Hemolytic disease of the newborn due to anti-Di: a case study and review of the literature.

Abstract:

BACKGROUND:The severity of hemolytic disease of the newborn (HDN) due to Diego(b) (Di(b)) mismatch ranges from no symptoms to severe jaundice that requires exchange transfusion (ET). The clinical significance of anti-Di(b) is incompletely recognized. CASE REPORT:A male newborn, referred with jaundice, was revealed to have HDN due to Di(b) mismatch and was treated successfully with phototherapy and high-dose intravenous gamma globulin (IVGG). STUDY DESIGN AND METHODS:The literature of HDN caused by Di(b) mismatch was reviewed. The cases were classified into three groups according to their severity: the mildest needed no therapy (NO), the moderate group received phototherapy alone (PHOTO), and the most severe was treated with ET and/or high-dose IVGG therapy plus phototherapy (ET/IVGG). RESULTS:Among 27 cases of HDN due to Di(b) reported to date, 10, 6, and 11 cases required NO, PHOTO, and ET/IVGG, respectively. A significant correlation (p < 0.01) was found between the maternal anti-Di(b) titer and the severity of the disease when the ET/IVGG group was compared with the NO group. All mothers of the group that needed ET/IVGG had an anti-Di(b) titer of 64 or greater. CONCLUSION:A maternal high titer (> or =64) of anti-Di(b) is associated with a higher risk of severe hyperbilirubinemia for mismatched newborns.

journal_name

Transfusion

journal_title

Transfusion

authors

Mochizuki K,Ohto H,Hirai S,Ujiie N,Amanuma F,Kikuta A,Miura S,Yasuda H,Ishijima A,Suzuki H

doi

10.1111/j.1537-2995.2006.00743.x

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

454-60

issue

3

eissn

0041-1132

issn

1537-2995

pii

TRF00743

journal_volume

46

pub_type

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