Maintenance rituximab for relapsing thrombotic thrombocytopenic purpura: a case report.


BACKGROUND:Appropriate management to prevent relapses of acquired, autoimmune thrombotic thrombocytopenic purpura (TTP) is not clear. Rituximab (375 mg/m2 /week × 4) is effective treatment for acute episodes but it is not consistently effective for prevention of relapses. Maintenance rituximab, 375 mg/m2 /3 months for 2 years, is commonly used to prevent progression of follicular lymphoma, but the outcome of maintenance rituximab to prevent TTP relapses has been rarely reported. CASE REPORT:An 8-year-old girl was diagnosed with acquired TTP in 2008; her ADAMTS13 activity was less than 5%, with a functional inhibitor of greater than 8 Bethesda units/mL. She achieved remission with therapeutic plasma exchange, corticosteroids, and rituximab (375 mg/m2 /week × 4). During the following 6 years she had seven additional episodes. Each episode responded to therapeutic plasma exchange, sometimes requiring additional treatments (corticosteroids, rituximab, and cyclophosphamide). However, these treatments, as well as splenectomy and trials of cyclophosphamide and mycophenolate mofetil during clinical remissions, failed to prevent relapses. Her ADAMTS13 activity remained 8% or less throughout all of her remissions. Maintenance rituximab was begun in 2013: 500 mg (313 mg/m2 ) every 2-3 months × 5, then 600 mg (375 mg/m2 ) every 6 months × 2. After 1 year, her ADAMTS13 was 26%; after 2 years, 51%. During the past 3 years since stopping rituximab, she has remained well, with normal ADAMTS13 activity (70%-78%). CONCLUSION:Maintenance rituximab treatment may be effective for prevention of relapses in patients with acquired, autoimmune TTP, even when splenectomy and intensive immunosuppression, including multiple conventional courses of rituximab, fail to prevent subsequent relapses.






Saleem R,Rogers ZR,Neunert C,George JN




Has Abstract


2019-03-01 00:00:00












  • A review of blood donor motivation and recruitment.

    abstract::Sixty English-language articles on the motivation and recruitment of blood donors and nondonors are reviewed and evaluated. Apparently researchers have been finding essentially the same results for approximately twenty years. Motivations to donate are: altruism/humanitarian, personal or family credit, social pressure,...


    pub_type: 杂志文章


    authors: Oswalt RM

    更新日期:1977-03-01 00:00:00

  • Sampling errors and the precision associated with counting very low numbers of white cells in blood components.

    abstract::Attention to the accurate and precise measurement of the white cell (WBC) content of transfused products has risen in response to awareness of the potential benefits of WBC-depleted components and the development of technical capabilities to produce these components. The techniques thus far reported have focused on th...


    pub_type: 杂志文章


    authors: Dumont LJ

    更新日期:1991-06-01 00:00:00

  • Absence of acute adverse in vitro effects on aged AS-1 red blood cells and thawed plasma after prolonged exposure to 13.56-MHz radio energy.

    abstract:BACKGROUND:There is growing interest in radio frequency identification (RFID) technology for tracking blood products to improve productivity and safety in the transfusion medicine supply chain. We conducted a limited study to assess the temperature and biologic effects after extreme exposure to 13.56-MHz RF radiation o...


    pub_type: 杂志文章


    authors: Davis R,Gottschall J,Gutierrez A,Hohberger C,Graminske S,Veeramani D,Holcombe J

    更新日期:2012-09-01 00:00:00

  • Fanconi syndrome in a patient with β-thalassemia major after using deferasirox for 27 months.

    abstract:BACKGROUND:Deferasirox (DFRA) is a new approved oral iron chelator. Its advantages are that it is convenient and better tolerated and adhered to due to "once-daily" oral dosage. However, its use in the field is limited and it is yet to be subjected to postmarketing surveillance. CASE REPORT:A 18.75-year-old male with ...


    pub_type: 杂志文章


    authors: Wei HY,Yang CP,Cheng CH,Lo FS

    更新日期:2011-05-01 00:00:00

  • Stability after thawing of RBCs frozen with the high- and low-glycerol method.

