Adoption trends of point of issue Verax PGD rapid test for bacterial screening of platelets between 2013 and 2018 among hospitals supplied by the American Red Cross and impact on platelet availability.

Abstract:

BACKGROUND:Point-of-issue tests, such as the Verax Pan Genera Detection (PGD) test, can be used to mitigate the occurrence of septic reactions. Little is known about how widespread the adoption of the PGD test is across US hospitals. STUDY DESIGN/METHODS:The Red Cross hemovigilance database was used to determine the numbers of PGD-positive test results between 2013 and 2018. An examination of the impact of a reactive PGD test on product availability was performed for 2018. RESULTS:The number of reported cases doubled, rising from approximately 50 to 100 per year between 2013 and 2018. A total of 475 initially reactive PGD tests during the entire study period were reported, and 7 (1.5%) of these were determined to be true positives. Hospitals surveyed reported testing platelet units once, with no repeat testing if the unit was PGD reactive. Evaluation of the reported PGD reactive cases for apheresis platelets for 2018 (n = 93) resulted in an estimated cost to the blood center of $87,000, which included the labor and material costs of working up the cases and the estimated value of the lost 64 units and co-components. In addition, there was a loss of the opportunity to collect over 85 apheresis platelets during the time the implicated donor was temporarily deferred. CONCLUSIONS:The number of hospital reports of reactive PGD tests has shown modest growth in the past 5 years. The number of initially reactive PGD tests that were confirmed was minimal. Blood centers can incur cost and platelet inventory loss from initially false-positive test results.

journal_name

Transfusion

journal_title

Transfusion

authors

Rios J,Westra J,Dy B,Young PP

doi

10.1111/trf.15817

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

1364-1372

issue

7

eissn

0041-1132

issn

1537-2995

journal_volume

60

pub_type

杂志文章
  • A new radioimmunoassay for the detection of small amounts of white cells and platelets in red cell concentrates: implications for blood transfusion.

    abstract::In the procedure for quality control of red cell concentrates, made white cell (WBC)-poor by filtration, the particle-counting technique was found to be insufficiently sensitive in detecting the remaining WBCs and platelets. Therefore, direct radioimmunoassays were developed using murine monoclonal antibodies specific...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30290162896.x

    authors: Webster MR,Prins HK,Huisman JG

    更新日期:1990-02-01 00:00:00

  • Donor and nondonor motivations.

    abstract::In an attempt to gain insight into the motivations of blood donors and nondonors, two paper and pencil questionnaires were developed and mailed to approximately 7,000 individuals. In response, 1,429 nondonors and 200 donors completed and returned usable questionnaires. Among donors, awareness of the need for blood, al...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1976.16276155116.x

    authors: Leibrecht BC,Hogan JM,Luz GA,Tobias KI

    更新日期:1976-03-01 00:00:00

  • The value of transfusion of phenotyped blood units for thalassemia and sickle cell anemia patients at an academic center.

    abstract:BACKGROUND:Blood transfusion is the first-line treatment for patients with thalassemia and many sickle cell patients. However, cases of unregulated blood transfusion are shown to carry a high risk of alloimmunization to red blood cells (RBCs), which can lead to a hemolytic transfusion reaction and be fatal to patients....

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15682

    authors: Hindawi S,Badawi M,Elfayoumi R,Elgemmezi T,Al Hassani A,Raml M,Alamoudi S,Gholam K

    更新日期:2020-02-01 00:00:00

  • A new ABCG2 null allele with a 27-kb deletion including the promoter region causing the Jr(a-) phenotype.

    abstract:BACKGROUND:The high-prevalence antigen Jr(a) is carried on the ATP-binding cassette transporter ABCG2. The ABCG2 gene consists of 16 exons and its translation start codon is located on the second exon. Although the occurrence of the Jr(a-) phenotype is rare, several ABCG2 null alleles have been reported. We report a ne...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12969

    authors: Ogasawara K,Osabe T,Suzuki Y,Tsuneyama H,Isa K,Kawai M,Obara K,Ogiyama Y,Ito S,Uchikawa M,Satake M,Tadokoro K

    更新日期:2015-06-01 00:00:00

  • Four-year survival of transfusion recipients identified by hepatitis C lookback.

    abstract:BACKGROUND:Information on the probability of survival of transfused patients is needed for policy making, but there is a paucity of empirical research into this question. A Swedish population-based study reported that the 40-month posttransfusion probability of survival was 51 percent in all patients and 41 percent in ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00109.x

    authors: Vamvakas EC,Goldstein R

    更新日期:2002-06-01 00:00:00

  • Factors affecting umbilical cord blood stem cell suitability for transplantation in an in utero collection program.

