Maintenance rituximab for relapsing thrombotic thrombocytopenic purpura: a case report.

Abstract:

BACKGROUND:Appropriate management to prevent relapses of acquired, autoimmune thrombotic thrombocytopenic purpura (TTP) is not clear. Rituximab (375 mg/m2 /week × 4) is effective treatment for acute episodes but it is not consistently effective for prevention of relapses. Maintenance rituximab, 375 mg/m2 /3 months for 2 years, is commonly used to prevent progression of follicular lymphoma, but the outcome of maintenance rituximab to prevent TTP relapses has been rarely reported. CASE REPORT:An 8-year-old girl was diagnosed with acquired TTP in 2008; her ADAMTS13 activity was less than 5%, with a functional inhibitor of greater than 8 Bethesda units/mL. She achieved remission with therapeutic plasma exchange, corticosteroids, and rituximab (375 mg/m2 /week × 4). During the following 6 years she had seven additional episodes. Each episode responded to therapeutic plasma exchange, sometimes requiring additional treatments (corticosteroids, rituximab, and cyclophosphamide). However, these treatments, as well as splenectomy and trials of cyclophosphamide and mycophenolate mofetil during clinical remissions, failed to prevent relapses. Her ADAMTS13 activity remained 8% or less throughout all of her remissions. Maintenance rituximab was begun in 2013: 500 mg (313 mg/m2 ) every 2-3 months × 5, then 600 mg (375 mg/m2 ) every 6 months × 2. After 1 year, her ADAMTS13 was 26%; after 2 years, 51%. During the past 3 years since stopping rituximab, she has remained well, with normal ADAMTS13 activity (70%-78%). CONCLUSION:Maintenance rituximab treatment may be effective for prevention of relapses in patients with acquired, autoimmune TTP, even when splenectomy and intensive immunosuppression, including multiple conventional courses of rituximab, fail to prevent subsequent relapses.

journal_name

Transfusion

journal_title

Transfusion

authors

Saleem R,Rogers ZR,Neunert C,George JN

doi

10.1111/trf.15093

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

921-926

issue

3

eissn

0041-1132

issn

1537-2995

journal_volume

59

pub_type

  • A review of blood donor motivation and recruitment.

    abstract::Sixty English-language articles on the motivation and recruitment of blood donors and nondonors are reviewed and evaluated. Apparently researchers have been finding essentially the same results for approximately twenty years. Motivations to donate are: altruism/humanitarian, personal or family credit, social pressure,...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1977.17277151916.x

    authors: Oswalt RM

    更新日期:1977-03-01 00:00:00

  • Sampling errors and the precision associated with counting very low numbers of white cells in blood components.

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31591263198.x

    authors: Dumont LJ

    更新日期:1991-06-01 00:00:00

  • Absence of acute adverse in vitro effects on aged AS-1 red blood cells and thawed plasma after prolonged exposure to 13.56-MHz radio energy.

    abstract:BACKGROUND:There is growing interest in radio frequency identification (RFID) technology for tracking blood products to improve productivity and safety in the transfusion medicine supply chain. We conducted a limited study to assess the temperature and biologic effects after extreme exposure to 13.56-MHz RF radiation o...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03534.x

    authors: Davis R,Gottschall J,Gutierrez A,Hohberger C,Graminske S,Veeramani D,Holcombe J

    更新日期:2012-09-01 00:00:00

  • Fanconi syndrome in a patient with β-thalassemia major after using deferasirox for 27 months.

    abstract:BACKGROUND:Deferasirox (DFRA) is a new approved oral iron chelator. Its advantages are that it is convenient and better tolerated and adhered to due to "once-daily" oral dosage. However, its use in the field is limited and it is yet to be subjected to postmarketing surveillance. CASE REPORT:A 18.75-year-old male with ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02939.x

    authors: Wei HY,Yang CP,Cheng CH,Lo FS

    更新日期:2011-05-01 00:00:00

  • Stability after thawing of RBCs frozen with the high- and low-glycerol method.

