Removal of prion challenge from an immune globulin preparation by use of a size-exclusion filter.

abstract：BACKGROUND:The testing of cord blood (CB) progenitor and stem cell units for transplantation suitability involves enumeration of total nucleated cells before freezing. CD34+ cell counts may also be a means of determining suitability. Studies have been conducted to evaluate how specific storage conditions influence cell...

journal_title：Transfusion

authors： Kurtz J,Seetharaman S,Greco N,Moroff G

更新日期：2007-09-01 00:00:00

abstract：:Dextran 40 is the main component of the solution used to wash or dilute thawed cord blood unit (CBU) products for stem cell transplant. Dextran 40 became unavailable in the United States as of April 2014. Like many other cellular therapy laboratories in the United States, we found ourselves with limited dextran 40 inv...

journal_title：Transfusion

authors： Reich-Slotky R,Bachegowda LS,Ancharski M,Mendeleyeva L,Rubinstein P,Rennert H,Shore T,van Besien K,Cushing M

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Thrombocytopenia is a serious side effect following high-dose chemotherapy or whole-body irradiation. For many patients, a hematopoietic stem cell (HSC) transplant is required as part of the treatment or to restore the integrity of the hematopoietic system. In this article, we first review the origin of thro...

journal_title：Transfusion

authors： Pineault N,Boyer L

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Photodynamic virus inactivation of plasma with methylene blue significantly decreases the recovery of fibrinogen and coagulation factors V and VIII. Because an adequate supply of fibrinogen is essential for the therapeutic efficacy of transfused plasma in many clinical settings, it was plausible that transfu...

journal_title：Transfusion

authors： Atance R,Pereira A,Ramírez B

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Hypoxia is a major cause of painful vaso-occlusive crisis in sickle cell disease (SCD). Simple transfusion and red blood cell (RBC) exchange are commonly used as preventive therapies whose aim is to dilute hemoglobin (Hb)S-containing RBCs (SS-RBCs) with normal RBCs (AA-RBCs) to prevent sickling. We hypothesi...

journal_title：Transfusion

authors： Bourgeaux V,Hequet O,Campion Y,Delcambre G,Chevrier AM,Rigal D,Godfrin Y

更新日期：2010-10-01 00:00:00

abstract：:Data collected from 50 saline washed units of red blood cells shows that units washed with one liter of 0.9 per cent NaCl on an IBM cell processor have an average hematocrit of 72.2 per cent, with 84.7 per cent of the white blood cells removed, and only 0.6 per cent of the original total protein remaining. The red blo...

journal_title：Transfusion

authors： Wooten MJ

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:By regulation, ongoing process control of WBC-reduced processes is performed on 1 percent of WBC-reduced components, typically four to five samples per month. However, prospective study of the power of this small sample has been difficult. Using computer-generated "residual WBC" distributions, sample size se...

journal_title：Transfusion

authors： Adams MR,Fisher DM,Dumont LJ,Dzik WH,Heaton WA

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Transfusion-induced serum sickness reactions are rarely reported in the literature. The Type III hypersensitivity reaction to heterologous proteins involves deposition of complement and immune complexes in small vessel walls resulting in a leukocytoclastic vasculitis. A case of a multiply transfused patient ...

journal_title：Transfusion

authors： Saegeman V,Wynendaele W,Kerre S,Dedeurwaerdere F,Van den Driessche M,Moerman J

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) are the most potent antigen-presenting cells that initiate and regulate immune responses. They are unique in their feature to produce bioactive interleukin (IL)-12, a major proinflammatory cytokine connecting innate and adaptive immunity. Platelets (PLTs) are highly reactive components ...

journal_title：Transfusion

authors： Kissel K,Berber S,Nockher A,Santoso S,Bein G,Hackstein H

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:The use of hematopoietic progenitor cell (HPC) transplantation has rapidly expanded in recent years. Currently, several sources of HPCs are available for transplantation including peripheral blood HPCs (PBPCs), cord blood cells, and marrow cells. Of these, PBPC collection has become the major source of HPCs....

journal_title：Transfusion

authors： Chen J,Burns KM,Babic A,Carrum G,Kennedy M,Segura FJ,Garcia S,Potts S,Leveque C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:It is not known whether increasing the dose of filgrastim after mobilizing chemotherapy improves collection of peripheral blood progenitor cells (PBPC) and leads to faster hematopoietic engraftment after autologous transplantation. STUDY DESIGN AND METHODS:A randomized, open-label, multicenter trial was car...

