Extended survival of neocytes produced by a new system.

Abstract:

:Red cells (RBCs) prepared by a new system using centrifugation to produce neocyte enrichment were studied in two laboratories. The system used a blood bag with a geometric configuration such that younger, less dense cells could be separated from older, denser cells. Phthalate ester density gradient curves determined that neocyte enrichment was 81.3 percent in one laboratory and 82 percent in the other. RBC viability was studied by 51Cr autologous transfusion in normal volunteer donors. A randomized, paired design was used in which each donor was transfused once each with neocytes and with RBCs of all ages. The mean control half-life was 34.8 +/- 5.4 days in one laboratory and 34.0 +/- 3.6 days in the other. The mean half-life of the neocyte-enriched RBCs was 45.2 +/- 8.2 days in one laboratory and 45.1 +/- 4.4 days in the other. This represented a more than 30 percent increase in half-life for the neocyte-enriched RBCs, a significant difference. This new system, a two-bag set that costs +15, allows the simple, efficient separation of neocyte-enriched RBCs that would have a longer half-life and could reduce the transfusion requirement in patients receiving chronic transfusion therapy.

journal_name

Transfusion

journal_title

Transfusion

authors

Simon TL,Sohmer P,Nelson EJ

doi

10.1046/j.1537-2995.1989.29389162727.x

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

221-5

issue

3

eissn

0041-1132

issn

1537-2995

journal_volume

29

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::Many significant events have occurred in the recent past that beg a broad audience to address the question "What is pediatric transfusion medicine?" Herein, we list some of these events and their relevance below and attempt to provide an answer for this question. Indeed, several issues regarding the subspecialty of pe...

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    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.02015.x

    authors: Hillyer CD,Mondoro TH,Josephson CD,Sanchez R,Sloan SR,Ambruso DR

    更新日期:2009-03-01 00:00:00

  • Estimating the risk of blood donation fainting for self versus others: the moderating effect of fear.

    abstract:BACKGROUND:People overestimate the likelihood that blood donors will experience faint and prefaint reactions, particularly if they are themselves fearful of having blood drawn. This study investigated the influence of making a risk assessment for oneself versus others, and examined whether providing information about t...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15225

    authors: France CR,France JL

    更新日期:2019-06-01 00:00:00

  • Influence of a 12-hour, 22 degrees C holding period for buffy coats on the preparation of platelet concentrates stored in plasma.

    abstract:BACKGROUND:The preparation of platelet concentrates (PCs) from buffy coats (BCs) stored at room temperature is controversial, because of the strong metabolic activity of cells in BCs and the possible detrimental effect of neutrophil enzymes on platelets when the holding time before separation is prolonged. Despite good...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1994.341095026974.x

    authors: Boeri N,Saleun S,Pelissier E,Saleun JP,Aiach M,Rendu F

    更新日期:1994-10-01 00:00:00

  • Plasma treated with amotosalen and ultraviolet A light retains activity for hemostasis after 5 days post-thaw storage at 1 to 6o C.

    abstract:BACKGROUND:Plasma thawed and stored at 1 to 6° C for up to 5 days (thawed plasma [TP]) provides rapid availability in emergencies and reduces plasma waste, but it carries risks of coagulation factor loss or activation, bacterial outgrowth, and viral contamination. We characterized changes in amotosalen/ultraviolet A (U...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13973

    authors: Erickson A,Waldhaus K,David T,Huang N,Rico S,Corash L,Mufti N,Benjamin RJ

    更新日期:2017-04-01 00:00:00

  • Packed blood cells stored in AS-5 become proinflammatory during storage.

    abstract:BACKGROUND:Studies have shown that packed blood cells (PBCs) stored in AS-1 (Adsol, Baxter) and AS-3 (Nutricel, Medsep Corp.) accumulate proinflammatory substances, which may contribute to increased complications from allogeneic blood transfusion. This study assessed whether supernates from PBCs stored in AS-5 (Optisol...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02158.x

    authors: McFaul SJ,Corley JB,Mester CW,Nath J

    更新日期:2009-07-01 00:00:00

  • Differentiation of autologous ABO, RHD, RHCE, KEL, JK, and FY blood group genotypes by analysis of peripheral blood samples of patients who have recently received multiple transfusions.

    abstract:BACKGROUND:After multiple transfusions, the serologic typing of autologous blood group phenotypes is difficult, because of mixed RBC populations. The genotyping of ABO, Rh, Kell, Kidd, and Duffy systems could be used to determine autologous blood group antigen status. STUDY DESIGN AND METHODS:Blood samples from patien...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40080936.x

    authors: Rozman P,Dovc T,Gassner C

    更新日期:2000-08-01 00:00:00

  • Significance of the signal-to-cutoff ratios of anti-hepatitis C virus enzyme immunoassays in screening of Chinese blood donors.

