Multiple hemolytic transfusion reactions misinterpreted as severe vaso-occlusive crisis in a patient with sickle cell disease.

Abstract:

BACKGROUND:Hemolytic transfusion reactions are a rare, yet serious complication of red blood cell (RBC) transfusion. Patients with sickle cell disease (SCD) are at an increased risk for such reactions, because they are prone to make alloantibodies against transfused RBCs, complicating this integral part of their disease management. These reactions may be missed, and the patient's state may be attributed to vaso-occlusive crisis (VOC), with misguided therapy ensuing. CASE REPORT:Herein, we report the clinical course of a patient with complex SCD with a delayed hemolytic transfusion reaction, followed by multiple acute hemolytic transfusion reactions mistaken for severe VOC. These reactions were diagnosed on retrospective review of the patient's clinical course in consult with the transfusion medicine service. Optimal immunosuppressive therapy ensued and resulted in the stabilization of the anemia and hemolysis laboratory values. Despite these efforts, the patient died 2 months after admission. CONCLUSION:This case provides insight into some of the challenges of managing patients with SCD with multiple comorbidities. Hemolytic transfusion reactions can be difficult to diagnose and may be overlooked in patients with SCD with severe VOC.

journal_name

Transfusion

journal_title

Transfusion

authors

Dean CL,Maier CL,Roback JD,Stowell SR

doi

10.1111/trf.15010

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

448-453

issue

2

eissn

0041-1132

issn

1537-2995

journal_volume

59

pub_type

杂志文章
  • Fatal erythroderma (suspected graft-versus-host disease) after cholecystectomy. Retrospective analysis.

    abstract::Fatal postoperative erythroderma (POE) developed in a 52-year-old woman with gallstones who underwent elective cholecystectomy. During surgery, she was transfused with 3 units of unirradiated packed red cells stored in the liquid state for at least 4 days after collection. The POE is believed to have been the result o...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1989.29689318456.x

    authors: Otsuka S,Kunieda K,Hirose M,Takeuchi H,Mizutani Y,Nagaya M,Sato G,Kasuya S,Matsutomo K,Noma A

    更新日期:1989-07-01 00:00:00

  • Clinical outcomes among low-titer group O whole blood recipients compared to recipients of conventional components in civilian trauma resuscitation.

    abstract:BACKGROUND:The serological safety of transfusing ≤4 units of low titer group O whole blood (LTOWB) in civilian trauma patients has been demonstrated. This study investigated clinical outcomes of LTOWB recipients compared to patients who received only conventional blood components during their resuscitation. STUDY DESI...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14779

    authors: Seheult JN,Anto V,Alarcon LH,Sperry JL,Triulzi DJ,Yazer MH

    更新日期:2018-08-01 00:00:00

  • Establishment of an unrelated umbilical cord blood bank qualification program: ensuring quality while meeting Food and Drug Administration vendor qualification requirements.

    abstract:BACKGROUND:Qualification of a cord blood bank (CBB) is a complex process that includes evaluation of multiple aspects of donor screening and testing, processing, accreditation and approval by professional cell therapy groups, and results of received cord blood units. The University of Minnesota Medical Center Cell Ther...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12085

    authors: Rabe F,Kadidlo D,Van Orsow L,McKenna D

    更新日期:2013-10-01 00:00:00

  • Retrograde transmission of Proteus mirabilis during platelet transfusion and the use of arbitrarily primed polymerase chain reaction for bacteria typing in suspected cases of transfusion transmission of infection.

    abstract:BACKGROUND:When bacteria are found, after a platelet transfusion, in the recipient's blood as well as in the platelet concentrate (PC), a causal relationship is normally suspected, with the PC as the causative agent. The other alternative, that the patient has bacteremia and contaminated the PC, is less well documented...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1995.351096026371.x

    authors: Engstrand M,Engstrand L,Högman CF,Hambraeus A,Branth S

    更新日期:1995-10-01 00:00:00

  • Blood transfusion in acute and chronic pediatric settings: beliefs and practices.

    abstract:BACKGROUND:Blood has been imbued with powerful connotations through history and across cultures. Currently bestowed with scientific meaning, blood nevertheless carries symbolic resonance. This study examines these representations among practitioners and sheds light on the clinical and nonclinical factors that guide blo...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13352

    authors: Fortin S,Cardona LG,Latreille M,Tucci M,Lacroix J

    更新日期:2016-01-01 00:00:00

  • Differentiation of autologous ABO, RHD, RHCE, KEL, JK, and FY blood group genotypes by analysis of peripheral blood samples of patients who have recently received multiple transfusions.

