Reduced ferritin levels in individuals with non-O blood group: results from the Danish Blood Donor Study.

Abstract:

BACKGROUND:Genomewide association studies have reported alleles in the ABO locus to be associated with ferritin levels. These studies warrant the investigation of a possible association between the ABO blood group and ferritin levels. We aimed to explore if ABO blood group is associated with iron stores expressed as ferritin levels. STUDY DESIGN AND METHODS:Ferritin levels were measured at least once for 30,595 Danish Blood Donor Study participants. Linear regression analyses were performed with the ABO blood group as explanatory variable and adjusted for age, number of donations 3 years before the ferritin measurement, and time since latest donation. In addition, a subanalysis was performed on 15,280 individuals in which further adjustments for body mass index, smoking status, and C-reactive protein levels were possible. Furthermore, logistic regression analyses were performed to determine if ABO blood group was associated with a ferritin level of less than 15 ng/mL. RESULTS:Non-O blood group donors had lower ferritin levels than blood group O donors, regardless of sex. Accordingly, risk of ferritin level of less than 15 ng/mL was increased for individuals with non-O blood group compared with O blood group. In subanalyses similar associations were observed, albeit in women the association between blood group and risk of a ferritin level below 15 ng/mL was no longer significant. ABO blood group was not associated with red blood cell indices such as mean cell volume and mean cell hemoglobin content. CONCLUSION:Donors with non-O blood group have lower ferritin levels than donors with other blood groups.

journal_name

Transfusion

journal_title

Transfusion

authors

Rigas AS,Berkfors AA,Pedersen OB,Sørensen E,Nielsen KR,Larsen MH,Paarup HM,Wandall HH,Erikstrup C,Hjalgrim H,Ullum H

doi

10.1111/trf.14364

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

2914-2919

issue

12

eissn

0041-1132

issn

1537-2995

journal_volume

57

pub_type

杂志文章
  • Treatment of hyperkalemia with exchange transfusion.

    abstract::Exchange transfusions using whole blood less than 24 hours old and deglycerolized red cells reconstituted with fresh-frozen plasma were performed in two premature infants for the treatment of hyperkalemia and cardiac arrhythmia. Improvement of their condition was immediate. ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25485273824.x

    authors: Lorch V,Jones FS,Hoersten IR

    更新日期:1985-07-01 00:00:00

  • Additional evidence for more than one agent of human non-A, non-B hepatitis. Transmission and passage studies in chimpanzees.

    abstract::Evidence supporting the existence of two agents of human non-A, non-B hepatitis was obtained by the inoculation of chimpanzees sequentially with serum from a chronically infected human (Inoculum I) and with fibrinogen prepared from pooled plasma (Inoculum IV), each of which had transmitted non-A, non-B hepatitis to hu...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1984.24384225027.x

    authors: Tabor E,Snoy P,Jackson DR,Schaff Z,Blatt PM,Gerety RJ

    更新日期:1984-05-01 00:00:00

  • Identifying mild and severe preeclampsia in asymptomatic pregnant women by levels of cell-free fetal DNA.

    abstract:BACKGROUND:The objective was to investigate whether women who develop preeclampsia can be identified in a routine analysis when determining fetal RHD status at 25 weeks' gestation in combination with PAPP-A levels at the first-trimester combined risk assessment for Trisomy 21. STUDY DESIGN AND METHODS:D- women partici...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12073

    authors: Jakobsen TR,Clausen FB,Rode L,Dziegiel MH,Tabor A

    更新日期:2013-09-01 00:00:00

  • Granulocyte transfusion kinetics measured by chemiluminescence, nitroblue tetrazolium reduction, and recovery of indium-111-labeled granulocytes.

    abstract::A 20-year-old man with chronic granulomatous disease (CGD) and who was receiving granulocyte transfusions for a refractory liver abscess was studied to compare the kinetics of 111In-labeled granulocytes with those of two functional granulocyte assays, nitroblue tetrazolium reduction and chemiluminescence. Transfused g...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27187121467.x

    authors: Elliott GR,Clay ME,Mills EL,Abramson JS,McCullough J,Quie PG

    更新日期:1987-01-01 00:00:00

  • Flow cytometric quantitation of serum anti-D in pregnancy.

    abstract:BACKGROUND:The major cause of fetal hemolytic disease is maternal immunization to D in D-incompatible pregnancies. To prevent complications, D-incompatible pregnancies are monitored for the level of maternal anti-D. At present, the monitoring of anti-D levels is performed by the indirect antiglobulin test complemented ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1996.36696269507.x

    authors: Christensson M,Bremme K,Shanwell A,Westgren M,Christensson B

    更新日期:1996-06-01 00:00:00

  • Implementing mass-scale red cell genotyping at a blood center.

