Abstract:
BACKGROUND:Techniques for banking cord blood units (CBUs) as source for hematopoietic stem cell transplantation have been developed over the past 20 years, aimed to improve laboratory efficiency without altering the biologic properties of the graft. A large-scale, registry-based assessment of the impact of the banking variables on the clinical outcome is currently missing. STUDY DESIGN AND METHODS:A total of 677 single cord blood transplants (CBTs) carried out for acute leukemia in complete remission in centers affiliated with the European Society for Blood and Marrow Transplantation were selected. An extensive set of data concerning CBU banking were collected and correlations with clinical outcome were assessed. Clinical endpoints were transplant-related mortality, engraftment, and graft-versus-host disease (GVHD). RESULTS:The median time between collection and CBT was 4.1 years (range, 0.2-16.3 years). Volume reduction (VR) of CBUs before freezing was performed in 59.2% of available reports; in half of these the frozen volume was less than 30 mL. Cumulative incidences of neutrophil engraftment on Day 60, 100-day acute GVHD (II-IV), and 4-year chronic GVHD were 87, 29, and 21 ± 2%. The cumulative incidence of nonrelapse mortality (NRM) at 100 days and 4-year NRM were, respectively, 16 ± 2 and 30 ± 2%. Neither the variables related to banking procedures nor the interval between collection and CBT influenced the clinical outcome. CONCLUSION:These findings indicate a satisfactory validation of the techniques associated with CBU VR across the banks. Cell viability assessment varied among the banks, suggesting that efforts to improve the standardization of CBU quality controls are needed.
journal_name
Transfusionjournal_title
Transfusionauthors
Saccardi R,Tucunduva L,Ruggeri A,Ionescu I,Koegler G,Querol S,Grazzini G,Lecchi L,Nanni Costa A,Navarrete C,Pouthiers F,Larghero J,Regan D,Freeman T,Bittencourt H,Kenzey C,Labopin M,Baudoux E,Rocha V,Gluckman Edoi
10.1111/trf.13661subject
Has Abstractpub_date
2016-08-01 00:00:00pages
2021-9issue
8eissn
0041-1132issn
1537-2995journal_volume
56pub_type
杂志文章相关文献
TRANSFUSION文献大全abstract:BACKGROUND:The FcgammaRIIA gene is expressed in two polymorphic forms, R131 and H131, which differ by the replacement of histidine by arginine at position 131. The FCGR3B (FcgammaRIIIB) gene exists in two allelic isoforms, known as FCGR3B1 (FcgammaRIIIB-NA1) and FCGR3B2 (FcgammaRIIIB-NA2), which differ in nucleotides 1...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.2000.40111388.x
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:A simple and rapid slide Polybrene method (SP) for pretransfusion compatibility testing is described. SP is particularly suitable for use in developing countries where, due to limited resources, centrifuges and biologic reagents may not be readily available. STUDY DESIGN AND METHODS:The original manual Poly...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2004.00659.x
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Critically bleeding trauma patients require coordinated and efficient decision-making processes to ensure optimal management of their massive transfusion (MT) requirements. Human factors (HFs) is a discipline that investigates factors influencing work processes from the organizational, group, and individual ...
journal_title:Transfusion
pub_type: 杂志文章,评审
doi:10.1111/j.1537-2995.2012.03648.x
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The ABO blood group is a major determinant in living donor kidney transplantation since AB antigens are expressed on renal tissue. Little attention has been directed to the ABH-secretor status of the donor kidney. As renal tissue is capable of secreting soluble ABH antigens in secretors, we examined the infl...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.13711
更新日期:2016-09-01 00:00:00
abstract::Sera from three unrelated persons whose red cells (RBC) had the common Scianna phenotype (Sc:1,-2) contained IgG alloantibodies directed against high-frequency RBC antigens. In each case, sera or eluates or both failed to react only with Scianna null (Sc:-1,-2) cells, although an eluate from one person was compatible ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1988.28488265264.x
更新日期:1988-07-01 00:00:00
abstract::Three examples of an antibody defining a 'new' high frequency red blood cell antigen, Era, are described. Family studies show Era to be inherited, but the mode of inheritance may not be straightforward. ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1982.22382224938.x
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Routine quantification of platelet-derived extracellular vesicles (PL-EVs) may be useful in the quality control (QC) of platelet concentrates (PCs). The aim of this multicenter study was to establish and validate a consensus protocol for the standardized PL-EV quantification using conventional flow cytometer...
