Two-year follow-up of donors in a large national study of ferritin testing.

Abstract:

BACKGROUND:We assessed donor return rates, donation frequency, and factors related to the evolution of ferritin levels 2 years after entering donors into a large operational study of ferritin testing. STUDY DESIGN AND METHODS:Ferritin testing was done on donors from representative clinics (n = 12,595). Low-ferritin donors (<25 μg/L) were informed and not called for 6 months to book a donation. Approximately 37% of donors had ferritin retested on a return donation. Return rate and donation frequency were monitored, and a logistic regression model was constructed. RESULTS:The return rate was lower in low-ferritin donors (67% vs. 78%), particularly in women who were first-time donors (36% vs. 61%). Returning low-ferritin donors made fewer donations in the 2 years after notification compared to the 2 years prenotification (4.5 vs. 7.5 for men, 3.0 vs. 5.0 for women), while donation frequency was lower and increased slightly for normal-ferritin donors (4.7 vs. 4.4 for men, 3.6 vs. 3.1 for women). An increased number of donations, shorter interdonation intervals, female sex, and younger age are associated with low ferritin levels on initial and repeat testing. Some recovery of ferritin occurred, but most low-ferritin donors continued to have low or borderline levels on retesting. CONCLUSION:Informing donors of low ferritin results had a long-lasting impact on return rates and donation frequency, requiring recruitment efforts to maintain adequacy of supply. Increasing the interdonation interval leads to some improvement in ferritin levels; more sustained efforts to encourage donors to improve iron intake are needed to achieve long-term benefit.

journal_name

Transfusion

journal_title

Transfusion

authors

Goldman M,Uzicanin S,Osmond L,Yi QL,Scalia V,O'Brien SF

doi

10.1111/trf.14941

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

2868-2873

issue

12

eissn

0041-1132

issn

1537-2995

journal_volume

58

pub_type

杂志文章,多中心研究,随机对照试验
  • Prospective-concurrent audits and medical consultation for platelet transfusions.

    abstract::Prospective-concurrent audits and medical consultation were associated with a 56 percent decrease in the use of platelet concentrates at a tertiary care medical center. This study documents that mandatory pretransfusion review of component requests can alter hospital transfusion practices. ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27287150198.x

    authors: Simpson MB

    更新日期:1987-03-01 00:00:00

  • Anaphylaxis after treatment with recombinant factor VIII.

    abstract:BACKGROUND:Treatment of hemophilia patients with recombinant factor VIII concentrates has not previously been associated with anaphylaxis. STUDY DESIGN AND METHODS:A 5-week-old boy with severe hemophilia A developed dyspnea, cyanosis, hypotension, and a diffuse urticarial rash following treatment with a recombinant fa...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1996.36496226153.x

    authors: Shopnick RI,Kazemi M,Brettler DB,Buckwalter C,Yang L,Bray G,Gomperts ED

    更新日期:1996-04-01 00:00:00

  • Effect of delayed centrifugation or reading on the detection of ABO incompatibility by the immediate-spin crossmatch.

    abstract::The immediate-spin (IS) crossmatch is a method that detects ABO incompatibility. However, under certain circumstances, this test may show unwanted negative or weak results, even though the red cells (RBCs) and serum being tested are ABO incompatible with each other. The present study investigated the potential effect ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31391165166.x

    authors: Shulman IA,Calderón C

    更新日期:1991-03-01 00:00:00

  • Development of a rapid emergency hemorrhage panel.

    abstract:BACKGROUND:Evaluation of hemostasis in bleeding patients requires both accuracy and speed. STUDY DESIGN AND METHODS:As an alternative to point-of-care testing, we developed an emergency hemorrhage panel (EHP: prothrombin time [PT], fibrinogen, platelet count, hematocrit) for use in making transfusion decisions on blee...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02753.x

    authors: Chandler WL,Ferrell C,Trimble S,Moody S

    更新日期:2010-12-01 00:00:00

  • A sensitive quantitative single-platform flow cytometry protocol to measure human platelets in mouse peripheral blood.

