Incidence of transfusion reactions: a multicenter study utilizing systematic active surveillance and expert adjudication.

Abstract:

BACKGROUND:Prevalence estimates of the serious hazards of transfusion vary widely. We hypothesized that the current reporting infrastructure in the United States fails to capture many transfusion reactions and undertook a multicenter study using active surveillance, data review, and adjudication to test this hypothesis. STUDY DESIGN AND METHODS:A retrospective record review was completed for a random sample of 17% of all inpatient transfusion episodes over 6 months at four academic tertiary care hospitals, with an episode defined as all blood products released to a patient in 6 hours. Data were recorded by trained clinical research nurses, and serious reactions were adjudicated by a panel of transfusion medicine experts. RESULTS:Of 4857 transfusion episodes investigated, 1.1% were associated with a serious reaction. Transfusion-associated circulatory overload was the most frequent serious reaction noted, being identified in 1% of transfusion episodes. Despite clinical notes describing a potential transfusion association in 59% of these cases, only 5.1% were reported to the transfusion service. Suspected transfusion-related acute lung injury/possible transfusion-related acute lung injury, anaphylactic, and hypotensive reactions were noted in 0.08, 0.02, and 0.02% of transfusion episodes, respectively. Minor reactions, including febrile nonhemolytic and allergic, were noted in 0.62 and 0.29% of transfusion episodes, respectively, with 30 and 50% reported to the transfusion service. CONCLUSION:Underreporting of cardiopulmonary transfusion reactions is striking among academic, tertiary care hospitals. Complete and accurate reporting is essential to identify, define, establish pathogenesis, and mitigate/treat transfusion reactions. A better understanding of the failure to report may improve the accuracy of passive reporting systems.

journal_name

Transfusion

journal_title

Transfusion

authors

Hendrickson JE,Roubinian NH,Chowdhury D,Brambilla D,Murphy EL,Wu Y,Ness PM,Gehrie EA,Snyder EL,George Hauser R,Gottschall JL,Kleinman S,Kakaiya R,Strauss RG,National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemio

doi

10.1111/trf.13730

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

2587-2596

issue

10

eissn

0041-1132

issn

1537-2995

journal_volume

56

pub_type

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