Validation and assessment of a blood-donor arm disinfectant containing chlorhexidine and alcohol.


BACKGROUND:To minimize the bacterial contamination rate in blood collected from donors, a study was designed to evaluate the suitability of a single-use chlorhexidine-alcohol antiseptic for donor arm preparation at all blood collection venues in Australia. STUDY DESIGN AND METHODS:A prospective study of bacterial load on the skin was performed on 616 blood donors' arms before and after disinfection using a direct swabbing and plating technique. Disinfection was achieved with a swab containing 1 percent chlorhexidine gluconate with 75 percent alcohol, which was applied to the skin in a prescribed method. Feedback from blood donors and staff was obtained using questionnaires. RESULTS:After disinfection, 99 percent of donor arms had bacterial counts of 5 cfu per plate or less, and 99.5 percent had counts of 10 cfu per plate or less, respectively. The mean colony count for all donors after disinfection was 0.39, and the percentage reduction was 99 compared to predisinfection. Sixteen donors (3%) noted transient skin irritation. The majority of staff (64%) preferred not to use the new disinfectant due to the difficulty opening the packaging and an excessive amount of antiseptic solution per pack. CONCLUSION:The bacteriologic study showed that the disinfectant satisfied the requirements of the Australian Red Cross Blood Service for use to prepare blood-donor arms before venesection. An improvement to the packaging was required before it could be acceptable to all staff.






Wong PY,Colville VL,White V,Walker HM,Morris RA,Microbial Contamination and Infection Control Subcommittee, Australian Red Cross Blood Service.




Has Abstract


2004-08-01 00:00:00














  • A revised classification scheme for acute transfusion reactions.

    abstract:BACKGROUND:Although the standard classification system for acute transfusion reactions adequately describes the general features associated with the various types of reactions, it was not designed to provide strict criteria for diagnosis and classification. Consequently, its use to classify individual reactions can res...


    pub_type: 杂志文章


    authors: Sanders RP,Geiger TL,Heddle N,Pui CH,Howard SC

    更新日期:2007-04-01 00:00:00

  • Frequently used plateletpheresis techniques result in variable target yields and platelet recruitment of donors.

    abstract:BACKGROUND:Standard plateletpheresis techniques and effects on platelet (PLT) donors were investigated to provide an informative basis for advancement of apheresis software. STUDY DESIGN AND METHODS:Three paired groups with 33 male and 22 female blood donors were prospectively investigated by analyzing blood counts of...


    pub_type: 杂志文章


    authors: Strasser EF,Schuster M,Egler K,Bauer J,Weisbach V,Ringwald J,Zimmermann R,Zingsem J,Eckstein R

    更新日期:2005-05-01 00:00:00

  • Blood transfusion safety in sub-Saharan Africa: A literature review of changes and challenges in the 21st century.

    abstract:BACKGROUND:Access to a safe, adequate blood supply has proven challenging in sub-Saharan Africa, where systemic deficiencies spanning policy, collections, testing, and posttransfusion surveillance have long been recognized. Progress in transfusion safety in the early 2000s was in large part due to intervention by the W...


    pub_type: 杂志文章,评审


    authors: Weimer A,Tagny CT,Tapko JB,Gouws C,Tobian AAR,Ness PM,Bloch EM

    更新日期:2019-01-01 00:00:00

  • Severe hemolysis resulting from D incompatibility in a case of ABO-identical liver transplant.

    abstract:BACKGROUND:Hemolysis due to D incompatibility in the setting of liver transplantation is less frequent than that associated with ABO incompatibility, but can represent an equally adverse event. Approximately 10 percent of ABO-compatible liver transplants involve a D- donor and a D+ recipient. CASE REPORT:A case of sev...


    pub_type: 杂志文章


    authors: Fung MK,Sheikh H,Eghtesad B,Lopez-Plaza I

    更新日期:2004-11-01 00:00:00

  • Depressed blood group antigens on red cells from a Mexican donor.

