Impact of donor ABH-secretor status in ABO-mismatched living donor kidney transplantation.

Abstract:

BACKGROUND:The ABO blood group is a major determinant in living donor kidney transplantation since AB antigens are expressed on renal tissue. Little attention has been directed to the ABH-secretor status of the donor kidney. As renal tissue is capable of secreting soluble ABH antigens in secretors, we examined the influence of the ABH-secretor status of kidney donors on outcome in ABO-mismatched living donor kidney transplantation. STUDY DESIGN AND METHODS:We retrospectively analyzed all patients who underwent ABO-mismatched kidney transplantation at the University Hospital Basel from September 2005 to October 2013. The ABH-secretor status was determined in all donors by molecular genetic analysis. RESULTS:Of all 55 patients who received transplants, we excluded all patients with donor-specific antibodies (n = 4). Forty-one donors were secretors (78%) and 11 were nonsecretors (22%). Recipients of ABH-secretor donor organs showed a significantly higher glomerular filtration rate throughout the first 6 months posttransplant, whereas no significant influence on posttransplant anti-A/B titers was found. Regression analysis revealed a significant impact on humoral rejection, whereas not on vascular or interstitial rejection in protocol kidney biopsies. CONCLUSION:The donor ABH-secretor status may have an influence on early posttransplant renal function in patients undergoing ABO-mismatched living donor kidney transplantation. Further prospective studies with long-term follow-up are needed to elucidate involved pathomechanisms.

journal_name

Transfusion

journal_title

Transfusion

authors

Drexler B,Holbro A,Sigle J,Gassner C,Frey BM,Schaub S,Amico P,Plattner A,Infanti L,Menter T,Mihatsch MJ,Stern M,Buser A,Dickenmann M

doi

10.1111/trf.13711

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

2355-61

issue

9

eissn

0041-1132

issn

1537-2995

journal_volume

56

pub_type

杂志文章
  • Evaluation of commercial antiglobulin sera over a two-year period. Part I. Anti-beta 1A, anti-alpha 2D, and anti-beta 1E levels.

    abstract::Antiglobulin sera from nine different manufacturers have been tested, over a two-year period, for their ability to detect the complement components beta 1A, alpha 2D, and beta 1E. The results demontrate considerable variation in the abilities of sera from different manufacturers to detect these components and indicate...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.1974.tb04498.x

    authors: Issitt PD,Issitt CH,Wilkinson SL

    更新日期:1974-03-01 00:00:00

  • False-positive eluate reactivity due to the low-ionic wash solution used with commercial acid-elution kits.

    abstract:BACKGROUND:During the use of commercial red cell (RBC) acid-elution kits for adsorption and elution (adsorption/elution) studies with anti-D, unexpected reactive eluates (anti-D) were obtained from D- RBCs. Such results were not obtained with a parallel xylene method or, historically, with heat and ether methods. STUD...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38698326336.x

    authors: Leger RM,Arndt PA,Ciesielski DJ,Garratty G

    更新日期:1998-06-01 00:00:00

  • Adoptive therapy by transfusing expanded donor murine natural killer T cells can suppress acute graft-versus-host disease in allogeneic bone marrow transplantation.

    abstract:BACKGROUND:Invariant natural killer T cells (iNKT cells) may suppress graft-versus-host disease (GVHD) after allogeneic transplantation. The purpose of this study was to investigate the therapeutic potential of iNKT cells from major histocompatibility complex (MHC)-mismatched donors for preventing GVHD after allogeneic...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02395.x

    authors: Yang J,Gao L,Liu Y,Ren Y,Xie R,Fan H,Qian K

    更新日期:2010-02-01 00:00:00

  • Plasma and plasma derivatives in therapeutic plasmapheresis.

    abstract::In therapeutic plasmapheresis, patient plasma is withdrawn and a colloid replacement solution is infused in its place. A 4% to 5% human serum albumin solution in saline is the preferred replacement solution in most instances, even though this practice causes transient mild deficiencies of most plasma proteins. Albumin...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2012.03623.x

    authors: McLeod BC

    更新日期:2012-05-01 00:00:00

  • Packed blood cells stored in AS-5 become proinflammatory during storage.