journal_title：Transfusion

authors： André M,Baudoux E,Bron D,Canon JL,D'Hondt V,Fassotte MF,D'Hondt L,Fillet G,Humblet Y,Jerusalem G,Vermeulen P,Symann M,Beguin Y

更新日期：2003-01-01 00:00:00

abstract：:We investigated the possibility that the functional impairment in neutrophil (PMN) chemotaxis which occurs during granulocyte concentrate storage might be due to autotoxicity from the release of neutrophil granule contents during storage. Preliminary experiments confirmed that the exposure of fresh PMNs to the intrace...

journal_title：Transfusion

authors： Lane TA,Lamkin GE

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:This randomized controlled study was undertaken to determine the effect of recombinant human erythropoietin (rHuEPO) on erythropoiesis, autologous blood collection, and allogeneic transfusion risk in elective surgery patients with low baseline hematocrits. STUDY DESIGN AND METHODS:Patients (n = 204) with lo...

journal_title：Transfusion

authors： Price TH,Goodnough LT,Vogler WR,Sacher RA,Hellman RM,Johnston MF,Bolgiano DC,Abels RI

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Platelet (PLT) transfusion is the primary treatment for thrombocytopenia. PLTs are obtained exclusively from volunteer donors, and the PLT product has only a 5-day shelf life, which can limit supply and result in PLT shortages. PLTs derived from stem cells could help to fill this clinical need. However, curr...

journal_title：Transfusion

authors： Avanzi MP,Oluwadara OE,Cushing MM,Mitchell ML,Fischer S,Mitchell WB

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Vitamin K is reported to begin reversing warfarin within 6 to 12 hours, but this may occur sooner. We sought to determine the rate of international normalized ratio (INR) reversal following vitamin K and relationships with dose, route, and baseline INR. METHODS:We evaluated adult patients receiving vitamin ...

journal_title：Transfusion

authors： Polito NB,Kanouse E,Jones CMC,McCann M,Refaai MA,Acquisto NM

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:In 2010, health care facilities in the United States began voluntary enrollment in the National Healthcare Safety Network (NHSN) Hemovigilance Module. Participants report transfusion practices; red blood cell, platelet (PLT), plasma, and cryoprecipitate units transfused; and transfusion-related adverse react...

journal_title：Transfusion

authors： Harvey AR,Basavaraju SV,Chung KW,Kuehnert MJ

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Red blood cell (RBC) alloimmunization is reported to occur at an incidence of 5.2% to 23.5% among patients with thalassemia requiring chronic transfusion. With very limited data on alloimmunization among the Chinese population, a territory-wide study has been performed to look at its prevalence among Chinese...

journal_title：Transfusion

authors： Cheng CK,Lee CK,Lin CK

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:To meet European guidelines for plasma for fractionation, plasma fractionators have implemented parvovirus B19 (B19V) and hepatitis A virus (HAV) nucleic acid test (NAT) screening on test pools. In this study we evaluate recently developed in-house NAT assays for B19V DNA and HAV RNA. The B19V NAT was design...

journal_title：Transfusion

authors： Molenaar-de Backer MW,de Waal M,Sjerps MC,Koppelman MH

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Much effort and resources have been devoted to programs that provide transfusion support for patients with sickle cell disease (SCD). The focus of many donor programs is to prevent alloimmunization by recruiting racially matched African American donors to limit the red blood cell (RBC) antigenic differences ...

journal_title：Transfusion

authors： Karafin MS,Field JJ,Gottschall JL,Denomme GA

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:The prevalence of hepatitis G virus (HGV) and its strain variant, the GB agent (GBV-C) is high in non-virus-inactivated plasma products, but, persistent infection in recipients is relatively low. STUDY DESIGN AND METHODS:Stored samples from transfusion donors and recipients in a prospective study of posttra...

journal_title：Transfusion

authors： Wang JT,Chen PJ,Liu DP,Sheu JC,Wang TH,Chen DS

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Idarucizumab (IDA) is approved for emergency reversal of dabigatran; prothrombin complex concentrates (PCCs) are recommended in the absence of specific antidote. The combined effects of IDA and PCC in trauma-related bleeding are unknown. The efficacy and safety of combined IDA + PCC were assessed in a lethal...