    abstract:BACKGROUND:When problems with compatibility beyond ABO and D arise, currently transfusion services search their inventories and perform time-consuming serologic testing to locate antigen-negative blood. These clinically important blood group antigens can be detected reliably by red cell genotyping, which is a technolog...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13168

    authors: Flegel WA,Gottschall JL,Denomme GA

    更新日期:2015-11-01 00:00:00

  • Autologous blood donation: hemodynamics in a high-risk patient population.

    abstract::Transfusion practices have changed dramatically in recent years as a result of the acquired immune deficiency syndrome crisis. The use of preoperative donation of autologous blood units has gained popularity. Healthy individuals tolerate phlebotomy well, experiencing a 2- to 5-percent incidence of vasovagal reactions....

    journal_title:Transfusion

    pub_type: 评论,杂志文章

    doi:10.1046/j.1537-2995.1992.32192116425.x

    authors: Spiess BD,Sassetti R,McCarthy RJ,Narbone RF,Tuman KJ,Ivankovich AD

    更新日期:1992-01-01 00:00:00

  • Effects of filtration and gamma radiation on the accumulation of RANTES and transforming growth factor-beta1 in apheresis platelet concentrates during storage.

    abstract:BACKGROUND:Platelet-derived biologic response modifiers (BRMs) including RANTES and transforming growth factor (TGF)-beta1 accumulate in platelet components during storage because of platelet activation, and they may play a causative role in nonhemolytic febrile transfusion reactions. The majority of PCs with high unit...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1537-2995.1999.39050498.x

    authors: Fujihara M,Ikebuchi K,Wakamoto S,Sekiguchi S

    更新日期:1999-05-01 00:00:00

  • Safety profile of high molecular weight polymerized hemoglobins.

    abstract:BACKGROUND:Hemoglobin (Hb)-based oxygen (O2 ) carriers (HBOCs) are being developed as alternatives to red blood cells and blood when these products are unavailable. Clinical trials of previous HBOC generations revealed side effects, including hypertension and vasoconstriction, that were not observed in preclinical stud...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16157

    authors: Muller CR,Williams AT,Munoz CJ,Eaker AM,Breton AN,Palmer AF,Cabrales P

    更新日期:2020-10-26 00:00:00

  • Storage of platelet concentrates after high-dose ultraviolet B irradiation.

    abstract::Ultraviolet B (UVB) irradiation of platelet concentrates (PCs) may prevent the development of posttransfusion HLA alloimmunization. As irradiation performed in a blood center or a hospital will probably be associated with a variable postirradiation delay before transfusion, the ability to store PCs after UVB irradiati...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31691306243.x

    authors: Snyder EL,Beardsley DS,Smith BR,Horne W,Johnson R,Wooten T,Napychank PA,Male P,Buchholz DH

    更新日期:1991-07-01 00:00:00

  • Anti-Ytb in pregnancy.

    abstract::Anti-Ytb was readily eluted from the cord red blood cells of the second child of a mother with both anti-Ytb and anti-Kell in her serum. The baby was Yt (a+b+) and Kell negative. The cord red blood cells were found to have a weakly positive direct antiglobulin test. Clinically evident hemolytic disease of the newborn ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1979.19580059814.x

    authors: Ferguson SJ,Boyce F,Blajchman MA

    更新日期:1979-09-01 00:00:00

  • Prepooled cryoprecipitate for treatment of hemophilia A.

    abstract::Lyophilized factor VIII concentrates, because of their convenience, are the most commonly used products for providing antihemophilic factor to patients with hemophilia A. Heightened concerns about associated complications indicate that cryoprecipitate usage will increase in the immediate future. We present a protocol ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1983.23383224913.x

    authors: Menitove JE,Spero JA,Richards WA,Lewis JH,Montgomery RR,Gill JC,Hasiba U,Wheeler DV,Sherwin JA,Russell-Vaskov S,Marlar RA,Maxwell NG,Aster RH

    更新日期:1983-05-01 00:00:00

  • Anti-D alloimmunization after D-mismatched allogeneic hematopoietic stem cell transplantation in patients with hematologic diseases.

    abstract:BACKGROUND:The de novo development of anti-D after D-mismatched allogeneic hematopoietic stem cell transplantation (AHSCT) is a possibility that must be considered. The transfusion of D- blood components after AHSCT has been recommended but anti-D alloimmunization in this setting has been studied little. Thus, the aim ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00698.x

    authors: Cid J,Lozano M,Fernández-Avilés F,Carreras E,Pereira A,Mazzara R,Ordinas A

    更新日期:2006-02-01 00:00:00

  • Prestorage universal WBC reduction of RBC units does not affect the incidence of transfusion reactions.