journal_title:Transfusion
pub_type: 杂志文章,多中心研究
doi:10.1111/trf.14109
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:A sample mix-up occurred in a tissue procurement laboratory in which aliquots of serum from two tissue donors were accidentally mislabeled. The clues to the apparent mixup involved discrepant Hepatitis C test results. In an attempt to resolve the apparent mix up, DNA typing was performed using serum samples ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.0041-1132.2004.04212.x
更新日期:2004-12-01 00:00:00
abstract::Anti-P1 is a cold-reactive antibody often found in the serum of P2 individuals. For the past two years our reference laboratory has encouraged the use of crossmatch compatible blood for patients with Anti-P1 rather than the use of reagent-typed P1 negative units. The authors recently surveyed those hospitals that refe...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1978.18679077956.x
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:Storage age of red blood cells (RBCs) has been reported to be associated with increased mortality and morbidity. During storage, RBCs undergo changes in biochemical and functional properties. Stored RBCs may also contain white blood cells (WBCs), activated platelets (PLTs), cytokines, immunoglobulin, and oth...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.12330
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Surgical patients receive platelet concentrates (PCs) for a variety of indications. However, there is limited evidence for efficacy or dosing of PCs. STUDY DESIGN AND METHODS:We performed a retrospective cohort study of surgical patients receiving isolated PC transfusion at a single academic tertiary medica...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.15156
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Determination of the white cell (WBC) count in WBC-reduced platelet components requires methods that have a detection limit in the range of approximately 5.0 x 10(2) to 5.0 x 10(4) per mL. STUDY DESIGN AND METHODS:With a 50-microL Nageotte hemocytometer and bright-field microscopy (200x magnification), stud...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1994.34194098600.x
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:In the Rh blood group system, variant RhD and RhCE express several partial antigens. We investigated RH in samples with partial DIVa that demonstrated weak and variable reactivity with anti-C. STUDY DESIGN AND METHODS:Standard hemagglutination techniques, polymerase chain reaction-based assays, and RH seque...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2012.03800.x
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:In the pandemic, testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time polymerase chain reaction is one of the pillars on which countermeasures are based. Factors limiting the output of laboratories interfere with the effectiveness of public health measures. Conserving reagent...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.15973
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND:Ultrasound-facilitated delivery of topical anesthetics has been used to achieve effective anesthesia within 5 minutes for venipuncture and the insertion of intravenous access devices, but has never been studied for blood donation. STUDY DESIGN AND METHODS:This study was a single-center, prospective, randomi...
