given collected unit. This study examines maternal, neonatal, and obstetric factors that influence the suitability for banking and transplantation of UCB units collected in utero. STUDY DESIGN AND METHODS:This study examined 7839 UCB units collected in utero at two hospitals from August 1, 2008, to August 31, 2011. The variables were collected from cord blood records, patient charts, delivery records, and data processed by StemCyte, Inc. (Covina, CA), our parent bank. The mean total nucleated cell (TNC) count between units selected for transplant and those banked but not selected for transplant were also compared. RESULTS:Of the 11 variables evaluated, six had a significant influence on the acceptable banking TNC count of at least 90 × 10(7) . Of these, cord blood volume was the best predictor. The other variables that were predictors of the acceptable TNC count of significance were gestational age, infant race, parity, birthweight, and infant sex. The minimal bankable TNC count for banking is considerably lower than the mean TNC count of units actually selected for transplantation. CONCLUSION:Maternal, neonatal, and obstetric factors can all influence the acceptability of a cord blood unit collected in utero for banking. Furthermore, units with high TNC counts are more likely to be selected for banking. Identifying these variables in potential donors can likely increase the number of adequate collections.

journal_name

Transfusion

journal_title

Transfusion

authors

Keersmaekers CL,Mason BA,Keersmaekers J,Ponzini M,Mlynarek RA

doi

10.1111/trf.12340

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

545-9

issue

3

eissn

0041-1132

issn

1537-2995

journal_volume

54

pub_type

杂志文章
  • Direct identification of Yersinia enterocolitica in blood by polymerase chain reaction amplification.

    abstract::Primers based on the nucleotide sequence of the virF gene in the pYV plasmid and the chromosomal ail gene were used in polymerase chain reaction (PCR) amplifications to directly identify Yersinia enterocolitica in blood. Approximately 500 bacteria seeded into 100 microL of blood can be extracted and amplified by PCR t...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1992.32993110759.x

    authors: Feng P,Keasler SP,Hill WE

    更新日期:1992-11-01 00:00:00

  • Red blood cell hemolysis during blood bank storage: using national quality management data to answer basic scientific questions.

    abstract:BACKGROUND:Hemolysis of red blood cells (RBCs) during blood bank storage is the most obvious manifestation of RBC storage system failure. However, its analysis is made difficult because the largest source of interunit difference is donor specific. Availability of data from national blood systems on large numbers of RBC...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02275.x

    authors: Hess JR,Sparrow RL,van der Meer PF,Acker JP,Cardigan RA,Devine DV

    更新日期:2009-12-01 00:00:00

  • The influence of bleeding on trigger changes for platelet transfusion in patients with chemotherapy-induced thrombocytopenia.

    abstract:BACKGROUND:For patients with thrombocytopenia without bleeding risk factors, a platelet transfusion trigger of 10 × 10(9) /L is recommended. No studies have evaluated the clinicians' decision-making process leading to trigger changes. STUDY DESIGN AND METHODS:We report on the evaluation of trigger changes and the rela...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2012.03727.x

    authors: Rioux-Massé B,Laroche V,Bowman RJ,Lindgren BR,Cohn CS,Pulkrabek SM,McCullough J

    更新日期:2013-02-01 00:00:00

  • Hepatitis E virus antibody prevalence, RNA frequency, and genotype among blood donors in Cambodia (Southeast Asia).

    abstract:BACKGROUND:Recent studies conducted in developed countries described hepatitis E virus (HEV) as an emerging infectious threat to blood safety. However, data on HEV among blood donors from southeast Asia are lacking. STUDY DESIGN AND METHODS:Between July and August 2014, we assessed the presence of HEV immunoglobulin (...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13731

    authors: Nouhin J,Prak S,Madec Y,Barennes H,Weissel R,Hok K,Pavio N,Rouet F

    更新日期:2016-10-01 00:00:00

  • Co-presence of a point mutation and a deletion of exon 3 in the glycophorin C gene and concomitant production of a Gerbich-related antibody.

    abstract:BACKGROUND:Antigens of the human blood group system Gerbich (Ge) are located on sialoglycoproteins glycophorin C (GPC) and glycophorin D (GPD). CASE REPORT:The Ge+ proposita (RW) produced an alloanti-Ge after receiving 2 units of red cells (RBCs) during surgery. Further studies were carried out to characterize the ant...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1997.371098016440.x

    authors: King MJ,Kosanke J,Reid ME,Poole J,Banks J,Hemming NJ,Smythe J,Martin PG

    更新日期:1997-10-01 00:00:00

  • Glucose-6-phosphate dehydrogenase activity decreases during storage of leukoreduced red blood cells.