    abstract:BACKGROUND:RBCs can be frozen with either the high-glycerol method (HGM) or the low-glycerol method (LGM). To date, the use of frozen RBCs is hampered by a 24-hour outdating period after thawing. A closed washing system (ACP 215) may solve this problem. STUDY DESIGN AND METHODS:We compared the effects of high- (40%) a...


    pub_type: 杂志文章


    authors: Lelkens CC,Noorman F,Koning JG,Truijens-de Lange R,Stekkinger PS,Bakker JC,Lagerberg JW,Brand A,Verhoeven AJ

    更新日期:2003-02-01 00:00:00

  • Return of autologous blood donors as homologous blood donors.

    abstract::Autologous blood donors (ABDs) have been reported to have favorable attitudes toward returning as homologous blood donors (HBDs), but the frequency of return has not been well documented. ABDs eligible by history to be HBDs were followed at one blood center: 255 donating for elective surgery and 234 donating during pr...


    pub_type: 杂志文章


    authors: McVay PA,Fung HC,Toy PT

    更新日期:1991-02-01 00:00:00

  • The effect of recombinant human erythropoietin on the efficacy of autologous blood donation in patients with low hematocrits: a multicenter, randomized, double-blind, controlled trial.

    abstract:BACKGROUND:This randomized controlled study was undertaken to determine the effect of recombinant human erythropoietin (rHuEPO) on erythropoiesis, autologous blood collection, and allogeneic transfusion risk in elective surgery patients with low baseline hematocrits. STUDY DESIGN AND METHODS:Patients (n = 204) with lo...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Price TH,Goodnough LT,Vogler WR,Sacher RA,Hellman RM,Johnston MF,Bolgiano DC,Abels RI

    更新日期:1996-01-01 00:00:00

  • Implementation of a script for predonation interviews: impact on human immunodeficiency virus risk in South African blood donors.

    abstract:BACKGROUND:The way in which the donor history questionnaire is conducted plays a crucial role in the self-disclosure of behavioral risk factors for human immunodeficiency virus (HIV) infection by prospective donors. The South African National Blood Service changed its policy on the process of donor assessment in May 20...


    pub_type: 杂志文章


    authors: Mitchel J,Custer B,Kaidarova Z,Murphy EL,van den Berg K,Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) South Africa Program.

    更新日期:2019-07-01 00:00:00

  • Storage of aliquots of apheresis platelets for neonatal use in syringes with and without agitation.

    abstract:BACKGROUND:To facilitate volume control in neonates, platelets (PLTs) are aliquoted and stored for short periods in non-gas-permeable syringes before infusion. Although agitation of PLTs during storage in gas-permeable bags is performed to maintain their quality, the effect of syringe agitation during storage is unknow...


    pub_type: 临床试验,杂志文章


    authors: Diab Y,Wong E,Criss VR,Moroff G,Wagner SJ,Luban NL

    更新日期:2011-12-01 00:00:00

  • Use of the manual Polybrene test in the routine hospital laboratory.

    abstract::The manual Polybrene test described by Lalezari and Jiang was tested in parallel with saline, papain, and antiglobulin tests routinely used in this laboratory for antibody detection and identification and compatibility testing. Among 5381 patient sera tested, 264 antibodies were detected in 244 patients. In all, 6353 ...


    pub_type: 杂志文章


    authors: Fisher GA

    更新日期:1983-03-01 00:00:00

  • New HIV infections from blood transfusions averted in 28 countries supported by PEPFAR blood safety programs, 2004-2015.

    abstract:BACKGROUND:To quantify the impact of the US President's Emergency Plan for AIDS Relief (PEPFAR) on the risk of HIV transmission through infected blood donations in countries supported by PEPFAR blood safety programs. METHODS:Data reported to the World Health Organization Global Database on Blood Safety were analyzed f...


    pub_type: 杂志文章


    authors: Mili FD,Teng Y,Shiraishi RW,Yu J,Bock N,Drammeh B,Watts DH,Benech I

    更新日期:2021-01-28 00:00:00

  • Development of a quality monitoring program for platelet components: a report of the first four years' experience at Canadian Blood Services.