    abstract:BACKGROUND:The correlation between signal-to-cutoff (S/CO) ratios of a second-generation hepatitis C virus (HCV) enzyme immunoassay (EIA; Abbott) and a third-generation HCV enzyme-linked immunosorbent assay (ELISA; Ortho) and confirmed HCV infection has been reported. The utility of the values for the Chinese anti-HCV ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00611.x

    authors: Ren FR,Lv QS,Zhuang H,Li JJ,Gong XY,Gao GJ,Liu CL,Wang JX,Yao FZ,Zheng YR,Zhu FM,Tiemuer MH,Bai XH,Shan H

    更新日期:2005-11-01 00:00:00

  • Donor body mass index is an important factor that affects peripheral blood progenitor cell yield in healthy donors after mobilization with granulocyte-colony-stimulating factor.

    abstract:BACKGROUND:The use of hematopoietic progenitor cell (HPC) transplantation has rapidly expanded in recent years. Currently, several sources of HPCs are available for transplantation including peripheral blood HPCs (PBPCs), cord blood cells, and marrow cells. Of these, PBPC collection has become the major source of HPCs....

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12238

    authors: Chen J,Burns KM,Babic A,Carrum G,Kennedy M,Segura FJ,Garcia S,Potts S,Leveque C

    更新日期:2014-01-01 00:00:00

  • Plateletpheresis does not cause long-standing platelet-derived growth factor release into the donor blood.

    abstract:BACKGROUND:Recently, long-standing elevations of soluble growth factors released from platelets (PLTs) after contact with artificial surfaces during dialysis were described. They could be jointly responsible for the high frequency of death from cardiovascular diseases in dialysis patients. There are no comparable data ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.04269.x

    authors: Zimmermann R,Loew D,Weisbach V,Strasser E,Ringwald J,Zingsem J,Eckstein R

    更新日期:2005-03-01 00:00:00

  • Administrative and research policies required to bring cellular therapies from the research laboratory to the patient's bedside.

    abstract::The research process is a balance between the inherent risks of new discoveries and the risks of research participant safety. Conflicts of interest, inherent to the research process, as well as those introduced by emerging cellular therapies, have the potential to compromise safety. The relationship of trust between t...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2005.00616.x

    authors: Yim R

    更新日期:2005-10-01 00:00:00

  • Multicenter performance evaluation of a transcription-mediated amplification assay for screening of human immunodeficiency virus-1 RNA, hepatitis C virus RNA, and hepatitis B virus DNA in blood donations.

    abstract:BACKGROUND:The performance of the recently launched Procleix Ultrio (Chiron/Gen-Probe) human immunodeficiency virus-1 (HIV-1), hepatitis C virus (HCV), and hepatitis B virus (HBV) blood screening assay was evaluated in a European multicenter study. STUDY DESIGN AND METHODS:Serial dilutions of reference materials were ...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1537-2995.2005.00197.x

    authors: Koppelman MH,Assal A,Chudy M,Torres P,de Villaescusa RG,Reesink HW,Lelie PN,Cuypers HT

    更新日期:2005-08-01 00:00:00

  • False-positive eluate reactivity due to the low-ionic wash solution used with commercial acid-elution kits.

    abstract:BACKGROUND:During the use of commercial red cell (RBC) acid-elution kits for adsorption and elution (adsorption/elution) studies with anti-D, unexpected reactive eluates (anti-D) were obtained from D- RBCs. Such results were not obtained with a parallel xylene method or, historically, with heat and ether methods. STUD...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38698326336.x

    authors: Leger RM,Arndt PA,Ciesielski DJ,Garratty G

    更新日期:1998-06-01 00:00:00

  • Evaluation of the putative role of C-C chemokines as protective factors of HIV-1 infection in seronegative hemophiliacs exposed to contaminated hemoderivatives.

    abstract:BACKGROUND:Overproduction of beta-chemokines and genetic variations in chemokine receptors have been correlated with protection against infection by HIV-1 or slow progression to AIDS in infected individuals. STUDY DESIGN AND METHODS:The protective role of chemokines and their receptors was evaluated in a group of seve...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40040461.x

    authors: Barretina J,Blanco J,Gutiérrez A,Puig L,Altisent C,Espanol T,Caragol I,Clotet B,Esté JA

    更新日期:2000-04-01 00:00:00

  • Prevalence of viable Chlamydia pneumoniae in peripheral blood mononuclear cells of healthy blood donors.