    abstract::Red cells from a Mexican blood donor had depressed H, IF, ID, i, Sda, Sdx, D, LW, Dib, Vel and JMH antigens. A wide range of other blood group antigens had normal activity. The unusual red cell phenotype may be caused by a membrane anomaly that alters orientation of certain cell surface components. The specificities o...


    pub_type: 杂志文章


    authors: Biro V,Garratty G,Johnson CL,Marsh WL

    更新日期:1983-01-01 00:00:00

  • Mitochondrial damage-associated molecular patterns as potential proinflammatory mediators in post-platelet transfusion adverse effects.

    abstract:BACKGROUND:Platelet concentrates (PCs) are the most common blood components eliciting nonhemolytic transfusion reactions (NHTRs), such as allergic transfusion reactions and febrile reactions. However, the precise mechanisms of NHTRs in PC transfusion remain largely unknown. Previous studies reported that mitochondria-d...


    pub_type: 杂志文章


    authors: Yasui K,Matsuyama N,Kuroishi A,Tani Y,Furuta RA,Hirayama F

    更新日期:2016-05-01 00:00:00

  • Does therapeutic plasma exchange have a role in the treatment of prosthetic hip-associated cobalt toxicity? A case report and literature review.

    abstract:BACKGROUND:Prosthetic hip-associated cobalt toxicity (PHACT) is an uncommon, but potentially devastating, complication for patients with metal-on-metal hip implants (MoMs). Clinical management of PHACT is poorly defined, with primary intervention being MoM explant followed by chelation therapy. Therapeutic plasma excha...


    pub_type: 杂志文章,评审


    authors: Grant ML,Karp JK,Palladino M,Le N,Hall N,Herman JH

    更新日期:2016-09-01 00:00:00

  • Infusible platelet membranes improve hemostasis in thrombocytopenic blood: experimental studies under flow conditions.

    abstract:BACKGROUND:The potential hemostatic effect of infusible platelet membranes (IPM; Cyplex, Cypress Bioscience) prepared from outdated human platelets is investigated. STUDY DESIGN AND METHODS:Increasing concentrations of IPM were added to blood samples anticoagulated with low-molecular-weight heparin, in which platelets...


    pub_type: 杂志文章


    authors: Galán AM,Bozzo J,Hernández MR,Pino M,Reverter JC,Mazzara R,Escolar G,Ordinas A

    更新日期:2000-09-01 00:00:00

  • Platelet crossmatches of single-donor platelet concentrates using a latex agglutination assay.

    abstract::A latex agglutination assay was evaluated for the purpose of identifying compatible platelet donors for alloimmunized recipients. Assay reagents were prepared by adsorbing detergent-solubilized, donor-specific platelets to polystyrene latex beads. Semiquantitative results for up to 30 donors can be completed in less t...


    pub_type: 杂志文章


    authors: Ogden DM,Asfour A,Koller C,Lichtiger B

    更新日期:1993-08-01 00:00:00

  • Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.

    abstract:BACKGROUND:Pulmonary transfusion reactions are important complications of blood transfusion, yet differentiating these clinical syndromes is diagnostically challenging. We hypothesized that biologic markers of inflammation could be used in conjunction with clinical predictors to distinguish transfusion-related acute lu...


    pub_type: 杂志文章


    authors: Roubinian NH,Looney MR,Kor DJ,Lowell CA,Gajic O,Hubmayr RD,Gropper MA,Koenigsberg M,Wilson GA,Matthay MA,Toy P,Murphy EL,TRALI Study Group.

