An acute hemolytic transfusion reaction caused by an anti-P1 that reacted at 37 degrees C.

Abstract:

BACKGROUND:Hemolytic transfusion reactions (HTRs) due to anti-P1 have rarely been reported. There is only one report (from 1945) of an acute HTR due to anti-P1. CASE REPORT:A 74-year-old woman with anti-P1 was given blood that had been found to be compatible by the use of prewarmed serum and saline-suspended red cells (RBCs) and of an antiglobulin test with anti-IgG. The test mixtures were not centrifuged or inspected for agglutination after the 37 degrees C incubation phase. After transfusion of 50 mL of P1 + blood, the patient had an acute HTR (hemoglobinemia, hemoglobinuria, and increased blood pressure, temperature, and respiration). RESULTS:When studied by a reference laboratory, the anti-P1 was shown to be easily detectable (3+ agglutination) by a prewarming technique (saline or low-ionic-strength saline [LISS]), which included centrifugation at 37 degrees C, but only weak reactions were observed when centrifugation after 37 degrees C incubation was omitted. The indirect antiglobulin test was weakly positive (1+) with anti-IgG, but polyspecific anti-human globulin reacted 2+. The anti-P1 agglutinin was IgM, and its titer was 16 at 37 degrees C (prewarmed) and 256 at 23 degrees C; it caused hemolysis of RBCs at 37 degrees C under conditions known to enhance hemolysis. An indirect monocyte monolayer assay gave results of 11.2 and 22 percent in testing of P1 + RBCs incubated with the patient's serum alone and with patient's serum plus fresh normal serum (as a source of complement), respectively (normal < or = 3%). CONCLUSION:An acute HTR was caused by a hemolytic anti-P1 that reacted at 37 degrees C. This antibody was not detected by the hospital in a prewarmed crossmatch that omitted 1) the addition of LISS, 2) the reading for agglutination after the 37 degrees C incubation, and 3) the use of antiglobulin sera containing anti-complement.

journal_name

Transfusion

journal_title

Transfusion

authors

Arndt PA,Garratty G,Marfoe RA,Zeger GD

doi

10.1046/j.1537-2995.1998.38498257376.x

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

373-7

issue

4

eissn

0041-1132

issn

1537-2995

journal_volume

38

pub_type

杂志文章
  • Lifeline for the front lines: blood products to support the warfighter.

    abstract:BACKGROUND:Hemorrhage is the leading cause of death on the battlefield. Damage control resuscitation guidelines in the US military recommend whole blood as the preferred resuscitation product. The Armed Services Blood Program (ASBP) has initiated low-titer group O whole blood (LTOWB) production and predeployment donor ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15165

    authors: Taylor AL,Corley JB,Swingholm MT,Sloan MA,McDonald H Jr,Quesada JF,Evans CL,Ceballos WA

    更新日期:2019-04-01 00:00:00

  • The restricted use of IGHV3 superspecies genes in anti-Rh is not limited to hyperimmunized anti-D donors.

    abstract:BACKGROUND:Antibodies produced against the D antigen make use of IGHV genes restricted to the IGHV3 superfamily. These findings are based on the IGHV gene analysis in anti-D-producing B cells from hyperimmunized donors, however, and therefore the restriction might be due to the hyperimmunization. In this study the IGHV...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.01047.x

    authors: Dohmen SE,Verhagen OJ,Muit J,Ligthart PC,van der Schoot CE

    更新日期:2006-12-01 00:00:00

  • Investigation of red blood cells from alpha1,3-galactosyltransferase-knockout pigs for human blood transfusion.

    abstract:BACKGROUND:Pigs are a potential source of red blood cells (RBCs) for transfusion into humans, but the presence of galactose-alpha1,3-galactose (Gal) epitopes on their surface, against which humans have anti-Gal, has been perceived as a major barrier. alpha1,3-Galactosyltransferase gene-knockout pigs, which do not expre...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.04002.x

    authors: Rouhani FJ,Dor FJ,Cooper DK

    更新日期:2004-07-01 00:00:00

  • The minimum number of cord blood units needed for Koreans is 51,000.

