Quantitative and thermodynamic studies of erythrocytic ABO antigens.

Abstract:

:This paper presents recent data from quantitative and thermodynamic investigations on A and B erythrocyte antigens. In regard to weak A phenotypes on the basis of quantitative data, practically no gap is observed from the weakest Aend to the strongest A3. Weak B phenotypes give a similar distribution. However, a more precise structural analysis including kinetics and thermodynamic measurements provides convincing evidence for the heterogeneity of each type of weak B reactive structures. Weak B antigens appear to be different from one to another, but similar inside one family. However, thermodynamics failed to demonstrate a qualitative difference between the weak B antigen in BX groups and the enhanced B antigen in ABX heterozygote, phenomenon that occurs in some very rare families. The same data were obtained from kinetic and thermodynamic analysis of B reactivity in cis AB samples; it can be assumed that such mutants are all different.

journal_name

Transfusion

journal_title

Transfusion

authors

Salmon C,Lopez M,Cartron JP,Bouguerra A

doi

10.1046/j.1537-2995.1976.16677060242.x

subject

Has Abstract

pub_date

1976-11-01 00:00:00

pages

580-93

issue

6

eissn

0041-1132

issn

1537-2995

journal_volume

16

pub_type

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