    abstract:BACKGROUND:RBCs can be frozen with either the high-glycerol method (HGM) or the low-glycerol method (LGM). To date, the use of frozen RBCs is hampered by a 24-hour outdating period after thawing. A closed washing system (ACP 215) may solve this problem. STUDY DESIGN AND METHODS:We compared the effects of high- (40%) a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2003.00293.x

    authors: Lelkens CC,Noorman F,Koning JG,Truijens-de Lange R,Stekkinger PS,Bakker JC,Lagerberg JW,Brand A,Verhoeven AJ

    更新日期:2003-02-01 00:00:00

  • Return of autologous blood donors as homologous blood donors.

    abstract::Autologous blood donors (ABDs) have been reported to have favorable attitudes toward returning as homologous blood donors (HBDs), but the frequency of return has not been well documented. ABDs eligible by history to be HBDs were followed at one blood center: 255 donating for elective surgery and 234 donating during pr...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31291142941.x

    authors: McVay PA,Fung HC,Toy PT

    更新日期:1991-02-01 00:00:00

  • The effect of recombinant human erythropoietin on the efficacy of autologous blood donation in patients with low hematocrits: a multicenter, randomized, double-blind, controlled trial.

    abstract:BACKGROUND:This randomized controlled study was undertaken to determine the effect of recombinant human erythropoietin (rHuEPO) on erythropoiesis, autologous blood collection, and allogeneic transfusion risk in elective surgery patients with low baseline hematocrits. STUDY DESIGN AND METHODS:Patients (n = 204) with lo...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1046/j.1537-2995.1996.36196190512.x

    authors: Price TH,Goodnough LT,Vogler WR,Sacher RA,Hellman RM,Johnston MF,Bolgiano DC,Abels RI

    更新日期:1996-01-01 00:00:00

  • Implementation of a script for predonation interviews: impact on human immunodeficiency virus risk in South African blood donors.

    abstract:BACKGROUND:The way in which the donor history questionnaire is conducted plays a crucial role in the self-disclosure of behavioral risk factors for human immunodeficiency virus (HIV) infection by prospective donors. The South African National Blood Service changed its policy on the process of donor assessment in May 20...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15288

    authors: Mitchel J,Custer B,Kaidarova Z,Murphy EL,van den Berg K,Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) South Africa Program.

    更新日期:2019-07-01 00:00:00

  • Storage of aliquots of apheresis platelets for neonatal use in syringes with and without agitation.

    abstract:BACKGROUND:To facilitate volume control in neonates, platelets (PLTs) are aliquoted and stored for short periods in non-gas-permeable syringes before infusion. Although agitation of PLTs during storage in gas-permeable bags is performed to maintain their quality, the effect of syringe agitation during storage is unknow...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2011.03230.x

    authors: Diab Y,Wong E,Criss VR,Moroff G,Wagner SJ,Luban NL

    更新日期:2011-12-01 00:00:00

  • Use of the manual Polybrene test in the routine hospital laboratory.

    abstract::The manual Polybrene test described by Lalezari and Jiang was tested in parallel with saline, papain, and antiglobulin tests routinely used in this laboratory for antibody detection and identification and compatibility testing. Among 5381 patient sera tested, 264 antibodies were detected in 244 patients. In all, 6353 ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1983.23283172855.x

    authors: Fisher GA

    更新日期:1983-03-01 00:00:00

  • New HIV infections from blood transfusions averted in 28 countries supported by PEPFAR blood safety programs, 2004-2015.

    abstract:BACKGROUND:To quantify the impact of the US President's Emergency Plan for AIDS Relief (PEPFAR) on the risk of HIV transmission through infected blood donations in countries supported by PEPFAR blood safety programs. METHODS:Data reported to the World Health Organization Global Database on Blood Safety were analyzed f...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16256

    authors: Mili FD,Teng Y,Shiraishi RW,Yu J,Bock N,Drammeh B,Watts DH,Benech I

    更新日期:2021-01-28 00:00:00

  • Development of a quality monitoring program for platelet components: a report of the first four years' experience at Canadian Blood Services.

