Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells.

Abstract:

BACKGROUND:Most alloantigens on transfused red blood cells (RBCs) are weakly immunogenic, with only a 2 to 6 percent overall immunization rate even in patients receiving multiple transfusions. Although recipient genetics may contribute to responder and/or nonresponder status, in most cases HLA type does not predict humoral response to RBC antigens. In contrast, rates of alloimmunization do correspond to the underlying disease status of transfusion recipients, suggesting that acquired host factors may play an important role. In this context, it was hypothesized that the inflammatory status of a transfusion recipient would influence immunization to transfused RBCs. STUDY DESIGN AND METHODS:A novel murine model for alloimmunization to RBC antigens was developed with the mHEL mouse, which expresses hen egg lysozyme (HEL) as a model blood group antigen. Leukoreduced mHEL RBCs were transfused into wild-type recipient mice, and anti-HEL responses were monitored. To test the stated hypothesis, some recipient animals were injected with polyinosinic polycytidylic acid (poly(I:C)), a synthetic double-stranded RNA molecule that induces viral-like inflammation. RESULTS:Similar to the immunogenicity of most RBC antigens in humans, transfusion of mHEL RBCs into uninflamed mice was only a weak immunogen. In contrast, poly(I:C)-treated mice had a significant increase in both the frequency and the magnitude of alloimmunization to the mHEL antigen. CONCLUSIONS:These findings demonstrate that recipient inflammation with poly(I:C) significantly enhances humoral immunization to transfused alloantigens in a murine model. Moreover, these data suggest that the inflammatory status of human transfusion recipients may regulate the immunogenicity of transfused RBCs.

journal_name

Transfusion

journal_title

Transfusion

authors

Hendrickson JE,Desmarets M,Deshpande SS,Chadwick TE,Hillyer CD,Roback JD,Zimring JC

doi

10.1111/j.1537-2995.2006.00946.x

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

1526-36

issue

9

eissn

0041-1132

issn

1537-2995

pii

TRF00946

journal_volume

46

pub_type

杂志文章
  • Selective protection of RBCs against photodynamic damage by the band 3 ligand dipyridamole.

    abstract:BACKGROUND:All studied photosensitizers for virus inactivation impair RBCs. To reduce damage to the RBCs without affecting virucidal activity, selective protection of the RBCs is necessary. The ability of the band 3 ligand, dipyridamole, to react with singlet oxygen and to increase the selectivity of photosterilization...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40111330.x

    authors: vanSteveninck J,Trannoy LL,Besselink GA,Dubbelman TM,Brand A,de Korte D,Verhoeven AJ,Lagerberg JW

    更新日期:2000-11-01 00:00:00

  • Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review.

    abstract:BACKGROUND:Patients with thalassemia major require iron chelation therapy (ICT) to prevent complications from transfusional iron overload. Deferoxamine is effective, but requires administration as a slow continuous subcutaneous or intravenous infusion five to seven times per week. Deferiprone is a three-times-daily ora...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2007.01416.x

    authors: Delea TE,Edelsberg J,Sofrygin O,Thomas SK,Baladi JF,Phatak PD,Coates TD

    更新日期:2007-10-01 00:00:00

  • Benefits to blood banks of a sales and operations planning process.

    abstract::A formal sales and operations planning (S&OP) process is a decision making and communication process that balances supply and demand while integrating all business operational components with customer-focused business plans that links high level strategic plans to day-to-day operations. Furthermore, S&OP can assist in...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02945.x

    authors: Keal DA,Hebert P

    更新日期:2010-12-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report.

    abstract:BACKGROUND:Platelet transfusion-associated sepsis is usually due to donor skin flora introduced into the unit during phlebotomy. An unusual case of a platelet component contaminated with methicillin-resistant Staphylococcus aureus (MRSA) is reported. CASE REPORT:A 54-year-old man, terminally ill with progressive non-H...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41111426.x

    authors: Sapatnekar S,Wood EM,Miller JP,Jacobs MR,Arduino MJ,McAllister SK,Kellum ME,Roth V,Yomtovian R

    更新日期:2001-11-01 00:00:00

  • A nonenveloped virus with a lipid envelope: hepatitis A virus as used in virus-reduction studies.

    abstract:BACKGROUND:Recently, a quasi-lipid-enveloped (LE) form of the traditionally nonlipid-enveloped (NLE) hepatitis A virus (HAV) was described in human serum and cell culture-derived HAV stocks. This discovery challenges the understanding of HAV reduction in virus clearance studies of plasma products, which were performed ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14091

    authors: Kapsch AM,Farcet MR,Antoine G,Kreil TR

    更新日期:2017-06-01 00:00:00

  • Hemostatic profile under fluid resuscitation during rivaroxaban anticoagulation: an in vitro survey.

