Filtration leukapheresis: the influence of granulocyte counts upon the donors' yield.

abstract：BACKGROUND:We set out to define the impact of collection, processing, and storage on plasma product microparticle (MP) abundance, potential for nitric oxide (NO) scavenging, and vasoactivity. STUDY DESIGN AND METHODS:Three currently US licensed products were tested: liquid plasma (LP), fresh frozen plasma (FFP), and s...

journal_title：Transfusion

authors： Rogers SC,Moynihan FT 4th,McDonough R,Timm DD,Hovmand-Warner E,Frazier E,Thomas KA,Spinella PC,Doctor A

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Pigs are a potential source of red blood cells (RBCs) for transfusion into humans, but the presence of galactose-alpha1,3-galactose (Gal) epitopes on their surface, against which humans have anti-Gal, has been perceived as a major barrier. alpha1,3-Galactosyltransferase gene-knockout pigs, which do not expre...

journal_title：Transfusion

authors： Rouhani FJ,Dor FJ,Cooper DK

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Storage of pooled platelet concentrates (PCs) with yields above 3.0 x 10(11) platelets per unit in a 1-L PL-732 polyolefin container for 5 days often results in a drop in pH to below 6.0. Recently, new oxygen-permeable platelet containers (1-L PL-2410, 1-L and 1.5-L Compoflex) have been developed. The maxima...

journal_title：Transfusion

authors： de Wildt-Eggen J,Schrijver JG,Bouter-Valk HJ,Fijnheer R,Bins M,van Prooijen HC

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:An optimal cooling rate is critical for cryopreserving cord blood stem cells, so it is generally achieved by using controlled-rate freezers (CRFs). The cooling rate can be interrupted by many factors during cooling; therefore, a proper response to the interruption in cryopreservation is crucial to prevent th...

journal_title：Transfusion

authors： Yang H,Pidgorna A,Loutfy MR,Shuen P

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Blood collection centers are charged with creating donor educational materials (DnEM) that are easily understood across all prospective donor populations, while addressing mandates and recommendations from regulatory agencies and professional standard setting organizations. Donors must have sufficient inform...

journal_title：Transfusion

authors： Wehrli G,Rossmann SN,Waxman DA,Katz LM

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Point-of-issue tests, such as the Verax Pan Genera Detection (PGD) test, can be used to mitigate the occurrence of septic reactions. Little is known about how widespread the adoption of the PGD test is across US hospitals. STUDY DESIGN/METHODS:The Red Cross hemovigilance database was used to determine the n...

journal_title：Transfusion

authors： Rios J,Westra J,Dy B,Young PP

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Interventions intended to motivate donors to return can be costly and time consuming. The current study examined the effect of a Web-based automated interview, informed by motivational interviewing and self-determination theory, on donor intention, motivation, and behavior in a sample of highly experienced d...

journal_title：Transfusion

authors： Livitz IE,France CR,France JL,Fox KR,Ankawi B,Slepian PM,Kessler DA,Rebosa M,Shaz BH

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The term platelet storage lesion (PSL) describes the structural and biochemical changes in platelets (PLTs) during storage. These are typified by alterations of morphologic features and PLT metabolism leading to reduced functionality and hence reduced viability for transfusion. While the manifestations of th...

journal_title：Transfusion

authors： Schubert P,Thon JN,Walsh GM,Chen CH,Moore ED,Devine DV,Kast J

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Senescent RBCs bear IgG and C3 opsonins that are three to four times less than required for similar phagocytosis of experimentally opsonized RBCs. STUDY DESIGN AND METHODS:Studies were performed to determine the phagocyte receptors involved in phagocytosis in vitro. The effect of clustering of opsonins and ...

journal_title：Transfusion

authors： Tartakover-Matalon S,Shoham-Kessary H,Foltyn V,Gershon H

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Dengue fever and hemorrhagic disease are caused by four dengue virus (DENV) serotypes (DENV-1 to -4), mosquito-borne flaviviruses with increasing incidence, and expanding global distributions. Documented transfusion transmission of West Nile virus raised concern regarding transfusion-transmitted DENV. METHO...

journal_title：Transfusion

authors： Linnen JM,Vinelli E,Sabino EC,Tobler LH,Hyland C,Lee TH,Kolk DP,Broulik AS,Collins CS,Lanciotti RS,Busch MP

