Is flow cytometry accurate enough to screen platelet autoantibodies?

abstract：:The serum of a pregnant woman whose red cells typed as Co(a-b-) contained an alloantibody that, at the time of the infants delivery, was hemolytic in vitro and had a titer of 32,000 by the antiglobulin test. This antibody, which reacted with cells of all Colton-phenotypes except the proposita's own cells, showed very ...

journal_title：Transfusion

authors： Lacey PA,Robinson J,Collins ML,Bailey DG,Evans CC,Moulds JJ,Daniels GL

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Fetal and neonatal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-1a more commonly occurs in first pregnancies, unlike hemolytic disease of the newborn. Anti-D is produced after D+ fetomaternal hemorrhage; this usually occurs at parturition. Anti-HPA-1a could develop during pregnancy if...

journal_title：Transfusion

authors： Kumpel BM,Sibley K,Jackson DJ,White G,Soothill PW

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:To prevent donor loss and improve retention, it is important to understand the major deterrents to blood donation and to identify factors that can be effectively addressed by blood centers. STUDY DESIGN AND METHODS:A 30-item self-administered questionnaire was completed in 2003 by 1705 first-time and 2437 r...

journal_title：Transfusion

authors： Schreiber GB,Schlumpf KS,Glynn SA,Wright DJ,Tu Y,King MR,Higgins MJ,Kessler D,Gilcher R,Nass CC,Guiltinan AM,National Heart, Lung, Blood Institute Retrovirus Epidemiology Donor Study.

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Fever accompanying vaso-occlusive crisis is a common presentation in patients with sickle cell disease (SCD) and carries a broad differential diagnosis. Here, we report a case of transfusion-transmitted malaria in a patient with SCD presenting with acute vaso-occlusive crisis and rapidly decompensating to mu...

journal_title：Transfusion

authors： Maier CL,Gross PJ,Dean CL,Chonat S,Ip A,McLemore M,El Rassi F,Stowell SR,Josephson CD,Fasano RM

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Besides ABO and RH, the KEL blood group system, including the two antithetical antigens KEL1 and KEL2, is the most important owing to the frequent appearance of anti-KEL alloantibodies and their considerable clinical significance. So far, only limited information was available on KEL variant alleles determin...

journal_title：Transfusion

authors： Körmöczi GF,Wagner T,Jungbauer C,Vadon M,Ahrens N,Moll W,Mühlbacher A,Ozgül-Gülce S,Kleinrath T,Kilga-Nogler S,Schönitzer D,Gassner C

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Previous studies showed that Mirasol (Navigant Biotechnologies, Inc.) pathogen reduction technology (PRT) treatment resulted in an increase in platelet (PLT) glucose consumption and lactate production rates and decrease in pH in media during PLT storage. Increased glycolytic flux could result from damage to ...

journal_title：Transfusion

authors： Li J,Lockerbie O,de Korte D,Rice J,McLean R,Goodrich RP

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:RhIG is obtained from hyperimmunized healthy anti-D donors (HIDs) boosted with D+ red blood cells (RBCs). One hypothesis for its mechanism of action is fast clearance of opsonized D+ RBCs through Fcγ receptor (FcγR)III. Levels of immunoglobulin (Ig)G Fc-fucosylation influence interactions with FcγRIII, with ...

journal_title：Transfusion

authors： Kapur R,Della Valle L,Verhagen OJ,Hipgrave Ederveen A,Ligthart P,de Haas M,Kumpel B,Wuhrer M,van der Schoot CE,Vidarsson G

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Determination of the white cell (WBC) count in WBC-reduced platelet components requires methods that have a detection limit in the range of approximately 5.0 x 10(2) to 5.0 x 10(4) per mL. STUDY DESIGN AND METHODS:With a 50-microL Nageotte hemocytometer and bright-field microscopy (200x magnification), stud...

journal_title：Transfusion

authors： Moroff G,Eich J,Dabay M

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Transfusion-induced serum sickness reactions are rarely reported in the literature. The Type III hypersensitivity reaction to heterologous proteins involves deposition of complement and immune complexes in small vessel walls resulting in a leukocytoclastic vasculitis. A case of a multiply transfused patient ...

journal_title：Transfusion

authors： Saegeman V,Wynendaele W,Kerre S,Dedeurwaerdere F,Van den Driessche M,Moerman J