    abstract:BACKGROUND:A quality monitoring program (QMP) for platelet concentrates (PCs) was implemented at Canadian Blood Services (CBS) to improve standards and to better understand platelet (PLT) products by supplementing routine quality control (QC). STUDY DESIGN AND METHODS:Annual surveys of PCs from CBS production sites we...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03402.x

    authors: Levin E,Jenkins C,Culibrk B,Gyöngyössy-Issa MI,Serrano K,Devine DV

    更新日期:2012-04-01 00:00:00

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    abstract:BACKGROUND:Accurate typing of a patient's RBCs in the setting of prior transfusion or a hemolytic transfusion reaction is crucial in the selection of compatible blood but is time consuming, technically difficult, and sometimes impossible. To address this problem, a simple, rapid, and inexpensive quantitative PCR method...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.03303.x

    authors: Montalvo L,Walker P,Wen L,Lim W,Reed W,Busch MP,Lee TH

    更新日期:2004-05-01 00:00:00

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    abstract::Intravenous immune globulin (IVIG) therapy has shown great success in a number of autoimmune and inflammatory conditions and its use continues to increase worldwide. There is growing awareness of significant side effects of high-dose IVIG: however, particularly severe hemolysis in patients that are non-group O. It has...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.13097

    authors: Pendergrast J,Willie-Ramharack K,Sampson L,Laroche V,Branch DR

    更新日期:2015-07-01 00:00:00

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02958.x

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    更新日期:2011-01-01 00:00:00

  • Impact of rituximab on stem cell mobilization following ACVBP regimen in poor-risk patients with diffuse large B-cell lymphoma: results from a large cohort of patients.

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03683.x

    authors: Lefrère F,Bastit-Barrau D,Hequet O,Bourin P,Mathieu-Nafissi S,Bohbot A,Tilly H,Salles G,Fermé C,Lapierre V,Fornecker L,Micléa JM,Isebaert L,Bologna S,Fitoussi O,Mounier N,Haioun C

    更新日期:2013-01-01 00:00:00

  • Removal of prion challenge from an immune globulin preparation by use of a size-exclusion filter.

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    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00160.x

    authors: Van Holten RW,Autenrieth S,Boose JA,Hsieh WT,Dolan S

    更新日期:2002-08-01 00:00:00

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12774

    authors: Yang H,Pidgorna A,Loutfy MR,Shuen P

    更新日期:2015-01-01 00:00:00

  • Self-reported historic human immunodeficiency virus (HIV) testing in a Brazilian blood donor HIV case-control study.

    abstract:BACKGROUND:There has been increased worldwide emphasis on the many benefits of human immunodeficiency virus (HIV) serostatus awareness for both infection prevention and improved treatment outcomes. Previous studies indicate that donors may use blood donation to be tested; the objectives of this analysis were to assess,...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13792

    authors: Bruhn R,Moreno E,Sabino EC,Ferreira NA,Carneiro-Proietti AB,Lopes ME,Sampaio D,Loureiro P,Custer B,Goncalez TT,National Heart, Lung and Blood Institute Retrovirus Epidemiology Donor Study-II (REDS-II) International Component.

    更新日期:2016-11-01 00:00:00

  • Collection of mobilized blood progenitor cells for hematopoietic rescue by large-volume leukapheresis.

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    journal_title:Transfusion

    pub_type: 杂志文章

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    更新日期:1995-06-01 00:00:00

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    abstract:BACKGROUND:Qualification of a cord blood bank (CBB) is a complex process that includes evaluation of multiple aspects of donor screening and testing, processing, accreditation and approval by professional cell therapy groups, and results of received cord blood units. The University of Minnesota Medical Center Cell Ther...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12085

    authors: Rabe F,Kadidlo D,Van Orsow L,McKenna D

    更新日期:2013-10-01 00:00:00

  • Development of a validated exam to assess physician transfusion medicine knowledge.

