Abstract:
:Alloagglutinins of M and N specificites with unique characteristics found in normal sera are described. Specific M or N agglutination by these sera occurred only when erythrocytes had been exposed to glucose-containing solutions. Conversion to the form of MN recognized by these sera required incubation of the cells in 1 to 2% glucose buffered to physiological or alkaline pH and was dependent on time and temperature of exposure, occurring in hours at 37 C and in days at 4 C. The sera appeared to be detecting an antigenic structure in which interaction between glucose and the amino group of the N-terminal amino acid of the MN receptor has produced a new specificity, analogous to the action of formaldehyde on N receptors and the resulting N-like structure detected by sera from hemodialysis patients.
journal_name
Transfusionjournal_title
Transfusionauthors
Morel PA,Bergren MO,Hill V,Garratty G,Perkins HAdoi
10.1046/j.1537-2995.1981.21682085751.xsubject
Has Abstractpub_date
1981-11-01 00:00:00pages
652-62issue
6eissn
0041-1132issn
1537-2995journal_volume
21pub_type
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