    abstract:BACKGROUND:Studies have shown that packed blood cells (PBCs) stored in AS-1 (Adsol, Baxter) and AS-3 (Nutricel, Medsep Corp.) accumulate proinflammatory substances, which may contribute to increased complications from allogeneic blood transfusion. This study assessed whether supernates from PBCs stored in AS-5 (Optisol...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02158.x

    authors: McFaul SJ,Corley JB,Mester CW,Nath J

    更新日期:2009-07-01 00:00:00

  • Assessment of cell viability, early apoptosis, and hematopoietic potential in umbilical cord blood units after storage.

    abstract:BACKGROUND:Successful hematopoietic stem cell transplantation using stored umbilical cord blood (CB) largely depends on cell dose and quality of CB units. The aim of this study was to assess the degree of early apoptosis, in addition to cell viability and hematopoietic potential, in umbilical CB units after storage. S...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13120

    authors: Kim KM,Huh JY,Hong SS,Kang MS

    更新日期:2015-08-01 00:00:00

  • First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage.

    abstract:BACKGROUND:In cases of massive hemorrhage in the US military, improved outcomes have been reported with the use of warm, fresh whole blood transfusions. Cold-stored low-titer type O whole blood (LTOWB) has become the preferred product for resuscitation of severe bleeding in deployed surgical units. Reports of LTOWB use...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.15492

    authors: Bahr TM,DuPont TL,Morris DS,Pierson SE,Esplin MS,Brown SM,O'Brien EA,Ilstrup SJ,Christensen RD

    更新日期:2019-10-01 00:00:00

  • Different growth kinetics in blood components and genetic analysis of Lactococcus garvieae isolated from platelet concentrates.

    abstract:BACKGROUND:In 2014, we experienced the first isolation of Lactococcus garvieae from a platelet concentrate (PC). Thereafter, L. garvieae contamination of PCs occurred in two more cases in Japan. It is rare that bacterial contamination with uncommon strains like this species occurs frequently within a short period. Ther...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15836

    authors: Kozakai M,Matsumoto C,Matsumoto M,Takakura A,Matsubayashi K,Satake M

    更新日期:2020-07-01 00:00:00

  • A single-center prospective study on the safety of plasma exchange procedures using a double-viral-inactivated and prion-reduced solvent/detergent fresh-frozen plasma as the replacement fluid in the treatment of thrombotic microangiopathy.

    abstract:BACKGROUND:Patients presenting with acute episodes of thrombotic microangiopathies (TMAs) require urgent access to plasma exchange (PEX). OctaplasLG, a solvent/detergent fresh-frozen plasma product that has undergone viral inactivation and prion reduction step, has been used in our institution since 2013, replacing Oct...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/trf.13877

    authors: Vendramin C,McGuckin S,Alwan F,Westwood JP,Thomas M,Scully M

    更新日期:2017-01-01 00:00:00

  • Automatic depletion with Spectra Optia allows a safe 16% reduction of red blood cell pack consumption in exchanged sickle cell anemia patients.

    abstract:BACKGROUND:Chronic red blood cell exchanges (RBCXs) are frequently used to prevent complications in patients with sickle cell anemia, but the scarcity of matched red blood cell packs (RBCPs) is a serious concern. The main goal of this study was to compare the number of RBCPs used during RBCXs between the Spectra Optia ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15188

    authors: Hequet O,Poutrel S,Connes P,Revesz D,Chelghoum Y,Kebaili K,Cannas G,Gauthier A,Guironnet-Paquet A,Vocanson M,Nicolas JF,Renoux C,Raba M,Cognasse F,Bertrand Y,Hot A,Joly P

    更新日期:2019-05-01 00:00:00

  • Preparation of commercial quantities of a hyperimmune human intravenous immunoglobulin preparation against an emerging infectious disease: the example of pandemic H1N1 influenza.

