Low incidence of D alloimmunization among patients with a serologic weak D phenotype after D+ transfusion.

Abstract:

BACKGROUND:By consensus definition, the red blood cells (RBCs) of patients that react weak to 2+ in the serologic D test are classified as having the serologic weak D phenotype (weak D). The risk of D alloimmunization in patients with weak D is not well studied. This study retrospectively determined the incidence of D alloimmunization in patients with weak D who received D+ blood products. STUDY DESIGN AND METHODS:Patient records at four institutions were reviewed. Eligible patients had at least 1 D typing result with agglutination strength that was weak to 2+ result in gel or tube (Institutions 1-3) or weak to 2+ result in solid phase or a positive tube weak D test using antihuman globulin reagent (Institution 4). All patients received at least 1 D+ allogeneic RBC or platelet transfusion and had a subsequent antibody detection test performed at least 30 days after the first D+ transfusion. RESULTS:The incidence of alloanti-D formation was 0.15% (6/4011, at Institutions 1-3) and 5.1% (3/59, at Institution 4; these incidences were significantly different [p = 0.0002]). There were 0.15% (6/4011) patients who had autoanti-D detected; all were at Institutions 1 to 3. CONCLUSIONS:Until RHD genotyping is widely available, these data support the fact that patients with serologic weak D may be transfused with D+ RBCs if an urgent transfusion is required. At Institution 4, inclusion of a higher proportion of black patients compared to the other institutions may have affected the incidence of alloimmunization by perhaps including partial D recipients who are at risk of forming D antibodies.

journal_name

Transfusion

journal_title

Transfusion

authors

Yazer MH,Brunker PA,Bakdash S,Tobian AA,Triulzi DJ,Earnest V,Harris S,Delaney M

doi

10.1111/trf.13725

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

2502-2509

issue

10

eissn

0041-1132

issn

1537-2995

journal_volume

56

pub_type

杂志文章
  • Continuous-flow leukapheresis for rapid cytoreduction in leukemia.

    abstract::Three patients with leukemia were treated for acute leukostasis using the continuous-flow cell separator. The first patient, treated with a standard procedure sustained only a 14 per cent decrease in leukocyte count even though 50 X 10(10) leukocytes were removed. A more aggressive approach was taken with the second t...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1980.20480260280.x

    authors: Lane TA

    更新日期:1980-07-01 00:00:00

  • A new method for monitoring the sterility of blood donation.

    abstract::Sterility of blood products is a cardinal contributor to patient safety. Bacteriologic controls of stable products comply with strict regulations, but legislation imposes only limited constraints in the case of perishable products, such as packed red cells (RBCs) or fresh-frozen plasma (FFP). Therefore, it is essentia...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26386209392.x

    authors: Guéguen M,Durand F,Delamaire D,Beauplet A,Tardivel R,Genetet B,Chalumeau H,Balme MC

    更新日期:1986-05-01 00:00:00

  • Evaluation of a lateral flow-based technology card for blood typing using a simplified protocol in a model of extreme blood sampling conditions.

    abstract:BACKGROUND:Life-threatening situations requiring blood transfusion under extreme conditions or in remote and austere locations, such as the battlefield or in traffic accidents, would benefit from reliable blood typing practices that are easily understood by a nonscientist or nonlaboratory technician and provide quick r...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14420

    authors: Clavier B,Pouget T,Sailliol A

    更新日期:2018-02-01 00:00:00

  • Plasma treated with amotosalen and ultraviolet A light retains activity for hemostasis after 5 days post-thaw storage at 1 to 6o C.

    abstract:BACKGROUND:Plasma thawed and stored at 1 to 6° C for up to 5 days (thawed plasma [TP]) provides rapid availability in emergencies and reduces plasma waste, but it carries risks of coagulation factor loss or activation, bacterial outgrowth, and viral contamination. We characterized changes in amotosalen/ultraviolet A (U...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13973

    authors: Erickson A,Waldhaus K,David T,Huang N,Rico S,Corash L,Mufti N,Benjamin RJ

    更新日期:2017-04-01 00:00:00

  • Immune-mediated hemolysis associated with the administration of a radiographic contrast medium.

    abstract::A female patient developed serious hemolysis in association with the injection of a radiographic contrast medium (RCM). Serologic investigation of her serum suggested complement-mediated hemolysis, induced by an RCM-dependent IgM antibody in her serum. The antibody was of high titer and low avidity. The antibody showe...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31992094673.x

    authors: Nordhagen R,Vik H,Wolthuis K,Bøhn HP,Urdahl P,Michaelsen TE

    更新日期:1991-11-01 00:00:00

  • Hepatitis B virus nucleic acid amplification testing of Australian blood donors highlights the complexity of confirming occult hepatitis B virus infection.

    abstract:BACKGROUND:We present an analysis of the first 2 years of hepatitis B virus (HBV) nucleic acid testing (NAT) of the Australian donor population. STUDY DESIGN AND METHODS:Between July 5, 2010, and July 4, 2012, all blood donations were screened for HBV DNA and hepatitis B surface antigen (HBsAg). Donors who tested HBsA...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12556

    authors: Kiely P,Margaritis AR,Seed CR,Yang H,Australian Red Cross Blood Service NAT Study Group.