    abstract:BACKGROUND:The inventory size for cord blood (CB) depends on the ethnic diversity of human leukocyte antigen (HLA) and the size estimation is important for public health in each ethnicity. STUDY DESIGN AND METHODS:We estimate the CB inventory size in Koreans with stored CB units (CBUs) and patients who underwent allog...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12284

    authors: Yoon JH,Oh S,Shin S,Park JS,Roh EY,Song EY,Park MH,Han KS

    更新日期:2014-03-01 00:00:00

  • Effect of vitamin K administration on rate of warfarin reversal.

    abstract:BACKGROUND:Vitamin K is reported to begin reversing warfarin within 6 to 12 hours, but this may occur sooner. We sought to determine the rate of international normalized ratio (INR) reversal following vitamin K and relationships with dose, route, and baseline INR. METHODS:We evaluated adult patients receiving vitamin ...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/trf.15146

    authors: Polito NB,Kanouse E,Jones CMC,McCann M,Refaai MA,Acquisto NM

    更新日期:2019-04-01 00:00:00

  • Further evaluation of a new standard of efficacy for stored platelets.

    abstract:BACKGROUND:The proposal to assess the viability capabilities of platelets (PLTs) collected, treated, or stored in a developmental system against "fresh" PLTs from the same subject poses several important methodologic issues pertaining to the timing and manner of the collecting and separating the fresh PLTs. This study ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00177.x

    authors: AuBuchon JP,Herschel L,Roger J

    更新日期:2005-07-01 00:00:00

  • Storage of platelet concentrates after high-dose ultraviolet B irradiation.

    abstract::Ultraviolet B (UVB) irradiation of platelet concentrates (PCs) may prevent the development of posttransfusion HLA alloimmunization. As irradiation performed in a blood center or a hospital will probably be associated with a variable postirradiation delay before transfusion, the ability to store PCs after UVB irradiati...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31691306243.x

    authors: Snyder EL,Beardsley DS,Smith BR,Horne W,Johnson R,Wooten T,Napychank PA,Male P,Buchholz DH

    更新日期:1991-07-01 00:00:00

  • Lactic acidemia in baboons after transfusion of red blood cells with improved oxygen transport function and exposure to severe arterial hypoxemia.

    abstract::Baboons were bled one-third of their blood volume and then transfused with an equivalent volume of compatible donor red blood cells with 160 per cent of normal 2,3-diphosphoglycerate (2,3-DPG) levels and improved capacity to release oxygen to tissue. The mixture of baboon donor-recipient red blood cells in the circula...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1979.19479250179.x

    authors: Zaroulis CG,Pivacek LE,Lowrie GB,Valeri CR

    更新日期:1979-07-01 00:00:00

  • Postdonation iron replacement for maintaining iron stores in female whole blood donors in routine donor practice: results of two feasibility studies in Australia.

    abstract:BACKGROUND:Iron deficiency represents a risk to donor health and the blood supply. Efficacy trials indicate that postdonation iron replacement improves iron stores but they do not account for complexities of implementation in the routine collection context. We therefore conducted two prospective feasibility studies in ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14173

    authors: Pasricha SR,Marks DC,Salvin H,Brama T,Keller AJ,Pink J,Speedy J

    更新日期:2017-08-01 00:00:00

  • Risk of exposure to blood products during pregnancy: guidance for Zika and other donor deferral policies.

    abstract:BACKGROUND:Exposure to blood products during pregnancy carries a potential risk of transfusion transmission of infectious agents. Blood agencies have historically sought optimal deferral and testing strategies to protect blood supplies in part to ensure the protection of pregnant women and their unborn infants. The Zik...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14001

    authors: Murphy MS,Shehata N,Colas JA,Chassé M,Fergusson DA,O'Brien SF,Goldman M,Tinmouth A,Forster AJ,Wilson K