    更新日期:2015-08-01 00:00:00

  • Characteristics of thawed autologous umbilical cord blood.

    abstract:BACKGROUND:Autologous umbilical cord blood (AutoUCB) has historically been cryopreserved for potential use in hematopoietic transplantation. Increasingly, private AutoUCB banking is performed for therapies unavailable today. A Phase I trial using AutoUCB treatment for early pediatric Type 1 diabetes afforded us an oppo...


    pub_type: 杂志文章


    authors: Rosenau EH,Sugrue MW,Haller M,Fisk D,Kelly SS,Chang M,Hou W,Eldjerou L,Slayton W,Cogle CR,Wingard JR

    更新日期:2012-10-01 00:00:00

  • Cesarean section due to fetal distress increases the number of stem cells in umbilical cord blood.

    abstract:BACKGROUND:Umbilical cord blood (UCB) can be used as hematopoietic stem cell source for transplantation. The success of a transplantation is highly correlated with the number of total nucleated cells (TNCs) and CD34+ cells in the UCB. Certain obstetric factors increase the yield of stem cells in the UCB. It is necessar...


    pub_type: 杂志文章


    authors: Manegold G,Meyer-Monard S,Tichelli A,Pauli D,Holzgreve W,Troeger C

    更新日期:2008-05-01 00:00:00

  • A highly specialized and motivated volunteer population: platelet donors.

    abstract::The plateletpheresis program of the M.D. Anderson Hospital was established in 1963. Approximately 20,000 units of platelet concentrates are produced per year. Credit for the nonreplacement fee generates the greatest number of donors. No organized recruitment campaign exists. Each donor becomes a recruiter for the prog...


    pub_type: 杂志文章


    authors: Wendlandt GM,Lichtiger B

    更新日期:1977-05-01 00:00:00

  • Variation in intraoperative and postoperative red blood cell transfusion in pediatric surgery.

    abstract:BACKGROUND:Intraoperative and postoperative red blood cell (RBC) transfusions are relatively frequent events tracked in the American College of Surgeons' National Surgical Quality Improvement Program-Pediatric (ACS-NSQIP-P). This study sought to quantify variation in RBC transfusion practices among hospitals. STUDY DE...


    pub_type: 杂志文章


    authors: Stey AM,Vinocur CD,Moss RL,Hall BL,Cohen ME,Kraemer K,Ko CY,Kenney BD

    更新日期:2016-03-01 00:00:00

  • Risk of chikungunya virus transmission associated with European travelers returning from southern Thailand (2008-2015).

    abstract:BACKGROUND:The impact of the spread of chikungunya virus (CHIKV) by autochthonous transmission and blood transfusion in nonendemic areas via travelers returning from CHIKV-affected locations is a concern. METHODS:We analyzed the risks of potential CHIKV importation and transfusion transmission from Thailand to Europe ...


    pub_type: 杂志文章


    authors: Appassakij H,Khuntikij P,Silpapojakul K,Promwong C,Rujirojindakul P,Suddeaugrai O,Chullasara A

    更新日期:2019-08-01 00:00:00

  • Phase III randomized study comparing 5 or 10 microg per kg per day of filgrastim for mobilization of peripheral blood progenitor cells with chemotherapy, followed by intensification and autologous transplantation in patients with nonmyeloid malignancies.

    abstract:BACKGROUND:It is not known whether increasing the dose of filgrastim after mobilizing chemotherapy improves collection of peripheral blood progenitor cells (PBPC) and leads to faster hematopoietic engraftment after autologous transplantation. STUDY DESIGN AND METHODS:A randomized, open-label, multicenter trial was car...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: André M,Baudoux E,Bron D,Canon JL,D'Hondt V,Fassotte MF,D'Hondt L,Fillet G,Humblet Y,Jerusalem G,Vermeulen P,Symann M,Beguin Y

    更新日期:2003-01-01 00:00:00

  • Outliers in RhD membrane integration are explained by variant RH haplotypes.

    abstract:BACKGROUND:Variations in a multipass transmembrane protein may affect its membrane integration. To study this effect, the systematic molecular characterization of variant D antigen density is a suitable model. Unlike most other membrane proteins, the expression of the D antigen is often determined by a single allele, b...


    pub_type: 杂志文章


    authors: Yu X,Wagner FF,Witter B,Flegel WA

    更新日期:2006-08-01 00:00:00

  • The value of 10-minute posttransfusion platelet counts.

