The effect of recombinant human erythropoietin on the efficacy of autologous blood donation in patients with low hematocrits: a multicenter, randomized, double-blind, controlled trial.

Abstract:

BACKGROUND:This randomized controlled study was undertaken to determine the effect of recombinant human erythropoietin (rHuEPO) on erythropoiesis, autologous blood collection, and allogeneic transfusion risk in elective surgery patients with low baseline hematocrits. STUDY DESIGN AND METHODS:Patients (n = 204) with low baseline hematocrits ( < or = 39%), scheduled for orthopedic surgery within 25 to 35 days, were seen every 3 to 4 days for 21 days. At each visit, 450 mL of blood was collected if the hematocrit was > or = 33 percent, and rHuEPO (600 U/kg) or placebo was administered intravenously. RESULTS:One hundred seventy-three patients were evaluable. The number of autologous units collected from the rHuEPO and control groups, respectively, was 4.5 +/- 1.0 and 3.0 +/- 1.1 (p < 0.001), and marrow production of red cells increased by 668 +/- 222 and 353 +/- 155 mL over and above baseline production (p < 0.05). Allogeneic blood transfusion was required by 31 percent of control and 20 percent of rHuEPO patients (p = 0.09). Excluding 8 patients who received > 6 units, 29 percent of control and 14 percent of rHuEPO patients required allogeneic blood (p = 0.015). Logistic regression modeling determined that the risk of allogeneic transfusion was reduced by rHuEPO (p = 0.025). CONCLUSION:The use of rHuEPO stimulates erythropoiesis, permits the storage of more autologous blood, and reduces allogeneic transfusion risk in patients with low hematocrits who are undergoing elective orthopedic surgery. Additional studies are necessary to determine the optimal schedules of rHuEPO administration and autologous blood collection as well as the cost-effectiveness of this strategy.

journal_name

Transfusion

journal_title

Transfusion

authors

Price TH,Goodnough LT,Vogler WR,Sacher RA,Hellman RM,Johnston MF,Bolgiano DC,Abels RI

doi

10.1046/j.1537-2995.1996.36196190512.x

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

29-36

issue

1

eissn

0041-1132

issn

1537-2995

journal_volume

36

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Detection and identification of platelet antibodies using a sensitive multiplex assay system-platelet antibody bead array.

    abstract:BACKGROUND:Tests for platelet-specific antibodies are important in the diagnosis of immune platelet disorders. Monoclonal antibody glycoprotein capture assays have been the gold standards in platelet antibody detection for almost 30 years. However, such assays are complex and cumbersome to perform, which limits their r...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14122

    authors: Metzner K,Bauer J,Ponzi H,Ujcich A,Curtis BR

    更新日期:2017-07-01 00:00:00

  • Recruitment of unrelated persons as bone marrow donors. A preliminary experience.

    abstract::Seven hundred and sixty-three blood donors previously typed for HLA-A and B antigens were asked to consider donating bone marrow to unrelated patients for whom no HLA-matched sibling was available. Eighty-eight percent (668) indicated willingness to donate marrow, and of these, 615 (81%) participated in testing and 53...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26486262736.x

    authors: McElligott MC,Menitove JE,Aster RH

    更新日期:1986-07-01 00:00:00

  • Radioactive antiglobulin testing with 125I anti-C4 and anti-C3.

    abstract::The report describes methods for quantitating C4 and C3 coating of red blood cells using 125I anti-C4 and anti-C3. Two methods of preparing antisera were used; one involving absorption and elution from complement coated cells, and the other employing IgG fractions of antisera prepared on DEAE cellulose. White-cell-fre...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18478251233.x

    authors: Jenkins DE Jr,Johnson RM,Moore WH

    更新日期:1978-07-01 00:00:00

  • Risk for malaria in United States donors deferred for travel to malaria-endemic areas.

    abstract:BACKGROUND:Deferral for travel to malaria-endemic areas excludes many blood donors in the United States. Most transfusion-transmitted malaria is associated with lengthy residence in malaria-endemic areas rather than routine travel. This study compares the impact of existing deferral requirements to the risk that a pres...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02290.x

    authors: Spencer B,Steele W,Custer B,Kleinman S,Cable R,Wilkinson S,Wright D

    更新日期:2009-11-01 00:00:00

  • Sensitivity of hepatitis C virus core antigen and antibody combination assays in a global panel of window period samples.

    abstract:BACKGROUND:Hepatitis C virus (HCV) antigen and antibody combination assays have been launched as a cost-effective alternative to nucleic acid testing (NAT) for reducing the antibody-negative window period (WP). Later, a HCV antigen chemiluminescence immunoassay (CLIA) became available. STUDY DESIGN AND METHODS:A panel...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13179

    authors: Laperche S,Nübling CM,Stramer SL,Brojer E,Grabarczyk P,Yoshizawa H,Kalibatas V,El Elkyabi M,Moftah F,Girault A,van Drimmelen H,Busch MP,Lelie N

