Abstract:
BACKGROUND:Full siblings were compared with half-siblings to observe how well the two relationships could be distinguished by informative tests. STUDY AND DESIGN METHODS: Parentage analysis ascertained 25 pairs of full siblings and 25 pairs of half-siblings. The pairs were then examined for the sharing of alleles at three independent variable number of tandem repeat (VNTR) loci. A sibling index (SI) and a half-sibling index (HSI) were calculated for each pair, and an SI:HSI ratio was determined. RESULTS:The SI:HSI ratio favored full siblings in 18 of 25 full sibling pairs. The SI:HSI ratio exceeded 100 in 8 of those 25 pairs. Although the ratio favored half-siblings in 23 of 25 half-sibling pairs, as was expected with the use of only 3 loci, it exceeded 0.1 in all 25 pairs. CONCLUSION:Study of more than three highly informative loci is required to improve the identification of full siblings and might well permit the identification of half-siblings.
journal_name
Transfusionjournal_title
Transfusionauthors
Wenk RE,Chiafari FAdoi
10.1046/j.1537-2995.2000.40010044.xsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
44-7issue
1eissn
0041-1132issn
1537-2995journal_volume
40pub_type
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