Antibodies to vaccine antigens in pooled polyclonal human IgG products.


:Immune-deficient patients depend on the antibodies in pooled human immunoglobulin G (IgG) preparations to remain free from serious infections. The potency of IgG preparations is therefore an ongoing concern. The use of pooled IgG to prevent infection is based on the concept that healthy adults have recovered from infections earlier in life and maintain relatively high antibody titers. In general, vaccine-induced immunity is less robust or long-lasting than immunity after natural infection, and many infectious diseases which were formerly widely prevalent have become much less common due to improved hygiene and vaccines. This raises questions as to the adequacy of protective antibodies in current IgG preparations. This paper reviews available data on antibodies against selected bacterial and virus vaccine antigens in current IgG products. Most products contain sufficient antibody to yield levels above minimal protective concentrations to a broad range of pathogens and toxins. Illustrative examples of effects of vaccines on antibody content of IgG products are also discussed: antibody titers to hepatitis A virus in donor plasma pools in both the US and EU are dropping due to decreased natural infection, but they are still sufficient to provide robust protection. Increasing seroprevalence of hepatitis B virus as a result of immunization suggests that antibody titers against this virus may actually be increasing. Finally, serial studies suggest that pooled IgG provides protection against seasonal influenza viruses despite year-to-year antigenic drift, and is also likely to provide at least some protective antibody against potentially pandemic strains.






Berger M




Has Abstract


2018-12-01 00:00:00








58 Suppl 3


  • Systematic review of rituximab for autoimmune diseases: a potential alternative to intravenous immune globulin.

    abstract:BACKGROUND:The anti-CD20 monoclonal antibody rituximab has immune-modulatory effects similar to intravenous immunoglobulin (IVIG). We performed a systematic review and meta-analysis to determine the efficacy and safety of rituximab in autoimmune diseases that are also treated with IVIG. STUDY DESIGN AND METHODS:The mo...


    pub_type: 杂志文章


    authors: MacIsaac J,Siddiqui R,Jamula E,Li N,Baker S,Webert KE,Evanovitch D,Heddle NM,Arnold DM

    更新日期:2018-11-01 00:00:00

  • Diethylenetriaminopentaacetic acid is unsuitable for long-term preservation of RBCs.

    abstract:BACKGROUND:The addition of an appropriate metal chelator, such as diethylenetriaminopentaacetic acid (DTPA) to stored blood has been shown to be effective in a short-term (0-12 days) prevention of lipid peroxidation of stored RBCS: However, its long-term effectiveness has not been carefully evaluated. STUDY DESIGN AND...


    pub_type: 杂志文章


    authors: Liu TZ,Chiu DT,Stern A

    更新日期:2001-04-01 00:00:00

  • Quantity, quality, and functionality of peripheral blood cells derived from residual blood of different apheresis kits.

    abstract:BACKGROUND:Research with primary human white blood cell (WBC) subpopulations requires high quantity, quality, and functionality of peripheral blood mononuclear cells (PBMCs) as a source to further characterize cellular subpopulations such as T and B lymphocytes, monocytes, or natural killer cells. Apart from buffy coat...


    pub_type: 杂志文章


    authors: Knörck A,Marx S,Friedmann KS,Zöphel S,Lieblang L,Hässig C,Müller I,Pilch J,Sester U,Hoth M,Eichler H,Sester M,Schwarz EC

    更新日期:2018-06-01 00:00:00

  • Donor and nondonor motivations.

    abstract::In an attempt to gain insight into the motivations of blood donors and nondonors, two paper and pencil questionnaires were developed and mailed to approximately 7,000 individuals. In response, 1,429 nondonors and 200 donors completed and returned usable questionnaires. Among donors, awareness of the need for blood, al...


    pub_type: 杂志文章


    authors: Leibrecht BC,Hogan JM,Luz GA,Tobias KI

    更新日期:1976-03-01 00:00:00

  • False-positive eluate reactivity due to the low-ionic wash solution used with commercial acid-elution kits.

    abstract:BACKGROUND:During the use of commercial red cell (RBC) acid-elution kits for adsorption and elution (adsorption/elution) studies with anti-D, unexpected reactive eluates (anti-D) were obtained from D- RBCs. Such results were not obtained with a parallel xylene method or, historically, with heat and ether methods. STUD...


    pub_type: 杂志文章


    authors: Leger RM,Arndt PA,Ciesielski DJ,Garratty G

    更新日期:1998-06-01 00:00:00

  • Cellular therapy services provided by blood centers and hospitals in the United States, 1999: an analysis from the Nationwide Blood Collection and Utilization Survey.

    abstract:BACKGROUND:The 2000 Nationwide Blood Collection and Utilization Survey was designed to assess cellular therapy product services in US blood centers and hospitals. STUDY DESIGN AND METHODS:Questionnaires were returned by 2,040 institutions. Data were analyzed for 30 quantitative variables related to cellular therapy pr...