    更新日期:2014-08-01 00:00:00

  • RHCE*ceTI encodes partial c and partial e and is often in cis to RHD*DIVa.

    abstract:BACKGROUND:In the Rh blood group system, variant RhD and RhCE express several partial antigens. We investigated RH in samples with partial DIVa that demonstrated weak and variable reactivity with anti-C. STUDY DESIGN AND METHODS:Standard hemagglutination techniques, polymerase chain reaction-based assays, and RH seque...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03800.x

    authors: Westhoff CM,Vege S,Halter Hipsky C,Hue-Roye K,Copeland T,Velliquette RW,Horn T,Lomas-Francis C,Reid ME

    更新日期:2013-04-01 00:00:00

  • Are we underestimating reverse TRALI?

    abstract:BACKGROUND:Transfusion-related acute lung injury (TRALI) is a rare but serious adverse transfusion reaction and is known to be related to anti-human leukocyte antigen (HLA) or anti-human neutrophil antigen (HNA) antibodies in donor plasma. In 2016, four of eight reported TRALI cases could not be explained by donor anti...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15431

    authors: De Clippel D,Emonds MP,Compernolle V

    更新日期:2019-09-01 00:00:00

  • Iron deficiency anemia at admission for labor and delivery is associated with an increased risk for Cesarean section and adverse maternal and neonatal outcomes.

    abstract:BACKGROUND:Maternal iron deficiency anemia (IDA) impacts placenta and fetus. We evaluated effects of IDA at admission for delivery on cesarean rates, and adverse maternal and neonatal outcomes. STUDY DESIGN AND METHODS:Medical records from Jerusalem (2005-2012) identified women with a live-birth singleton fetus in cep...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13252

    authors: Drukker L,Hants Y,Farkash R,Ruchlemer R,Samueloff A,Grisaru-Granovsky S

    更新日期:2015-12-01 00:00:00

  • High deferral rate for maternal-neonatal donor pairs for an allogeneic umbilical cord blood bank.

    abstract:BACKGROUND:To fully evaluate the safety and efficacy of umbilical cord blood (UCB) as a source of hematopoietic progenitor cells, UCB banks are being established worldwide to provide a readily accessible resource of stem and progenitor cells for allogeneic transplantation. Guidelines for UCB donor criteria have been pr...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1999.39499235676.x

    authors: Jefferies LC,Albertus M,Morgan MA,Moolten D

    更新日期:1999-04-01 00:00:00

  • A highly specialized and motivated volunteer population: platelet donors.

    abstract::The plateletpheresis program of the M.D. Anderson Hospital was established in 1963. Approximately 20,000 units of platelet concentrates are produced per year. Credit for the nonreplacement fee generates the greatest number of donors. No organized recruitment campaign exists. Each donor becomes a recruiter for the prog...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1977.17377196353.x

    authors: Wendlandt GM,Lichtiger B

    更新日期:1977-05-01 00:00:00

  • Donor body mass index is an important factor that affects peripheral blood progenitor cell yield in healthy donors after mobilization with granulocyte-colony-stimulating factor.

    abstract:BACKGROUND:The use of hematopoietic progenitor cell (HPC) transplantation has rapidly expanded in recent years. Currently, several sources of HPCs are available for transplantation including peripheral blood HPCs (PBPCs), cord blood cells, and marrow cells. Of these, PBPC collection has become the major source of HPCs....

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12238

    authors: Chen J,Burns KM,Babic A,Carrum G,Kennedy M,Segura FJ,Garcia S,Potts S,Leveque C

    更新日期:2014-01-01 00:00:00

  • Severe immune-mediated hemolytic anemia secondary to treatment with cefotetan.

    abstract::Severe acute hemolytic anemia developed in a woman following treatment with multiple antibiotics for possible postpartum uterine infection. On admission, the hemoglobin was 5 g per dL (50 g/L), the reticulocytes were 35 percent (0.350), the direct antiglobulin test was strongly positive for IgG and C3d (mixed fields),...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1992.32392213812.x

    authors: Gallagher NI,Schergen AK,Sokol-Anderson ML,Sheahan EJ,Chaplin H

    更新日期:1992-03-01 00:00:00

  • Differentiation of autologous ABO, RHD, RHCE, KEL, JK, and FY blood group genotypes by analysis of peripheral blood samples of patients who have recently received multiple transfusions.