    abstract:BACKGROUND:Uncontrollable bleeding is the leading cause of death in traumatically injured patients. The extent to which direct factor Xa inhibitors interfere with the applied resuscitation measures is presently unknown. STUDY DESIGN AND METHODS:In this study, we investigated the effect of the resuscitation fluids sali...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14933

    authors: Helin TA,Zuurveld M,Manninen M,Meijers JCM,Lassila R,Brinkman HJM

    更新日期:2018-12-01 00:00:00

  • Clinical significance of RBC alloantibodies and autoantibodies in sickle cell patients who received transfusions.

    abstract:BACKGROUND:The clinical significance of alloimmunization to RBC antigens in sickle cell patients was analyzed by a retrospective review of the records of pediatric and adult sickle cell patients who received transfusions and who were followed over a 10-year period. STUDY DESIGN AND METHODS:Charts of pediatric and adul...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1046/j.1537-2995.2002.00007.x

    authors: Aygun B,Padmanabhan S,Paley C,Chandrasekaran V

    更新日期:2002-01-01 00:00:00

  • Trends in blood utilization in United States cardiac surgical patients.

    abstract:BACKGROUND:We sought to determine whether publication of blood conservation guidelines by the Society of Thoracic Surgeons in 2007 influenced transfusion rates and to understand how patient- and hospital-level factors influenced blood product usage. STUDY DESIGN AND METHODS:We identified 4,465,016 patients in the Nati...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12903

    authors: Robich MP,Koch CG,Johnston DR,Schiltz N,Chandran Pillai A,Hussain ST,Soltesz EG

    更新日期:2015-04-01 00:00:00

  • The effect of volume replacement during therapeutic leukapheresis on white blood cell reduction in patients with extreme leukocytosis.

    abstract:BACKGROUND:Extreme leukocytosis, generally defined as a white blood cell (WBC) count of more than 100 × 10(9) /L consisting largely of blast cells, especially when accompanied by clinical signs and symptoms of leukostasis or hyperviscosity, often predicts a poor clinical outcome in patients with acute leukemia. In this...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12141

    authors: Kurnaz F,Sivgin S,Pala C,Yildirim R,Baldane S,Kaynar L,Solmaz M,Ozturk A,Eser B,Cetin M,Unal A

    更新日期:2013-11-01 00:00:00

  • Role of glycoprotein Ibalpha in phagocytosis of platelets by macrophages.

    abstract:BACKGROUND:Platelet (PLT) storage at 0 to 4 degrees C suppresses bacterial multiplication, but induces clusters of glycoprotein (GP) Ibalpha that trigger their phagocytosis by macrophages and reduce their survival after transfusion. A method was sought that detects cold-induced changes in GPIbalpha involved in phagocyt...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.01034.x

    authors: Badlou BA,Spierenburg G,Ulrichts H,Deckmyn H,Smid WM,Akkerman JW

    更新日期:2006-12-01 00:00:00

  • Frequency of glucose-6-phosphate dehydrogenase-deficient red blood cell units in a metropolitan transfusion service.

    abstract:BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is characterized by red blood cell (RBC) destruction in response to oxidative stress. Although blood donors are not routinely screened for G6PD deficiency, the transfusion of stored G6PD-deficient RBCs may have serious adverse outcomes. By measuring G6PD en...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03765.x

    authors: Francis RO,Jhang J,Hendrickson JE,Zimring JC,Hod EA,Spitalnik SL

    更新日期:2013-03-01 00:00:00

  • RHCE*ceTI encodes partial c and partial e and is often in cis to RHD*DIVa.

    abstract:BACKGROUND:In the Rh blood group system, variant RhD and RhCE express several partial antigens. We investigated RH in samples with partial DIVa that demonstrated weak and variable reactivity with anti-C. STUDY DESIGN AND METHODS:Standard hemagglutination techniques, polymerase chain reaction-based assays, and RH seque...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03800.x

    authors: Westhoff CM,Vege S,Halter Hipsky C,Hue-Roye K,Copeland T,Velliquette RW,Horn T,Lomas-Francis C,Reid ME

    更新日期:2013-04-01 00:00:00

  • Epidemiological trends of HIV-1 infection in blood donors from Catalonia, Spain (2005-2014).

    abstract:BACKGROUND:Human immunodeficiency virus 1 (HIV-1) subtype B is predominant in Spain. However, the recent arrival of immigrant populations has increased the prevalence of non-B subtypes and circulating recombinant forms. The objective of this study was to determine the prevalence of HIV-1 subtypes and transmitted drug-r...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14195

    authors: Bes M,Piron M,Casamitjana N,Gregori J,Esteban JI,Ribera E,Quer J,Puig L,Sauleda S

    更新日期:2017-09-01 00:00:00

  • Poor harvest of peripheral blood stem cell in donors with microcytic red blood cells.