    abstract:BACKGROUND:A quality monitoring program (QMP) for platelet concentrates (PCs) was implemented at Canadian Blood Services (CBS) to improve standards and to better understand platelet (PLT) products by supplementing routine quality control (QC). STUDY DESIGN AND METHODS:Annual surveys of PCs from CBS production sites we...


    pub_type: 杂志文章


    authors: Levin E,Jenkins C,Culibrk B,Gyöngyössy-Issa MI,Serrano K,Devine DV

    更新日期:2012-04-01 00:00:00

  • Clinical investigation of posttransfusion Kidd blood group typing using a rapid normalized quantitative polymerase chain reaction.

    abstract:BACKGROUND:Accurate typing of a patient's RBCs in the setting of prior transfusion or a hemolytic transfusion reaction is crucial in the selection of compatible blood but is time consuming, technically difficult, and sometimes impossible. To address this problem, a simple, rapid, and inexpensive quantitative PCR method...


    pub_type: 杂志文章


    authors: Montalvo L,Walker P,Wen L,Lim W,Reed W,Busch MP,Lee TH

    更新日期:2004-05-01 00:00:00

  • The role of inflammation in intravenous immune globulin-mediated hemolysis.

    abstract::Intravenous immune globulin (IVIG) therapy has shown great success in a number of autoimmune and inflammatory conditions and its use continues to increase worldwide. There is growing awareness of significant side effects of high-dose IVIG: however, particularly severe hemolysis in patients that are non-group O. It has...


    pub_type: 杂志文章,评审


    authors: Pendergrast J,Willie-Ramharack K,Sampson L,Laroche V,Branch DR

    更新日期:2015-07-01 00:00:00

  • Evaluation of the properties of components prepared and stored after holding of whole blood units for 8 and 24 hours at ambient temperature.

    abstract:BACKGROUND:The capability of holding whole blood (WB) units at ambient temperature, overnight, should help in platelet (PLT) concentrate preparation logistics. We summarize the results of a study conducted in the early 1990s that compared, in particular, PLT and red blood cell (RBC) in vivo viability properties followi...


    pub_type: 杂志文章


    authors: Moroff G,AuBuchon JP,Pickard C,Whitley PH,Heaton WA,Holme S

    更新日期:2011-01-01 00:00:00

  • Impact of rituximab on stem cell mobilization following ACVBP regimen in poor-risk patients with diffuse large B-cell lymphoma: results from a large cohort of patients.

    abstract:BACKGROUND:The ACVBP regimen is an efficient induction regimen for poor-risk patients with diffuse large B-cell lymphoma (DLBCL) before consolidative autologous stem cell transplantation. Adjunction of the monoclonal anti-CD20 antibody rituximab (R-ACVBP) was recently found to be superior to ACVBP alone. This study ass...


    pub_type: 杂志文章


    authors: Lefrère F,Bastit-Barrau D,Hequet O,Bourin P,Mathieu-Nafissi S,Bohbot A,Tilly H,Salles G,Fermé C,Lapierre V,Fornecker L,Micléa JM,Isebaert L,Bologna S,Fitoussi O,Mounier N,Haioun C

    更新日期:2013-01-01 00:00:00

  • Removal of prion challenge from an immune globulin preparation by use of a size-exclusion filter.

    abstract:BACKGROUND:A size-exclusion filter (Viresolve 180, Millipore Corp.) was tested for its ability to remove transmissible spongiform encephalopathies prion protein from an immune globulin preparation during ultrafiltration. STUDY DESIGN AND METHODS:Hamster-adapted 263K scrapie brain homogenate (SBH) was spiked into Rh0(D...


    pub_type: 杂志文章


    authors: Van Holten RW,Autenrieth S,Boose JA,Hsieh WT,Dolan S

    更新日期:2002-08-01 00:00:00

  • Effects of interruptions of controlled-rate freezing on the viability of umbilical cord blood stem cells.

