Abstract:
:This paper presents recent data from quantitative and thermodynamic investigations on A and B erythrocyte antigens. In regard to weak A phenotypes on the basis of quantitative data, practically no gap is observed from the weakest Aend to the strongest A3. Weak B phenotypes give a similar distribution. However, a more precise structural analysis including kinetics and thermodynamic measurements provides convincing evidence for the heterogeneity of each type of weak B reactive structures. Weak B antigens appear to be different from one to another, but similar inside one family. However, thermodynamics failed to demonstrate a qualitative difference between the weak B antigen in BX groups and the enhanced B antigen in ABX heterozygote, phenomenon that occurs in some very rare families. The same data were obtained from kinetic and thermodynamic analysis of B reactivity in cis AB samples; it can be assumed that such mutants are all different.
journal_name
Transfusionjournal_title
Transfusionauthors
Salmon C,Lopez M,Cartron JP,Bouguerra Adoi
10.1046/j.1537-2995.1976.16677060242.xsubject
Has Abstractpub_date
1976-11-01 00:00:00pages
580-93issue
6eissn
0041-1132issn
1537-2995journal_volume
16pub_type
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