Maintenance rituximab for relapsing thrombotic thrombocytopenic purpura: a case report.

Abstract:

BACKGROUND:Appropriate management to prevent relapses of acquired, autoimmune thrombotic thrombocytopenic purpura (TTP) is not clear. Rituximab (375 mg/m2 /week × 4) is effective treatment for acute episodes but it is not consistently effective for prevention of relapses. Maintenance rituximab, 375 mg/m2 /3 months for 2 years, is commonly used to prevent progression of follicular lymphoma, but the outcome of maintenance rituximab to prevent TTP relapses has been rarely reported. CASE REPORT:An 8-year-old girl was diagnosed with acquired TTP in 2008; her ADAMTS13 activity was less than 5%, with a functional inhibitor of greater than 8 Bethesda units/mL. She achieved remission with therapeutic plasma exchange, corticosteroids, and rituximab (375 mg/m2 /week × 4). During the following 6 years she had seven additional episodes. Each episode responded to therapeutic plasma exchange, sometimes requiring additional treatments (corticosteroids, rituximab, and cyclophosphamide). However, these treatments, as well as splenectomy and trials of cyclophosphamide and mycophenolate mofetil during clinical remissions, failed to prevent relapses. Her ADAMTS13 activity remained 8% or less throughout all of her remissions. Maintenance rituximab was begun in 2013: 500 mg (313 mg/m2 ) every 2-3 months × 5, then 600 mg (375 mg/m2 ) every 6 months × 2. After 1 year, her ADAMTS13 was 26%; after 2 years, 51%. During the past 3 years since stopping rituximab, she has remained well, with normal ADAMTS13 activity (70%-78%). CONCLUSION:Maintenance rituximab treatment may be effective for prevention of relapses in patients with acquired, autoimmune TTP, even when splenectomy and intensive immunosuppression, including multiple conventional courses of rituximab, fail to prevent subsequent relapses.

journal_name

Transfusion

journal_title

Transfusion

authors

Saleem R,Rogers ZR,Neunert C,George JN

doi

10.1111/trf.15093

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

921-926

issue

3

eissn

0041-1132

issn

1537-2995

journal_volume

59

pub_type

  • Large scale preparation of leukocyte concentrates and further purification of lymphocytes and granulocytes with the IBM 2991 cell processor.

    abstract::A procedure is described for the large-scale production of pure suspensions of human lymphocytes and granulocytes. Platelet-poor buffy-coats, obtained by centrifugation of six units of ABO-compatible ACD blood, were pooled and centrifuged again, resulting in a crude leukocyte concentrate containing approximately 60 pe...

    journal_title:Transfusion

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    doi:10.1046/j.1537-2995.1977.17578014593.x

    authors: de la Rivière AB,Verhoef-Karssen PR,de Wit JJ,Loos JA,Prins HK

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  • Enhanced ascertainment of microchimerism with real-time quantitative polymerase chain reaction amplification of insertion-deletion polymorphisms.

    abstract:BACKGROUND:The characterization of microchimerism (MC) by gene amplification has been limited by few allogeneic markers, ascertainment bias, and assay analytic performance. To address this, a panel of 12 MC assays based on insertion-deletion (InDel) polymorphisms had been optimized. STUDY DESIGN AND METHODS:The InDel ...

    journal_title:Transfusion

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1537-2995.2006.00992.x

    authors: Lee TH,Chafets DM,Reed W,Wen L,Yang Y,Chen J,Utter GH,Owings JT,Busch MP

    更新日期:2006-11-01 00:00:00

  • Ranking the effectiveness of autologous blood conservation measures through validated modeling of independent clinical data.

    abstract:BACKGROUND:Future supply with allogeneic blood transfusions faces several crucial challenges that warrant thorough (re-)evaluation of existing alternatives. Meta-analyses have indicated a significant potential for autologous blood conservation (ABC) measures to reduce the need for allogeneic blood transfusions. The qua...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12233

    authors: Singbartl G,Held AL,Singbartl K

    更新日期:2013-12-01 00:00:00

  • Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia.

    abstract:BACKGROUND:In experimental pneumonia we found that transfused older blood increased mortality and lung injury that was associated with increased in vivo hemolysis and elevated plasma cell-free hemoglobin (CFH), non-transferrin-bound iron (NTBI), and plasma labile iron (PLI) levels. In this study, we additionally analyz...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12607

    authors: Wang D,Cortés-Puch I,Sun J,Solomon SB,Kanias T,Remy KE,Feng J,Alimchandani M,Quezado M,Helms C,Perlegas A,Gladwin MT,Kim-Shapiro DB,Klein HG,Natanson C

    更新日期:2014-07-01 00:00:00

  • Adverse effects in blood donors after whole-blood donation: a study of 1000 blood donors interviewed 3 weeks after whole-blood donation.