    更新日期:2015-10-01 00:00:00

  • Probability of receiving testing in a national lookback program: the English HCV experience.

    abstract:BACKGROUND:The HCV lookback program was designed to trace and offer testing to recipients who received transfusion of blood components from donors subsequently found to be anti-HCV positive. Only approximately 20 percent of transfusable components entering lookback did result in a recipient obtaining testing through th...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00171.x

    authors:

    更新日期:2002-09-01 00:00:00

  • Platelet storage. Effects of leachable materials on morphology and function.

    abstract::A polyolefin plastic (PL 732) bag formulated without liquid plasticizer allows storage of platelets for 5 and, now, up to 7 days. In order to assess the leaching of compounds from this new plastic, extracts of the supernatant from platelet concentrates stored in these bags were analyzed by high-performance liquid chro...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26486262743.x

    authors: Labow RS,Tocchi M,Rock G

    更新日期:1986-07-01 00:00:00

  • Progressive platelet activation with storage: evidence for shortened survival of activated platelets after transfusion.

    abstract::Platelets are known to become activated during storage, but it is unclear whether such activation affects recovery or survival after platelet concentrate (PC) transfusion. With the use of flow cytometry to determine the percentage of platelets expressing the alpha-granule membrane protein 140 (GMP-140), a known adhesi...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31591263195.x

    authors: Rinder HM,Murphy M,Mitchell JG,Stocks J,Ault KA,Hillman RS

    更新日期:1991-06-01 00:00:00

  • Prospective randomized and crossover comparison of two apheresis machines for peripheral blood stem cell collection: a multicenter study.

    abstract:BACKGROUND:Improving apheresis technology may lead to an efficient and safe peripheral blood stem cell (PBSC) collection. Recently, the Spectra Optia (Optia, Terumo BCT) was introduced as an automated apheresis instrument, but comparisons with other instruments have been few. This is the first randomized multicenter an...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/trf.13777

    authors: Ikeda K,Minakawa K,Muroi K,Fujiwara SI,Yamada-Fujiwara M,Fujimori Y,Tanosaki R,Ohto H,Study Group for Peripheral Blood Stem Cell Collection, Cell Therapy Committee, The Japan Society of Transfusion Medicine and Cell Therapy.

    更新日期:2016-11-01 00:00:00

  • Transfusion of red cells after autologous bone marrow harvest in patients with acute leukemia and malignant lymphoma.

    abstract::Bone marrow was harvested for the purpose of autologous bone marrow transplantation (ABMT) in 21 patients previously treated with chemotherapy and in complete remission from acute leukemia or non-Hodgkin's lymphoma. The volume required to obtain 2 x 10(8) nucleated cells per kg was less than 15 mL per kg in 13 patient...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30490273437.x

    authors: Sonneveld P,de Leeuw CA,Schipperus M,Lindemans J,Abels J

    更新日期:1990-05-01 00:00:00

  • Semiautomated data analysis of flow cytometric estimation of fetomaternal hemorrhage in D- women.

    abstract:BACKGROUND:Accurate and reliable measurement of the volume of fetal D+ cells in D- women is required for adequate anti-D prophylaxis. A semiautomated flow cytometry assay based on a standardized calibration curve that was created with simulated fetomatemal hemorrhage (FMH) mixtures was developed. STUDY DESIGN AND METH...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00159.x

    authors: Greiss MA,Armstrong-Isher SS,Perera WS,Brown PM,Urbaniak SJ

    更新日期:2002-08-01 00:00:00

  • Prospective comparison of high-dose plateletpheresis with the latest apheresis systems on the same donors.

    abstract:BACKGROUND:To improve productivity of automated platelet (PLT) collection, the industry has introduced new instruments or modifications to existing equipment. STUDY DESIGN AND METHODS:With the same 8 donors for double (DDC) and triple-dose PLT collection (TDC), the Baxter Amicus (AM), the Haemonetics MCS Plus (MCS+), ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00928.x

    authors: Picker SM,Radojska SM,Gathof BS

    更新日期:2006-09-01 00:00:00

  • Effective storage of granulocytes collected by centrifugation leukapheresis from donors stimulated with granulocyte-colony-stimulating factor.

    abstract:BACKGROUND:Donor stimulation with granulocyte-colony-stimulating factor (G-CSF) has increased the number of neutrophils (PMNs) that can be collected for granulocyte transfusion therapy. Clinical utility, however, has been limited by the inability to store functional PMNs ex vivo. This study was conducted to determine w...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2005.00636.x

    authors: Hubel K,Rodger E,Gaviria JM,Price TH,Dale DC,Liles WC

    更新日期:2005-12-01 00:00:00

  • Studies on the blood of a Co (a-b-) proposita and her family.