    更新日期:2017-03-01 00:00:00

  • Impact of a policy to permit the return of donors repeat-reactive to the Abbott PRISM antibody to hepatitis B core antigen assay.

    abstract:BACKGROUND:The expected donor loss from recent implementation of antibody to hepatitis B core antigen (anti-HBc) testing in Canada was uncertain but potentially significant based on US experience. To reduce donor loss from false-reactive tests, repeat-reactive donors without other evidence of infection were eligible to...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.01973.x

    authors: O'Brien SF,Yi QL,Fan W,Fearon MA,Scalia V,Goldman M

    更新日期:2009-02-01 00:00:00

  • A comparative study of reducing the extracellular potassium concentration in red blood cells by washing and by reduction of additive solution.

    abstract:BACKGROUND:Extracellular potassium concentration (K(+)) increases in the supernatant of whole and packed red blood cell units (pRBCs) with duration of refrigerated storage in citrate-phosphate-dextrose-adenine (CPDA-1) and additive solution (AS). Studies have shown that to avoid hyperkalemia, washed pRBCs are preferred...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01095.x

    authors: Bansal I,Calhoun BW,Joseph C,Pothiawala M,Baron BW

    更新日期:2007-02-01 00:00:00

  • Successful storage of RBCs for 9 weeks in a new additive solution.

    abstract:BACKGROUND:This study explored the effect of storing packed RBCs suspended in 200 mL of an alkaline, hypotonic, experimental additive solution (EAS 61). STUDY DESIGN AND METHODS:Packed RBC units prepared from RBCs collected from healthy donors in CPD were stored for 8 (n = 10) and 9 (n = 10) weeks under blood bank con...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40081007.x

    authors: Hess JR,Rugg N,Knapp AD,Gormas JF,Silberstein EB,Greenwalt TJ

    更新日期:2000-08-01 00:00:00

  • Zinc protoporphyrin levels have added value in the prediction of low hemoglobin deferral in whole blood donors.

    abstract:BACKGROUND:Increased zinc protoporphyrin (ZPP) levels can indicate iron deficiency and may be predictive for low hemoglobin (Hb) deferral in blood donors. Prediction models for Hb deferral in whole blood donors have already been developed. In this study, we examined if addition of ZPP to these prediction models improve...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2012.03957.x

    authors: Baart AM,de Kort WL,Moons KG,Atsma F,Vergouwe Y

    更新日期:2013-08-01 00:00:00

  • Uneventful plasma exchange with albumin replacement in a patient with a previous anaphylactoid reaction to albumin.

    abstract::A patient who had a previous anaphylactoid reaction to albumin required plasma exchange for myasthenia gravis. She was rechallenged with albumin from a different manufacturer after premedication with diphenhydramine. No adverse reaction occurred during five exchanges over a 10-day period. Possible pathogenic mechanism...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25586020118.x

    authors: Edelman BB,Straughn MA,Getz P,Schwartz E

    更新日期:1985-09-01 00:00:00

  • Validation of simple prediction algorithms to consistently achieve CD3+ and postselection CD34+ targets with leukapheresis.

    abstract:BACKGROUND:Cellular therapies using engineered T cells, haploidentical transplants, and autologous gene therapy are increasing. Specified CD3+ or high CD34+ doses are typically required for subsequent manufacturing, manipulation, or CD34+ selection. Simple, practical, and reliable lymphocyte and hematopoietic progenito...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15576

    authors: Yoon EJ,Zhang J,Weinberg RS,Brochstein JA,Nandi V,Sachais BS,Shi PA

    更新日期:2020-01-01 00:00:00

  • Cases of transfusion-transmitted babesiosis occurring in nonendemic areas: a diagnostic dilemma.