    abstract::Monitoring of platelet counts 1 hour after transfusion has become standard practice in most centers. In this study, platelet counts obtained 10 and 60 minutes after 48 platelet transfusions were compared. There was a close, linear relationship (r = 0.98) between these values over a wide range of posttransfusion counts...


    pub_type: 杂志文章


    authors: O'Connell B,Lee EJ,Schiffer CA

    更新日期:1988-01-01 00:00:00

  • Improving platelet supply chains through collaborations between blood centers and transfusion services.

    abstract:BACKGROUND:Blood centers and hospital transfusion services are challenged with maintaining an adequate platelet (PLT) inventory to minimize the number of outdated units without risking a major shortage. A novel approach to inventory management was established at our institution through a collaboration between the Stanf...


    pub_type: 杂志文章


    authors: Fontaine MJ,Chung YT,Rogers WM,Sussmann HD,Quach P,Galel SA,Goodnough LT,Erhun F

    更新日期:2009-10-01 00:00:00

  • Differential induction of P-selectin expression on platelets by two cell separators during plateletpheresis and the effect of gender on the release of soluble P-selectin.

    abstract:BACKGROUND:Though a number of studies have elegantly characterized platelet activation during storage, less attention has been paid to the initial activation caused by different collection procedures. STUDY DESIGN AND METHODS:The effects of two blood cell separators on the initial activation of platelets were measured...


    pub_type: 临床试验,杂志文章


    authors: Stohlawetz P,Hergovich N,Stiegler G,Eichler HG,Höcker P,Kapiotis S,Jilma B

    更新日期:1998-01-01 00:00:00

  • Rapid identification of microorganisms from platelet concentrates by matrix-assisted laser desorption ionization time-of-flight mass spectrometry after short-term incubation on liquid medium.

    abstract:BACKGROUND:Platelets (PLTs) are especially affected by the risk of bacterial contamination. Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) is an accurate method for the routine identification of bacterial isolates in microbiology laboratories. We directly applied the MALDI-TOF method to bacteria...


    pub_type: 杂志文章


    authors: Chetouane Y,Dubourg G,Gallian P,Flaudrops C,Chiaroni J,Chabrière E,Raoult D,Camoin-Jau L

    更新日期:2018-03-01 00:00:00

  • Granulocyte collections: comparison of two apheresis systems.

    abstract:BACKGROUND:Donor granulocyte concentrates are routinely administered to patients with granulocyte function defects or transient neutropenia and (risk of) bacterial or fungal exacerbations, despite lack of definitive clinical proof for patient-relevant outcome improvement. Granulocytes are collected by apheresis from he...


    pub_type: 杂志文章


    authors: Thorausch K,Schulz M,Bialleck H,Luxembourg B,Seifried E,Bonig H

    更新日期:2013-12-01 00:00:00

  • Effects of immediate or delayed addition of platelet additive solution on the in vitro quality of apheresis platelets.

    abstract:BACKGROUND:There is little knowledge how different hold times of hyperconcentrated platelet (PLT) suspensions (HPSs) before the addition of platelet additive solution (PAS) might affect PLT quality. We compared the in vitro quality of single-donor PLT concentrates (SDPs) with immediate or delayed PAS addition and studi...


    pub_type: 杂志文章


    authors: Ringwald J,Tully S,Geier C,Hauck B,Weiss D,Callaert M,Eckstein R

    更新日期:2012-06-01 00:00:00

  • Incidence of Wra antigen and anti-Wra in a Spanish population.

    abstract:BACKGROUND:This study reports the incidence of Wr(a) antigen and anti-Wr(a) in Valencia, Spain. STUDY DESIGN AND METHODS:The incidence of the Wr(a) antigen in 110,000 healthy blood donors was estimated. Likewise, the incidence of anti-Wr(a) was analyzed in a population consisting of 730 healthy blood donors, 356 pregn...


