Mobilization of hemopoietic stem cells with high-dose methotrexate plus granulocyte-colony-stimulating factor in patients with primary central nervous system lymphoma.

Abstract:

BACKGROUND:High-dose therapy with autologous stem cell support after standard dose induction is a promising approach for therapy of primary central nervous system lymphoma (PCNSL). High-dose methotrexate (HD-MTX) is a standard drug for induction of PCNSL; however, data about the capacity of HD-MTX plus granulocyte-colony-stimulating factor (G-CSF) to mobilize hemopoietic progenitors are lacking. STUDY DESIGN AND METHODS:This investigation describes the data from stem cell mobilization and apheresis procedures after one or two cycles of HD-MTX for induction of PCNSL within the East German Study Group for Haematology and Oncology 053 trial. Eligible patients proceeded to high-dose busulfan/thiotepa after induction therapy and mobilization. RESULTS:Data were available from nine patients with a median age of 58 years. The maximal CD34+ cell count per microL of blood after the first course of HD-MTX was 13.89 (median). Determination was repeated in six patients after the second course with a significantly higher median CD34+ cell count of 33.69 per microL. Five patients required two apheresis procedures and in four patients a single procedure was sufficient. The total yield of CD34+ cells per kg of body weight harvested by one or two leukapheresis procedures was 6.60 x 10(6) (median; range, 2.68 x 10(6)-15.80 x 10(6)). The yield of CD34+ cells exceeded the commonly accepted lower threshold of 3 x 10(6) cells per kg of body weight in eight of nine cases. Even in the ninth, hemopoietic recovery after stem cell reinfusion was rapid and safe. CONCLUSION:HD-MTX plus G-CSF is a powerful combination for stem cell mobilization in patients with PCNSL and permits safe conduction of time-condensed and dose-intense protocols with high-dose therapy followed by stem cell reinfusion after HD-MTX induction.

journal_name

Transfusion

journal_title

Transfusion

authors

Kiefer T,Krüger WH,Montemurro M,Schüler F,Hirt C,Pasold R,Niederwieser D,Schwenke M,Dölken G

doi

10.1111/j.1537-2995.2008.01927.x

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

2624-8

issue

12

eissn

0041-1132

issn

1537-2995

pii

TRF01927

journal_volume

48

pub_type

杂志文章
  • Transfusion of red cells after autologous bone marrow harvest in patients with acute leukemia and malignant lymphoma.

    abstract::Bone marrow was harvested for the purpose of autologous bone marrow transplantation (ABMT) in 21 patients previously treated with chemotherapy and in complete remission from acute leukemia or non-Hodgkin's lymphoma. The volume required to obtain 2 x 10(8) nucleated cells per kg was less than 15 mL per kg in 13 patient...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30490273437.x

    authors: Sonneveld P,de Leeuw CA,Schipperus M,Lindemans J,Abels J

    更新日期:1990-05-01 00:00:00

  • A novel GYPB-A-B hybrid gene responsible for Ss and MN typing discrepancies.

    abstract:BACKGROUND:Transfusion support of S-s- patients is very challenging but can now be alleviated by genotyping mutations in the GYPB gene to predict their U- or U+(var) phenotype. However, the phenotype predicted by genotyping does not always correspond to the observed phenotype of red blood cells (RBCs), which requires f...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13216

    authors: Willemetz A,Nataf J,Peyrard T,Arnaud L

    更新日期:2015-11-01 00:00:00

  • Use and analysis of saline washed red blood cells.

    abstract::Data collected from 50 saline washed units of red blood cells shows that units washed with one liter of 0.9 per cent NaCl on an IBM cell processor have an average hematocrit of 72.2 per cent, with 84.7 per cent of the white blood cells removed, and only 0.6 per cent of the original total protein remaining. The red blo...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1976.16577039304.x

    authors: Wooten MJ

    更新日期:1976-09-01 00:00:00

  • Storage of platelets prepared by discontinuous flow centrifugation.