    abstract:BACKGROUND:After multiple transfusions, the serologic typing of autologous blood group phenotypes is difficult, because of mixed RBC populations. The genotyping of ABO, Rh, Kell, Kidd, and Duffy systems could be used to determine autologous blood group antigen status. STUDY DESIGN AND METHODS:Blood samples from patien...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40080936.x

    authors: Rozman P,Dovc T,Gassner C

    更新日期:2000-08-01 00:00:00

  • How we handled the dextran shortage: an alternative washing or dilution solution for cord blood infusions.

    abstract::Dextran 40 is the main component of the solution used to wash or dilute thawed cord blood unit (CBU) products for stem cell transplant. Dextran 40 became unavailable in the United States as of April 2014. Like many other cellular therapy laboratories in the United States, we found ourselves with limited dextran 40 inv...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13015

    authors: Reich-Slotky R,Bachegowda LS,Ancharski M,Mendeleyeva L,Rubinstein P,Rennert H,Shore T,van Besien K,Cushing M

    更新日期:2015-06-01 00:00:00

  • The National Marrow Donor Program.

    abstract::As the number of successful marrow transplants has increased, the lack of HLA-identical sibling donors for 60 to 70 percent of transplant candidates has become a serious problem. Pilot studies established that marrow transplantation between phenotypically HLA-identical, unrelated individuals can be accomplished succes...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.33793325052.x

    authors: Stroncek D,Bartsch G,Perkins HA,Randall BL,Hansen JA,McCullough J

    更新日期:1993-07-01 00:00:00

  • Preparation and storage of platelet concentrates.

    abstract::A technique of platelet concentrate preparation and storage is presented which permits the maximum number of viable and functional platelets to be preserved for periods of 72 hours. Although the storage conditions must be followed precisely, the method is nevertheless simple to perform and does not require specialized...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1976.16176130842.x

    authors: Slichter SJ,Harker LA

    更新日期:1976-01-01 00:00:00

  • A nonenveloped virus with a lipid envelope: hepatitis A virus as used in virus-reduction studies.

    abstract:BACKGROUND:Recently, a quasi-lipid-enveloped (LE) form of the traditionally nonlipid-enveloped (NLE) hepatitis A virus (HAV) was described in human serum and cell culture-derived HAV stocks. This discovery challenges the understanding of HAV reduction in virus clearance studies of plasma products, which were performed ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14091

    authors: Kapsch AM,Farcet MR,Antoine G,Kreil TR

    更新日期:2017-06-01 00:00:00

  • Evaluation and comparison of coagulation factor activity in fresh-frozen plasma and 24-hour plasma at thaw and after 120 hours of 1 to 6°C storage.

    abstract:BACKGROUND:Current transfusion-related acute lung injury reduction strategies include avoiding transfusion of plasma products collected from female donors or female donors that have been pregnant to reduce transfusion of plasma-containing HLA antibodies. Such a policy considerably decreases the number of donors availab...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02198.x

    authors: Scott E,Puca K,Heraly J,Gottschall J,Friedman K

    更新日期:2009-08-01 00:00:00

  • Inactivation of Japanese encephalitis virus in plasma by methylene blue combined with visible light and in platelet concentrates by ultraviolet C light.

    abstract::Japanese encephalitis virus (JEV) is endemic to tropical areas in Asia and the Western Pacific. It can cause fatal encephalitis, although most infected individuals are asymptomatic. JEV is mainly transmitted to humans through the bite of an infected mosquito, but can also be transmitted through blood transfusion. To m...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16021

    authors: Rustanti L,Hobson-Peters J,Colmant AMG,Hall RA,Young PR,Reichenberg S,Tolksdorf F,Sumian C,Gravemann U,Seltsam A,Marks DC,Faddy HM

    更新日期:2020-11-01 00:00:00

  • Economic impact on US Medicare of a new diagnosis of myelodysplastic syndromes and the incremental costs associated with blood transfusion need.

    abstract:BACKGROUND:Recent retrospective studies suggest myelodysplastic syndromes (MDSs) are more common than previously recognized and patients who develop transfusional dependence may be at risk for increased comorbid complications. STUDY DESIGN AND METHODS:A retrospective review was undertaken of Medicare claims focusing o...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03626.x

    authors: Goldberg SL,Chen E,Sasane M,Paley C,Guo A,Laouri M

    更新日期:2012-10-01 00:00:00

  • Filtration leukapheresis: the influence of granulocyte counts upon the donors' yield.

