Abstract:
:Leukapheresis by continuous flow centrifugation (CFC) or filtration (FL) were compared in untreated and corticosteroid-treated donors. The administration of prednisone 60 mg orally 10 to 12 hours before leukapheresis increased significantly both the donor's prepheresis WBC counts and the total granulocyte yields by CFC or FL. Dexamethasone 6 mg iv at the start of FL did not increase granulocyte yields significantly. In untreated donors FL yielded 0.25 x 10(10) granulocytes per liter donor blood processed as compared with 0.05 x 10(10) per liter in CFC donors. Corticosteroid premedication has a greater relative effect in increasing yields by CFC than by FL. Donor reaction rates were between 4 and 6 per cent for both procedures.
journal_name
Transfusionjournal_title
Transfusionauthors
MacPherson JL,Nusbacher J,Bennett JMdoi
10.1046/j.1537-2995.1976.16376225492.xsubject
Has Abstractpub_date
1976-05-01 00:00:00pages
221-8issue
3eissn
0041-1132issn
1537-2995journal_volume
16pub_type
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