    abstract::Platelet concentrates were prepared by plateletpheresis using discontinuous flow centrifugation. Platelet units were stored in PL-146 bags of 300 ml and 2,000 ml capacity, and in vitro measures helpful in predicting platelet viability were compared. Storage in bags of 300 ml capacity led to significant fall in pH, dec...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18278160588.x

    authors: Katz A,Houx J,Ewald L

    更新日期:1978-03-01 00:00:00

  • Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation.

    abstract:BACKGROUND:A recently published study has reported that donor-recipient Rhesus (Rh)-mismatched allogeneic hematopoietic stem cell transplantation independently led to significantly poorer survival. This suggests that donor-recipient Rh mismatching is a risk factor in allogeneic hematopoietic stem cell transplantation a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01501.x

    authors: Wirk B,Klumpp TR,Ulicny J,Herman JH,Gajewski JL,Martin ME,Emmons RV,Mangan KF

    更新日期:2008-01-01 00:00:00

  • Evaluation of a new whole-blood filter that allows preparation of platelet concentrates by platelet-rich plasma methods.

    abstract:BACKGROUND:A novel WBC-reduction in-line whole-blood (WB) filter that does not retain platelets was evaluated to assess the filtration performance and, after processing WB by the platelet-rich plasma (PRP) method, to analyze the storage quality of filtered platelet concentrate (PC) units. STUDY DESIGN AND METHODS:To a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.0041-1132.2003.00587.x

    authors: Lozano ML,Pérez-Ceballos E,Rivera J,Paunovic D,Candela MJ,Vicente V

    更新日期:2003-12-01 00:00:00

  • Multicenter performance evaluation of a transcription-mediated amplification assay for screening of human immunodeficiency virus-1 RNA, hepatitis C virus RNA, and hepatitis B virus DNA in blood donations.

    abstract:BACKGROUND:The performance of the recently launched Procleix Ultrio (Chiron/Gen-Probe) human immunodeficiency virus-1 (HIV-1), hepatitis C virus (HCV), and hepatitis B virus (HBV) blood screening assay was evaluated in a European multicenter study. STUDY DESIGN AND METHODS:Serial dilutions of reference materials were ...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1537-2995.2005.00197.x

    authors: Koppelman MH,Assal A,Chudy M,Torres P,de Villaescusa RG,Reesink HW,Lelie PN,Cuypers HT

    更新日期:2005-08-01 00:00:00

  • Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay.

    abstract:BACKGROUND:As clinical diagnosis of heparin-associated thrombocytopenia (HAT) is often difficult, confirmation by sensitive laboratory assays is desirable. STUDY DESIGN AND METHODS:The sensitivity of the heparin-induced platelet activation (HIPA) test and the platelet aggregation test (PAT) was prospectively compared ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1994.34594249047.x

    authors: Greinacher A,Amiral J,Dummel V,Vissac A,Kiefel V,Mueller-Eckhardt C

    更新日期:1994-05-01 00:00:00

  • Effects of hydroxyethyl starch on blood coagulation, particularly factor VIII.

    abstract::The effects of hydroxyethyl starch (HES) on hemostasis were investigated extensively. In order to simulate acute blood loss due to surgery or trauma, one unit (450 ml) of blood was drawn from normal healthy men. This was followed by a 1-liter infusion over 60 minutes of either 6 percent HES, 5 percent albumin, or 0.9 ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25485273815.x

    authors: Stump DC,Strauss RG,Henriksen RA,Petersen RE,Saunders R

    更新日期:1985-07-01 00:00:00

  • First-time blood donors: demographic trends.

    abstract:BACKGROUND:With changing demographics of the United States population and the continuous need to recruit new donors, it is important to monitor the demographic profile of first-time donors and to evaluate changes in the donor pool to improve recruitment targeting. STUDY DESIGN AND METHODS:First-time whole blood (n = 9...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41030360.x

    authors: Wu Y,Glynn SA,Schreiber GB,Wright DJ,Lo A,Murphy EL,Kleinman SH,Garratty G,Retrovirus Epidemiology Donor Study (REDS) Group.