    abstract:BACKGROUND:Febrile nonhemolytic transfusion reaction (FNHTR) has been identified as a pivotal reason for prestorage universal WBC reduction. A regional blood center implemented universal prestorage WBC reduction for RBCs on January 1, 2000. Whether prestorage universal WBC reduction of RBC units will affect FNHTR is no...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41080997.x

    authors: Uhlmann EJ,Isgriggs E,Wallhermfechtel M,Goodnough LT

    更新日期:2001-08-01 00:00:00

  • Red blood cell product utilization in patients undergoing allogeneic stem cell transplantation.

    abstract:BACKGROUND:The risk of transfusion reactions (TR) and the cost of blood has led to efforts to reduce blood use. We changed our practice to transfuse just one instead of two units of red blood cells (RBC) when hemoglobin ≤8 g/dL due to patient blood management (PBM) recommendations. METHODS AND MATERIALS:We compared RB...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15285

    authors: Gastecki K,Shanley R,Welbig J,Cohn C,Brunstein CG

    更新日期:2019-07-01 00:00:00

  • Genotyping of RHD by multiplex polymerase chain reaction analysis of six RHD-specific exons.

    abstract:BACKGROUND:Qualitative RHD variants are the result of the replacement of RHD exons by their RHCE counterparts or of point mutations in RHD causing amino acid substitutions. For RHD typing, the use of at least two RHD typing polymerase chain reaction (PCR) assays directed at different regions of RHD is advised to preven...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38111299056309.x

    authors: Maaskant-van Wijk PA,Faas BH,de Ruijter JA,Overbeeke MA,von dem Borne AE,van Rhenen DJ,van der Schoot CE

    更新日期:1998-11-01 00:00:00

  • Evaluation of riboflavin photochemical treatment for inactivation of HCT116 tumor cells mixed in simulative intraoperative salvage blood.

    abstract:BACKGROUND:Radiation and filtration have achieved satisfactory results in inactivation or removal of tumor cells mixed in salvage blood, but some drawbacks remain. This study evaluated the inactivation on HCT116 cells mixed in simulative salvage blood by riboflavin photochemical treatment. METHODS:HCT116 cells were ad...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15499

    authors: Yu Y,Yang L,He C,Tai S,Ma C,Yang T,Wang D

    更新日期:2019-10-01 00:00:00

  • Anti-Cob causing acute hemolytic transfusion reaction.

    abstract::An example of anti-Cob which caused an acute hemolytic transfusion reaction is reported. Immunohematologic studies showed this antibody to be an IgG immunoglobulin that weakly bound complement and reacted in the antiglobulin phase of the crossmatch. The unit of whole blood implicated in the hemolytic transfusion react...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22282177127.x

    authors: Lee EL,Bennett C

    更新日期:1982-03-01 00:00:00

  • Radioactive antiglobulin testing with 125I anti-C4 and anti-C3.

    abstract::The report describes methods for quantitating C4 and C3 coating of red blood cells using 125I anti-C4 and anti-C3. Two methods of preparing antisera were used; one involving absorption and elution from complement coated cells, and the other employing IgG fractions of antisera prepared on DEAE cellulose. White-cell-fre...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18478251233.x

    authors: Jenkins DE Jr,Johnson RM,Moore WH

    更新日期:1978-07-01 00:00:00

  • Removal of prion challenge from an immune globulin preparation by use of a size-exclusion filter.

    abstract:BACKGROUND:A size-exclusion filter (Viresolve 180, Millipore Corp.) was tested for its ability to remove transmissible spongiform encephalopathies prion protein from an immune globulin preparation during ultrafiltration. STUDY DESIGN AND METHODS:Hamster-adapted 263K scrapie brain homogenate (SBH) was spiked into Rh0(D...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00160.x

    authors: Van Holten RW,Autenrieth S,Boose JA,Hsieh WT,Dolan S

    更新日期:2002-08-01 00:00:00

  • Ammonia accumulation in platelet concentrates during storage.

    abstract::Newly prepared platelet concentrates (PC) and platelet poor plasma (PPP) stored at either room temperature (RT) or 4 C were analyzed for ammonia content initially, and after storage at 24, 48, and 72 hours. These studies demonstrate that ammonia rapidly accumulates in PC stored at RT. This accumulation appears to be t...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:

    authors: Ukrainski CT,Goldfinger D,Pomerance JJ,Lee HC,Farber S,Sanchez R

    更新日期:1981-01-01 00:00:00

  • Blood safety and availability: continuing challenges in China's blood banking system.

    abstract::Social and economic development, along with increased health care coverage, has caused a sharp increase in the clinical demand for blood in China. Whole blood collection has increased rapidly in the past decade but has failed to keep pace with the ever-increasing demand. Overall, the country's blood safety has been im...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.12273

    authors: Shi L,Wang JX,Stevens L,Ness P,Shan H

    更新日期:2014-02-01 00:00:00

  • An active hemovigilance program characterizing the safety profile of 7483 transfusions with plasma components prepared with amotosalen and UVA photochemical treatment.