    pub_type: 杂志文章


    authors: Read EJ,Sullivan MT

    更新日期:2004-04-01 00:00:00

  • The RADAR repository: a resource for studies of infectious agents and their transmissibility by transfusion.

    abstract:BACKGROUND:An ongoing issue in transfusion medicine is whether newly identified or emerging pathogens can be transmitted by transfusion. One method to study this question is through the use of a contemporary linked donor-recipient repository. STUDY DESIGN AND METHODS:The Retrovirus Epidemiology Donor Study Allogeneic ...


    pub_type: 杂志文章


    authors: Kleinman SH,Glynn SA,Higgins MJ,Triulzi DJ,Smith JW,Nass CC,Garratty G,Murphy EL,LeParc GF,Schreiber GB,King MR,Chamberland ME,Nemo GJ

    更新日期:2005-07-01 00:00:00

  • Natural anti-A and anti-B of the ABO system: allo- and autoantibodies have different epitope specificity.

    abstract:BACKGROUND:According to Landsteiner's law, alloantibodies are prevalent and autoantibodies are absent in the ABO blood group system. However, one study (Spalter et al., Blood 1999;93:4418-24) has suggested that low-affinity ABO autoantibodies, mitigated by anti-idiotypic immunoglobulins are also prevalent, while anothe...


    pub_type: 杂志文章


    authors: Obukhova P,Korchagina E,Henry S,Bovin N

    更新日期:2012-04-01 00:00:00

  • Evaluation of an experimental filter designed for improving the quality of red blood cells (RBCs) during storage by simultaneously removing white blood cells and immunomodulators and improving RBC viscoelasticity and Band 3 proteins.

    abstract:BACKGROUND:Storage age of red blood cells (RBCs) has been reported to be associated with increased mortality and morbidity. During storage, RBCs undergo changes in biochemical and functional properties. Stored RBCs may also contain white blood cells (WBCs), activated platelets (PLTs), cytokines, immunoglobulin, and oth...


    pub_type: 杂志文章


    authors: Sowemimo-Coker SO

    更新日期:2014-03-01 00:00:00

  • Isolated platelet concentrate transfusion during surgery: a single-center observational cohort study.

    abstract:BACKGROUND:Surgical patients receive platelet concentrates (PCs) for a variety of indications. However, there is limited evidence for efficacy or dosing of PCs. STUDY DESIGN AND METHODS:We performed a retrospective cohort study of surgical patients receiving isolated PC transfusion at a single academic tertiary medica...


    pub_type: 杂志文章


    authors: Anders M,Rock P,Cartron A,Chow J,Henderson R,Martz D,Tanaka K,Mazzeffi M

    更新日期:2019-05-01 00:00:00

  • Changes in minimum hemoglobin and interdonation interval: impact on donor hemoglobin and donation frequency.

    abstract:BACKGROUND:To reduce donor iron deficiency in whole blood donors, we changed our hemoglobin (Hb) cutoff in males and interdonation interval in females. STUDY DESIGN AND METHODS:A change in messaging to females in fall 2016 was followed by changing the interdonation interval from 56 to 84 days in the appointment bookin...


    pub_type: 杂志文章


    authors: Goldman M,Yi QL,Steed T,O'Brien SF

    更新日期:2019-05-01 00:00:00

  • Plasma ectonucleotidases prevent desensitization of purinergic receptors in stored platelets: importance for platelet activity during thrombus formation.

    abstract:BACKGROUND:Platelets (PLTs) contain purinergic receptors for ATP (P2X1) and ADP (P2Y1 and P2Y12) that rapidly desensitize upon stimulation with these nucleotides. In vivo, this is antagonized by ectonucleotidases on the surface of endothelial cells and white blood cells (WBCs). The receptor desensitization of ATP- and ...


    pub_type: 杂志文章


    authors: Cauwenberghs S,Feijge MA,Hageman G,Hoylaerts M,Akkerman JW,Curvers J,Heemskerk JW

    更新日期:2006-06-01 00:00:00

  • Transfusion-induced serum sickness.

    abstract:BACKGROUND:Transfusion-induced serum sickness reactions are rarely reported in the literature. The Type III hypersensitivity reaction to heterologous proteins involves deposition of complement and immune complexes in small vessel walls resulting in a leukocytoclastic vasculitis. A case of a multiply transfused patient ...


    pub_type: 杂志文章


    authors: Saegeman V,Wynendaele W,Kerre S,Dedeurwaerdere F,Van den Driessche M,Moerman J

    更新日期:2009-02-01 00:00:00

  • Mitochondrial damage-associated molecular patterns as potential proinflammatory mediators in post-platelet transfusion adverse effects.