    abstract::The purpose of this investigation was to determine the influence of granulocyte count on the yield of granulocytes. Healthy adult volunteer donors underwent filtration leukapheresis without premedication. The granulocyte count was measured before and immediately after the procedure. In 73 donors, there was an increase...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1979.19479250187.x

    authors: Kosmidis PA,Lewandowski S

    更新日期:1979-07-01 00:00:00

  • Severe hemolysis resulting from D incompatibility in a case of ABO-identical liver transplant.

    abstract:BACKGROUND:Hemolysis due to D incompatibility in the setting of liver transplantation is less frequent than that associated with ABO incompatibility, but can represent an equally adverse event. Approximately 10 percent of ABO-compatible liver transplants involve a D- donor and a D+ recipient. CASE REPORT:A case of sev...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.03382.x

    authors: Fung MK,Sheikh H,Eghtesad B,Lopez-Plaza I

    更新日期:2004-11-01 00:00:00

  • Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities.

    abstract:BACKGROUND:Fresh-frozen plasma (FFP) is frequently transfused to patients with mild prolongation of coagulation values under the assumption that FFP will correct the coagulopathy. There is little evidence to support this practice, however. To determine the effect of FFP on coagulation variables and correlation with ble...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00891.x

    authors: Abdel-Wahab OI,Healy B,Dzik WH

    更新日期:2006-08-01 00:00:00

  • Iron status and dietary iron intake of female blood donors.

    abstract:BACKGROUND:The aim was to assess iron status and dietary iron intake in a sample of premenopausal female regular and new blood donors. STUDY DESIGN AND METHODS:Premenopausal women blood donors were invited to participate. Blood samples were analyzed for serum ferritin and hemoglobin. An iron checklist assessed dietary...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12347

    authors: Booth AO,Lim K,Capper H,Irving D,Fisher J,McNaughton SA,Riddell L,Keller A,Nowson CA

    更新日期:2014-03-01 00:00:00

  • Cytokine generation in stored, white cell-reduced, and bacterially contaminated units of red cells.

    abstract:BACKGROUND:Proinflammatory cytokines were measured in the supernatant portion of stored, bacterially contaminated, and/or white cell (WBC)-reduced units of red cells (RBCs). Previous studies from this laboratory and others have shown that cytokines are generated in platelet concentrates during storage. This earlier wor...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1995.35395184274.x

    authors: Stack G,Baril L,Napychank P,Snyder EL

    更新日期:1995-03-01 00:00:00

  • Frequency of glucose-6-phosphate dehydrogenase-deficient red blood cell units in a metropolitan transfusion service.

    abstract:BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is characterized by red blood cell (RBC) destruction in response to oxidative stress. Although blood donors are not routinely screened for G6PD deficiency, the transfusion of stored G6PD-deficient RBCs may have serious adverse outcomes. By measuring G6PD en...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03765.x

    authors: Francis RO,Jhang J,Hendrickson JE,Zimring JC,Hod EA,Spitalnik SL

    更新日期:2013-03-01 00:00:00

  • Rapid controlled thawing of fresh-frozen plasma in a modified microwave oven.

    abstract::A microwave oven has been specifically modified to permit rapid thawing of fresh-frozen plasma (FFP) by using a rotating disc with a temperature sensor to hold the plasma bag. This modification makes it possible to mix the FFP continuously during thawing, and automatically shuts the oven off when the plasma reaches 21...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1984.24184122564.x

    authors: Rock G,Tackaberry ES,Dunn JG,Kashyap S

    更新日期:1984-01-01 00:00:00

  • Enhanced HPC recruitment in children using LVL and a new automated apheresis system.

    abstract:BACKGROUND:A new automated apheresis system has recently been reported as useful in improving peripheral blood HPC collection in adults. The aim of this study has been to verify the utility of this system (AutoPBSC, COBE BCT) for standard leukapheresis and for LVL in the pediatric setting. STUDY DESIGN AND METHODS:A p...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40040404.x

    authors: Torrabadella M,Olivé T,Ortega JJ,Massuet L

    更新日期:2000-04-01 00:00:00

  • M and N specific hemagglutinins of human erythrocytes stored in glucose solutions.

    abstract::Alloagglutinins of M and N specificites with unique characteristics found in normal sera are described. Specific M or N agglutination by these sera occurred only when erythrocytes had been exposed to glucose-containing solutions. Conversion to the form of MN recognized by these sera required incubation of the cells in...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1981.21682085751.x

    authors: Morel PA,Bergren MO,Hill V,Garratty G,Perkins HA

    更新日期:1981-11-01 00:00:00

  • Prevalence of serologic markers for hepatitis B and C viruses in Brazilian blood donors and incidence and residual risk of transfusion transmission of hepatitis C virus.