    abstract:BACKGROUND:During storage, the activity of the red blood cell (RBC) antioxidant system decreases. Glucose-6-phosphate dehydrogenase (G6PD) is essential for protection against oxidative stress by producing NADPH. G6PD function of RBC transfusion products is reported to remain stable during storage, but activity was meas...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13378

    authors: Peters AL,van Bruggen R,de Korte D,Van Noorden CJ,Vlaar AP

    更新日期:2016-02-01 00:00:00

  • Hemotherapy bedside biovigilance involving vital sign values and characteristics of patients with suspected transfusion reactions associated with fluid challenges: can some cases of transfusion-associated circulatory overload have proinflammatory aspects?

    abstract:BACKGROUND:Monitoring of patients' vital sign values (VSVs) during hemotherapy may have an important role in the recognition and mitigation of transfusion-associated circulatory overload (TACO). Knowledge regarding VSVs and other patient characteristics in bedside-reported TACO or fluid challenge-suspected transfusion ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03595.x

    authors: Andrzejewski C Jr,Popovsky MA,Stec TC,Provencher J,O'Hearn L,Visintainer P,Steingrub J

    更新日期:2012-11-01 00:00:00

  • Isolation of Kell-active protein from the red cell membrane.

    abstract::Kell blood-group-active protein has been isolated by labeling red cell surface proteins with 125I, sensitizing intact cells with anti-K1, anti-K2, anti-K7, or anti-K22, solubilizing the cell membranes, isolating immune complexes, and separating their components by sodium dodecyl sulfate polyacrylamide gel electrophore...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1984.24284173356.x

    authors: Redman CM,Marsh WL,Mueller KA,Avellino GP,Johnson CL

    更新日期:1984-03-01 00:00:00

  • Quality of freeze-dried (lyophilized) quarantined single-donor plasma.

    abstract:BACKGROUND:Transfusion of plasma is a basic treatment for complex coagulopathies as well as in major blood loss. Early transfusion of plasma after trauma with major hemorrhage has been recommended by retrospective studies. However, the use of plasma is often hampered by the need to maintain a cold chain and the time ne...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12191

    authors: Bux J,Dickhörner D,Scheel E

    更新日期:2013-12-01 00:00:00

  • Five-day storage of platelets in a non-diethylhexyl phthalate-plasticized container.

    abstract::A non-diethylhexyl phthalate (DEHP)-plasticized blood bag for 5-day storage of random-donor platelet concentrates has been developed. The plastic bag is composed of polyvinylchloride plastic with a butyryl trihexyl citrate plasticizer. The suitability of this plastic for the storage of platelet concentrates for use in...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1537-2995.1992.32893032101.x

    authors: Snyder EL,Aster RH,Heaton A,Grode G,Napychank P,Kagen L,Jefferies LC,Hedberg S,Buchholz DH

    更新日期:1992-10-01 00:00:00

  • Human T-lymphotropic virus and transfusion safety: does one size fit all?

    abstract::Human T-cell leukemia viruses (HTLV-1 and HTLV-2) are associated with a variety of human diseases, including some severe ones. Transfusion transmission of HTLV through cellular blood components is undeniable. HTLV screening of blood donations became mandatory in different countries to improve the safety of blood suppl...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.13329

    authors: Marano G,Vaglio S,Pupella S,Facco G,Catalano L,Piccinini V,Liumbruno GM,Grazzini G

    更新日期:2016-01-01 00:00:00

  • Evidence of an anti-A1 inhibited by EDTA.

    abstract::EDTA is added to some commercial A and B cells as a means of preventing hemolysis in serum testing. Unexpected results in serum testing have been reported with EDTA-dependent agglutinins, but not with agglutinins inhibited by EDTA. A serum sample was found to contain an anti-A1 undetected by serum testing, but resulti...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28288179026.x

    authors: Tedrow HE,Zeigler ZR

    更新日期:1988-03-01 00:00:00

  • A microplate system for ABO and Rh(D) blood grouping.

    abstract::A microplate system for performing ABO and Rh(D) blood group determinations with a Kemble Kemtek 1000SP liquid handling processor, an Anthos 2001 microplate reader, an IBM Personal System 2 microcomputer, and Sanguin Forma software is described. The performance of this Kemble/Anthos/IBM/Sanguin microplate system for A...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.33593255597.x

    authors: Chung A,Birch P,Ilagan K

    更新日期:1993-05-01 00:00:00

  • Alteration of red cell aggregability and shape during blood storage.