    更新日期:2001-03-01 00:00:00

  • Clinical outcomes and transfusion management following intracranial hemorrhage in patients with acute leukemia.

    abstract:BACKGROUND:There is little evidence to guide management of patients with acute leukemia and intracranial hemorrhage (ICH). Predictors of long-term outcome following ICH are unknown. STUDY DESIGN AND METHODS:This study included adult patients with acute leukemia and ICH over an 8-year period. The primary outcome was da...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15621

    authors: Nixon S,Lieberman L,Atenafu EG,Doherty M,Murray C,Wolfe A,Brandys D,Rowland S,Kwan BY,Yu E,Lechner B,Maze D

    更新日期:2020-02-01 00:00:00

  • Sterility and quality of blood dispensed in syringes for infants.

    abstract::A unit-dose system was designed to dispense precise quantities of blood in a form ready for immediate transfusion into neonatal patients. The principles were similar to those used by pharmacies to dispense individual doses of drugs. In the blood center, the precise volume of blood ordered for a neonatal patient was as...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26286152907.x

    authors: Strauss RG,Crawford GF,Elbert C,Floss AM,Liesch M

    更新日期:1986-03-01 00:00:00

  • A single-center prospective study on the safety of plasma exchange procedures using a double-viral-inactivated and prion-reduced solvent/detergent fresh-frozen plasma as the replacement fluid in the treatment of thrombotic microangiopathy.

    abstract:BACKGROUND:Patients presenting with acute episodes of thrombotic microangiopathies (TMAs) require urgent access to plasma exchange (PEX). OctaplasLG, a solvent/detergent fresh-frozen plasma product that has undergone viral inactivation and prion reduction step, has been used in our institution since 2013, replacing Oct...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/trf.13877

    authors: Vendramin C,McGuckin S,Alwan F,Westwood JP,Thomas M,Scully M

    更新日期:2017-01-01 00:00:00

  • Transfusion of banked red blood cells and the effects on hemorrheology and microvascular hemodynamics in anemic hematology outpatients.

    abstract:BACKGROUND:The aim of this study was to investigate the effects of red blood cell (RBC) transfusion on the hemorrheologic properties and microcirculatory hemodynamics in anemic hematology outpatients receiving 2 to 4 RBC units of either "fresh" (leukoreduced storage for less than 1 week) or "aged" (leukoreduced storage...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2012.03905.x

    authors: Yürük K,Milstein DM,Bezemer R,Bartels SA,Biemond BJ,Ince C

    更新日期:2013-06-01 00:00:00

  • Transfusion of ABO-nonidentical platelets is not associated with adverse clinical outcomes in cardiovascular surgery patients.

    abstract:BACKGROUND:Current blood transfusion standards in Canada and the United States permit transfusion of ABO-nonidentical platelets when ABO-identical platelets are not available. This practice increases the availability of platelets, a component in chronic shortage in Ontario, Canada because of the 5-day shelf-life. The i...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00037.x

    authors: Lin Y,Callum JL,Coovadia AS,Murphy PM

    更新日期:2002-02-01 00:00:00

  • Detection of dengue, chikungunya, and Zika RNA in blood donors from Southeast Asia.

    abstract:BACKGROUND:Chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses are of concern due to the potential of transfusion transmission in blood, especially in regions such as Southeast Asia where the viruses are endemic. The recent availability of nucleic acid testing (NAT) to screen blood donations on an automated pla...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16110

    authors: Stanley J,Chongkolwatana V,Duong PT,Kitpoka P,Stramer SL,Dung NTT,Grimm KE,Pojanasingchod A,Suksomboonvong P,Galel SA

    更新日期:2020-10-07 00:00:00

  • The association of blood transfusion with mortality after cardiac surgery: cause or confounding? (CME).

