Abstract:
BACKGROUND:The inventory size for cord blood (CB) depends on the ethnic diversity of human leukocyte antigen (HLA) and the size estimation is important for public health in each ethnicity. STUDY DESIGN AND METHODS:We estimate the CB inventory size in Koreans with stored CB units (CBUs) and patients who underwent allogeneic hematopoietic stem cell transplantation. Two-digit HLA specificities were determined using intermediate DNA typing. From 17,508 stored Korean CBUs, 1460 haplotypes with a frequency greater than 0.001% were used for reconstitution of the HLA. A total of 1002 transplanted patients' HLA was used for matching probability calculation. RESULTS:The best probability for 6/6 matching is 47% in 500,000 hypothetical size. Ninety-five percent probability is achieved with 51,000 CBUs in 5/6, and 2150 in 4/6 matching condition. Because 4/6 matched CB is rarely selected in the Korean situation, 51,000 units is the lowest limit of CBUs required and the number will be adjusted depending on the cell number required for patients and the resolution of HLA typing. CONCLUSION:Approximately 51,000 units could provide the minimum requirement for hematopoietic transplantation in Korea.
journal_name
Transfusionjournal_title
Transfusionauthors
Yoon JH,Oh S,Shin S,Park JS,Roh EY,Song EY,Park MH,Han KSdoi
10.1111/trf.12284subject
Has Abstractpub_date
2014-03-01 00:00:00pages
504-8issue
3eissn
0041-1132issn
1537-2995journal_volume
54pub_type
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