    abstract:BACKGROUND:The recent H1N1 pandemic provided an opportunity to conceptually assess the possibility of rapidly providing a "hyperimmune" human immunoglobulin (H-IVIG) to an emerging infectious disease, in useful quantities with respect to public health. Commercial-scale H-IVIG production from plasma collected from donor...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03347.x

    authors: Kreil TR,Mc Vey JK,Lei LS,Camacho L,Wodal W,Kerschbaum A,Segura E,Vandamme E,Gavit P,Ehrlich HJ,Barrett PN,Baker DA

    更新日期:2012-04-01 00:00:00

  • Prevalence of serologic markers for hepatitis B and C viruses in Brazilian blood donors and incidence and residual risk of transfusion transmission of hepatitis C virus.

    abstract:BACKGROUND:We evaluate the current prevalence of serologic markers for hepatitis B virus (HBV) and hepatitis C virus (HCV) in blood donors and estimated HCV incidence and residual transfusion-transmitted risk at three large Brazilian blood centers. STUDY DESIGN AND METHODS:Data on whole blood and platelet donations we...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1537-2995.2012.03840.x

    authors: de Almeida-Neto C,Sabino EC,Liu J,Blatyta PF,Mendrone-Junior A,Salles NA,Leão SC,Wright DJ,Basques FV,Ferreira JE,Busch MP,Murphy EL,NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component.

    更新日期:2013-04-01 00:00:00

  • Differences in quality between privately and publicly banked umbilical cord blood units: a pilot study of autologous cord blood infusion in children with acquired neurologic disorders.

    abstract:BACKGROUND:A pilot study was conducted to determine the safety and feasibility of intravenous administration of autologous umbilical cord blood (CB) in young children with acquired neurologic disorders. Most CB units (CBUs) were electively stored in private CB banks. Unlike public banks, which utilize specific criteria...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02720.x

    authors: Sun J,Allison J,McLaughlin C,Sledge L,Waters-Pick B,Wease S,Kurtzberg J

    更新日期:2010-09-01 00:00:00

  • Hemolytic transfusion reaction due to anti-IH.

    abstract:BACKGROUND:Anti-IH is usually a clinically insignificant antibody that may complicate a serologic workup. However, it can occasionally cause hemolysis. We report a rare case of acute hemolysis caused by anti-IH. CASE REPORT:A 60-year-old man with a long history of chronic myelomonocytic leukemia and anemia, blood grou...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03209.x

    authors: Irani MS,Richards C

    更新日期:2011-12-01 00:00:00

  • Transfusion and component characteristics are not associated with allergic transfusion reactions to apheresis platelets.

    abstract:BACKGROUND:Transfusion-related characteristics have been hypothesized to cause allergic transfusion reactions (ATRs) but they have not been thoroughly studied. The primary objective of this study is to evaluate the associations of infusion rate, infusion volume, ABO mismatching, component age, and pretransfusion medica...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/trf.12852

    authors: Savage WJ,Tobian AA,Savage JH,Hamilton RG,Borge PD,Kaufman RM,Ness PM

    更新日期:2015-02-01 00:00:00

  • "Pseudo-hemolytic" transfusion reaction caused by intravenous iron-dextran therapy.

    abstract::Intravenous iron-dextran therapy can cause a red-brown discoloration of the plasma, simulating a hemolytic transfusion reaction. A rapid and simple test to differentiate between true hemolysis and plasma discoloration due to circulating iron-dextran complexes is described. ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22482251227.x

    authors: Simon SD,Kuriyan MA,Kim HC

    更新日期:1982-07-01 00:00:00

  • Severe immune-mediated hemolytic anemia secondary to treatment with cefotetan.