    abstract:BACKGROUND:The NOD/SCID mouse is a widely used model for human cord blood (CB) transplantation. Engraftment is generally estimated with semiquantitative methods, measuring the percentage of human cells among mouse cells. To compare protocols aiming to improve hematopoietic recovery, quantitative methods to enumerate hu...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01472.x

    authors: Schipper LF,van Hensbergen Y,Fibbe WE,Brand A

    更新日期:2007-12-01 00:00:00

  • Evidence of acute primary occult hepatitis B virus infection in an Italian repeat blood donor.

    abstract:BACKGROUND:Preliminary evidence of cases of acute occult hepatitis B virus (HBV) infection (OBI) has been recently reported in the literature. Furthermore, OBI definition has been the object of an international consensus conference. STUDY DESIGN AND METHODS:A case of acute primary OBI was identified and followed up in...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.02041.x

    authors: Manzini P,Abate ML,Valpreda C,Milanesi P,Curti F,Rizzetto M,Smedile A

    更新日期:2009-04-01 00:00:00

  • Pediatric transfusion medicine: development of a critical mass.

    abstract::Many significant events have occurred in the recent past that beg a broad audience to address the question "What is pediatric transfusion medicine?" Herein, we list some of these events and their relevance below and attempt to provide an answer for this question. Indeed, several issues regarding the subspecialty of pe...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.02015.x

    authors: Hillyer CD,Mondoro TH,Josephson CD,Sanchez R,Sloan SR,Ambruso DR

    更新日期:2009-03-01 00:00:00

  • Quantitation of passively acquired human immunodeficiency virus (HIV) antibodies in AIDS patients transfused with a plasma that is rich in HIV antibodies.

    abstract:BACKGROUND:Passive immunotherapy in human immunodeficiency virus (HIV) infection is based on transfusions of plasma that is rich in HIV antibodies. STUDY DESIGN AND METHODS:To verify whether the clearance of transfused antibodies will maintain an elevated titer of specific antibodies between biweekly transfusions of p...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1996.36896374379.x

    authors: Lefrère JJ,Roudot-Thoraval F,Vittecoq D,Heshmati F,Audat F,Lerable J,Reed D,Petit JC,Burghoffer B,Morand-Joubert L

    更新日期:1996-08-01 00:00:00

  • Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities.

    abstract:BACKGROUND:Fresh-frozen plasma (FFP) is frequently transfused to patients with mild prolongation of coagulation values under the assumption that FFP will correct the coagulopathy. There is little evidence to support this practice, however. To determine the effect of FFP on coagulation variables and correlation with ble...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00891.x

    authors: Abdel-Wahab OI,Healy B,Dzik WH

    更新日期:2006-08-01 00:00:00

  • Radioactive antiglobulin testing with 125I anti-C4 and anti-C3.

    abstract::The report describes methods for quantitating C4 and C3 coating of red blood cells using 125I anti-C4 and anti-C3. Two methods of preparing antisera were used; one involving absorption and elution from complement coated cells, and the other employing IgG fractions of antisera prepared on DEAE cellulose. White-cell-fre...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18478251233.x

    authors: Jenkins DE Jr,Johnson RM,Moore WH

    更新日期:1978-07-01 00:00:00

  • A fluorometric assay for red blood cell antibodies.

    abstract::A fluorometric assay is described for the detection of red blood cell antibodies. The assay reveals as little as 600 molecules of bound, fluoresceinated rabbit anti-human IgG antibodies per erythrocyte. Eleven patients with possible autoimmune erythrocyte disorder and negative direct antiglobulin test were studied by ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1981.21281178153.x

    authors: Schreiber AB,Lambermont M,Strosberg AD,Wybran J

    更新日期:1981-03-01 00:00:00

  • Risk factors for HCV infection among blood donors confirmed to be positive for the presence of HCV RNA and not reactive for the presence of anti-HCV.