    abstract:BACKGROUND:The greatest limiting factor in the use of umbilical cord blood (UCB) for transplantations is the number of stem cells available in any given collected unit. This study examines maternal, neonatal, and obstetric factors that influence the suitability for banking and transplantation of UCB units collected in ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12340

    authors: Keersmaekers CL,Mason BA,Keersmaekers J,Ponzini M,Mlynarek RA

    更新日期:2014-03-01 00:00:00

  • Implementation of a script for predonation interviews: impact on human immunodeficiency virus risk in South African blood donors.

    abstract:BACKGROUND:The way in which the donor history questionnaire is conducted plays a crucial role in the self-disclosure of behavioral risk factors for human immunodeficiency virus (HIV) infection by prospective donors. The South African National Blood Service changed its policy on the process of donor assessment in May 20...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15288

    authors: Mitchel J,Custer B,Kaidarova Z,Murphy EL,van den Berg K,Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) South Africa Program.

    更新日期:2019-07-01 00:00:00

  • Increased risk of a positive test for antibody to hepatitis B core antigen (anti-HBC) in autologous blood donors.

    abstract::Controversy exists about the suitability of blood from autologous donors for homologous use. We compared the infectious disease test results of 426 autologous donors, designated by donor history as suitable for homologous use, to those of 86,138 volunteer donations collected over the same 5 month period. Although dono...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28388219162.x

    authors: Grossman BJ,Stewart NC,Grindon AJ

    更新日期:1988-05-01 00:00:00

  • RhCE protein variants in Southwestern Germany detected by serologic routine testing.

    abstract:BACKGROUND:Variant RHCE alleles with diminished expression of C, c, E, and e antigens have been described and indicate the genetic diversity of this gene locus in several populations. In this study the molecular background of variant RhCE antigens identified by standard serologic routine testing in German blood donors ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02220.x

    authors: Bugert P,Scharberg EA,Geisen C,von Zabern I,Flegel WA

    更新日期:2009-09-01 00:00:00

  • Incest diagnosis by comparison of alleles of mother and offspring at highly heterozygous loci.

    abstract:BACKGROUND:Methods that detect a child's homozygosity by examination of allelic products are insensitive for diagnosing incest because, at a given locus, a homozygous state is expected with a frequency of only 0.25 when parents are first-degree relatives. Furthermore, these methods are not specific if the population co...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1994.34294143949.x

    authors: Wenk RE,Chiafari FA,Houtz T

    更新日期:1994-02-01 00:00:00

  • Comparison of plateletapheresis with two continuous-flow cell separators using identical donors.

    abstract::Each of 20 donors underwent plateletapheresis on both the CS-3000 (Fenwal) and the 2997 (IBM) blood cell separators. The same operator performed both procedures and conducted all product studies for each donor. Platelet collection efficiency was significantly greater with the 2997 (81%) than the CS-3000 (60%) (p less ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25485273811.x

    authors: Mintz PD

    更新日期:1985-07-01 00:00:00

  • Murine monoclonal antibodies associated with Rh17, Rh29, and Rh46 antigens.

    abstract::After immunization with native human red cells and red cells infected with Plasmodium falciparum, mouse splenocytes were fused with a myeloma cell line to obtain hybridomas. Among the antibodies specific for blood group antigens, four antibodies (iB3C4, F12, MR432, and iB4) directed against epitopes related to the Rh ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28188127953.x

    authors: Rouger P,Edelman L

    更新日期:1988-01-01 00:00:00

  • Detection of dengue, chikungunya, and Zika RNA in blood donors from Southeast Asia.

    abstract:BACKGROUND:Chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses are of concern due to the potential of transfusion transmission in blood, especially in regions such as Southeast Asia where the viruses are endemic. The recent availability of nucleic acid testing (NAT) to screen blood donations on an automated pla...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16110

    authors: Stanley J,Chongkolwatana V,Duong PT,Kitpoka P,Stramer SL,Dung NTT,Grimm KE,Pojanasingchod A,Suksomboonvong P,Galel SA

    更新日期:2020-10-07 00:00:00

  • Effects of hydroxyethyl starch on blood coagulation, particularly factor VIII.