    abstract:BACKGROUND:Bleeding into the chest is a life-threatening complication of cardiac surgery. Blood transfusion has been implicated as an important cause of harm associated with bleeding, based largely on studies demonstrating an independent association between transfusion and mortality. These studies did not, however, con...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03697.x

    authors: Dixon B,Santamaria JD,Reid D,Collins M,Rechnitzer T,Newcomb AE,Nixon I,Yii M,Rosalion A,Campbell DJ

    更新日期:2013-01-01 00:00:00

  • Safety and impact of donor-type red blood cell transfusion before allogeneic peripheral blood progenitor cell transplantation with major ABO mismatch.

    abstract:BACKGROUND:Changes within the ABO system are regularly observed phenomena in allogeneic bone marrow transplantation (BMT) and peripheral blood progenitor cell transplantation (PBPCT). Major ABO mismatch can lead to different clinical problems including acute hemolysis after infusion of the allograft, delay of red blood...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2005.00578.x

    authors: Scholl S,Klink A,Mügge LO,Schilling K,Höffken K,Sayer HG

    更新日期:2005-10-01 00:00:00

  • Evaluation of a visual risk communication tool: effects on knowledge and perception of blood transfusion risk.

    abstract:BACKGROUND:Effective risk communication in transfusion medicine is important for health-care consumers, but understanding the numerical magnitude of risks can be difficult. The objective of this study was to determine the effect of a visual risk communication tool on the knowledge and perception of transfusion risk. S...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1537-2995.2003.00402.x

    authors: Lee DH,Mehta MD

    更新日期:2003-06-01 00:00:00

  • Anti-Rd (Radin) following the transfusion of a Radin positive unit of blood.

    abstract::Anti-Rd (Radin) was first described in association with five cases of hemolytic disease of the newborn. The authors report an anti-Rd that was demonstrated following the transfusion of a Radin positive unit of blood. The antibody appears to be of the IgG immunoglobulin class and increased in titer following the transf...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1976.16476247056.x

    authors: Winn LC,Eska PL,Grindon AJ

    更新日期:1976-07-01 00:00:00

  • Peripartum hyperhemolysis prophylaxis and management in sickle cell disease: A case report and narrative review.

    abstract:BACKGROUND:Sickle cell disease (SCD) is associated with hematologic complications including delayed hemolytic transfusion reactions (DHTRs) and pregnancy-related morbidity and mortality. Hyperhemolysis syndrome (HS) is the most severe form of DHTR in patients with SCD, in which both transfused and native red blood cell...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.16003

    authors: Vasanthamohan L,Choo S,Marshall T,Symons YT,Matsui D,Eastabrook G,Solh Z

    更新日期:2020-08-26 00:00:00

  • Platelet glycolytic flux increases stimulated by ultraviolet-induced stress is not the direct cause of platelet morphology and activation changes: possible implications for the role of glucose in platelet storage.

    abstract:BACKGROUND:Stress-enhanced platelet (PLT) storage lesions include increased glycolysis, discoid-to-sphere morphology change, and spontaneous PLT activation. It is not clear if reduction in glycolysis can alleviate storage lesion development. STUDY DESIGN AND METHODS:Apheresis PLT concentrates were exposed to 17.2 J/mL...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00582.x

    authors: Li J,Goodrich L,Hansen E,Edrich R,Gampp D,Goodrich RP

    更新日期:2005-11-01 00:00:00

  • Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities.

    abstract:BACKGROUND:Fresh-frozen plasma (FFP) is frequently transfused to patients with mild prolongation of coagulation values under the assumption that FFP will correct the coagulopathy. There is little evidence to support this practice, however. To determine the effect of FFP on coagulation variables and correlation with ble...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00891.x

    authors: Abdel-Wahab OI,Healy B,Dzik WH

    更新日期:2006-08-01 00:00:00

  • Validation and assessment of a blood-donor arm disinfectant containing chlorhexidine and alcohol.

    abstract:BACKGROUND:To minimize the bacterial contamination rate in blood collected from donors, a study was designed to evaluate the suitability of a single-use chlorhexidine-alcohol antiseptic for donor arm preparation at all blood collection venues in Australia. STUDY DESIGN AND METHODS:A prospective study of bacterial load...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.03362.x

    authors: Wong PY,Colville VL,White V,Walker HM,Morris RA,Microbial Contamination and Infection Control Subcommittee, Australian Red Cross Blood Service.