    abstract::Severe acute hemolytic anemia developed in a woman following treatment with multiple antibiotics for possible postpartum uterine infection. On admission, the hemoglobin was 5 g per dL (50 g/L), the reticulocytes were 35 percent (0.350), the direct antiglobulin test was strongly positive for IgG and C3d (mixed fields),...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1992.32392213812.x

    authors: Gallagher NI,Schergen AK,Sokol-Anderson ML,Sheahan EJ,Chaplin H

    更新日期:1992-03-01 00:00:00

  • The effects of dilution on the outcome of pooled plasma testing with HIV type 1 (HIV-1) RNA genome amplification as compared to the outcome of individual-unit testing with other HIV-1 markers.

    abstract:BACKGROUND:Proposed testing of large plasma pools with genome amplification technology (GAT) for detection of transfusion-transmissible viruses may have unanticipated complications not associated with individual unit testing. One such potential complication, the effect of dilution resulting from pool formation, was the...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38598297216.x

    authors: Kemper M,Witt D,Madsen T,Kuramoto K,Holland P

    更新日期:1998-05-01 00:00:00

  • RBC autoantibodies in autoimmune lymphoproliferative syndrome.

    abstract:BACKGROUND:Patients with autoimmune lymphoproliferative syndrome (ALPS) have an autosomal dominant genetic defect that affects lymphocyte apoptosis and is associated with chronic nonmalignant lymphadenopathy, splenomegaly, and autoimmunity, particularly affecting RBCs, WBCs, and platelets. STUDY DESIGN AND METHODS:DAT...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41010018.x

    authors: Stroncek DF,Carter LB,Procter JL,Dale JK,Straus SE

    更新日期:2001-01-01 00:00:00

  • Solid-phase ABO grouping and Rh typing.

    abstract::A solid-phase adherence method (SPAM) for ABO grouping and Rh typing of red cells (RBCs) has been developed. Adherence reactions were read spectrophotometrically and interpreted by a computer. The SPAM had a 99.6 percent correlation with conventional microplate agglutination methods for ABO grouping and Rh typing. The...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25185116494.x

    authors: Sinor LT,Rachel JM,Beck ML,Bayer WL,Coenen WM,Plapp FV

    更新日期:1985-01-01 00:00:00

  • Antibodies to co-trimoxazole (trimethoprim and/or sulfamethoxazole) related to the presence of the drug in a commercial low-ionic-strength solution.

    abstract:BACKGROUND:Drug-dependent antibodies have been associated with approximately 10% of acquired immune hemolytic anemia cases. These antibodies are a rare cause of interference in pretransfusion red blood cell (RBC) serologic testing. The aim of this work was to report three cases of subjects developing antibodies against...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03327.x

    authors: Pham BN,Gien D,Bensaad F,Babinet J,Dubeaux I,Rouger P,Le Pennec PY

    更新日期:2012-04-01 00:00:00

  • Skin disinfection methods: prospective evaluation and postimplementation results.

    abstract:BACKGROUND:Optimal skin disinfection ensures blood safety. In this study, efficacies of the two-step skin disinfection methods used at Canadian Blood Services (CBS) and two one-step methods produced by different manufacturers were compared. STUDY DESIGN AND METHODS:In each of the three phases of the study, two methods...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2009.02434.x

    authors: Ramirez-Arcos S,Goldman M

    更新日期:2010-01-01 00:00:00

  • Prestorage universal WBC reduction of RBC units does not affect the incidence of transfusion reactions.

    abstract:BACKGROUND:Febrile nonhemolytic transfusion reaction (FNHTR) has been identified as a pivotal reason for prestorage universal WBC reduction. A regional blood center implemented universal prestorage WBC reduction for RBCs on January 1, 2000. Whether prestorage universal WBC reduction of RBC units will affect FNHTR is no...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41080997.x

    authors: Uhlmann EJ,Isgriggs E,Wallhermfechtel M,Goodnough LT

    更新日期:2001-08-01 00:00:00

  • Role of glycoprotein Ibalpha in phagocytosis of platelets by macrophages.