    abstract:BACKGROUND:After multiple transfusions, the serologic typing of autologous blood group phenotypes is difficult, because of mixed RBC populations. The genotyping of ABO, Rh, Kell, Kidd, and Duffy systems could be used to determine autologous blood group antigen status. STUDY DESIGN AND METHODS:Blood samples from patien...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40080936.x

    authors: Rozman P,Dovc T,Gassner C

    更新日期:2000-08-01 00:00:00

  • Additional molecular bases of the clinically important p blood group phenotype.

    abstract:BACKGROUND:The purpose of this study was to explore the molecular basis of the p phenotype by analysis of the recently cloned 4-alpha-galactosyltransferase gene responsible for synthesis of Pk (Gb3) antigen. STUDY DESIGN AND METHODS:Forty samples from individuals of eight different nationalities were investigated by s...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2003.00425.x

    authors: Hellberg A,Steffensen R,Yahalom V,Sojka BN,Heier HE,Levene C,Poole J,Olsson ML

    更新日期:2003-07-01 00:00:00

  • Iron status and dietary iron intake of female blood donors.

    abstract:BACKGROUND:The aim was to assess iron status and dietary iron intake in a sample of premenopausal female regular and new blood donors. STUDY DESIGN AND METHODS:Premenopausal women blood donors were invited to participate. Blood samples were analyzed for serum ferritin and hemoglobin. An iron checklist assessed dietary...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12347

    authors: Booth AO,Lim K,Capper H,Irving D,Fisher J,McNaughton SA,Riddell L,Keller A,Nowson CA

    更新日期:2014-03-01 00:00:00

  • Distinguishing full siblings from half-siblings in limited pedigrees.

    abstract:BACKGROUND:Full siblings were compared with half-siblings to observe how well the two relationships could be distinguished by informative tests. STUDY AND DESIGN METHODS: Parentage analysis ascertained 25 pairs of full siblings and 25 pairs of half-siblings. The pairs were then examined for the sharing of alleles at th...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40010044.x

    authors: Wenk RE,Chiafari FA

    更新日期:2000-01-01 00:00:00

  • Anti-D alloimmunization after D-mismatched allogeneic hematopoietic stem cell transplantation in patients with hematologic diseases.

    abstract:BACKGROUND:The de novo development of anti-D after D-mismatched allogeneic hematopoietic stem cell transplantation (AHSCT) is a possibility that must be considered. The transfusion of D- blood components after AHSCT has been recommended but anti-D alloimmunization in this setting has been studied little. Thus, the aim ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00698.x

    authors: Cid J,Lozano M,Fernández-Avilés F,Carreras E,Pereira A,Mazzara R,Ordinas A

    更新日期:2006-02-01 00:00:00

  • Lower alloimmunization rates in pediatric sickle cell patients on chronic erythrocytapheresis compared to chronic simple transfusions.

    abstract:BACKGROUND:Erythrocytapheresis (ECP), automated red blood cell exchange, is increasingly being used for chronic transfusion therapy in sickle cell disease (SCD) as it is an isovolumetric transfusion, is more effective in lowering hemoglobin (Hb)S, and can limit iron overload. Because ECP requires increased blood exposu...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03659.x

    authors: Wahl SK,Garcia A,Hagar W,Gildengorin G,Quirolo K,Vichinsky E

    更新日期:2012-12-01 00:00:00

  • Evaluation of the manual hexadimethrine bromide (Polybrene) technique in the investigation of autoimmune hemolytic anemia.

    abstract::The use of the direct manual hexadimethrine bromide (Polybrene) test (DPT) in the investigation of patients for autoimmune hemolytic anemia (AIHA) was evaluated. Seventy-nine blood samples from 68 patients were tested. A direct antiglobulin test (DAT) using monospecific reagents and the DPT were performed, and a conce...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30991048787.x

    authors: Owen I,Hows J

    更新日期:1990-11-01 00:00:00

  • Comparative morphology of granulocytes collected by three methods of leukapheresis. A light microscopy and transmission electron microscopy study.

    abstract::The morphology of granulocytes collected by continuous-flow centrifugation (CFC), discontinuous-flow centrifugation (DFC), and continuous-flow filtration (CFF) was investigated in 18 healthy donors by means of light microscopy and transmission electron microscopy. Light microscopy study of semithin sections of granulo...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1981.21582040813.x

    authors: Feliu E,Woessner S,Matutes E,Cardellach F,Grañena A,Marin P,Puig L,Vives-Corrons JL,Montserrat E,Rozman C

    更新日期:1981-09-01 00:00:00

  • An immediate, allergic skin reaction to aprotinin after reexposure to fibrin sealant.