    abstract:BACKGROUND:In 1999, NAT of blood donations was implemented to detect "window-period" infections. Blood donors who have confirmed NAT results positive for the presence of HCV in the absence of anti-HCV are likely to have been recently infected. Of over 26.8 million donations tested between March 3, 1999, and March 31, 2...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.00623.x

    authors: Orton SL,Stramer SL,Dodd RY,Alter MJ

    更新日期:2004-02-01 00:00:00

  • Adequacy of physician documentation and correlation with assessment of transfusion appropriateness: a follow-up study in the setting of prospective audits and patient blood management.

    abstract:BACKGROUND:A previous study in our hospitals correlated suboptimal documentation and failure to justify transfusions. In light of implemented blood-conservation strategies, including patient blood management (PBM) and prospective audits (PAs), we performed a follow-up study. STUDY DESIGN AND METHODS:We reviewed prospe...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/trf.13917

    authors: Madrigal E,Prajapati S,Avadhani V,Annen K,Friedman MT

    更新日期:2017-02-01 00:00:00

  • Effective storage of granulocytes collected by centrifugation leukapheresis from donors stimulated with granulocyte-colony-stimulating factor.

    abstract:BACKGROUND:Donor stimulation with granulocyte-colony-stimulating factor (G-CSF) has increased the number of neutrophils (PMNs) that can be collected for granulocyte transfusion therapy. Clinical utility, however, has been limited by the inability to store functional PMNs ex vivo. This study was conducted to determine w...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2005.00636.x

    authors: Hubel K,Rodger E,Gaviria JM,Price TH,Dale DC,Liles WC

    更新日期:2005-12-01 00:00:00

  • Evaluation of a prototype Trypanosoma cruzi antibody assay with recombinant antigens on a fully automated chemiluminescence analyzer for blood donor screening.

    abstract:BACKGROUND:Chagas disease is caused by Trypanosoma cruzi, a protozoan parasite that can be transmitted by transfusion. The diagnosis of chronic T. cruzi infection is generally made by detecting specific antibodies that bind to parasite antigens. The aim of this study was to assess the sensitivity and specificity of a n...

    journal_title:Transfusion

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1537-2995.2006.00965.x

    authors: Chang CD,Cheng KY,Jiang LX,Salbilla VA,Haller AS,Yem AW,Bryant JD,Kirchhoff LV,Leiby DA,Schochetman G,Shah DO

    更新日期:2006-10-01 00:00:00

  • A possible role for the production of multiple HLA antibodies in fatal platelet transfusion refractoriness after peripheral blood progenitor cell transplantation from the mother in a patient with relapsed leukemia.

    abstract:BACKGROUND:There has been controversy over whether HLA alloimmunization is a risk factor for platelet (PLT) transfusion refractoriness (PTR) in hematopoietic peripheral blood progenitor cell transplantation (HPBPCT). STUDY DESIGN AND METHODS:Reported here is a boy with relapsed leukemia who developed fatal PTR after a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01109.x

    authors: Nakazawa Y,Saito S,Hasegawa Y,Yanagisawa R,Sakashita K,Kamijo T,Miyazaki T,Sato S,Ikeda H,Ikebuchi K,Koike K

    更新日期:2007-02-01 00:00:00

  • Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation.

    abstract:BACKGROUND:A recently published study has reported that donor-recipient Rhesus (Rh)-mismatched allogeneic hematopoietic stem cell transplantation independently led to significantly poorer survival. This suggests that donor-recipient Rh mismatching is a risk factor in allogeneic hematopoietic stem cell transplantation a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01501.x

    authors: Wirk B,Klumpp TR,Ulicny J,Herman JH,Gajewski JL,Martin ME,Emmons RV,Mangan KF