    abstract:BACKGROUND:The outcome of peripheral blood stem cell (PBSC) harvest depends on mobilization and leukapheresis. Some poor harvests might not be directly related to poor mobilizations. STUDY DESIGN AND METHODS:We retrospectively analyzed the results of 793 consecutive healthy donors who underwent PBSC donation to evalua...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03751.x

    authors: Wang TF,Chen SH,Yang SH,Su YC,Chu SC,Li DK

    更新日期:2013-01-01 00:00:00

  • Red cell use during cesarean delivery.

    abstract::The transfusion of red cells (RBCs) was analyzed over a 4-year period (1984-1987), during which 9596 cesarean deliveries were performed. A total of 336 patients were identified as receiving RBC transfusions during or after cesarean delivery; 747 units of RBCs were administered. The overall incidence of transfusion in ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31191096177.x

    authors: Camann WR,Datta S

    更新日期:1991-01-01 00:00:00

  • Sequence analysis of two variable cytomegalovirus genes for distinction between transfusion- and breast milk-transmitted infections in a very-low-birthweight infant.

    abstract:BACKGROUND:Cytomegalovirus (CMV) infections in very-low-birthweight infants can lead to serious clinical consequences. When CMV-related symptoms occur after transfusion, CMV transmission is often attributed to the transfusion products rather than to breast milk. However, it is sometimes difficult to distinguish between...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.13547

    authors: Yamagishi N,Furui Y,Koshinami S,Ichijo K,Shimizu Y,Hoshi Y,Gotanda Y,Miyakawa K,Uchida S,Tadokoro K,Nagai T,Satake M

    更新日期:2016-06-01 00:00:00

  • Exchange transfusion in sickle cell disease using a continuous-flow blood cell separator.

    abstract::An exchange transfusion was performed preoperatively on a patient with sickle cell disease using a continuous-flow blood cell separator. An exchange of 2,825 ml red blood cells achieved a hemoglobin A level of 90.8 per cent. The continuous-flow blood cell separator appears to offer a safe and effective method of excha...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1977.17377196364.x

    authors: Kernoff LM,Botha MC,Jacobs P

    更新日期:1977-05-01 00:00:00

  • Effective use of a strategy using assigned red cell units to limit donor exposure for neonatal patients.

    abstract::Critically ill neonatal infants receive frequent small-volume red cell (RBC) transfusions for replacement of blood drawn for laboratory analysis or for treatment of symptomatic anemia secondary to underlying medical conditions and/or a relative bleeding diathesis. Retrospective review of transfusion practice in a hosp...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.33593255596.x

    authors: Cook S,Gunter J,Wissel M

    更新日期:1993-05-01 00:00:00

  • Noninvasive determination of fetal RHD status by examination of cell-free DNA in maternal plasma.

    abstract:BACKGROUND:Cell-free fetal DNA in maternal plasma opens the way for routine risk-free diagnosis of fetal D status of D- mothers. The focus was on accuracy of RHD typing and confirmation of fetal DNA in maternal plasma while RHD was not detected. STUDY DESIGN AND METHODS:Plasma DNA was extracted (by manual and/or autom...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00559.x

    authors: Brojer E,Zupanska B,Guz K,Orziñska A,Kaliñska A

    更新日期:2005-09-01 00:00:00

  • Plateletapheresis program. I. Donor recruitment and commitment.

    abstract::A dedicated cytapheresis donor program was developed to meet the need for granulocytes and single-donor platelets. A study was undertaken to determine the most effective way to recruit a panel of 500 HLA-typed committed volunteer cytapheresis donors. Factors analyzed included ease of donor recruitment, information nec...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1984.24484275565.x

    authors: Meyer DM,Hillman RS,Slichter SJ

    更新日期:1984-07-01 00:00:00

  • Impact of a policy to permit the return of donors repeat-reactive to the Abbott PRISM antibody to hepatitis B core antigen assay.

    abstract:BACKGROUND:The expected donor loss from recent implementation of antibody to hepatitis B core antigen (anti-HBc) testing in Canada was uncertain but potentially significant based on US experience. To reduce donor loss from false-reactive tests, repeat-reactive donors without other evidence of infection were eligible to...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.01973.x

    authors: O'Brien SF,Yi QL,Fan W,Fearon MA,Scalia V,Goldman M

    更新日期:2009-02-01 00:00:00

  • Cold-stored leukoreduced CPDA-1 whole blood: in vitro quality and hemostatic properties.

    abstract:BACKGROUND:Some jurisdictions require leukoreduction of cellular blood components. The only whole blood collection set with a platelet-saving filter uses citrate-phosphate-dextrose (CPD) as storage solution. Substituting CPD with citrate-phosphate-dextrose-adenine (CPDA-1) increases shelf life from 21 to 35 days. This ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15748

    authors: Sivertsen J,Braathen H,Lunde THF,Kristoffersen EK,Hervig T,Strandenes G,Apelseth TO