    abstract:BACKGROUND:Platelet (PLT) storage at 0 to 4 degrees C suppresses bacterial multiplication, but induces clusters of glycoprotein (GP) Ibalpha that trigger their phagocytosis by macrophages and reduce their survival after transfusion. A method was sought that detects cold-induced changes in GPIbalpha involved in phagocyt...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.01034.x

    authors: Badlou BA,Spierenburg G,Ulrichts H,Deckmyn H,Smid WM,Akkerman JW

    更新日期:2006-12-01 00:00:00

  • WBC alloimmunization: effects on the laboratory and clinical endpoints of therapeutic granulocyte transfusions.

    abstract:BACKGROUND:Although the subject of many previous studies, the importance of white blood cell (WBC) alloimmunization in granulocyte transfusion therapy has not been settled. In this study, we report the results of the effects of WBC antibodies in the RING (Resolving Infection in Neutropenia with Granulocytes) study, a r...

    journal_title:Transfusion

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/trf.14551

    authors: Price TH,McCullough J,Strauss RG,Ness PM,Hamza TH,Harrison RW,Assmann SF

    更新日期:2018-05-01 00:00:00

  • Investigation of whether the acute hemolysis associated with Rh(o)(D) immune globulin intravenous (human) administration for treatment of immune thrombocytopenic purpura is consistent with the acute hemolytic transfusion reaction model.

    abstract:BACKGROUND:Immune thrombocytopenic purpura and secondary thrombocytopenia patients treated with Rh(o)(D) immune globulin intravenous (human; anti-D IGIV) have experienced acute hemolysis, which is inconsistent with the typical presentation of extravascular hemolysis -- the presumed mechanism of action of anti-D IGIV. A...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.02083.x

    authors: Gaines AR,Lee-Stroka H,Byrne K,Scott DE,Uhl L,Lazarus E,Stroncek DF

    更新日期:2009-06-01 00:00:00

  • Noninvasive fetal RHD genotyping by maternal plasma with capillary electrophoresis.

    abstract:BACKGROUND:Recently, a more accurate and reliable screening test has been investigated for noninvasive prenatal fetal RHD genotyping from D- women. The objective of this study was to perform the new method of noninvasive fetal RHD genotyping with maternal plasma from D- women by use of capillary electrophoresis. STUDY...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.01681.x

    authors: Kimura M,Sato C,Hara M,Ishihara O,Ikebuchi K

    更新日期:2008-06-01 00:00:00

  • Genotyping of RHD by multiplex polymerase chain reaction analysis of six RHD-specific exons.

    abstract:BACKGROUND:Qualitative RHD variants are the result of the replacement of RHD exons by their RHCE counterparts or of point mutations in RHD causing amino acid substitutions. For RHD typing, the use of at least two RHD typing polymerase chain reaction (PCR) assays directed at different regions of RHD is advised to preven...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38111299056309.x

    authors: Maaskant-van Wijk PA,Faas BH,de Ruijter JA,Overbeeke MA,von dem Borne AE,van Rhenen DJ,van der Schoot CE

    更新日期:1998-11-01 00:00:00

  • The impact of e-mail in acquiring and retaining whole-blood donors: a comparative analysis of the Puget Sound Blood Center donor e-mail communication program.

    abstract:BACKGROUND:With the emergence of e-mail as a common form of communication, it is important to understand the role and impact e-mail can have on acquiring and retaining whole-blood donors. STUDY DESIGN AND METHODS:Whole-blood donors who opted in to receive e-mail communications (n = 43,232) from the Puget Sound Blood C...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00642.x

    authors: Geyer ME

    更新日期:2005-12-01 00:00:00

  • Platelet counting in platelet concentrates with various automated hematology analyzers.

    abstract:BACKGROUND:Hematology analyzers use impedance, optical, and/or immunologic techniques for counting platelets (PLTs). PLT counting in whole blood has been validated thoroughly; however, this is not the case for PLT counting in PLT concentrates (PCs), in which red cells (RBCs) are absent. Therefore, this study is focused...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01337.x

    authors: Dijkstra-Tiekstra MJ,Kuipers W,Setroikromo AC,de Wildt-Eggen J

    更新日期:2007-09-01 00:00:00