    abstract:BACKGROUND:Transfusion-transmitted babesiosis (TTB) has been rapidly increasing in incidence since the beginning of the 21st century. Asymptomatic individuals with Babesia infection are able to donate blood in the United States because of the lack of specific blood donation testing. Blood products collected in Babesia-...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14246

    authors: LeBel DP 2nd,Moritz ED,O'Brien JJ,Lazarchick J,Tormos LM,Duong A,Fontaine MJ,Squires JE,Stramer SL

    更新日期:2017-10-01 00:00:00

  • Convenience, the bane of our existence, and other barriers to donating.

    abstract:BACKGROUND:To prevent donor loss and improve retention, it is important to understand the major deterrents to blood donation and to identify factors that can be effectively addressed by blood centers. STUDY DESIGN AND METHODS:A 30-item self-administered questionnaire was completed in 2003 by 1705 first-time and 2437 r...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00757.x

    authors: Schreiber GB,Schlumpf KS,Glynn SA,Wright DJ,Tu Y,King MR,Higgins MJ,Kessler D,Gilcher R,Nass CC,Guiltinan AM,National Heart, Lung, Blood Institute Retrovirus Epidemiology Donor Study.

    更新日期:2006-04-01 00:00:00

  • Use of the gel agglutination technique for determination of fetomaternal hemorrhage.

    abstract:BACKGROUND:Adequate administration of Rh immune globulin requires an accurate determination of the number of D-positive cells in the circulation of D-negative women. Although several tests have been described for the detection of fetomaternal hemorrhage, there is still a need for a rapid, simple, and clinically relevan...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38298193101.x

    authors: Salama A,David M,Wittmann G,Stelzer A,Dudenhausen JW

    更新日期:1998-02-01 00:00:00

  • Clinical and serologic management of patients with methyldopa-induced positive antiglobulin tests.

    abstract::Methyldopa can produce both a positive direct antiglobulin test and less commonly a positive indirect antiglobulin test. When the drug-induced antibody is present in the serum, it acts as a panagglutinin and reacts with all normal red blood cells; consequently crossmatch-compatible blood cannot be prepared. Although t...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1979.19379204213.x

    authors: Snyder EL,Spivack M

    更新日期:1979-05-01 00:00:00

  • Red blood cell alloimmunization in transfused patients with bone marrow failure syndromes.

    abstract:BACKGROUND:Red blood cell (RBC) alloimmunization is a concern for patients who receive multiple or chronic transfusions. Alloimmunization prevalence in transfused patients with bone marrow failure syndrome (BMFS) is unknown. This study aimed to determine physician practice for RBC antigen matching, immunization rates, ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13608

    authors: Cohen D,Hartung H,Evans P,Friedman DF,Chou ST

    更新日期:2016-06-01 00:00:00

  • Nuclear matrix protein is released from apoptotic white cells during cold (1-6 degrees C) storage of concentrated red cell units and might induce antibody response in multiply transfused patients.

    abstract:BACKGROUND:A previous study showed that white cells in blood units undergo apoptosis during storage. STUDY DESIGN AND METHODS:The present study attempts to show the release of nuclear matrix protein (NMP) in the supernatants of red cell units and to determine whether antibodies against nuclear components may be presen...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40020169.x

    authors: Martelli AM,Tazzari PL,Bortul R,Riccio M,Tabellini G,Santi S,Frabetti F,Musiani D,Bareggi R,Conte R

    更新日期:2000-02-01 00:00:00

  • How we treat: transfusion medicine support of obstetric services.

    abstract:BACKGROUND:Obstetric services depend on the transfusion service (TS) to provide diagnostic testing and blood component therapy for clinical care pathways. STUDY DESIGN AND METHODS:We describe three quality improvement (QI) initiatives implemented to improve TS support of obstetric services. RESULTS:We implemented a p...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2011.03152.x

    authors: Goodnough LT,Daniels K,Wong AE,Viele M,Fontaine MF,Butwick AJ

    更新日期:2011-12-01 00:00:00

  • Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States.