    abstract::The serum of a pregnant woman whose red cells typed as Co(a-b-) contained an alloantibody that, at the time of the infants delivery, was hemolytic in vitro and had a titer of 32,000 by the antiglobulin test. This antibody, which reacted with cells of all Colton-phenotypes except the proposita's own cells, showed very ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27387235637.x

    authors: Lacey PA,Robinson J,Collins ML,Bailey DG,Evans CC,Moulds JJ,Daniels GL

    更新日期:1987-05-01 00:00:00

  • Evaluation of the properties of components prepared and stored after holding of whole blood units for 8 and 24 hours at ambient temperature.

    abstract:BACKGROUND:The capability of holding whole blood (WB) units at ambient temperature, overnight, should help in platelet (PLT) concentrate preparation logistics. We summarize the results of a study conducted in the early 1990s that compared, in particular, PLT and red blood cell (RBC) in vivo viability properties followi...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02958.x

    authors: Moroff G,AuBuchon JP,Pickard C,Whitley PH,Heaton WA,Holme S

    更新日期:2011-01-01 00:00:00

  • Functional antibodies to Haemophilus influenzae type B, Neisseria meningitidis, and Streptococcus pneumoniae contained in intravenous immunoglobulin products.

    abstract:BACKGROUND:Intravenous immunoglobulin G (IVIG) replacement therapy is used to prevent invasive infections in patients with primary antibody deficiency (PAD). However, few studies have functionally evaluated specific antibodies against encapsulated bacteria that cause invasive infection in patients with PAD. In this stu...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13869

    authors: Lee S,Kim HW,Kim KH

    更新日期:2017-01-01 00:00:00

  • Evaluation of an automated cell processing device to reduce the dimethyl sulfoxide from hematopoietic grafts after thawing.

    abstract:BACKGROUND:The direct transfusion of thawed hematopoietic progenitor cells (HPCs) is associated to transfusion-related side effects that are thought to be dose-dependent on the infused dimethyl sulfoxide (DMSO). Both the effectiveness of a fully automated cell processing device to washing out DMSO and the effects of DM...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00213.x

    authors: Rodríguez L,Velasco B,García J,Martín-Henao GA

    更新日期:2005-08-01 00:00:00

  • Identifying mild and severe preeclampsia in asymptomatic pregnant women by levels of cell-free fetal DNA.

    abstract:BACKGROUND:The objective was to investigate whether women who develop preeclampsia can be identified in a routine analysis when determining fetal RHD status at 25 weeks' gestation in combination with PAPP-A levels at the first-trimester combined risk assessment for Trisomy 21. STUDY DESIGN AND METHODS:D- women partici...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12073

    authors: Jakobsen TR,Clausen FB,Rode L,Dziegiel MH,Tabor A

    更新日期:2013-09-01 00:00:00

  • Clinical outcomes and transfusion management following intracranial hemorrhage in patients with acute leukemia.

    abstract:BACKGROUND:There is little evidence to guide management of patients with acute leukemia and intracranial hemorrhage (ICH). Predictors of long-term outcome following ICH are unknown. STUDY DESIGN AND METHODS:This study included adult patients with acute leukemia and ICH over an 8-year period. The primary outcome was da...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15621

    authors: Nixon S,Lieberman L,Atenafu EG,Doherty M,Murray C,Wolfe A,Brandys D,Rowland S,Kwan BY,Yu E,Lechner B,Maze D

    更新日期:2020-02-01 00:00:00

  • Sources and sequelae of bacterial contamination of hematopoietic stem cell components: implications for the safety of hematotherapy and graft engineering.

    abstract:BACKGROUND:It is important to compare the incidence of bacterial contamination of components collected from the peripheral blood or bone marrow (BM), as well as of components processed with or without cell selection or depletion, and to evaluate the sequelae of such contamination. STUDY DESIGN AND METHODS:Bacterial co...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1996.36996420753.x

    authors: Webb IJ,Coral FS,Andersen JW,Elias AD,Finberg RW,Nadler LM,Ritz J,Anderson KC

    更新日期:1996-09-01 00:00:00

  • Further studies on the dependence of some examples of anti-M and anti-N on the presence of red-cell-borne sialic acid.

    abstract::Previous studies have shown that some examples of anti-M and anti-N fail to agglutinate neuraminidase-treated (NeuNAc-depleted) red cells. This investigation extends those observations and shows that the antibodies fail to bind to such treated red cells. These observations may mean that NeuNAc residues act to orient t...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1983.23283172846.x

    authors: Issitt PD,Wilkinson SL

    更新日期:1983-03-01 00:00:00

  • A monoclonal antibody with anti-D-like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects.