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the effects of red blood cell (RBC) transfusion on the hemorrheologic properties and microcirculatory hemodynamics in anemic hematology outpatients receiving 2 to 4 RBC units of either "fresh" (leukoreduced storage for less than 1 week) or "aged" (leukoreduced storage...

journal_title：Transfusion

authors： Yürük K,Milstein DM,Bezemer R,Bartels SA,Biemond BJ,Ince C

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:RBC components collected from donors with sickle cell trait frequently occlude WBC-reduction filters. In vitro, sickle trait RBCs have the potential for sickle Hb (Hb S) polymerization at low oxygen saturations and high Hb concentrations. STUDY DESIGN AND METHOD:To determine if the low pH and high osmolarit...

journal_title：Transfusion

authors： Stroncek DF,Rainer T,Sharon V,Byrne KM,Noguchi CT,Klein HG,Schechter AN,Leitman SF

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:There is little knowledge how different hold times of hyperconcentrated platelet (PLT) suspensions (HPSs) before the addition of platelet additive solution (PAS) might affect PLT quality. We compared the in vitro quality of single-donor PLT concentrates (SDPs) with immediate or delayed PAS addition and studi...

journal_title：Transfusion

authors： Ringwald J,Tully S,Geier C,Hauck B,Weiss D,Callaert M,Eckstein R

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:By NAT, HBV DNA is occasionally detectable in blood donors with past HBV infection but negative for HBsAg. Whether or not these donors can cause transfusion-transmitted HBV infections is uncertain. STUDY DESIGN AND METHODS:To determine whether or not donors with past HBV infection but negative for HbsAg can...

journal_title：Transfusion

authors： Wang JT,Lee CZ,Chen PJ,Wang TH,Chen DS

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:We sought to determine whether publication of blood conservation guidelines by the Society of Thoracic Surgeons in 2007 influenced transfusion rates and to understand how patient- and hospital-level factors influenced blood product usage. STUDY DESIGN AND METHODS:We identified 4,465,016 patients in the Nati...

journal_title：Transfusion

authors： Robich MP,Koch CG,Johnston DR,Schiltz N,Chandran Pillai A,Hussain ST,Soltesz EG

更新日期：2015-04-01 00:00:00

abstract：:Four commercial test kits for detecting cytomegalovirus (CMV) antibodies (indirect hemagglutination assay, indirect fluorescent antibody technique, enzyme immunoassay, and passive latex agglutination technique) were compared according to their technical demand, hands-on time, turnaround time, concordance with other te...

journal_title：Transfusion

authors： Feng CS,Williams IB,Gohd RS,Causey AP

更新日期：1986-03-01 00:00:00

abstract：:This paper presents recent data from quantitative and thermodynamic investigations on A and B erythrocyte antigens. In regard to weak A phenotypes on the basis of quantitative data, practically no gap is observed from the weakest Aend to the strongest A3. Weak B phenotypes give a similar distribution. However, a more ...

journal_title：Transfusion

authors： Salmon C,Lopez M,Cartron JP,Bouguerra A

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:Plasma thawed and stored at 1 to 6° C for up to 5 days (thawed plasma [TP]) provides rapid availability in emergencies and reduces plasma waste, but it carries risks of coagulation factor loss or activation, bacterial outgrowth, and viral contamination. We characterized changes in amotosalen/ultraviolet A (U...

journal_title：Transfusion

authors： Erickson A,Waldhaus K,David T,Huang N,Rico S,Corash L,Mufti N,Benjamin RJ

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:This study explored the effect of storing packed RBCs suspended in 200 mL of an alkaline, hypotonic, experimental additive solution (EAS 61). STUDY DESIGN AND METHODS:Packed RBC units prepared from RBCs collected from healthy donors in CPD were stored for 8 (n = 10) and 9 (n = 10) weeks under blood bank con...

journal_title：Transfusion

authors： Hess JR,Rugg N,Knapp AD,Gormas JF,Silberstein EB,Greenwalt TJ

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Acoustic cell separation uses ultrasound waves to separate cells from plasma to perform plasmapheresis. Although the fundamental process has been studied for decades, no acoustic cell separation has been studied in a disposable plastic format suitable for clinical applications. STUDY DESIGN AND METHODS:We d...