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Liberal transfusion strategy increases the risk of acute lung injury (ALI), but specific transfusion-related factors have not been characterized. We tested the hypotheses that storage age and specific type of blood products are associated with increased risk of ALI in mechanically ventilated patients. STUDY...

journal_title：Transfusion

authors： Gajic O,Rana R,Mendez JL,Rickman OB,Lymp JF,Hubmayr RD,Moore SB

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:We set out to define the impact of collection, processing, and storage on plasma product microparticle (MP) abundance, potential for nitric oxide (NO) scavenging, and vasoactivity. STUDY DESIGN AND METHODS:Three currently US licensed products were tested: liquid plasma (LP), fresh frozen plasma (FFP), and s...

journal_title：Transfusion

authors： Rogers SC,Moynihan FT 4th,McDonough R,Timm DD,Hovmand-Warner E,Frazier E,Thomas KA,Spinella PC,Doctor A

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Blood transfusion has been cited as one of the five most overutilized therapeutic procedures in the United States. We assessed the impact of clinical decision support at computerized physician order entry and education on red blood cell (RBC) transfusions and clinical patient outcomes at our institution. ST...

journal_title：Transfusion

authors： Goodnough LT,Maggio P,Hadhazy E,Shieh L,Hernandez-Boussard T,Khari P,Shah N

更新日期：2014-10-01 00:00:00

abstract：:During the first 5 years (1981-1985) of the liver transplantation program in Pittsburgh, a total (preoperative, intraoperative, and postoperative) of 18,668 packed red cell units, 23,627 fresh-frozen plasma units, 20,590 platelet units, and 4241 cryoprecipitate units was transfused for the procedures. This represents ...

journal_title：Transfusion

authors： Lewis JH,Bontempo FA,Cornell F,Kiss JE,Larson P,Ragni MV,Rice EO,Spero JA,Starzl TE

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Thrombotic microangiopathies (TMA) are systemic vasoocclusive disorders associated with significant morbidity and mortality. Rapid and reliable diagnosis of TMA is critical. The diagnosis is complicated by a lack of objective and sensitive laboratory testing as well as multiple concurrent diseases, including...

journal_title：Transfusion

authors： Dwyre DM,Bell AM,Siechen K,Sethi S,Raife TJ

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:New alloantibody formation is unpredictable in patients who have been previously alloimmunized. Pretransfusion testing is designed to detect these antibodies while antibody identification (ABI) techniques are designed to identify the specificity of the antibody. Pretransfusion testing intervals are prescribe...

journal_title：Transfusion

authors： Goss C,Avecilla ST,Garbaini J,Degtyaryova D,Lo D,Chang DY,Cushing M

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:To investigate how a delay between pretransfusion platelet count measurement and actual platelet transfusion affects the assessment of platelet transfusion responses, the rate of reduction in platelet counts was determined in 30 patients with relatively uncomplicated thrombocytopenia. STUDY DESIGN AND METHO...

journal_title：Transfusion

authors： del Rosario ML,Kao KI

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Techniques for banking cord blood units (CBUs) as source for hematopoietic stem cell transplantation have been developed over the past 20 years, aimed to improve laboratory efficiency without altering the biologic properties of the graft. A large-scale, registry-based assessment of the impact of the banking ...

journal_title：Transfusion

authors： Saccardi R,Tucunduva L,Ruggeri A,Ionescu I,Koegler G,Querol S,Grazzini G,Lecchi L,Nanni Costa A,Navarrete C,Pouthiers F,Larghero J,Regan D,Freeman T,Bittencourt H,Kenzey C,Labopin M,Baudoux E,Rocha V,Gluckman E

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Advances in the past two decades in dendritic cell (DC) biology paved the way to exploit them as a promising tool in cancer immunotherapy. The prerequisite for DC vaccine preparations is large-scale in vitro generations of homogeneous, mature, and functional DCs. Frequent improvements are being made in the e...

journal_title：Transfusion

authors： Balan S,Kale VP,Limaye LS

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Collections and transfusions of blood in the United States in 1994 were measured and compared with those in 1992. STUDY DESIGN AND METHODS:Completed survey questionnaires were returned by all 147 regional blood centers, 1340 American Association of Blood Banks (AABB) member hospitals, and 523 non-AABB hospi...

journal_title：Transfusion

authors： Wallace EL,Churchill WH,Surgenor DM,Cho GS,McGurk S

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Umbilical cord blood (UCB) can be used as hematopoietic stem cell source for transplantation. The success of a transplantation is highly correlated with the number of total nucleated cells (TNCs) and CD34+ cells in the UCB. Certain obstetric factors increase the yield of stem cells in the UCB. It is necessar...