    abstract::The effects of hydroxyethyl starch (HES) on hemostasis were investigated extensively. In order to simulate acute blood loss due to surgery or trauma, one unit (450 ml) of blood was drawn from normal healthy men. This was followed by a 1-liter infusion over 60 minutes of either 6 percent HES, 5 percent albumin, or 0.9 ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25485273815.x

    authors: Stump DC,Strauss RG,Henriksen RA,Petersen RE,Saunders R

    更新日期:1985-07-01 00:00:00

  • Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D.

    abstract:BACKGROUND:RhIG is obtained from hyperimmunized healthy anti-D donors (HIDs) boosted with D+ red blood cells (RBCs). One hypothesis for its mechanism of action is fast clearance of opsonized D+ RBCs through Fcγ receptor (FcγR)III. Levels of immunoglobulin (Ig)G Fc-fucosylation influence interactions with FcγRIII, with ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12880

    authors: Kapur R,Della Valle L,Verhagen OJ,Hipgrave Ederveen A,Ligthart P,de Haas M,Kumpel B,Wuhrer M,van der Schoot CE,Vidarsson G

    更新日期:2015-03-01 00:00:00

  • Effects of UVB radiation on cytokine generation, cell adhesion molecules, and cell activation markers in T-lymphocytes and peripheral blood HPCs.

    abstract:BACKGROUND:Immunomodulatory effects of UV light have increasingly become a focus in transfusion medicine, BMT and transplantation immunology. In the transplant setting, the use of UVB radiation may reduce or abolish T-cell activation without compromising either bone marrow (BM) engraftment or graft-versus-leukemia effe...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40030361.x

    authors: Lankford KV,Mosunjac M,Hillyer CD

    更新日期:2000-03-01 00:00:00

  • Genotyping of RHD by multiplex polymerase chain reaction analysis of six RHD-specific exons.

    abstract:BACKGROUND:Qualitative RHD variants are the result of the replacement of RHD exons by their RHCE counterparts or of point mutations in RHD causing amino acid substitutions. For RHD typing, the use of at least two RHD typing polymerase chain reaction (PCR) assays directed at different regions of RHD is advised to preven...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38111299056309.x

    authors: Maaskant-van Wijk PA,Faas BH,de Ruijter JA,Overbeeke MA,von dem Borne AE,van Rhenen DJ,van der Schoot CE

    更新日期:1998-11-01 00:00:00

  • A novel approach to pathogen reduction in platelet concentrates using short-wave ultraviolet light.

    abstract:BACKGROUND:Transfusion of platelet concentrates (PCs) is the basic treatment for severe platelet disorders. PCs carry the risk of pathogen transmission, especially bacteria. Pathogen reduction (PR) by addition of photochemical reagents and irradiation with visible or ultraviolet (UV) light can significantly reduce this...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02334.x

    authors: Mohr H,Steil L,Gravemann U,Thiele T,Hammer E,Greinacher A,Müller TH,Völker U

    更新日期:2009-12-01 00:00:00

  • Dimethyl sulfoxide: effects on function of fresh platelets and on the viability of platelets in storage.

    abstract::Dimethyl sulfoxide (DMSO) is used as a cryoprotective agent when platelets are frozen. We examined the effect of DMSO (0.1 to 10%) on platelet aggregation, release, and prostaglandin synthesis (as indicated by malondialdehyde formation) in response to thrombin, collagen, arachidonic acid and calcium ionophore. Inhibit...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1983.23283172844.x

    authors: Fratantoni JC,Poindexter BJ

    更新日期:1983-03-01 00:00:00

  • Associated factors of umbilical cord blood collection quality.

    abstract::After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be gr...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.14447

    authors: Faivre L,Couzin C,Boucher H,Domet T,Desproges A,Sibony O,Bechard M,Vanneaux V,Larghero J,Cras A

    更新日期:2018-02-01 00:00:00

  • Anti-K formation is not associated with the storage time of transfused red blood cells.

    abstract:BACKGROUND:The formation of red blood cell (RBC) antibodies could be enhanced by the presence of inflammation caused by prolonged RBC storage, as was shown in animal studies. The low occurrence (<10%) of K-antigen in most populations often enables identification of the K+ RBC unit that triggered anti-K formation and de...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12974

    authors: Hogervorst E,Middelburg R,Brand A,van de Watering L,Schonewille H

    更新日期:2015-06-01 00:00:00

  • Extension of platelet shelf life with an improved bacterial testing algorithm.