    abstract:BACKGROUND:We evaluate the current prevalence of serologic markers for hepatitis B virus (HBV) and hepatitis C virus (HCV) in blood donors and estimated HCV incidence and residual transfusion-transmitted risk at three large Brazilian blood centers. STUDY DESIGN AND METHODS:Data on whole blood and platelet donations we...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1537-2995.2012.03840.x

    authors: de Almeida-Neto C,Sabino EC,Liu J,Blatyta PF,Mendrone-Junior A,Salles NA,Leão SC,Wright DJ,Basques FV,Ferreira JE,Busch MP,Murphy EL,NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component.

    更新日期:2013-04-01 00:00:00

  • Pictorial representation of transfusion over the years.

    abstract:BACKGROUND:The writings of the 17th and 19th centuries about experiments and debates about transfusion were often analyzed and discussed in articles and books, but an analysis of illustrations of transfusion during this pioneering epoch can throw new light on the subject. The first transfusion attempts were as sensatio...

    journal_title:Transfusion

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1537-2995.2008.02068.x

    authors: Lefrère JJ,Danic B

    更新日期:2009-05-01 00:00:00

  • Preparation of pooled cryoprecipitate for treatment of hemophilia A in a home care program.

    abstract::Cryoprecipitate is used infrequently in home therapy for patients with hemophilia A since freezer storage is required and resuspension and pooling of thawed cryoprecipitate is cumbersome. We evaluated procedures for preparation of cryoprecipitate in an "open system" so that four to six bags of cryoprecipitate could be...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1984.24685066816.x

    authors: Smith KJ,Hodges PA

    更新日期:1984-11-01 00:00:00

  • Computerized selection of donors for inclusion in red cell antibody panels.

    abstract::This study evaluated various algorithms for the generation of a red cell antibody identification panel by computer. The algorithms depended on schemes that optimized Fisher's exact p value for each specificity in the panel rather than using predetermined formulations of desired phenotypic combinations. Panels produced...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27187121480.x

    authors: AuBuchon JP,Roberts GC

    更新日期:1987-01-01 00:00:00

  • Therapeutic plasma exchange and intravenous immunoglobulin as primary therapy for D alloimmunization in pregnancy precludes the need for intrauterine transfusion.

    abstract:BACKGROUND:Maternal D alloimmunization detected in early gestation requires aggressive intervention to prevent severe fetal anemia. An intrauterine transfusion (IUT) is indicated to prevent fetal death once severe fetal anemia has been detected, but is not without risk. Protocols combining therapeutic plasma exchange (...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12633

    authors: Bellone M,Boctor FN

    更新日期:2014-08-01 00:00:00

  • Platelet crossmatches of single-donor platelet concentrates using a latex agglutination assay.

    abstract::A latex agglutination assay was evaluated for the purpose of identifying compatible platelet donors for alloimmunized recipients. Assay reagents were prepared by adsorbing detergent-solubilized, donor-specific platelets to polystyrene latex beads. Semiquantitative results for up to 30 donors can be completed in less t...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.33893342745.x

    authors: Ogden DM,Asfour A,Koller C,Lichtiger B

    更新日期:1993-08-01 00:00:00

  • Detection of bacterial contamination of platelet components: six years' experience with the BacT/ALERT system.

    abstract:BACKGROUND:Hemovigilance has shown that bacteria cause more fatalities than other infections together. Surveillance for detection of bacteria in platelets (PLTs) was initiated. Concomitantly, the storage period for PLTs was extended from 5 to 7 days to reduce cost. STUDY DESIGN AND METHODS:Analysis was performed of al...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.04019.x

    authors: Munksgaard L,Albjerg L,Lillevang ST,Gahrn-Hansen B,Georgsen J

    更新日期:2004-08-01 00:00:00

  • Hemotherapy bedside biovigilance involving vital sign values and characteristics of patients with suspected transfusion reactions associated with fluid challenges: can some cases of transfusion-associated circulatory overload have proinflammatory aspects?

    abstract:BACKGROUND:Monitoring of patients' vital sign values (VSVs) during hemotherapy may have an important role in the recognition and mitigation of transfusion-associated circulatory overload (TACO). Knowledge regarding VSVs and other patient characteristics in bedside-reported TACO or fluid challenge-suspected transfusion ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03595.x

    authors: Andrzejewski C Jr,Popovsky MA,Stec TC,Provencher J,O'Hearn L,Visintainer P,Steingrub J

    更新日期:2012-11-01 00:00:00