journal_title：Transfusion

authors： Manegold G,Meyer-Monard S,Tichelli A,Pauli D,Holzgreve W,Troeger C

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Hemolytic transfusion reactions are a rare, yet serious complication of red blood cell (RBC) transfusion. Patients with sickle cell disease (SCD) are at an increased risk for such reactions, because they are prone to make alloantibodies against transfused RBCs, complicating this integral part of their diseas...

journal_title：Transfusion

authors： Dean CL,Maier CL,Roback JD,Stowell SR

更新日期：2019-02-01 00:00:00

abstract：:Anemia is common in pregnant women and is associated with increased morbidity for the mother and the fetus, including increased risk of allogeneic blood transfusion. Iron deficiency is the most common etiology for anemia during pregnancy. Oral iron therapy remains the standard treatment but is often poorly tolerated d...

journal_title：Transfusion

authors： Guinn NR,Cooter ML,Maisonave Y,Grimsley A,Cellura C,Grotegut CA,Lamon A,Aronson S,Duke Perioperative Enhancement Team (POET).

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Clinical performance of human platelet (PLT) products processed or stored under novel conditions is difficult to predict based on in vitro studies alone. Recovery and survival of radiolabeled PLTs in human subjects are used as surrogate markers for PLT efficacy in development of new products. Such experiment...

journal_title：Transfusion

authors： Piper JT,Gelderman MP,Vostal JG

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:The expected donor loss from recent implementation of antibody to hepatitis B core antigen (anti-HBc) testing in Canada was uncertain but potentially significant based on US experience. To reduce donor loss from false-reactive tests, repeat-reactive donors without other evidence of infection were eligible to...

journal_title：Transfusion

authors： O'Brien SF,Yi QL,Fan W,Fearon MA,Scalia V,Goldman M

更新日期：2009-02-01 00:00:00

abstract：:Previous studies have shown that some examples of anti-M and anti-N fail to agglutinate neuraminidase-treated (NeuNAc-depleted) red cells. This investigation extends those observations and shows that the antibodies fail to bind to such treated red cells. These observations may mean that NeuNAc residues act to orient t...

journal_title：Transfusion

authors： Issitt PD,Wilkinson SL

更新日期：1983-03-01 00:00:00

abstract：:Platelets are known to become activated during storage, but it is unclear whether such activation affects recovery or survival after platelet concentrate (PC) transfusion. With the use of flow cytometry to determine the percentage of platelets expressing the alpha-granule membrane protein 140 (GMP-140), a known adhesi...

journal_title：Transfusion

authors： Rinder HM,Murphy M,Mitchell JG,Stocks J,Ault KA,Hillman RS

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Uncontrollable bleeding is the leading cause of death in traumatically injured patients. The extent to which direct factor Xa inhibitors interfere with the applied resuscitation measures is presently unknown. STUDY DESIGN AND METHODS:In this study, we investigated the effect of the resuscitation fluids sali...

journal_title：Transfusion

authors： Helin TA,Zuurveld M,Manninen M,Meijers JCM,Lassila R,Brinkman HJM

更新日期：2018-12-01 00:00:00

abstract：:A method is described which absorbs anti-Chido from serum without reducing the strength of other alloantibodies. Autologous red blood cells are coated with homologous C4 by a low-ionic-strength method and then used for the absorption. This is a practical method for removing anti-Chido from serum so that underlying all...

journal_title：Transfusion

authors： Ellisor SS,Shoemaker MM,Reid ME

更新日期：1982-05-01 00:00:00

abstract：:Many significant events have occurred in the recent past that beg a broad audience to address the question "What is pediatric transfusion medicine?" Herein, we list some of these events and their relevance below and attempt to provide an answer for this question. Indeed, several issues regarding the subspecialty of pe...

journal_title：Transfusion

authors： Hillyer CD,Mondoro TH,Josephson CD,Sanchez R,Sloan SR,Ambruso DR

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Autoimmune hemolytic anemia (AIHA) is usually classified as either warm or cold type. During the past few decades, mixed types (Mxs) have also been described in a number of cases (6%-8% of AIHA), often without serologic data to support the diagnosis. In this study, we demonstrate that the incidence of Mx AIH...

journal_title：Transfusion

authors： Mayer B,Yürek S,Kiesewetter H,Salama A

更新日期：2008-10-01 00:00:00