    abstract:BACKGROUND:Platelet concentrates (PCs) are the most common blood components eliciting nonhemolytic transfusion reactions (NHTRs), such as allergic transfusion reactions and febrile reactions. However, the precise mechanisms of NHTRs in PC transfusion remain largely unknown. Previous studies reported that mitochondria-d...


    pub_type: 杂志文章


    authors: Yasui K,Matsuyama N,Kuroishi A,Tani Y,Furuta RA,Hirayama F

    更新日期:2016-05-01 00:00:00

  • A novel bioreactor and culture method drives high yields of platelets from stem cells.

    abstract:BACKGROUND:Platelet (PLT) transfusion is the primary treatment for thrombocytopenia. PLTs are obtained exclusively from volunteer donors, and the PLT product has only a 5-day shelf life, which can limit supply and result in PLT shortages. PLTs derived from stem cells could help to fill this clinical need. However, curr...


    pub_type: 杂志文章


    authors: Avanzi MP,Oluwadara OE,Cushing MM,Mitchell ML,Fischer S,Mitchell WB

    更新日期:2016-01-01 00:00:00

  • A delayed transfusion reaction caused by anti-K6.

    abstract::This case report documents the demonstration of anti-K6 as the single antibody responsible for a delayed transfusion reaction. A 42-year-old white woman received three units of red blood cells for an episode of gastrointestinal bleeding from a duodenal ulcer. Twenty-three days following transfusion, laboratory and cli...


    pub_type: 杂志文章


    authors: Taddie SJ,Barrasso C,Ness PM

    更新日期:1982-01-01 00:00:00

  • Protein quality in Mirasol pathogen reduction technology-treated, apheresis-derived fresh-frozen plasma.

    abstract:BACKGROUND:The Mirasol pathogen reduction technology (PRT) system for plasma is based on a riboflavin (vitamin B(2)) and ultraviolet (UV) light treatment process resulting in pathogen inactivation due to irreversible photo-oxidative damage of nucleic acids. The purpose of this study was to evaluate the in vitro protein...


    pub_type: 杂志文章


    authors: Smith J,Rock G

    更新日期:2010-04-01 00:00:00

  • The National Marrow Donor Program.

    abstract::As the number of successful marrow transplants has increased, the lack of HLA-identical sibling donors for 60 to 70 percent of transplant candidates has become a serious problem. Pilot studies established that marrow transplantation between phenotypically HLA-identical, unrelated individuals can be accomplished succes...


    pub_type: 杂志文章


    authors: Stroncek D,Bartsch G,Perkins HA,Randall BL,Hansen JA,McCullough J

    更新日期:1993-07-01 00:00:00

  • Erythrocytapheresis for chronic transfusion therapy in sickle cell disease: survey of current practices and review of the literature.

    abstract:BACKGROUND:Chronic red blood cell (RBC) transfusion therapy (CTT) is an integral component of the management of severe sickle cell disease (SCD) and can prevent complications, such as stroke. RBC units can be administered via simple transfusion or exchange transfusion, and erythrocytapheresis (automated RBC exchange tr...


    pub_type: 杂志文章,评审


    authors: Kelly S,Quirolo K,Marsh A,Neumayr L,Garcia A,Custer B

    更新日期:2016-11-01 00:00:00

  • Prevalence, incidence, and residual risk of human immunodeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testing.

    abstract:BACKGROUND:Nucleic acid testing (NAT) for human immunodeficiency virus (HIV) and hepatitis C virus (HCV) was introduced for blood donation screening in the United States in 1999. This study analyzes temporal trends of these two infections since NAT introduction. STUDY DESIGN AND METHODS:Donation data from 1999 to 2008...


    pub_type: 杂志文章


    authors: Zou S,Dorsey KA,Notari EP,Foster GA,Krysztof DE,Musavi F,Dodd RY,Stramer SL

    更新日期:2010-07-01 00:00:00

  • Effects of blood storage age on immune, coagulation, and nitric oxide parameters in transfused patients undergoing cardiac surgery.

    abstract:BACKGROUND:Retrospective studies suggested that storage age of RBCs is associated with inflammation and thromboembolism. The Red Cell Storage Duration Study (RECESS) trial randomized subjects undergoing complex cardiac surgery to receive RBCs stored for shorter versus longer periods, and no difference was seen in the p...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Spinella PC,Sniecinski RM,Trachtenberg F,Inglis HC,Ranganathan G,Heitman JW,Szlam F,Danesh A,Stone M,Keating SM,Levy JH,Assmann SF,Steiner ME,Doctor A,Norris PJ

    更新日期:2019-04-01 00:00:00

  • Associated factors of umbilical cord blood collection quality.

    abstract::After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be gr...