journal_title:Transfusion
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1537-2995.2008.01939.x
更新日期:2009-01-01 00:00:00
abstract::In spite of growing awareness of the potential risks associated with transfusion, the number of platelet units transfused in the United States continues to increase each year. There is a growing interest in ensuring that all transfusions are administered for appropriate reasons. Prospective review of requests for tran...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1991.31791368335.x
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Transfusion-induced serum sickness reactions are rarely reported in the literature. The Type III hypersensitivity reaction to heterologous proteins involves deposition of complement and immune complexes in small vessel walls resulting in a leukocytoclastic vasculitis. A case of a multiply transfused patient ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2008.01956.x
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Concerns have been raised that aging of the general population will increase the demand for blood products. Modeling can be applied to assess trends in blood demand and supply and predict how these will develop over time. STUDY DESIGN AND METHODS:We developed mathematical models to describe and predict the ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2010.02716.x
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:A novel WBC-reduction in-line whole-blood (WB) filter that does not retain platelets was evaluated to assess the filtration performance and, after processing WB by the platelet-rich plasma (PRP) method, to analyze the storage quality of filtered platelet concentrate (PC) units. STUDY DESIGN AND METHODS:To a...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.0041-1132.2003.00587.x
更新日期:2003-12-01 00:00:00
abstract::Simple methods have been developed for adding and removing glycerol during freeze-preservation with 20 per cent W/V glycerol at minus 150 C, or with 40 per cent W/V glycerol at minus 80 C. A one-step method with a 35 per cent W/V glycerol solution is used to prepare 20 per cent W/V glycerolized red blood cells, and a ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1975.15375160354.x
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:Detection of viral nucleic acids might increase blood transfusion safety through the detection of recently infected blood donors during the preseroconversion window period. Individual screening is difficult to apply, because of technical and financial constraints. STUDY DESIGN AND METHODS:A polymerase chain...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1998.381098440854.x
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:The safety of fibrin tissue adhesives has been a concern since they entered wide clinical application. Most commercially available kits contain the proteolytic inhibitor, aprotinin, to stabilize the fibrin clot. A bovine protein, this substance has an allergenic potency. CASE REPORT:This case report present...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.2000.40030302.x
更新日期:2000-03-01 00:00:00
abstract::HLA and granulocyte-specific antibodies have been implicated in the production of transfusion-related acute lung injury (TRALI). Reported here is a case that suggests that the patient's preexisting condition may play an important role in determining whether TRALI develops upon transfusion of blood products containing ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1990.30190117629.x
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Blood donations collected at the National Blood Center, the Thai Red Cross Society, Bangkok, in 2007 were tested by nucleic acid amplification technology (NAT) using the Chiron TIGRIS/Procleix Ultrio test and the Roche cobas s 201/cobas TaqScreen multiplex (MPX) test. STUDY DESIGN AND METHODS:The sensitivit...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2009.02176.x
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Human natural killer (NK) cells are thought to play a role in antiviral response and tumor immune surveillance. The molecular mechanisms of down regulation of NK-cell activity observed after red blood cell (RBC) transfusion is still undefined. STUDY DESIGN AND METHODS:Both effects of blood transfusion (ex v...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2010.03000.x
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Storage of pooled platelet concentrates (PCs) with yields above 3.0 x 10(11) platelets per unit in a 1-L PL-732 polyolefin container for 5 days often results in a drop in pH to below 6.0. Recently, new oxygen-permeable platelet containers (1-L PL-2410, 1-L and 1.5-L Compoflex) have been developed. The maxima...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1997.37597293876.x
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Transfusion-transmitted babesiosis (TTB) has been rapidly increasing in incidence since the beginning of the 21st century. Asymptomatic individuals with Babesia infection are able to donate blood in the United States because of the lack of specific blood donation testing. Blood products collected in Babesia-...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.14246
更新日期:2017-10-01 00:00:00
abstract::Pathogen inactivation/reduction technologies for platelet components have been developed to enhance microbial safety, and many studies have been carried out to determine whether this technique adversely affects the platelet's ability to stop or prevent bleeding. These clinical trials require inclusion of several hundr...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/trf.15779
更新日期:2020-07-01 00:00:00
abstract::With an interval of eight weeks between collections, blood was drawn twice from 120 blood donors. At one of the donations, 0.25 ml of synthetic vasopressin, (DDAVP, 1300 micrograms/ml), was administered intranasally 60 minutes prior to collection of the blood. No drug was given at the other donation. The yield of fact...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1046/j.1537-2995.1982.22382224947.x
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Most patients with severe aplastic anemia (sAA) respond to immunosuppression, but a significant number relapse or develop clonal abnormalities such as paroxysmal nocturnal hemoglobinuria, myelodysplasia, or leukemia. In principle, patients without matched sibling donors and older patients might benefit from ...
journal_title:Transfusion
pub_type: 杂志文章
doi:10.1111/j.1537-2995.2007.01258.x
更新日期:2007-07-01 00:00:00