Abstract:
BACKGROUND:Current blood transfusion standards in Canada and the United States permit transfusion of ABO-nonidentical platelets when ABO-identical platelets are not available. This practice increases the availability of platelets, a component in chronic shortage in Ontario, Canada because of the 5-day shelf-life. The impact of transfusing ABO-nonidentical platelets on patient outcomes is unknown. STUDY DESIGN AND METHODS. A retrospective review of 1721 patients who had cardiovascular surgery between November 1989 and December 1999 and who had also received a platelet transfusion perioperatively was conducted. The impact of platelet and plasma incompatibility on clinical outcomes was analyzed. RESULTS:The analysis included 1691 patients who were divided into two groups according to the compatibility of the first platelet transfusion received: ABO-identical platelet transfusion (n = 1008) and ABO-nonidentical platelet transfusion (n = 683). The only difference in baseline characteristics between the two groups was that there were more urgent cases in the ABO-identical platelet transfusion group (p = 0.04). There were no significant differences in mortality at 30 days (10% for both groups, p = NS) or in postoperative length of stay (median, 7.0 days for both groups, p = NS). No significant differences were found with respect to the use of blood components, indices of bleeding, incidence of infection, or platelet CCIs. CONCLUSION:Transfusion of ABO-nonidentical platelets in patients undergoing cardiovascular surgery is not associated with an adverse impact on patient outcome.
journal_name
Transfusionjournal_title
Transfusionauthors
Lin Y,Callum JL,Coovadia AS,Murphy PMdoi
10.1046/j.1537-2995.2002.00037.xsubject
Has Abstractpub_date
2002-02-01 00:00:00pages
166-72issue
2eissn
0041-1132issn
1537-2995journal_volume
42pub_type
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