    abstract:BACKGROUND:Demonstration of viable Chlamydia (Chlamydophila) pneumoniae in peripheral blood mononuclear cells (PBMNCs) is essential to understand the involvement of C. pneumoniae in atherosclerosis. Nevertheless, the prevalence of viable C. pneumoniae in the blood of healthy donors has not yet been studied. STUDY DESI...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.04005.x

    authors: Yamaguchi H,Yamada M,Uruma T,Kanamori M,Goto H,Yamamoto Y,Kamiya S

    更新日期:2004-07-01 00:00:00

  • Prepooled cryoprecipitate for treatment of hemophilia A.

    abstract::Lyophilized factor VIII concentrates, because of their convenience, are the most commonly used products for providing antihemophilic factor to patients with hemophilia A. Heightened concerns about associated complications indicate that cryoprecipitate usage will increase in the immediate future. We present a protocol ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1983.23383224913.x

    authors: Menitove JE,Spero JA,Richards WA,Lewis JH,Montgomery RR,Gill JC,Hasiba U,Wheeler DV,Sherwin JA,Russell-Vaskov S,Marlar RA,Maxwell NG,Aster RH

    更新日期:1983-05-01 00:00:00

  • Predonation hematocrit measurement by whole blood electrical conductivity assay.

    abstract::The whole blood electrical conductivity method for predonation hematocrit determinations was studied. Forty capillary and venous blood samples were tested concurrently with electrical conductivity and centrifugation methods. The electrical conductivity method demonstrated acceptable accuracy but was less precise than ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25385219908.x

    authors: Schifman RB,Rivers SL,Delduca M

    更新日期:1985-05-01 00:00:00

  • Transfusion and blood donation on the screen.

    abstract:BACKGROUND:In the 20th century, blood transfusion has become an indispensable therapy in carrying out and improving many medical and surgical applications. Its scope of influence goes well beyond that of medicine, because blood donation, an action with high social significance, is completely connected to progress in th...

    journal_title:Transfusion

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1537-2995.2007.01634.x

    authors: Danic B,Lefrère JJ

    更新日期:2008-05-01 00:00:00

  • Expanded evaluation of blood donors in the United States for human immunodeficiency virus type 1 non-B subtypes and antiretroviral drug-resistant strains: 2005 through 2007.

    abstract:BACKGROUND:In a previous study of 66 human immunodeficiency virus (HIV)-infected US blood donors from 1999 to 2005, HIV-1 non-B and antiretroviral drug-resistant strains accounted for 4.7 and 6.5% of HIV infections, respectively. This study was expanded to include an additional 11 recently acquired infections and 197 e...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02767.x

    authors: Brennan CA,Yamaguchi J,Devare SG,Foster GA,Stramer SL

    更新日期:2010-12-01 00:00:00

  • Coagulopathy after traumatic brain injury: incidence, pathogenesis, and treatment options.

    abstract::Coagulopathy after traumatic brain injury (TBI) is frequent and represents a powerful predictor related to outcome and prognosis. The complex pathophysiological mechanisms of the coagulopathy of TBI are multifactorial and remain still undefined. The nature of the coagulation abnormalities differs between severe TBI an...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.12033

    authors: Maegele M

    更新日期:2013-01-01 00:00:00

  • "Naturally-occurring" anti-K1: possible association with mycobacterium infection.

    abstract::We report a case of "naturally-occurring" (nonred blood cell stimulated) anti-K1. The patient had never received a blood transfusion. Red blood cell antibody screening panels showed agglutination with K:1 red blood cells at room temperature and not in the anti-globulin test. Testing with 2-mercaptoethanol showed the a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18478251244.x

    authors: Kanel GC,Davis I,Bowman JE

    更新日期:1978-07-01 00:00:00

  • The prevalence of human parvovirus B19 DNA and antibodies in blood donors from four Chinese blood centers.

    abstract:BACKGROUND:Human parvovirus B19 is a common human pathogen that causes a variety of diseases with outcomes ranging from asymptomatic to severe, especially in immunocompromised patients. The B19 virus can be transmitted via blood and/or blood products and its resistance to common viral inactivation and/or removal method...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03067.x

    authors: Ke L,He M,Li C,Liu Y,Gao L,Yao F,Li J,Bi X,Lv Y,Wang J,Hirsch ML,Li W

    更新日期:2011-09-01 00:00:00

  • Creating a uniform donor medical history questionnaire.

    abstract::Blood Centers of California, Inc. (BCC) is a consortium of 19 independent blood centers that collectively draw approximately 800,000 units of whole blood each year. Over the past several years, a committee of BCC, composed primarily of medical and nursing directors at member institutions, developed a Uniform Donor Med...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31491213302.x

    authors: Kolins J,Silvergleid AJ

    更新日期:1991-05-01 00:00:00

  • Epitope mapping of antibodies directed against the human neutrophil alloantigen 3a.