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12425

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    更新日期:2014-05-01 00:00:00

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    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2012.03585.x

    authors: Sánchez-Salinas A,Cabañas-Perianes V,Blanquer M,Majado MJ,Insausti CL,Monserrat J,Sánchez-Ibáñez MV,Menchón P,García-Hernández A,Gómez-Espuch J,Morales A,Moraleda JM

    更新日期:2012-11-01 00:00:00

  • The crossmatch. A brief historical perspective.

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    journal_title:Transfusion

    pub_type: 历史文章,杂志文章

    doi:10.1046/j.1537-2995.1981.21682085750.x

    authors: Oberman HA

    更新日期:1981-11-01 00:00:00

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    abstract::The report describes methods for quantitating C4 and C3 coating of red blood cells using 125I anti-C4 and anti-C3. Two methods of preparing antisera were used; one involving absorption and elution from complement coated cells, and the other employing IgG fractions of antisera prepared on DEAE cellulose. White-cell-fre...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18478251233.x

    authors: Jenkins DE Jr,Johnson RM,Moore WH

    更新日期:1978-07-01 00:00:00

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13711

    authors: Drexler B,Holbro A,Sigle J,Gassner C,Frey BM,Schaub S,Amico P,Plattner A,Infanti L,Menter T,Mihatsch MJ,Stern M,Buser A,Dickenmann M

    更新日期:2016-09-01 00:00:00

  • A possible role for the production of multiple HLA antibodies in fatal platelet transfusion refractoriness after peripheral blood progenitor cell transplantation from the mother in a patient with relapsed leukemia.

    abstract:BACKGROUND:There has been controversy over whether HLA alloimmunization is a risk factor for platelet (PLT) transfusion refractoriness (PTR) in hematopoietic peripheral blood progenitor cell transplantation (HPBPCT). STUDY DESIGN AND METHODS:Reported here is a boy with relapsed leukemia who developed fatal PTR after a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01109.x

    authors: Nakazawa Y,Saito S,Hasegawa Y,Yanagisawa R,Sakashita K,Kamijo T,Miyazaki T,Sato S,Ikeda H,Ikebuchi K,Koike K

    更新日期:2007-02-01 00:00:00

  • Hematopoietic cell infusion-related adverse events in pediatric/small recipients in a prospective/multicenter study.

    abstract:BACKGROUND:Hematopoietic cell infusion-related adverse events (HCI-AEs) in hematopoietic stem cell transplantations (HSCTs) have been largely attributed to toxicity of dimethyl sulfoxide (DMSO) for cryopreservation, but HSC products also contain various cells and plasma components. Our recent prospective study of 1125 ...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/trf.15786

    authors: Ikeda K,Ohto H,Yamada-Fujiwara M,Okuyama Y,Fujiwara SI,Muroi K,Mori T,Kasama K,Kanamori H,Iseki T,Nagamura-Inoue T,Kameda K,Kanda J,Nagai K,Fujii N,Ashida T,Hirose A,Takahashi T,Minakawa K,Tanosaki R

    更新日期:2020-05-01 00:00:00

  • "Pseudo-hemolytic" transfusion reaction caused by intravenous iron-dextran therapy.

    abstract::Intravenous iron-dextran therapy can cause a red-brown discoloration of the plasma, simulating a hemolytic transfusion reaction. A rapid and simple test to differentiate between true hemolysis and plasma discoloration due to circulating iron-dextran complexes is described. ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22482251227.x

    authors: Simon SD,Kuriyan MA,Kim HC

    更新日期:1982-07-01 00:00:00

  • Blood group A and D negativity are associated with symptomatic West Nile virus infection.

    abstract:BACKGROUND:West Nile virus (WNV) infection is mostly asymptomatic (AS) but 20% of subjects report WNV fever and 1% of patients experience neurologic diseases with higher rates in elderly and immunosuppressed persons. With no treatment and no vaccine to prevent the development of symptomatic (S) infections, it is essent...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13622

    authors: Kaidarova Z,Bravo MD,Kamel HT,Custer BS,Busch MP,Lanteri MC

    更新日期:2016-07-01 00:00:00