    abstract:BACKGROUND:Storage of blood units (for 35-42 days, depending on the preservative solution) has been reported to induce changes (e.g., reduction of sialic acid level) in red cells that are expected to alter their aggregability. STUDY DESIGN AND METHODS:The aggregability of stored red cells was monitored in their autolo...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1999.39399219284.x

    authors: Hovav T,Yedgar S,Manny N,Barshtein G

    更新日期:1999-03-01 00:00:00

  • Effective use of a strategy using assigned red cell units to limit donor exposure for neonatal patients.

    abstract::Critically ill neonatal infants receive frequent small-volume red cell (RBC) transfusions for replacement of blood drawn for laboratory analysis or for treatment of symptomatic anemia secondary to underlying medical conditions and/or a relative bleeding diathesis. Retrospective review of transfusion practice in a hosp...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.33593255596.x

    authors: Cook S,Gunter J,Wissel M

    更新日期:1993-05-01 00:00:00

  • Partial C antigen in sickle cell disease patients: clinical relevance and prevention of alloimmunization.

    abstract:BACKGROUND:Partial Rh antigens have been widely described in black individuals. Carriers are prone to immunization when exposed to the normal antigens. In sickle cell disease (SCD), patient alloimmunization is a major cause of transfusion failure. The potential of individuals with partial C antigen to make anti-C has n...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02382.x

    authors: Tournamille C,Meunier-Costes N,Costes B,Martret J,Barrault A,Gauthier P,Galactéros F,Nzouékou R,Bierling P,Noizat-Pirenne F

    更新日期:2010-01-01 00:00:00

  • The accumulation of mono-2-ethylhexylphthalate (MEHP) during storage of whole blood and plasma.

    abstract::The accumulation of the plasticizer di-2-ethylhexylphthalate (DEHP) in blood and blood components has been of considerable concern for some time. We have followed the accumulation of DEHP and one of its major metabolities, mono-2-ethylhexylphthalate (MEHP) during storage of whole blood, platelet-rich plasma, platelet ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18579036383.x

    authors: Rock G,Secours VE,Franklin CA,Chu I,Villeneuve DC

    更新日期:1978-09-01 00:00:00

  • Difficulty in LW typing as revealed by a family study.

    abstract::A family is described in which two members of the second generation are of the phenotype LW3. In the course of the investigation the mother of the LW3 propositus was at first believed to be phenotypically LW3 as well. Eventually, it was shown that she is, in fact, phenotypically LW2 but that her R-1 (no D), LWlw, geno...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18478251248.x

    authors: Behzad O,Pothiawala M,Rolih SD,Issitt PD,Lee CL

    更新日期:1978-07-01 00:00:00

  • Inositol hexaphosphate-loaded red blood cells prevent in vitro sickling.

    abstract:BACKGROUND:Hypoxia is a major cause of painful vaso-occlusive crisis in sickle cell disease (SCD). Simple transfusion and red blood cell (RBC) exchange are commonly used as preventive therapies whose aim is to dilute hemoglobin (Hb)S-containing RBCs (SS-RBCs) with normal RBCs (AA-RBCs) to prevent sickling. We hypothesi...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02663.x

    authors: Bourgeaux V,Hequet O,Campion Y,Delcambre G,Chevrier AM,Rigal D,Godfrin Y

    更新日期:2010-10-01 00:00:00

  • The Brazilian experience of nucleic acid testing to detect human immunodeficiency virus, hepatitis C virus, and hepatitis B virus infections in blood donors.

    abstract:BACKGROUND:The history of the development and implementation of the Brazilian nucleic acid testing (NAT) platform to detect and discriminate among human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) infections in blood donors is described here. The results for the sensitivity, repro...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14478

    authors: Rocha D,Andrade E,Godoy DT,Fontana-Maurell M,Costa E,Ribeiro M,Ferreira AGP,Brindeiro R,Tanuri A,Alvarez P

    更新日期:2018-04-01 00:00:00

  • Coagulopathy after traumatic brain injury: incidence, pathogenesis, and treatment options.

    abstract::Coagulopathy after traumatic brain injury (TBI) is frequent and represents a powerful predictor related to outcome and prognosis. The complex pathophysiological mechanisms of the coagulopathy of TBI are multifactorial and remain still undefined. The nature of the coagulation abnormalities differs between severe TBI an...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.12033

    authors: Maegele M

    更新日期:2013-01-01 00:00:00

  • Administrative and research policies required to bring cellular therapies from the research laboratory to the patient's bedside.