    abstract:BACKGROUND:There are no reports in the transfusion medicine literature that describe adverse reactions and donor arm injuries after whole-blood donation based on solicited information. STUDY DESIGN AND METHODS:The present study solicited adverse reaction and donor arm injury information from 1000 randomly selected who...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2003.00368.x

    authors: Newman BH,Pichette S,Pichette D,Dzaka E

    更新日期:2003-05-01 00:00:00

  • The successful implementation of an automated institution-wide assessment of hemoglobin and ABO typing to dynamically estimate red blood cell inventory requirements.

    abstract:BACKGROUND:Blood bank inventories must balance adequate supply with minimal outdate rates. The day-to-day practice of ordering red blood cell (RBC) inventory usually involves manually comparing current inventory levels with predetermined thresholds calculated from historical usage and ordering the difference. To date, ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15272

    authors: Quinn J,Campbell C,Gomez A,Kumar-Misir A,Watson S,Liwski D,Covello T,Tennankore KK,Chisholm N,Sadek I,Cheng C

    更新日期:2019-07-01 00:00:00

  • Does an intrauterine exchange transfusion improve the fetal prognosis in parvovirus infection cases?

    abstract:BACKGROUND:Almost 20% of parvovirus B19 foetal infections require intrauterine transfusions. In addition, myocardial dysfunction has been observed in severe parvovirus B19 infections. One objective of an intrauterine exchange transfusion (IUET) is to avoid an overload during the transfusion. Our aim was to study the ob...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14968

    authors: Vanspranghels R,Houfflin-Debarge V,Vaast P,Coulon C,Clouqueur E,Hanssens S,Rakza T,Subtil D,Garabedian C

    更新日期:2019-01-01 00:00:00

  • The prevalence of human parvovirus B19 DNA and antibodies in blood donors from four Chinese blood centers.

    abstract:BACKGROUND:Human parvovirus B19 is a common human pathogen that causes a variety of diseases with outcomes ranging from asymptomatic to severe, especially in immunocompromised patients. The B19 virus can be transmitted via blood and/or blood products and its resistance to common viral inactivation and/or removal method...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03067.x

    authors: Ke L,He M,Li C,Liu Y,Gao L,Yao F,Li J,Bi X,Lv Y,Wang J,Hirsch ML,Li W

    更新日期:2011-09-01 00:00:00

  • Risk of chikungunya virus transmission associated with European travelers returning from southern Thailand (2008-2015).

    abstract:BACKGROUND:The impact of the spread of chikungunya virus (CHIKV) by autochthonous transmission and blood transfusion in nonendemic areas via travelers returning from CHIKV-affected locations is a concern. METHODS:We analyzed the risks of potential CHIKV importation and transfusion transmission from Thailand to Europe ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15401

    authors: Appassakij H,Khuntikij P,Silpapojakul K,Promwong C,Rujirojindakul P,Suddeaugrai O,Chullasara A

    更新日期:2019-08-01 00:00:00

  • A comparative study of reducing the extracellular potassium concentration in red blood cells by washing and by reduction of additive solution.

    abstract:BACKGROUND:Extracellular potassium concentration (K(+)) increases in the supernatant of whole and packed red blood cell units (pRBCs) with duration of refrigerated storage in citrate-phosphate-dextrose-adenine (CPDA-1) and additive solution (AS). Studies have shown that to avoid hyperkalemia, washed pRBCs are preferred...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01095.x

    authors: Bansal I,Calhoun BW,Joseph C,Pothiawala M,Baron BW

    更新日期:2007-02-01 00:00:00

  • Platelet storage in a plasma-free medium.

    abstract::Currently, platelet concentrates are stored in 50 to 60 ml of plasma. A major drawback to storage in plasma is the considerable loss of platelet function which occurs during storage. A modified Tyrodes medium has been developed for storage of platelets. A comparison between platelet concentrates stored in this medium ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25686071429.x

    authors: Rock G,Swenson SD,Adams GA

    更新日期:1985-11-01 00:00:00

  • Risk of iatrogenic human immunodeficiency virus infection through transfusion of blood tested by inappropriately stored or expired rapid antibody assays in a Zambian hospital.

    abstract:BACKGROUND:The purpose of this study was to estimate the risk of human immunodeficiency virus (HIV) infection via the transfusion of blood tested by inappropriately stored or expired rapid antibody assays in Zambia. STUDY DESIGN AND METHODS:Surgical patients (n = 370) were tested with antibody assays (HIV-spot and HIV...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1997.37997454020.x

    authors: Consten EC,van der Meer JT,de Wolf F,Heij HA,Henny PC,van Lanschot JJ

    更新日期:1997-09-01 00:00:00

  • Noninvasive determination of fetal RHD status by examination of cell-free DNA in maternal plasma.

