Abstract:
:Methyldopa can produce both a positive direct antiglobulin test and less commonly a positive indirect antiglobulin test. When the drug-induced antibody is present in the serum, it acts as a panagglutinin and reacts with all normal red blood cells; consequently crossmatch-compatible blood cannot be prepared. Although the methyldopa-induced antibody itself rarely produces hemolysis, difficulties can arise in previously unscreened patients in whom the panagglutinin may mask an unknown, pre-existing, and potentially hemolytic alloantibody. We report on our clinical and serologic management of 14 such patients for whom transfusions were requested.
journal_name
Transfusionjournal_title
Transfusionauthors
Snyder EL,Spivack Mdoi
10.1046/j.1537-2995.1979.19379204213.xsubject
Has Abstractpub_date
1979-05-01 00:00:00pages
313-6issue
3eissn
0041-1132issn
1537-2995journal_volume
19pub_type
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