    abstract:BACKGROUND:The safety of fibrin tissue adhesives has been a concern since they entered wide clinical application. Most commercially available kits contain the proteolytic inhibitor, aprotinin, to stabilize the fibrin clot. A bovine protein, this substance has an allergenic potency. CASE REPORT:This case report present...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40030302.x

    authors: Beierlein W,Scheule AM,Antoniadis G,Braun C,Schosser R

    更新日期:2000-03-01 00:00:00

  • Electronic enhancements to blood ordering reduce component waste.

    abstract:BACKGROUND:The effect on component wastage after enhancing the clinician's ability to order blood products in the computerized physician order entry (CPOE) system was investigated in a multihospital network. METHODS:A novel field was added to the CPOE of eight hospitals within a health care system allowing the physici...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13399

    authors: Yazer MH,Deandrade DS,Triulzi DJ,Wisniewski MK,Waters JH

    更新日期:2016-03-01 00:00:00

  • Extension of platelet shelf life with an improved bacterial testing algorithm.

    abstract:BACKGROUND:At Canadian Blood Services, platelet concentrate (PC) shelf life was extended to 7 days with a large-volume, delayed-sampling bacterial screening algorithm. We present the development study and postimplementation results. STUDY DESIGN AND METHODS:In the development study, PCs inoculated with five bacteria (...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16112

    authors: Ramirez-Arcos S,Evans S,McIntyre T,Pang C,Yi QL,DiFranco C,Goldman M

    更新日期:2020-12-01 00:00:00

  • Adoptive therapy by transfusing expanded donor murine natural killer T cells can suppress acute graft-versus-host disease in allogeneic bone marrow transplantation.

    abstract:BACKGROUND:Invariant natural killer T cells (iNKT cells) may suppress graft-versus-host disease (GVHD) after allogeneic transplantation. The purpose of this study was to investigate the therapeutic potential of iNKT cells from major histocompatibility complex (MHC)-mismatched donors for preventing GVHD after allogeneic...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02395.x

    authors: Yang J,Gao L,Liu Y,Ren Y,Xie R,Fan H,Qian K

    更新日期:2010-02-01 00:00:00

  • How we handled the dextran shortage: an alternative washing or dilution solution for cord blood infusions.

    abstract::Dextran 40 is the main component of the solution used to wash or dilute thawed cord blood unit (CBU) products for stem cell transplant. Dextran 40 became unavailable in the United States as of April 2014. Like many other cellular therapy laboratories in the United States, we found ourselves with limited dextran 40 inv...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13015

    authors: Reich-Slotky R,Bachegowda LS,Ancharski M,Mendeleyeva L,Rubinstein P,Rennert H,Shore T,van Besien K,Cushing M

    更新日期:2015-06-01 00:00:00

  • Sensitivity of hepatitis C virus core antigen and antibody combination assays in a global panel of window period samples.

    abstract:BACKGROUND:Hepatitis C virus (HCV) antigen and antibody combination assays have been launched as a cost-effective alternative to nucleic acid testing (NAT) for reducing the antibody-negative window period (WP). Later, a HCV antigen chemiluminescence immunoassay (CLIA) became available. STUDY DESIGN AND METHODS:A panel...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13179

    authors: Laperche S,Nübling CM,Stramer SL,Brojer E,Grabarczyk P,Yoshizawa H,Kalibatas V,El Elkyabi M,Moftah F,Girault A,van Drimmelen H,Busch MP,Lelie N

    更新日期:2015-10-01 00:00:00

  • Evaluation of commercial antiglobulin sera over a two-year period. Part I. Anti-beta 1A, anti-alpha 2D, and anti-beta 1E levels.

    abstract::Antiglobulin sera from nine different manufacturers have been tested, over a two-year period, for their ability to detect the complement components beta 1A, alpha 2D, and beta 1E. The results demontrate considerable variation in the abilities of sera from different manufacturers to detect these components and indicate...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.1974.tb04498.x

    authors: Issitt PD,Issitt CH,Wilkinson SL

    更新日期:1974-03-01 00:00:00

  • The use of recombinant activated factor VII in three patients with central nervous system hemorrhages associated with factor VII deficiency.

    abstract:BACKGROUND:Recombinant activated factor VII (rFVIIa) is being tested to improve hemostasis in a variety of bleeding disorders. Clinical indications and efficacy are still being evaluated for this product. CASE REPORT:Over a 17-month period, rFVIIa was used to treat central nervous system hemorrhage in three patients w...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.04080.x

    authors: Huang WY,Kruskall MS,Bauer KA,Uhl L,Shaz BH

    更新日期:2004-11-01 00:00:00

  • Transfusion, blood donation, and postage stamps: a worldwide review.

    abstract::Before the advent of electronic means of communication, postal stamps were one of the main international promotion tools on the planet and still remains an important support for the wide diffusion of a message. Since 1942, the promotion of blood donation has been one of them. To highlight these recurring or specific c...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2010.02671.x

    authors: Lefrère JJ,Danic B

    更新日期:2010-08-01 00:00:00