M and N specific hemagglutinins of human erythrocytes stored in glucose solutions.

Abstract:

:Alloagglutinins of M and N specificites with unique characteristics found in normal sera are described. Specific M or N agglutination by these sera occurred only when erythrocytes had been exposed to glucose-containing solutions. Conversion to the form of MN recognized by these sera required incubation of the cells in 1 to 2% glucose buffered to physiological or alkaline pH and was dependent on time and temperature of exposure, occurring in hours at 37 C and in days at 4 C. The sera appeared to be detecting an antigenic structure in which interaction between glucose and the amino group of the N-terminal amino acid of the MN receptor has produced a new specificity, analogous to the action of formaldehyde on N receptors and the resulting N-like structure detected by sera from hemodialysis patients.

journal_name

Transfusion

journal_title

Transfusion

authors

Morel PA,Bergren MO,Hill V,Garratty G,Perkins HA

doi

10.1046/j.1537-2995.1981.21682085751.x

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

652-62

issue

6

eissn

0041-1132

issn

1537-2995

journal_volume

21

pub_type

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