Abstract:
:We describe a nonanaphylactic hemoglobinuric reaction caused by transfusion of frozen red cells, deglycerolyzed by standard technique, obtained from a donor with undiagnosed sickle trait. Although significant hemoglobinemia and hemoglobinuria were noted, the recipient experienced no adverse clinical reactions. The benign clinical course supports the hypothesis that red cell antigen-antibody complexes, rather than free hemoglobin or red cell stroma, are responsible for the life-threatening complications of acute hemolytic transfusion reactions. This report also emphasizes the importance of screening donors of red cells for cryopreservation for sickle trait and the necessity of modifying deglycerolization technique should it be necessary to freeze red cells with AS hemoglobin.
journal_name
Transfusionjournal_title
Transfusionauthors
Kelleher JF Jr,Luban NLdoi
10.1046/j.1537-2995.1984.24284173352.xsubject
Has Abstractpub_date
1984-03-01 00:00:00pages
167-8issue
2eissn
0041-1132issn
1537-2995journal_volume
24pub_type
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