journal_title：Transfusion

authors： Honickel M,Braunschweig T,Rossaint R,Schöchl H,Grottke O

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:The risk of transfusion reactions (TR) and the cost of blood has led to efforts to reduce blood use. We changed our practice to transfuse just one instead of two units of red blood cells (RBC) when hemoglobin ≤8 g/dL due to patient blood management (PBM) recommendations. METHODS AND MATERIALS:We compared RB...

journal_title：Transfusion

authors： Gastecki K,Shanley R,Welbig J,Cohn C,Brunstein CG

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Although the need for whole blood is declining, so too are the number of first-time and repeat blood donors. To develop new recruitment and retention strategies, therefore, we need to draw on as wide a variation in blood donor motivations as possible. The primary aim of this study is to draw on a large surve...

journal_title：Transfusion

authors： Ferguson E,Hill A,Lam M,Reynolds C,Davison K,Lawrence C,Brailsford SR

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is characterized by red blood cell (RBC) destruction in response to oxidative stress. Although blood donors are not routinely screened for G6PD deficiency, the transfusion of stored G6PD-deficient RBCs may have serious adverse outcomes. By measuring G6PD en...

journal_title：Transfusion

authors： Francis RO,Jhang J,Hendrickson JE,Zimring JC,Hod EA,Spitalnik SL

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Maternal plasma and/or serum levels of anti-HPA-1a at delivery were compared to neonatal platelet (PLT) counts. STUDY DESIGN AND METHODS:Samples from HPA-1bb women who gave birth to children with thrombocytopenia or had anamnestic information about a previous child with neonatal alloimmune thrombocytopenia ...

journal_title：Transfusion

authors： Killie MK,Husebekk A,Kaplan C,Taaning E,Skogen B

更新日期：2007-01-01 00:00:00

abstract：:Sera from three unrelated persons whose red cells (RBC) had the common Scianna phenotype (Sc:1,-2) contained IgG alloantibodies directed against high-frequency RBC antigens. In each case, sera or eluates or both failed to react only with Scianna null (Sc:-1,-2) cells, although an eluate from one person was compatible ...

journal_title：Transfusion

authors： Devine P,Dawson FE,Motschman TL,Skradski KJ,Orsini L,Moulds JJ,Taswell HF

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Hematology analyzers use impedance, optical, and/or immunologic techniques for counting platelets (PLTs). PLT counting in whole blood has been validated thoroughly; however, this is not the case for PLT counting in PLT concentrates (PCs), in which red cells (RBCs) are absent. Therefore, this study is focused...

journal_title：Transfusion

authors： Dijkstra-Tiekstra MJ,Kuipers W,Setroikromo AC,de Wildt-Eggen J

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Stress-enhanced platelet (PLT) storage lesions include increased glycolysis, discoid-to-sphere morphology change, and spontaneous PLT activation. It is not clear if reduction in glycolysis can alleviate storage lesion development. STUDY DESIGN AND METHODS:Apheresis PLT concentrates were exposed to 17.2 J/mL...

journal_title：Transfusion

authors： Li J,Goodrich L,Hansen E,Edrich R,Gampp D,Goodrich RP

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Recombinant human G-CSF is widely used to mobilize PBPCs in healthy donors for allogeneic transplantation. There have been concerns about donor safety because of splenic ruptures during G-CSF application. To address this problem, changes in splenic size in 91 healthy donors during G-CSF mobilization of allog...

journal_title：Transfusion

authors： Platzbecker U,Prange-Krex G,Bornhäuser M,Koch R,Soucek S,Aikele P,Haack A,Haag C,Schuler U,Berndt A,Rutt C,Ehninger G,Hölig K

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:A case of donor cell leukemia (DCL) is reported. A 42-year-old female developed acute myeloid leukemia (AML) of donor cell origin 18 months after a bone marrow transplant (BMT) from her brother. At the time DCL presented, the donor-brother was also diagnosed with AML showing identical cytogenetic abnormaliti...

journal_title：Transfusion

authors： Glasser L,Meloni-Ehrig A,Greaves W,Demel KC,Butera J

更新日期：2009-03-01 00:00:00