    更新日期:2020-05-01 00:00:00

  • Transfusion-related adverse reactions reported to the National Healthcare Safety Network Hemovigilance Module, United States, 2010 to 2012.

    abstract:BACKGROUND:In 2010, health care facilities in the United States began voluntary enrollment in the National Healthcare Safety Network (NHSN) Hemovigilance Module. Participants report transfusion practices; red blood cell, platelet (PLT), plasma, and cryoprecipitate units transfused; and transfusion-related adverse react...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12918

    authors: Harvey AR,Basavaraju SV,Chung KW,Kuehnert MJ

    更新日期:2015-04-01 00:00:00

  • Variation in intraoperative and postoperative red blood cell transfusion in pediatric surgery.

    abstract:BACKGROUND:Intraoperative and postoperative red blood cell (RBC) transfusions are relatively frequent events tracked in the American College of Surgeons' National Surgical Quality Improvement Program-Pediatric (ACS-NSQIP-P). This study sought to quantify variation in RBC transfusion practices among hospitals. STUDY DE...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13479

    authors: Stey AM,Vinocur CD,Moss RL,Hall BL,Cohen ME,Kraemer K,Ko CY,Kenney BD

    更新日期:2016-03-01 00:00:00

  • Risk of iatrogenic human immunodeficiency virus infection through transfusion of blood tested by inappropriately stored or expired rapid antibody assays in a Zambian hospital.

    abstract:BACKGROUND:The purpose of this study was to estimate the risk of human immunodeficiency virus (HIV) infection via the transfusion of blood tested by inappropriately stored or expired rapid antibody assays in Zambia. STUDY DESIGN AND METHODS:Surgical patients (n = 370) were tested with antibody assays (HIV-spot and HIV...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1997.37997454020.x

    authors: Consten EC,van der Meer JT,de Wolf F,Heij HA,Henny PC,van Lanschot JJ

    更新日期:1997-09-01 00:00:00

  • Pseudoaneurysm of the brachial artery: a rare complication of blood donation.

    abstract:BACKGROUND:Serious complications of blood donation are rare. Reported here is a significant vascular event that resulted from whole-blood phlebotomy and required surgical repair. CASE REPORT:A 49-year-old woman donated whole blood without incident in November 1992, but reported ecchymosis and tenderness in the antecub...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1994.34394196625.x

    authors: Popovsky MA,McCarthy S,Hawkins RE

    更新日期:1994-03-01 00:00:00

  • Effect of repeat transfusion exposure on plasma cytokine and markers of endothelial activation in the extremely preterm neonate.

    abstract:BACKGROUND:Very preterm newborns receive up to three to five red blood cell (RBC) transfusions, often early, after birth. Despite awareness of the association of transfusion with increases in cytokines and markers of endothelial activation, research has focused on single transfusions weeks after birth. With pathophysio...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15952

    authors: Crawford TM,Andersen CC,Stark MJ

    更新日期:2020-07-25 00:00:00

  • Hepatitis B virus nucleic acid amplification testing of Australian blood donors highlights the complexity of confirming occult hepatitis B virus infection.

    abstract:BACKGROUND:We present an analysis of the first 2 years of hepatitis B virus (HBV) nucleic acid testing (NAT) of the Australian donor population. STUDY DESIGN AND METHODS:Between July 5, 2010, and July 4, 2012, all blood donations were screened for HBV DNA and hepatitis B surface antigen (HBsAg). Donors who tested HBsA...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12556

    authors: Kiely P,Margaritis AR,Seed CR,Yang H,Australian Red Cross Blood Service NAT Study Group.

    更新日期:2014-08-01 00:00:00

  • Iron supplementation by blood donors: demographics, patterns of use, and motivation.

    abstract:BACKGROUND:Iron supplements reduce the risk of iron depletion in blood donors. Recent initiatives have sought to increase use of donor iron supplementation (IS), but a baseline description of blood donor supplement practices is needed. STUDY DESIGN AND METHODS:Presenting blood donors received a questionnaire inquiring...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15407

    authors: Cable RG,Spencer BR

    更新日期:2019-09-01 00:00:00

  • The minimum number of cord blood units needed for Koreans is 51,000.

    abstract:BACKGROUND:The inventory size for cord blood (CB) depends on the ethnic diversity of human leukocyte antigen (HLA) and the size estimation is important for public health in each ethnicity. STUDY DESIGN AND METHODS:We estimate the CB inventory size in Koreans with stored CB units (CBUs) and patients who underwent allog...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12284

    authors: Yoon JH,Oh S,Shin S,Park JS,Roh EY,Song EY,Park MH,Han KS

    更新日期:2014-03-01 00:00:00