Serologic evidence that Scianna null (Sc:-1,-2) red cells lack multiple high-frequency antigens.

Abstract:

:Sera from three unrelated persons whose red cells (RBC) had the common Scianna phenotype (Sc:1,-2) contained IgG alloantibodies directed against high-frequency RBC antigens. In each case, sera or eluates or both failed to react only with Scianna null (Sc:-1,-2) cells, although an eluate from one person was compatible with a sibling's Sc:1,-2 cells. Cross-testing cells with sera or eluates, or both, from the three persons revealed no mutual compatibility. These studies show the existence of three additional RBC antigens phenotypically related to the Scianna blood group system. Sc:-1,-2 cells lack these antigens, which indicates that Scianna null cells lack multiple high-frequency antigens.

journal_name

Transfusion

journal_title

Transfusion

authors

Devine P,Dawson FE,Motschman TL,Skradski KJ,Orsini L,Moulds JJ,Taswell HF

doi

10.1046/j.1537-2995.1988.28488265264.x

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

346-9

issue

4

eissn

0041-1132

issn

1537-2995

journal_volume

28

pub_type

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