Abstract:
BACKGROUND:Maternal plasma and/or serum levels of anti-HPA-1a at delivery were compared to neonatal platelet (PLT) counts. STUDY DESIGN AND METHODS:Samples from HPA-1bb women who gave birth to children with thrombocytopenia or had anamnestic information about a previous child with neonatal alloimmune thrombocytopenia (NAIT) were collected at delivery. A modified monoclonal antibody immobilization of PLT antigen method was used for quantification of anti-HPA-1a. RESULTS:The anti-HPA-1a level in women with severely thrombocytopenic children was higher than the corresponding level in mothers of children born with moderate thrombocytopenia or normal PLT counts. CONCLUSION:Our data show a significant correlation between maternal anti-HPA-1a level and the neonatal PLT count and indicate strongly that this may be a reliable predictive measure for NAIT. Suitable test systems for quantitative measurements of anti-HPA-1a must be developed and evaluated for this particular purpose.
journal_name
Transfusionjournal_title
Transfusionauthors
Killie MK,Husebekk A,Kaplan C,Taaning E,Skogen Bdoi
10.1111/j.1537-2995.2007.01063.xsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
55-8issue
1eissn
0041-1132issn
1537-2995pii
TRF01063journal_volume
47pub_type
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