journal_title：Transfusion

authors： Savage WJ,Burns JR,Fiering J

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:A storage period of 42 days has been approved by the FDA for RBCs stored in NUTRICEL (AS-3). This study was undertaken to provide data to the FDA about the feasibility of salvaging AS-3 RBCs at the end of their storage period by rejuvenation and freezing, and to evaluate the effect of rejuvenation on indicat...

journal_title：Transfusion

authors： Lockwood WB,Hudgens RW,Szymanski IO,Teno RA,Gray AD

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:The history of the development and implementation of the Brazilian nucleic acid testing (NAT) platform to detect and discriminate among human immunodeficiency virus (HIV), hepatitis C virus (HCV), and hepatitis B virus (HBV) infections in blood donors is described here. The results for the sensitivity, repro...

journal_title：Transfusion

authors： Rocha D,Andrade E,Godoy DT,Fontana-Maurell M,Costa E,Ribeiro M,Ferreira AGP,Brindeiro R,Tanuri A,Alvarez P

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Recent blood shortages and the potential clinical impact of red blood cell (RBC) age highlight the need to understand blood supply delivery. This study addresses the characteristics and mechanics of RBC unit trafficking and storage across the transfusion service, previously undescribed in the literature. ST...

journal_title：Transfusion

authors： Cheng CK,Trethewey D,Sadek I

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:To prevent donor loss and improve retention, it is important to understand the major deterrents to blood donation and to identify factors that can be effectively addressed by blood centers. STUDY DESIGN AND METHODS:A 30-item self-administered questionnaire was completed in 2003 by 1705 first-time and 2437 r...

journal_title：Transfusion

authors： Schreiber GB,Schlumpf KS,Glynn SA,Wright DJ,Tu Y,King MR,Higgins MJ,Kessler D,Gilcher R,Nass CC,Guiltinan AM,National Heart, Lung, Blood Institute Retrovirus Epidemiology Donor Study.

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:The 2000 Nationwide Blood Collection and Utilization Survey was designed to assess cellular therapy product services in US blood centers and hospitals. STUDY DESIGN AND METHODS:Questionnaires were returned by 2,040 institutions. Data were analyzed for 30 quantitative variables related to cellular therapy pr...

journal_title：Transfusion

authors： Read EJ,Sullivan MT

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:The HCV lookback program was designed to trace and offer testing to recipients who received transfusion of blood components from donors subsequently found to be anti-HCV positive. Only approximately 20 percent of transfusable components entering lookback did result in a recipient obtaining testing through th...

journal_title：Transfusion

authors：

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Red blood cell (RBC) storage solutions work in a narrow pH range between 7.2 and 6.4. While keeping RBC within that pH range, ATP production can be increased by buffering or dilution. STUDY DESIGN AND METHODS:In the first study, 12 units of packed CP2D RBCs were pooled in groups of four, re-aliquoted, and a...

journal_title：Transfusion

authors： Hess JR,Rugg N,Joines AD,Gormas JF,Pratt PG,Silberstein EB,Greenwalt TJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Fever accompanying vaso-occlusive crisis is a common presentation in patients with sickle cell disease (SCD) and carries a broad differential diagnosis. Here, we report a case of transfusion-transmitted malaria in a patient with SCD presenting with acute vaso-occlusive crisis and rapidly decompensating to mu...

journal_title：Transfusion

authors： Maier CL,Gross PJ,Dean CL,Chonat S,Ip A,McLemore M,El Rassi F,Stowell SR,Josephson CD,Fasano RM

更新日期：2018-06-01 00:00:00

abstract：:Immune-deficient patients depend on the antibodies in pooled human immunoglobulin G (IgG) preparations to remain free from serious infections. The potency of IgG preparations is therefore an ongoing concern. The use of pooled IgG to prevent infection is based on the concept that healthy adults have recovered from infe...

journal_title：Transfusion

authors： Berger M

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Etoricoxib is a selective inhibitor of cyclooxygenase 2 used mainly to treat osteoarticular pain. Here, we report the case of a patient who developed acute kidney failure and immune hemolytic anemia after the use of etoricoxib. STUDY DESIGN AND METHODS:An 83-year-old female patient developed immune hemolyti...

journal_title：Transfusion

authors： Burgos Pratx L,Santoro D,Coca Mogro B,Valiente VL,Camino P,Scordo W,Salamone H

更新日期：2019-05-01 00:00:00