    pub_type: 杂志文章


    authors: Arriaga F,Llopis F,de la Rubia J,Carpio N,Moscardó J,Marty ML

    更新日期:2005-08-01 00:00:00

  • One-year experience of nucleic acid technology testing for human immunodeficiency virus Type 1, hepatitis C virus, and hepatitis B virus in Thai blood donations.

    abstract:BACKGROUND:Blood donations collected at the National Blood Center, the Thai Red Cross Society, Bangkok, in 2007 were tested by nucleic acid amplification technology (NAT) using the Chiron TIGRIS/Procleix Ultrio test and the Roche cobas s 201/cobas TaqScreen multiplex (MPX) test. STUDY DESIGN AND METHODS:The sensitivit...


    pub_type: 杂志文章


    authors: Phikulsod S,Oota S,Tirawatnapong T,Sakuldamrongpanich T,Chalermchan W,Louisirirotchanakul S,Tanprasert S,Chongkolwatana V,Kitpoka P,Phanuphak P,Wasi C,Nuchprayoon C,Working Group for NAT Study in Thai Blood Donations.

    更新日期:2009-06-01 00:00:00

  • Restrictive blood transfusion practices are associated with improved patient outcomes.

    abstract:BACKGROUND:Blood transfusion has been cited as one of the five most overutilized therapeutic procedures in the United States. We assessed the impact of clinical decision support at computerized physician order entry and education on red blood cell (RBC) transfusions and clinical patient outcomes at our institution. ST...


    pub_type: 杂志文章


    authors: Goodnough LT,Maggio P,Hadhazy E,Shieh L,Hernandez-Boussard T,Khari P,Shah N

    更新日期:2014-10-01 00:00:00

  • Impact of different hold time before addition of platelet additive solution on the in vitro quality of apheresis platelets.

    abstract:BACKGROUND:The quality of platelets (PLTs) stored in PLT additive solution (PAS) is dependent on the type and proportion of the used PAS. No data are available as to whether a different hold time before the addition of PAS to hyperconcentrated PLT suspensions has an impact on PLT quality. The in vitro quality between s...


    pub_type: 杂志文章


    authors: Ringwald J,Haager B,Krex D,Zimmermann R,Strasser E,Antoon M,De Schrijver E,Eckstein R

    更新日期:2006-06-01 00:00:00

  • In vivo viability and functional integrity of filtered platelets.

    abstract::The in vivo viability and functional integrity of filtered platelets were compared with those of nonfiltered platelets in a controlled study. On two occasions, after template bleeding time, 14 healthy volunteers underwent plateletpheresis and received 600 mg of aspirin. Autologous 111In-labeled platelets were transfus...


    pub_type: 杂志文章


    authors: Brecher ME,Pineda AA,Zylstra-Halling VW,Chowdhury S,Forstrom LA

    更新日期:1990-10-01 00:00:00

  • Semaphorin 3A alters endothelial cell immunogenicity by regulating Class II transactivator activity circuits.

    abstract:BACKGROUND:Endothelial cells (ECs) play a pivotal role in the allogeneic immune response upon transplantation. Semaphorin 3A (Sema3A) was implicated in the modulation of EC growth, but its effects on immunogenicity were not previously investigated. STUDY DESIGN AND METHODS:ECs were transduced with a lentiviral vector ...


    pub_type: 杂志文章


    authors: Schlahsa L,Zhang H,Battermann A,Verboom M,Immenschuh S,Eiz-Vesper B,Stripecke R,Engelmann K,Blasczyk R,Figueiredo C

    更新日期:2014-08-01 00:00:00

  • Anti-PP1Pk and early abortion.

    abstract::Anti-PP1Pk is found in the serum of individuals of phenotype p. Recurrent first trimester miscarriages have been reported in nearly 50 percent of mothers with the p phenotype. A comparative serologic study of three p phenotype mothers is reported. The proposita had three miscarriages while her two identical twin siste...


    pub_type: 杂志文章


    authors: Cantin G,Lyonnais J

    更新日期:1983-07-01 00:00:00