    abstract:BACKGROUND:An optimal cooling rate is critical for cryopreserving cord blood stem cells, so it is generally achieved by using controlled-rate freezers (CRFs). The cooling rate can be interrupted by many factors during cooling; therefore, a proper response to the interruption in cryopreservation is crucial to prevent th...


    pub_type: 杂志文章


    authors: Yang H,Pidgorna A,Loutfy MR,Shuen P

    更新日期:2015-01-01 00:00:00

  • Self-reported historic human immunodeficiency virus (HIV) testing in a Brazilian blood donor HIV case-control study.

    abstract:BACKGROUND:There has been increased worldwide emphasis on the many benefits of human immunodeficiency virus (HIV) serostatus awareness for both infection prevention and improved treatment outcomes. Previous studies indicate that donors may use blood donation to be tested; the objectives of this analysis were to assess,...


    pub_type: 杂志文章


    authors: Bruhn R,Moreno E,Sabino EC,Ferreira NA,Carneiro-Proietti AB,Lopes ME,Sampaio D,Loureiro P,Custer B,Goncalez TT,National Heart, Lung and Blood Institute Retrovirus Epidemiology Donor Study-II (REDS-II) International Component.

    更新日期:2016-11-01 00:00:00

  • Collection of mobilized blood progenitor cells for hematopoietic rescue by large-volume leukapheresis.

    abstract:BACKGROUND:Mobilized blood progenitor cells rapidly reconstitute hematopoiesis in patients after dose-intensive chemotherapy. However, optimal timing and methods of mobilized blood progenitor cell collection have yet to be fully defined. STUDY DESIGN AND METHODS:The utility of large-volume leukapheresis (LVL; > 15 L b...


    pub_type: 杂志文章


    authors: Comenzo RL,Vosburgh E,Weintraub LR,Tansan S,Arkin CF,Wright DG

    更新日期:1995-06-01 00:00:00

  • Establishment of an unrelated umbilical cord blood bank qualification program: ensuring quality while meeting Food and Drug Administration vendor qualification requirements.

    abstract:BACKGROUND:Qualification of a cord blood bank (CBB) is a complex process that includes evaluation of multiple aspects of donor screening and testing, processing, accreditation and approval by professional cell therapy groups, and results of received cord blood units. The University of Minnesota Medical Center Cell Ther...


    pub_type: 杂志文章


    authors: Rabe F,Kadidlo D,Van Orsow L,McKenna D

    更新日期:2013-10-01 00:00:00

  • Development of a validated exam to assess physician transfusion medicine knowledge.

    abstract:BACKGROUND:There is evidence that physicians lack adequate transfusion medicine knowledge. To design needs-based educational interventions to address this gap, a validated assessment tool is required. Previously published exams have not been created or validated using rigorous psychometric methods. STUDY DESIGN AND ME...


    pub_type: 杂志文章


    authors: Haspel RL,Lin Y,Fisher P,Ali A,Parks E,Biomedical Excellence for Safer Transfusion (BEST) Collaborative.

    更新日期:2014-05-01 00:00:00

  • An automatic wash method for dimethyl sulfoxide removal in autologous hematopoietic stem cell transplantation decreases the adverse effects related to infusion.

    abstract:BACKGROUND:Products cryopreserved with dimethyl sulfoxide (DMSO) in stem cell transplant (SCT) often cause many adverse effects during their infusion (major cardiovascular events, dyspnea … even death). These are especially frequent in pediatric patients. We tested if a fully automated and closed wash procedure (Sepax ...


    pub_type: 临床试验,杂志文章


    authors: Sánchez-Salinas A,Cabañas-Perianes V,Blanquer M,Majado MJ,Insausti CL,Monserrat J,Sánchez-Ibáñez MV,Menchón P,García-Hernández A,Gómez-Espuch J,Morales A,Moraleda JM

    更新日期:2012-11-01 00:00:00

  • The crossmatch. A brief historical perspective.

    abstract::First described in 1907, the crossmatch has been in a constant state of modification since that time. Major milestones in the evolution of the test include demonstration of the relative importance of red blood cell typing and of the matching test, development of rapid techniques for the test, advent of high protein, a...