    更新日期:2008-01-01 00:00:00

  • Red cell alloantibodies in thalassemia major. Results of an Italian cooperative study.

    abstract::Clinical and serological data on 1435 Italian thalassemia major patients were collected during a cooperative study involving 19 centers in 10 regions. The main findings were as follows: 18 percent of the patients were under 6 years of age, 63 percent between 6 and 15, and 19 percent over 15. Forty-one percent had unde...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25285169198.x

    authors: Sirchia G,Zanella A,Parravicini A,Morelati F,Rebulla P,Masera G

    更新日期:1985-03-01 00:00:00

  • Severe hemolysis resulting from D incompatibility in a case of ABO-identical liver transplant.

    abstract:BACKGROUND:Hemolysis due to D incompatibility in the setting of liver transplantation is less frequent than that associated with ABO incompatibility, but can represent an equally adverse event. Approximately 10 percent of ABO-compatible liver transplants involve a D- donor and a D+ recipient. CASE REPORT:A case of sev...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.03382.x

    authors: Fung MK,Sheikh H,Eghtesad B,Lopez-Plaza I

    更新日期:2004-11-01 00:00:00

  • Prospective randomized and crossover comparison of two apheresis machines for peripheral blood stem cell collection: a multicenter study.

    abstract:BACKGROUND:Improving apheresis technology may lead to an efficient and safe peripheral blood stem cell (PBSC) collection. Recently, the Spectra Optia (Optia, Terumo BCT) was introduced as an automated apheresis instrument, but comparisons with other instruments have been few. This is the first randomized multicenter an...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/trf.13777

    authors: Ikeda K,Minakawa K,Muroi K,Fujiwara SI,Yamada-Fujiwara M,Fujimori Y,Tanosaki R,Ohto H,Study Group for Peripheral Blood Stem Cell Collection, Cell Therapy Committee, The Japan Society of Transfusion Medicine and Cell Therapy.

    更新日期:2016-11-01 00:00:00

  • Liquid storage of marrow stromal cells.

    abstract:BACKGROUND:Marrow stromal cells (MSCs) for clinical trials are inevitably stored before administration, but little is known about the effects of storage on MSCs. The effects of short-term liquid storage on the in vitro function of MSCs intended for a clinical trial were studied. STUDY DESIGN AND METHODS:Early-passage ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02138.x

    authors: Lane TA,Garls D,Mackintosh E,Kohli S,Cramer SC

    更新日期:2009-07-01 00:00:00

  • Effect of vitamin K administration on rate of warfarin reversal.

    abstract:BACKGROUND:Vitamin K is reported to begin reversing warfarin within 6 to 12 hours, but this may occur sooner. We sought to determine the rate of international normalized ratio (INR) reversal following vitamin K and relationships with dose, route, and baseline INR. METHODS:We evaluated adult patients receiving vitamin ...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/trf.15146

    authors: Polito NB,Kanouse E,Jones CMC,McCann M,Refaai MA,Acquisto NM

    更新日期:2019-04-01 00:00:00

  • Partial C antigen in sickle cell disease patients: clinical relevance and prevention of alloimmunization.

    abstract:BACKGROUND:Partial Rh antigens have been widely described in black individuals. Carriers are prone to immunization when exposed to the normal antigens. In sickle cell disease (SCD), patient alloimmunization is a major cause of transfusion failure. The potential of individuals with partial C antigen to make anti-C has n...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02382.x

    authors: Tournamille C,Meunier-Costes N,Costes B,Martret J,Barrault A,Gauthier P,Galactéros F,Nzouékou R,Bierling P,Noizat-Pirenne F

    更新日期:2010-01-01 00:00:00

  • Red blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease.