    abstract:BACKGROUND:Trypanosoma cruzi, the protozoan cause of Chagas disease, causes life-long infection and is easily transmitted by blood transfusion. Our goals were to determine the prevalence of Chagas disease among donors in five Mexican blood banks, to look for evidence of transmission of T. cruzi by transfusion, and to e...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00715.x

    authors: Kirchhoff LV,Paredes P,Lomelí-Guerrero A,Paredes-Espinoza M,Ron-Guerrero CS,Delgado-Mejía M,Peña-Muñoz JG

    更新日期:2006-02-01 00:00:00

  • Collection of white blood cell-reduced plasma by apheresis.

    abstract:BACKGROUND:WBC reduction of cellular blood components has been introduced in many countries. Owing to concerns of residual WBCs in plasma, a new method to collect WBC-reduced plasma by apheresis was studied. STUDY DESIGN AND METHODS:An apheresis machine (PCS2, Haemonetics) was used, in combination with the "high-separ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.03314.x

    authors: Vrielink H,van der Meer PF

    更新日期:2004-06-01 00:00:00

  • Blood group incidence and Escherichia coli bacterial sepsis.

    abstract::Many strains of Escherichia coli possess an antigen that reacts with naturally occurring antibodies to human red cell B antigens. The authors tested the hypothesis that the presence of naturally occurring anti-B isoagglutinins afford protection against the development of E. coli septicemia. The blood groups found in 1...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26687043620.x

    authors: Wittels EG,Lichtman HC

    更新日期:1986-11-01 00:00:00

  • Autologous blood donation: hemodynamics in a high-risk patient population.

    abstract::Transfusion practices have changed dramatically in recent years as a result of the acquired immune deficiency syndrome crisis. The use of preoperative donation of autologous blood units has gained popularity. Healthy individuals tolerate phlebotomy well, experiencing a 2- to 5-percent incidence of vasovagal reactions....

    journal_title:Transfusion

    pub_type: 评论,杂志文章

    doi:10.1046/j.1537-2995.1992.32192116425.x

    authors: Spiess BD,Sassetti R,McCarthy RJ,Narbone RF,Tuman KJ,Ivankovich AD

    更新日期:1992-01-01 00:00:00

  • Pediatric transfusion medicine: development of a critical mass.

    abstract::Many significant events have occurred in the recent past that beg a broad audience to address the question "What is pediatric transfusion medicine?" Herein, we list some of these events and their relevance below and attempt to provide an answer for this question. Indeed, several issues regarding the subspecialty of pe...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.02015.x

    authors: Hillyer CD,Mondoro TH,Josephson CD,Sanchez R,Sloan SR,Ambruso DR

    更新日期:2009-03-01 00:00:00

  • Plasma ectonucleotidases prevent desensitization of purinergic receptors in stored platelets: importance for platelet activity during thrombus formation.

    abstract:BACKGROUND:Platelets (PLTs) contain purinergic receptors for ATP (P2X1) and ADP (P2Y1 and P2Y12) that rapidly desensitize upon stimulation with these nucleotides. In vivo, this is antagonized by ectonucleotidases on the surface of endothelial cells and white blood cells (WBCs). The receptor desensitization of ATP- and ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00837.x

    authors: Cauwenberghs S,Feijge MA,Hageman G,Hoylaerts M,Akkerman JW,Curvers J,Heemskerk JW

    更新日期:2006-06-01 00:00:00

  • Iron supplementation in female blood donors deferred by copper sulfate screening.

    abstract::Female blood donors with low hematocrit levels detected by copper sulfate screening were selected randomly to receive either 75 mg of iron per day, as ferrous gluconate, or a calcium phosphate placebo. Their ferritin, serum iron, total iron-binding capacity, zinc protoporphyrin, and hemoglobin values, as well as their...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1537-2995.1988.28588337328.x

    authors: Cable RG,Morse EE,Keltonic J,Kakaiya R,Kiraly T

    更新日期:1988-09-01 00:00:00