    abstract::The research process is a balance between the inherent risks of new discoveries and the risks of research participant safety. Conflicts of interest, inherent to the research process, as well as those introduced by emerging cellular therapies, have the potential to compromise safety. The relationship of trust between t...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2005.00616.x

    authors: Yim R

    更新日期:2005-10-01 00:00:00

  • Genetic mechanisms of Rhesus box variation.

    abstract:BACKGROUND:The RHD gene is flanked by two highly homologous DNA segments of approximately 9000 bp, the upstream and downstream Rhesus boxes. In haplotypes with an RHD deletion, the fusion of the two Rhesus boxes generates the single-hybrid Rhesus box, the detection of which has been applied for RHD zygosity determinati...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.04339.x

    authors: Wagner FF,Moulds JM,Flegel WA

    更新日期:2005-03-01 00:00:00

  • Ammonia accumulation in platelet concentrates during storage.

    abstract::Newly prepared platelet concentrates (PC) and platelet poor plasma (PPP) stored at either room temperature (RT) or 4 C were analyzed for ammonia content initially, and after storage at 24, 48, and 72 hours. These studies demonstrate that ammonia rapidly accumulates in PC stored at RT. This accumulation appears to be t...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:

    authors: Ukrainski CT,Goldfinger D,Pomerance JJ,Lee HC,Farber S,Sanchez R

    更新日期:1981-01-01 00:00:00

  • Blood groups: the past 50 years.

    abstract::Since the first issue of TRANSFUSION in 1961, there has been a tremendous expansion in not only the number of blood group antigens identified but also in our knowledge of their biochemical basis, function, and more recently, associated DNA changes. As certain techniques became available, our ability to discover and el...

    journal_title:Transfusion

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1537-2995.2009.02456.x

    authors: Daniels G,Reid ME

    更新日期:2010-02-01 00:00:00

  • Evaluation of combined idarucizumab and prothrombin complex concentrate treatment for bleeding related to dabigatran in a lethal porcine model of double trauma.

    abstract:BACKGROUND:Idarucizumab (IDA) is approved for emergency reversal of dabigatran; prothrombin complex concentrates (PCCs) are recommended in the absence of specific antidote. The combined effects of IDA and PCC in trauma-related bleeding are unknown. The efficacy and safety of combined IDA + PCC were assessed in a lethal...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15117

    authors: Honickel M,Braunschweig T,Rossaint R,Schöchl H,Grottke O

    更新日期:2019-04-01 00:00:00

  • Two-year follow-up of donors in a large national study of ferritin testing.

    abstract:BACKGROUND:We assessed donor return rates, donation frequency, and factors related to the evolution of ferritin levels 2 years after entering donors into a large operational study of ferritin testing. STUDY DESIGN AND METHODS:Ferritin testing was done on donors from representative clinics (n = 12,595). Low-ferritin do...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/trf.14941

    authors: Goldman M,Uzicanin S,Osmond L,Yi QL,Scalia V,O'Brien SF

    更新日期:2018-12-01 00:00:00

  • Benefits to blood banks of a sales and operations planning process.

    abstract::A formal sales and operations planning (S&OP) process is a decision making and communication process that balances supply and demand while integrating all business operational components with customer-focused business plans that links high level strategic plans to day-to-day operations. Furthermore, S&OP can assist in...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02945.x

    authors: Keal DA,Hebert P

    更新日期:2010-12-01 00:00:00

  • Red blood cells stored for increasing periods produce progressive impairments in nitric oxide-mediated vasodilation.

    abstract:BACKGROUND:Clinical outcomes in transfused patients may be affected by the duration of blood storage, possibly due to red blood cell (RBC)-mediated disruption of nitric oxide (NO) signaling, a key regulator of vascular tone and blood flow. STUDY DESIGN AND METHODS:AS-1 RBC units stored up to 42 days were sampled at se...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12111

    authors: Alexander JT,El-Ali AM,Newman JL,Karatela S,Predmore BL,Lefer DJ,Sutliff RL,Roback JD

    更新日期:2013-11-01 00:00:00

  • Accuracy of hepatitis C virus core antigen testing in pools among seroconverters.

    abstract:BACKGROUND:Screening blood units for hepatitis C virus (HCV) with nucleic acid testing (NAT) reduces the risk associated with the long "window period" (8-9 weeks) after HCV infection. The feasibility of adding the HCV core antigen assay in pools to the existing anti-HCV individual screening was examined as an alternati...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00972.x

    authors: Beer N,Shinar E,Novack L,Safi J,Soliman H,Yaari A,Goldman-Levi R,Yahalom V,Bolotin A,Sarov B

    更新日期:2006-10-01 00:00:00