    abstract:BACKGROUND:At Canadian Blood Services, platelet concentrate (PC) shelf life was extended to 7 days with a large-volume, delayed-sampling bacterial screening algorithm. We present the development study and postimplementation results. STUDY DESIGN AND METHODS:In the development study, PCs inoculated with five bacteria (...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16112

    authors: Ramirez-Arcos S,Evans S,McIntyre T,Pang C,Yi QL,DiFranco C,Goldman M

    更新日期:2020-12-01 00:00:00

  • Antibodies to vaccine antigens in pooled polyclonal human IgG products.

    abstract::Immune-deficient patients depend on the antibodies in pooled human immunoglobulin G (IgG) preparations to remain free from serious infections. The potency of IgG preparations is therefore an ongoing concern. The use of pooled IgG to prevent infection is based on the concept that healthy adults have recovered from infe...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.15017

    authors: Berger M

    更新日期:2018-12-01 00:00:00

  • Evaluation of algorithms for the diagnostic assessment and the reentry of blood donors who tested reactive for antibodies against hepatitis B core antigen.

    abstract:BACKGROUND:Screening of blood donations for antibodies against hepatitis B core antigen (anti-HBc) is an accepted method to prevent some transfusion-transmitted hepatitis B virus (HBV) infections. However, anti-HBc testing may result in donor loss due to unspecific results in the currently available anti-HBc tests. Alg...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.03031.x

    authors: Juhl D,Luhm J,Görg S,Ziemann M,Hennig H

    更新日期:2011-07-01 00:00:00

  • The RADAR repository: a resource for studies of infectious agents and their transmissibility by transfusion.

    abstract:BACKGROUND:An ongoing issue in transfusion medicine is whether newly identified or emerging pathogens can be transmitted by transfusion. One method to study this question is through the use of a contemporary linked donor-recipient repository. STUDY DESIGN AND METHODS:The Retrovirus Epidemiology Donor Study Allogeneic ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00171.x

    authors: Kleinman SH,Glynn SA,Higgins MJ,Triulzi DJ,Smith JW,Nass CC,Garratty G,Murphy EL,LeParc GF,Schreiber GB,King MR,Chamberland ME,Nemo GJ

    更新日期:2005-07-01 00:00:00

  • Toxoplasmosis transmitted by blood transfusions.

    abstract::Blood from humans collected into heparin or citrate was inoculated with toxoplasma organisms. After storage at 4 C up to 28 days, samples were injected into the ear veins of rabbits. The test rabbits developed toxoplasmosis. Similar results were obtained by transfusing rabbits with blood obtained from rabbits subcutan...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18378205142.x

    authors: Räisänen S

    更新日期:1978-05-01 00:00:00

  • Influence of enteral feeding and anemia on tissue oxygen extraction after red blood cell transfusion in preterm infants.

    abstract:BACKGROUND:Understanding factors that impact tissue oxygen extraction may guide red blood cell (RBC) transfusion decision making in preterm infants. Our objective was to assess the influence of enteral feeding and anemia on cerebral and mesenteric oxygen saturation (Csat and Msat) and fractional tissue oxygen extractio...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15680

    authors: Goldstein GP,Rao A,Ling AY,Ding VY,Chang IJ,Chock VY

    更新日期:2020-03-01 00:00:00

  • Emm. A red cell antigen of very high frequency.

    abstract::Anti-Emm, an antibody to a public red cell antigen, was found in the serums of four Emm-propositi and in the serum of the Emm-brother of one of them. Three of the propositi were men, and their antibodies, as well as that of the compatible brother, were believed to be "naturally occurring." Since there are two Emm-sibl...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27487264738.x

    authors: Daniels GL,Taliano V,Klein MT,McCreary J

    更新日期:1987-07-01 00:00:00

  • Trends in blood utilization in United States cardiac surgical patients.

    abstract:BACKGROUND:We sought to determine whether publication of blood conservation guidelines by the Society of Thoracic Surgeons in 2007 influenced transfusion rates and to understand how patient- and hospital-level factors influenced blood product usage. STUDY DESIGN AND METHODS:We identified 4,465,016 patients in the Nati...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12903

    authors: Robich MP,Koch CG,Johnston DR,Schiltz N,Chandran Pillai A,Hussain ST,Soltesz EG

    更新日期:2015-04-01 00:00:00

  • Chemical analysis of a 30-year-old bottle of lyophilized plasma.

    abstract::The biochemical constituents of a 30-year-old sealed bottle of lyophilized plasma were analyzed. The results in this communication show that the process of lyophilization and storage has not seemed to cause any great changes in plasma components, including hormones, enzymes, and proteins. ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1977.17177128892.x

    authors: Fu P,Myhre B

    更新日期:1977-01-01 00:00:00