    abstract:BACKGROUND:Photochemical pathogen inactivation treatment (PCT) of plasma components with amotosalen and UVA has been implemented in Europe. To establish a postapproval safety database, an active hemovigilance (HV) program utilizing an electronic data capture system (EDCS) was initiated. STUDY DESIGN AND METHODS:The re...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1537-2995.2009.02579.x

    authors: Cazenave JP,Waller C,Kientz D,Mendel I,Lin L,Jacquet M,Propst M,Liu W,Corash L,Sundin D,Defoin L,Messe N,Osselaer JC

    更新日期:2010-06-01 00:00:00

  • Hemostatic profile under fluid resuscitation during rivaroxaban anticoagulation: an in vitro survey.

    abstract:BACKGROUND:Uncontrollable bleeding is the leading cause of death in traumatically injured patients. The extent to which direct factor Xa inhibitors interfere with the applied resuscitation measures is presently unknown. STUDY DESIGN AND METHODS:In this study, we investigated the effect of the resuscitation fluids sali...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14933

    authors: Helin TA,Zuurveld M,Manninen M,Meijers JCM,Lassila R,Brinkman HJM

    更新日期:2018-12-01 00:00:00

  • First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage.

    abstract:BACKGROUND:In cases of massive hemorrhage in the US military, improved outcomes have been reported with the use of warm, fresh whole blood transfusions. Cold-stored low-titer type O whole blood (LTOWB) has become the preferred product for resuscitation of severe bleeding in deployed surgical units. Reports of LTOWB use...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.15492

    authors: Bahr TM,DuPont TL,Morris DS,Pierson SE,Esplin MS,Brown SM,O'Brien EA,Ilstrup SJ,Christensen RD

    更新日期:2019-10-01 00:00:00

  • Safety and impact of donor-type red blood cell transfusion before allogeneic peripheral blood progenitor cell transplantation with major ABO mismatch.

    abstract:BACKGROUND:Changes within the ABO system are regularly observed phenomena in allogeneic bone marrow transplantation (BMT) and peripheral blood progenitor cell transplantation (PBPCT). Major ABO mismatch can lead to different clinical problems including acute hemolysis after infusion of the allograft, delay of red blood...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2005.00578.x

    authors: Scholl S,Klink A,Mügge LO,Schilling K,Höffken K,Sayer HG

    更新日期:2005-10-01 00:00:00

  • Calcium is a key constituent for maintaining the in vitro properties of platelets suspended in the bicarbonate-containing additive solution M-sol with low plasma levels.

    abstract:BACKGROUND:Commercially available additive solutions (ASs) require 30% to 35% plasma for optimal storage of platelets (PLTs). PLTs suspended in M-sol, a bicarbonate-based experimental platelet additive solution (PAS), maintain in vitro PLT properties during storage with low levels of plasma (< or =5%). STUDY DESIGN AN...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02539.x

    authors: Wagner SJ,Skripchenko A,Myrup A,Thompson-Montgomery D,Awatefe H,Moroff G

    更新日期:2010-05-01 00:00:00

  • Evaluation of swirling, pH, and glucose tests for the detection of bacterial contamination in platelet concentrates.

    abstract:BACKGROUND:Although infrequent, episodes of transfusion-associated bacterial sepsis may lead to serious outcomes or death and therefore are of concern. This study evaluates the sensitivity of three surrogate tests for the presence of bacteria in platelet concentrates: cessation of swirling, low extracellular pH, and lo...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1996.36111297091744.x

    authors: Wagner SJ,Robinette D

    更新日期:1996-11-01 00:00:00

  • Severe hemolysis resulting from D incompatibility in a case of ABO-identical liver transplant.

    abstract:BACKGROUND:Hemolysis due to D incompatibility in the setting of liver transplantation is less frequent than that associated with ABO incompatibility, but can represent an equally adverse event. Approximately 10 percent of ABO-compatible liver transplants involve a D- donor and a D+ recipient. CASE REPORT:A case of sev...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.03382.x

    authors: Fung MK,Sheikh H,Eghtesad B,Lopez-Plaza I

    更新日期:2004-11-01 00:00:00

  • An immediate, allergic skin reaction to aprotinin after reexposure to fibrin sealant.

    abstract:BACKGROUND:The safety of fibrin tissue adhesives has been a concern since they entered wide clinical application. Most commercially available kits contain the proteolytic inhibitor, aprotinin, to stabilize the fibrin clot. A bovine protein, this substance has an allergenic potency. CASE REPORT:This case report present...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40030302.x

    authors: Beierlein W,Scheule AM,Antoniadis G,Braun C,Schosser R

    更新日期:2000-03-01 00:00:00