    abstract:BACKGROUND:Despite the clinical significance of red blood cell (RBC) alloantibodies, there are currently no laboratory tests available to predict which patients may be at risk of antibody formation after transfusion exposure. Given their phagocytic and inflammatory functions, we hypothesized that differences in circula...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15463

    authors: Balbuena-Merle R,Curtis SA,Devine L,Gibb DR,Karafin MS,Luckey CJ,Tormey CA,Siddon AJ,Roberts JD,Hendrickson JE

    更新日期:2019-10-01 00:00:00

  • Analysis of platelet-derived extracellular vesicles in plateletpheresis concentrates: a multicenter study.

    abstract:BACKGROUND:Routine quantification of platelet-derived extracellular vesicles (PL-EVs) may be useful in the quality control (QC) of platelet concentrates (PCs). The aim of this multicenter study was to establish and validate a consensus protocol for the standardized PL-EV quantification using conventional flow cytometer...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/trf.14109

    authors: Black A,Orsó E,Kelsch R,Pereira M,Kamhieh-Milz J,Salama A,Fischer MB,Meyer E,Frey BM,Schmitz G

    更新日期:2017-06-01 00:00:00

  • Geographic exposure risk of variant Creutzfeldt-Jakob disease in US blood donors: a risk-ranking model to evaluate alternative donor-deferral policies.

    abstract:BACKGROUND:Variant Creutzfeldt-Jakob disease (vCJD) has been transmitted by blood transfusion (TTvCJD). The US Food and Drug Administration (FDA) recommends deferring blood donors who resided in or traveled to 30 European countries where they may have been exposed to bovine spongiform encephalopathy (BSE) through beef ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13971

    authors: Yang H,Huang Y,Gregori L,Asher DM,Bui T,Forshee RA,Anderson SA

    更新日期:2017-04-01 00:00:00

  • Trends in red blood cell transfusion and 30-day mortality among hospitalized patients.

    abstract:BACKGROUND:Blood conservation strategies have been shown to be effective in decreasing red blood cell (RBC) utilization in specific patient groups. However, few data exist describing the extent of RBC transfusion reduction or their impact on transfusion practice and mortality in a diverse inpatient population. STUDY D...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/trf.12825

    authors: Roubinian NH,Escobar GJ,Liu V,Swain BE,Gardner MN,Kipnis P,Triulzi DJ,Gottschall JL,Wu Y,Carson JL,Kleinman SH,Murphy EL,NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III).

    更新日期:2014-10-01 00:00:00

  • Successful kidney transplantation in a patient with congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome).

    abstract:BACKGROUND:Congenital thrombotic thrombocytopenic purpura (TTP) may not be recognized until organ failure related to the microvascular thrombosis occurs. Kidney failure may be the initial presenting clinical feature. Kidney transplantation has been contraindicated because of the assumption that the continuing microvasc...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.14326

    authors: Fattah H,Kumar D,George JN,Massey HD,King AL,Friedman KD,Gupta G

    更新日期:2017-12-01 00:00:00

  • Rapid identification of microorganisms from platelet concentrates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry after short-term incubation on liquid medium.

    abstract:BACKGROUND:Platelets (PLTs) are especially affected by the risk of bacterial contamination. Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) is an accurate method for the routine identification of bacterial isolates in microbiology laboratories. We directly applied the MALDI-TOF method to bacteria...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14430

    authors: Chetouane Y,Dubourg G,Gallian P,Flaudrops C,Chiaroni J,Chabrière E,Raoult D,Camoin-Jau L

    更新日期:2018-03-01 00:00:00

  • Red blood cell hemolysis during blood bank storage: using national quality management data to answer basic scientific questions.

    abstract:BACKGROUND:Hemolysis of red blood cells (RBCs) during blood bank storage is the most obvious manifestation of RBC storage system failure. However, its analysis is made difficult because the largest source of interunit difference is donor specific. Availability of data from national blood systems on large numbers of RBC...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02275.x

    authors: Hess JR,Sparrow RL,van der Meer PF,Acker JP,Cardigan RA,Devine DV

    更新日期:2009-12-01 00:00:00