    abstract:BACKGROUND:The mechanism of action of anti-D in ameliorating immune thrombocytopenia (ITP) remains unclear. The monoclonal antibody (MoAb) Ter119, which targets murine red blood cells (RBCs), has been shown to mimic the effect of anti-D in improving antibody-mediated murine ITP. The mechanism of Ter119-mediated ITP ame...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13032

    authors: Yu X,Menard M,Seabright G,Crispin M,Lazarus AH

    更新日期:2015-06-01 00:00:00

  • Protein composition of clots detected in pooled cryoprecipitate units.

    abstract:BACKGROUND:On rare occasions, upon thawing of stored cryoprecipitate components, clots are observed on visual inspection. Although it has been assumed that the clot reflects fibrinogen to fibrin conversion, there are few published studies that document that this assumption is correct. Our studies were conducted to furt...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03778.x

    authors: MacPhee M,Wilmer B,Beall D,Moroff G

    更新日期:2013-03-01 00:00:00

  • Antibody response in an ABO-incompatible blood transfusion. Antigen specificity and immunoglobulin class.

    abstract::The anti-A response in a group B patient accidentally given 1 unit transfusion of A1 blood is described. The antibody response is characterized both with conventional agglutination techniques and with radioimmunoassay using pure group A antigens with different core saccharide structures (type 1, 2, and 4 chains) and c...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28588337343.x

    authors: Rydberg L,Breimer ME,Samuelsson BE

    更新日期:1988-09-01 00:00:00

  • Evaluation of swirling, pH, and glucose tests for the detection of bacterial contamination in platelet concentrates.

    abstract:BACKGROUND:Although infrequent, episodes of transfusion-associated bacterial sepsis may lead to serious outcomes or death and therefore are of concern. This study evaluates the sensitivity of three surrogate tests for the presence of bacteria in platelet concentrates: cessation of swirling, low extracellular pH, and lo...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1996.36111297091744.x

    authors: Wagner SJ,Robinette D

    更新日期:1996-11-01 00:00:00

  • Mixed-type autoimmune hemolytic anemia: differential diagnosis and a critical review of reported cases.

    abstract:BACKGROUND:Autoimmune hemolytic anemia (AIHA) is usually classified as either warm or cold type. During the past few decades, mixed types (Mxs) have also been described in a number of cases (6%-8% of AIHA), often without serologic data to support the diagnosis. In this study, we demonstrate that the incidence of Mx AIH...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2008.01805.x

    authors: Mayer B,Yürek S,Kiesewetter H,Salama A

    更新日期:2008-10-01 00:00:00

  • Monitoring for underutilization of RBC components and platelets.

    abstract:BACKGROUND:Monitoring blood transfusion for overutilization is standard practice at most institutions. STUDY DESIGN AND METHODS:This study monitored for underutilization of blood transfusion over a 14-month period, by evaluating patients who had Hb levels that were reported to be <5 g per dL or platelet counts <10 x 1...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41050587.x

    authors: Saxena S,Wehrli G,Makarewicz K,Sartorelli J,Shulman IA

    更新日期:2001-05-01 00:00:00

  • Disseminated histoplasmosis presenting as thrombotic microangiopathy.

    abstract:BACKGROUND:Thrombotic microangiopathies (TMA) are systemic vasoocclusive disorders associated with significant morbidity and mortality. Rapid and reliable diagnosis of TMA is critical. The diagnosis is complicated by a lack of objective and sensitive laboratory testing as well as multiple concurrent diseases, including...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00873.x

    authors: Dwyre DM,Bell AM,Siechen K,Sethi S,Raife TJ

    更新日期:2006-07-01 00:00:00

  • Collection and transfusion of blood and blood components in the United States, 1994.

    abstract:BACKGROUND:Collections and transfusions of blood in the United States in 1994 were measured and compared with those in 1992. STUDY DESIGN AND METHODS:Completed survey questionnaires were returned by all 147 regional blood centers, 1340 American Association of Blood Banks (AABB) member hospitals, and 523 non-AABB hospi...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38798346630.x

    authors: Wallace EL,Churchill WH,Surgenor DM,Cho GS,McGurk S

    更新日期:1998-07-01 00:00:00

  • Simplification of the methods for adding and removing glycerol during freeze-preservation of human red blood cells with the high or low glycerol methods: biochemical modification prior to freezing.

    abstract::Simple methods have been developed for adding and removing glycerol during freeze-preservation with 20 per cent W/V glycerol at minus 150 C, or with 40 per cent W/V glycerol at minus 80 C. A one-step method with a 35 per cent W/V glycerol solution is used to prepare 20 per cent W/V glycerolized red blood cells, and a ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1975.15375160354.x

    authors: Valeri CR

    更新日期:1975-05-01 00:00:00