    pub_type: 历史文章,杂志文章


    authors: Oberman HA

    更新日期:1981-11-01 00:00:00

  • Radioactive antiglobulin testing with 125I anti-C4 and anti-C3.

    abstract::The report describes methods for quantitating C4 and C3 coating of red blood cells using 125I anti-C4 and anti-C3. Two methods of preparing antisera were used; one involving absorption and elution from complement coated cells, and the other employing IgG fractions of antisera prepared on DEAE cellulose. White-cell-fre...


    pub_type: 杂志文章


    authors: Jenkins DE Jr,Johnson RM,Moore WH

    更新日期:1978-07-01 00:00:00

  • Impact of donor ABH-secretor status in ABO-mismatched living donor kidney transplantation.

    abstract:BACKGROUND:The ABO blood group is a major determinant in living donor kidney transplantation since AB antigens are expressed on renal tissue. Little attention has been directed to the ABH-secretor status of the donor kidney. As renal tissue is capable of secreting soluble ABH antigens in secretors, we examined the infl...


    pub_type: 杂志文章


    authors: Drexler B,Holbro A,Sigle J,Gassner C,Frey BM,Schaub S,Amico P,Plattner A,Infanti L,Menter T,Mihatsch MJ,Stern M,Buser A,Dickenmann M

    更新日期:2016-09-01 00:00:00

  • A possible role for the production of multiple HLA antibodies in fatal platelet transfusion refractoriness after peripheral blood progenitor cell transplantation from the mother in a patient with relapsed leukemia.

    abstract:BACKGROUND:There has been controversy over whether HLA alloimmunization is a risk factor for platelet (PLT) transfusion refractoriness (PTR) in hematopoietic peripheral blood progenitor cell transplantation (HPBPCT). STUDY DESIGN AND METHODS:Reported here is a boy with relapsed leukemia who developed fatal PTR after a...


    pub_type: 杂志文章


    authors: Nakazawa Y,Saito S,Hasegawa Y,Yanagisawa R,Sakashita K,Kamijo T,Miyazaki T,Sato S,Ikeda H,Ikebuchi K,Koike K

    更新日期:2007-02-01 00:00:00

  • Hematopoietic cell infusion-related adverse events in pediatric/small recipients in a prospective/multicenter study.

    abstract:BACKGROUND:Hematopoietic cell infusion-related adverse events (HCI-AEs) in hematopoietic stem cell transplantations (HSCTs) have been largely attributed to toxicity of dimethyl sulfoxide (DMSO) for cryopreservation, but HSC products also contain various cells and plasma components. Our recent prospective study of 1125 ...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Ikeda K,Ohto H,Yamada-Fujiwara M,Okuyama Y,Fujiwara SI,Muroi K,Mori T,Kasama K,Kanamori H,Iseki T,Nagamura-Inoue T,Kameda K,Kanda J,Nagai K,Fujii N,Ashida T,Hirose A,Takahashi T,Minakawa K,Tanosaki R

    更新日期:2020-05-01 00:00:00

  • "Pseudo-hemolytic" transfusion reaction caused by intravenous iron-dextran therapy.

    abstract::Intravenous iron-dextran therapy can cause a red-brown discoloration of the plasma, simulating a hemolytic transfusion reaction. A rapid and simple test to differentiate between true hemolysis and plasma discoloration due to circulating iron-dextran complexes is described. ...


    pub_type: 杂志文章


    authors: Simon SD,Kuriyan MA,Kim HC

    更新日期:1982-07-01 00:00:00

  • Blood group A and D negativity are associated with symptomatic West Nile virus infection.

    abstract:BACKGROUND:West Nile virus (WNV) infection is mostly asymptomatic (AS) but 20% of subjects report WNV fever and 1% of patients experience neurologic diseases with higher rates in elderly and immunosuppressed persons. With no treatment and no vaccine to prevent the development of symptomatic (S) infections, it is essent...


    pub_type: 杂志文章


    authors: Kaidarova Z,Bravo MD,Kamel HT,Custer BS,Busch MP,Lanteri MC

    更新日期:2016-07-01 00:00:00