    abstract:BACKGROUND:Cell-free fetal DNA in maternal plasma opens the way for routine risk-free diagnosis of fetal D status of D- mothers. The focus was on accuracy of RHD typing and confirmation of fetal DNA in maternal plasma while RHD was not detected. STUDY DESIGN AND METHODS:Plasma DNA was extracted (by manual and/or autom...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00559.x

    authors: Brojer E,Zupanska B,Guz K,Orziñska A,Kaliñska A

    更新日期:2005-09-01 00:00:00

  • Comparison of a manual hexadimethrine bromide-antiglobulin test with saline- and albumin-antiglobulin tests for pretransfusion testing.

    abstract::A prospective double-blind study compared a manual hexadimethrine bromide (Polybrene) antiglobulin antibody detection test (P-AHG) and crossmatch with the albumin-antiglobulin antibody detection test and saline-antiglobulin crossmatch routinely used in our laboratory. A total of 10,084 pretransfusion blood samples fro...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27287150183.x

    authors: Mintz PD,Anderson G

    更新日期:1987-03-01 00:00:00

  • Establishing a reentry procedure for human immunodeficiency virus screening-reactive donors in China.

    abstract:BACKGROUND:Screening of blood donors for antibody to human immunodeficiency virus Types 1 and 2 (anti-HIV-1/2) and/or HIV nucleic acid test (NAT) is a well-established venue to prevent HIV transfusion-transmitted disease. However, with the current available technologies, HIV testing may result in donor loss due to fals...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13282

    authors: Li L,Xu T,Yang T,Zang L,Cheng W,Lin H,Zhu S,Zhao B,Duan R,Li C,Huang M,Liu Y,Ming C,Xu S,Wang C,Wu Y,Liu Z

    更新日期:2016-01-01 00:00:00

  • Performance profile of an updated safety measure rapid assay for bacteria in platelets.

    abstract:BACKGROUND:The Verax PGD rapid test for bacteria in platelets (PLTs) has been updated to simplify workflow and improve specificity and sensitivity by employing a novel sequential format. The performance of this updated version, called PGDprime, was evaluated to determine its suitability for use as an FDA-cleared "safet...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16000

    authors: Vallejo RP,Shinefeld L,LaVerda D,Best N,Lawrence G,Lousararian A,Hornbaker N,Rasmusson P,Mintz PD

    更新日期:2020-11-01 00:00:00

  • A tale of two ports: an in vitro comparison of flow characteristics for therapeutic plasma exchange.

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14494

    authors: De Simone N,Sarode R

    更新日期:2018-02-01 00:00:00

  • Analysis of exome sequencing data sets reveals structural variation in the coding region of ABO in individuals of African ancestry.

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13797

    authors: Fox K,Johnsen JM,Coe BP,Frazar CD,Reiner AP,NHLBI Exome Sequencing Project, Minority Health-GRID Network.,Eichler EE,Nickerson DA

    更新日期:2016-11-01 00:00:00

  • Neonatal alloimmune thrombocytopenia associated with maternal-fetal incompatibility for blood group B.

    abstract:BACKGROUND:Blood group A and B antigens are expressed only weakly on platelets (PLTs) of most individuals but are very strongly expressed on PLTs from approximately 1 percent of normal subjects (Type II high expressers). The implications of this trait for transfusion medicine are undefined. STUDY DESIGN AND METHODS:A ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01531.x

    authors: Curtis BR,Fick A,Lochowicz AJ,McFarland JG,Ball RH,Peterson J,Aster RH

    更新日期:2008-02-01 00:00:00

  • Multiple pH measurement during storage may detect bacterially contaminated platelet concentrates.

    abstract:BACKGROUND:Bacterial contamination or platelet (PLT) metabolism can change the pH of stored PLT concentrates (PCs). Measurement of pH for quality control is currently done on a limited basis. An easy noninvasive method was developed to obtain sequential pH measurements over time, without risking contamination and/or co...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02727.x

    authors: Barker LM,Nanassy OZ,Reed MW,Geelhood SJ,Pfalzgraf RD,Cangelosi GA,De Korte D

    更新日期:2010-12-01 00:00:00

  • Buffering and dilution in red blood cell storage.

    abstract:BACKGROUND:Red blood cell (RBC) storage solutions work in a narrow pH range between 7.2 and 6.4. While keeping RBC within that pH range, ATP production can be increased by buffering or dilution. STUDY DESIGN AND METHODS:In the first study, 12 units of packed CP2D RBCs were pooled in groups of four, re-aliquoted, and a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00672.x

    authors: Hess JR,Rugg N,Joines AD,Gormas JF,Pratt PG,Silberstein EB,Greenwalt TJ

    更新日期:2006-01-01 00:00:00

  • Direct HIV testing in blood donations: variation of the yield with detection threshold and pool size.

    abstract:BACKGROUND:This study was designed to evaluate the potential yield of introducing nucleic acid amplification testing (NAT) in blood donation, according to the detection threshold and the pool size. STUDY DESIGN AND METHODS:A mathematical model of early HIV-1 population dynamics in blood has been developed and is used ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1999.39101141.x

    authors: Le Corfec E,Le Pont F,Tuckwell HC,Rouzioux C,Costagliola D

    更新日期:1999-10-01 00:00:00

  • Human red cell antigens. V. Expression of In(Lu)-related p80 antigens by recessive-type Lu(a-b-) red cells.