    更新日期:2004-08-01 00:00:00

  • Metabolism by the rabbit of intravenously administered adenine.

    abstract::A study was made of the metabolism by the rabbit of adenine administered intravenously at a dose of 35 mg/kg with 100 micronCi of 8-14C-adenine. The infused adenine was removed from the blood in two phases, first by diffusion into the tissues and second by metabolic reactions throughout the body. The adenine equilibra...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1977.17477216863.x

    authors: Bartlett GR

    更新日期:1977-07-01 00:00:00

  • Variation in concentration of prion protein in the peripheral blood of patients with variant and sporadic Creutzfeldt-Jakob disease detected by dissociation enhanced lanthanide fluoroimmunoassay and flow cytometry.

    abstract:BACKGROUND:A highly sensitive dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA) and flow cytometry techniques have previously been developed and employed to characterize soluble cellular prion protein (PrP(c)) expression in whole blood and separated components from healthy adult blood donors. No previous stud...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.0041-1132.2005.04342.x

    authors: Fagge T,Barclay GR,Macgregor I,Head M,Ironside J,Turner M

    更新日期:2005-04-01 00:00:00

  • A multicenter evaluation of reproducibility of swirling in platelet concentrates. Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society of Blood Transfusion.

    abstract:BACKGROUND:Eleven laboratories participated in a study investigating whether swirling can be used in monitoring platelet discoid morphology in platelet concentrates (PCs). STUDY DESIGN AND METHODS:In each laboratory, two readers observed the swirling pattern in 1- to 5-day-old PCs, in PCs containing spherical platelet...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1994.34994378282.x

    authors: Bertolini F,Murphy S

    更新日期:1994-09-01 00:00:00

  • Major transfusions remain frequent despite the generalized use of tranexamic acid: an audit of 3322 patients undergoing cardiac surgery.

    abstract:BACKGROUND:Aprotinin has been reapproved for use in Europe and in Canada. We sought to determine if its reintroduction was still pertinent given the widespread administration of tranexamic acid, another antifibrinolytic shown to reduce bleeding and transfusions. STUDY DESIGN AND METHODS:After institutional review boar...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13615

    authors: Stevens LM,Noiseux N,Prieto I,Hardy JF

    更新日期:2016-07-01 00:00:00

  • Hemovigilance survey of pathogen-reduced blood components in the Warsaw Region in the 2009 to 2013 period.

    abstract:BACKGROUND:In 2009 the Mirasol Pathogen Reduction Technology (PRT) was introduced to the routine blood component production of the Regional Blood Transfusion Center in Warsaw (RBTCW). The goal of this study was to investigate the safety of Mirasol-treated blood components. STUDY DESIGN AND METHODS:The accumulated pass...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.13330

    authors: Łętowska M,Przybylska Z,Piotrowski D,Lachert E,Rosiek A,Rzymkiewicz L,Cardoso M

    更新日期:2016-03-01 00:00:00

  • Iron deficiency anemia at admission for labor and delivery is associated with an increased risk for Cesarean section and adverse maternal and neonatal outcomes.

    abstract:BACKGROUND:Maternal iron deficiency anemia (IDA) impacts placenta and fetus. We evaluated effects of IDA at admission for delivery on cesarean rates, and adverse maternal and neonatal outcomes. STUDY DESIGN AND METHODS:Medical records from Jerusalem (2005-2012) identified women with a live-birth singleton fetus in cep...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13252

    authors: Drukker L,Hants Y,Farkash R,Ruchlemer R,Samueloff A,Grisaru-Granovsky S

    更新日期:2015-12-01 00:00:00