    pub_type: 杂志文章,评审


    authors: Faivre L,Couzin C,Boucher H,Domet T,Desproges A,Sibony O,Bechard M,Vanneaux V,Larghero J,Cras A

    更新日期:2018-02-01 00:00:00

  • Transfusion, blood donation, and postage stamps: a worldwide review.

    abstract::Before the advent of electronic means of communication, postal stamps were one of the main international promotion tools on the planet and still remains an important support for the wide diffusion of a message. Since 1942, the promotion of blood donation has been one of them. To highlight these recurring or specific c...


    pub_type: 杂志文章,评审


    authors: Lefrère JJ,Danic B

    更新日期:2010-08-01 00:00:00

  • A multicenter evaluation of reproducibility of swirling in platelet concentrates. Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society of Blood Transfusion.

    abstract:BACKGROUND:Eleven laboratories participated in a study investigating whether swirling can be used in monitoring platelet discoid morphology in platelet concentrates (PCs). STUDY DESIGN AND METHODS:In each laboratory, two readers observed the swirling pattern in 1- to 5-day-old PCs, in PCs containing spherical platelet...


    pub_type: 杂志文章


    authors: Bertolini F,Murphy S

    更新日期:1994-09-01 00:00:00

  • Frequently used plateletpheresis techniques result in variable target yields and platelet recruitment of donors.

    abstract:BACKGROUND:Standard plateletpheresis techniques and effects on platelet (PLT) donors were investigated to provide an informative basis for advancement of apheresis software. STUDY DESIGN AND METHODS:Three paired groups with 33 male and 22 female blood donors were prospectively investigated by analyzing blood counts of...


    pub_type: 杂志文章


    authors: Strasser EF,Schuster M,Egler K,Bauer J,Weisbach V,Ringwald J,Zimmermann R,Zingsem J,Eckstein R

    更新日期:2005-05-01 00:00:00

  • Surveillance for Creutzfeldt-Jakob disease among persons with hemophilia.

    abstract:BACKGROUND:Although Creutzfeldt-Jakob disease (CJD) has been shown to be transmissible through blood components in rodent models, no human blood-to-blood transmission has been documented. If blood transmission were possible in humans, persons with hemophilia in the United States would be at higher risk of contracting C...


    pub_type: 杂志文章


    authors: Evatt B,Austin H,Barnhart E,Schonberger L,Sharer L,Jones R,DeArmond S

    更新日期:1998-09-01 00:00:00

  • Leukocyte depletion of red cell units at the bedside by transfusion through a new filter.

    abstract::Standard packed red cell (PRC) units can be depleted of leukocytes and platelets if they are transfused through a blood administration set in which the usual 170-mu filter has been replaced by a leukocyte removal filter (Sepacell R-500). During a 6-month period, 1550 PRC units were transfused through this filter in 61...


    pub_type: 杂志文章


    authors: Sirchia G,Rebulla P,Parravicini A,Carnelli V,Gianotti GA,Bertolini F

    更新日期:1987-09-01 00:00:00

  • The survival and function of baboon red blood cells, platelets, and plasma proteins: a review of the experience from 1972 to 2002 at the Naval Blood Research Laboratory, Boston, Massachusetts.

    abstract::The studies reported in this monograph were performed between 1972 and 2002 when it was possible to study healthy male and female baboons. A colony of baboons was maintained for 30 years without any adverse events observed in these baboons in the numerous studies that were performed. These protocols were reviewed and ...


    pub_type: 杂志文章,评审


    authors: Valeri CR,Ragno G

    更新日期:2006-08-01 00:00:00

  • RHCE*ceTI encodes partial c and partial e and is often in cis to RHD*DIVa.

    abstract:BACKGROUND:In the Rh blood group system, variant RhD and RhCE express several partial antigens. We investigated RH in samples with partial DIVa that demonstrated weak and variable reactivity with anti-C. STUDY DESIGN AND METHODS:Standard hemagglutination techniques, polymerase chain reaction-based assays, and RH seque...


    pub_type: 杂志文章


    authors: Westhoff CM,Vege S,Halter Hipsky C,Hue-Roye K,Copeland T,Velliquette RW,Horn T,Lomas-Francis C,Reid ME

    更新日期:2013-04-01 00:00:00

  • Risk of chikungunya virus transmission associated with European travelers returning from southern Thailand (2008-2015).

    abstract:BACKGROUND:The impact of the spread of chikungunya virus (CHIKV) by autochthonous transmission and blood transfusion in nonendemic areas via travelers returning from CHIKV-affected locations is a concern. METHODS:We analyzed the risks of potential CHIKV importation and transfusion transmission from Thailand to Europe ...


    pub_type: 杂志文章


    authors: Appassakij H,Khuntikij P,Silpapojakul K,Promwong C,Rujirojindakul P,Suddeaugrai O,Chullasara A

    更新日期:2019-08-01 00:00:00