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    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28588337330.x

    authors: Telen MJ,Green AM

    更新日期:1988-09-01 00:00:00

  • A modified CD34+ hematopoietic stem and progenitor cell isolation strategy from cryopreserved human umbilical cord blood.

    abstract:BACKGROUND:Umbilical cord blood (UCB) is a source of hematopoietic stem cells for transplantation, offering an alternative for patients unable to find a matched adult donor. UCB is also a versatile source of hematopoietic stem and progenitor cells (hCD34 + HSPCs) for research into hematologic diseases, in vitro expansi...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15597

    authors: Mata MF,Hernandez D,Rologi E,Grandolfo D,Hassan E,Hua P,Kallmeier R,Hirani S,Heuts F,Tittrea V,Choo Y,Baradez MO,Watt SM,Tarunina M

    更新日期:2019-12-01 00:00:00

  • A pattern of 5-1-1 and c100-3 only on hepatitis C virus (HCV) recombinant immunoblot assay does not reflect HCV infection in blood donors.

    abstract::Current criteria for a reactive (positive) interpretation on hepatitis C virus (HCV) recombinant immunoblot assay (RIBA) require > or = 1+ reactivity to at least two of the four HCV antigens present in the assay. Given that 5-1-1 is a subcomponent of c100-3, there is concern that donor samples reacting only with these...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.33193142316.x

    authors: Busch MP,Tobler L,Quan S,Wilber JC,Johnson P,Polito A,Steane E,Zola A,Bahl C,Nelles M

    更新日期:1993-01-01 00:00:00

  • Quantification of the peripheral blood colony forming unit-culture rise following chemotherapy. Could leukocytaphereses replace bone marrow for autologous transplantation?

    abstract::Because hematopoietic stem cells circulate in the peripheral blood (PB), the possibility exists for using leukocytaphereses in place of marrow for autologous transplantation. Normal stem cells, measured by the colony forming unit-culture (CFU-C) assay, usually in extremely small numbers in PB, are increased after aggr...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1983.23684074271.x

    authors: Stiff PJ,Murgo AJ,Wittes RE,DeRisi MF,Clarkson BD

    更新日期:1983-11-01 00:00:00

  • Red blood cell product utilization in patients undergoing allogeneic stem cell transplantation.

    abstract:BACKGROUND:The risk of transfusion reactions (TR) and the cost of blood has led to efforts to reduce blood use. We changed our practice to transfuse just one instead of two units of red blood cells (RBC) when hemoglobin ≤8 g/dL due to patient blood management (PBM) recommendations. METHODS AND MATERIALS:We compared RB...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15285

    authors: Gastecki K,Shanley R,Welbig J,Cohn C,Brunstein CG

    更新日期:2019-07-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report.

    abstract:BACKGROUND:Platelet transfusion-associated sepsis is usually due to donor skin flora introduced into the unit during phlebotomy. An unusual case of a platelet component contaminated with methicillin-resistant Staphylococcus aureus (MRSA) is reported. CASE REPORT:A 54-year-old man, terminally ill with progressive non-H...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41111426.x

    authors: Sapatnekar S,Wood EM,Miller JP,Jacobs MR,Arduino MJ,McAllister SK,Kellum ME,Roth V,Yomtovian R

    更新日期:2001-11-01 00:00:00

  • A 'new' high frequency antigen Era.

    abstract::Three examples of an antibody defining a 'new' high frequency red blood cell antigen, Era, are described. Family studies show Era to be inherited, but the mode of inheritance may not be straightforward. ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22382224938.x

    authors: Daniels GL,Judd WJ,Moore BP,Neitzer G,Ouellet P,Plantos M,Verrette S

    更新日期:1982-05-01 00:00:00

  • The effect of hydroxyethyl starch on in vitro platelet and granulocyte function.

    abstract::The effect of hydroxyethyl starch (HES) on granulocyte and platelet functions was assessed. No alteration of granulocyte viability, morphology, phagocytic ability, or bactericidal capacity was detected after incubation with 6 per cent HES at 25 C for two hours. Platelet morphology, size distribution, aggregation, nucl...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1975.15576082223.x

    authors: Schiffer CA,Aisner J,Schmukler M,Whitaker CL,Wolff JH

    更新日期:1975-09-01 00:00:00