    abstract:BACKGROUND:Severe transfusion-related acute lung injury is often caused by antibodies directed against the human neutrophil alloantigen (HNA)-3a. HNA-3a results from an amino acid exchange (Arg154Gln) in the first extracellular loop of the choline transporter-like protein 2 (CTL2). The characteristics of the binding do...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03115.x

    authors: Berthold T,Wesche J,Kuhnert K,Fürll B,Hippe H,Hoppen J,Reil A,Muschter S,Bux J,Greinacher A

    更新日期:2011-10-01 00:00:00

  • Safety profile of high molecular weight polymerized hemoglobins.

    abstract:BACKGROUND:Hemoglobin (Hb)-based oxygen (O2 ) carriers (HBOCs) are being developed as alternatives to red blood cells and blood when these products are unavailable. Clinical trials of previous HBOC generations revealed side effects, including hypertension and vasoconstriction, that were not observed in preclinical stud...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16157

    authors: Muller CR,Williams AT,Munoz CJ,Eaker AM,Breton AN,Palmer AF,Cabrales P

    更新日期:2020-10-26 00:00:00

  • Reduced ferritin levels in individuals with non-O blood group: results from the Danish Blood Donor Study.

    abstract:BACKGROUND:Genomewide association studies have reported alleles in the ABO locus to be associated with ferritin levels. These studies warrant the investigation of a possible association between the ABO blood group and ferritin levels. We aimed to explore if ABO blood group is associated with iron stores expressed as fe...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14364

    authors: Rigas AS,Berkfors AA,Pedersen OB,Sørensen E,Nielsen KR,Larsen MH,Paarup HM,Wandall HH,Erikstrup C,Hjalgrim H,Ullum H

    更新日期:2017-12-01 00:00:00

  • Sickle Hb polymerization in RBC components from donors with sickle cell trait prevents effective WBC reduction by filtration.

    abstract:BACKGROUND:RBC components collected from donors with sickle cell trait frequently occlude WBC-reduction filters. In vitro, sickle trait RBCs have the potential for sickle Hb (Hb S) polymerization at low oxygen saturations and high Hb concentrations. STUDY DESIGN AND METHOD:To determine if the low pH and high osmolarit...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00206.x

    authors: Stroncek DF,Rainer T,Sharon V,Byrne KM,Noguchi CT,Klein HG,Schechter AN,Leitman SF

    更新日期:2002-11-01 00:00:00

  • Iron deficiency anemia at admission for labor and delivery is associated with an increased risk for Cesarean section and adverse maternal and neonatal outcomes.

    abstract:BACKGROUND:Maternal iron deficiency anemia (IDA) impacts placenta and fetus. We evaluated effects of IDA at admission for delivery on cesarean rates, and adverse maternal and neonatal outcomes. STUDY DESIGN AND METHODS:Medical records from Jerusalem (2005-2012) identified women with a live-birth singleton fetus in cep...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13252

    authors: Drukker L,Hants Y,Farkash R,Ruchlemer R,Samueloff A,Grisaru-Granovsky S

    更新日期:2015-12-01 00:00:00

  • Anti-Dob implicated as the cause of a delayed hemolytic transfusion reaction.

    abstract::A 27-year-old, gravida 3, para 2 woman experienced a delayed hemolytic transfusion reaction. She had anti-Dob in both serum and eluate 8 days after infusion of 6 units of Do(b+) red cells. No antibody had been detected prior to transfusion. By the 15th day after transfusion, there was no evidence of survival of red ce...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25185116501.x

    authors: Moheng MC,McCarthy P,Pierce SR

    更新日期:1985-01-01 00:00:00

  • Two-year follow-up of donors in a large national study of ferritin testing.

    abstract:BACKGROUND:We assessed donor return rates, donation frequency, and factors related to the evolution of ferritin levels 2 years after entering donors into a large operational study of ferritin testing. STUDY DESIGN AND METHODS:Ferritin testing was done on donors from representative clinics (n = 12,595). Low-ferritin do...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/trf.14941

    authors: Goldman M,Uzicanin S,Osmond L,Yi QL,Scalia V,O'Brien SF

    更新日期:2018-12-01 00:00:00

  • A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions.

    abstract:BACKGROUND:Acetaminophen and diphenhydramine are commonly used as pretransfusion medications to prevent transfusion reactions. The purpose of this study was to prospectively compare the risk of transfusion reactions in hematology/oncology patients who receive acetaminophen with diphenhydramine or placebo before transfu...

    journal_title:Transfusion

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1537-2995.2008.01858.x

    authors: Kennedy LD,Case LD,Hurd DD,Cruz JM,Pomper GJ

    更新日期:2008-11-01 00:00:00