Harmful effects of transfusion of older stored red blood cells: iron and inflammation.

abstract：BACKGROUND:In this study whether metabolic suppression can be used to preserve platelet (PLT) function during prolonged storage was investigated. STUDY DESIGN AND METHODS:Washed human PLTs were incubated without glucose and with antimycin A to block energy generation. Metabolic suppressed PLTs (MSPs) were stored for 7...

journal_title：Transfusion

authors： Badlou BA,Ijseldijk MJ,Smid WM,Akkerman JW

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:The clinical significance of alloimmunization to RBC antigens in sickle cell patients was analyzed by a retrospective review of the records of pediatric and adult sickle cell patients who received transfusions and who were followed over a 10-year period. STUDY DESIGN AND METHODS:Charts of pediatric and adul...

journal_title：Transfusion

authors： Aygun B,Padmanabhan S,Paley C,Chandrasekaran V

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Red blood cell (RBC) storage solutions work in a narrow pH range between 7.2 and 6.4. While keeping RBC within that pH range, ATP production can be increased by buffering or dilution. STUDY DESIGN AND METHODS:In the first study, 12 units of packed CP2D RBCs were pooled in groups of four, re-aliquoted, and a...

journal_title：Transfusion

authors： Hess JR,Rugg N,Joines AD,Gormas JF,Pratt PG,Silberstein EB,Greenwalt TJ

更新日期：2006-01-01 00:00:00

abstract：:HLA and granulocyte-specific antibodies have been implicated in the production of transfusion-related acute lung injury (TRALI). Reported here is a case that suggests that the patient's preexisting condition may play an important role in determining whether TRALI develops upon transfusion of blood products containing ...

journal_title：Transfusion

authors： Van Buren NL,Stroncek DF,Clay ME,McCullough J,Dalmasso AP

更新日期：1990-01-01 00:00:00

abstract：:The hemostat, sealant, and adhesive components of the surgical toolbox continue to evolve and enter clinical practice at a rapid rate. The goal of this comprehensive, sequential review is to update these components to include those now available (February 2012) as well as to explore cost and regulatory factors that im...

journal_title：Transfusion

authors： Spotnitz WD,Burks S

更新日期：2012-10-01 00:00:00

abstract：:The immediate-spin (IS) crossmatch is a method that detects ABO incompatibility. However, under certain circumstances, this test may show unwanted negative or weak results, even though the red cells (RBCs) and serum being tested are ABO incompatible with each other. The present study investigated the potential effect ...

journal_title：Transfusion

authors： Shulman IA,Calderón C

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Prevalence estimates of the serious hazards of transfusion vary widely. We hypothesized that the current reporting infrastructure in the United States fails to capture many transfusion reactions and undertook a multicenter study using active surveillance, data review, and adjudication to test this hypothesis...

journal_title：Transfusion

authors： Hendrickson JE,Roubinian NH,Chowdhury D,Brambilla D,Murphy EL,Wu Y,Ness PM,Gehrie EA,Snyder EL,George Hauser R,Gottschall JL,Kleinman S,Kakaiya R,Strauss RG,National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemio

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The prevalence of hepatitis G virus (HGV) and its strain variant, the GB agent (GBV-C) is high in non-virus-inactivated plasma products, but, persistent infection in recipients is relatively low. STUDY DESIGN AND METHODS:Stored samples from transfusion donors and recipients in a prospective study of posttra...

journal_title：Transfusion

authors： Wang JT,Chen PJ,Liu DP,Sheu JC,Wang TH,Chen DS

更新日期：1998-03-01 00:00:00

abstract：:Microaggregates in various blood preparations were studied, before and after filtration, using an optical scattering (laser) technique which measures number density and size of aggregates in flowing blood. These measurements were comparable to screen filtration pressures. In all blood units, storage increased aggregat...

journal_title：Transfusion

authors： Reynolds LO,Simon TL

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:There is controversy regarding the application of transfusion triggers in cardiac surgery. The goal of this study was to determine if lowering the hemoglobin threshold for red cell (RBC) transfusion to 8 g per dL after coronary artery bypass graft surgery would reduce blood use without adversely affecting pa...

journal_title：Transfusion

authors： Bracey AW,Radovancevic R,Riggs SA,Houston S,Cozart H,Vaughn WK,Radovancevic B,McAllister HA Jr,Cooley DA

更新日期：1999-10-01 00:00:00

abstract：:Acquired thrombotic thrombocytopenic purpura (TTP) is a disease characterized by microangiopathic hemolytic anemia and thrombocytopenia, in addition to variable fever and neurologic and renal dysfunction, without an underlying cause. Recent advances in elucidating the pathophysiology of acquired TTP have led to new te...

journal_title：Transfusion

authors： Raval JS,Mazepa MA,Brecher ME,Park YA

更新日期：2014-10-01 00:00:00

abstract：:Current criteria for a reactive (positive) interpretation on hepatitis C virus (HCV) recombinant immunoblot assay (RIBA) require > or = 1+ reactivity to at least two of the four HCV antigens present in the assay. Given that 5-1-1 is a subcomponent of c100-3, there is concern that donor samples reacting only with these...

journal_title：Transfusion

authors： Busch MP,Tobler L,Quan S,Wilber JC,Johnson P,Polito A,Steane E,Zola A,Bahl C,Nelles M

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:JMH is a high-frequency red cell blood group antigen that resides on a 76- to 80-kDa glycosylphosphatidylinositol-linked protein also known as CDw108. Antibodies with JMH specificity are often autoimmune and are usually, if not always, clinically benign. Some individuals with JMH-variant antigen produce allo...

journal_title：Transfusion

authors： Mudad R,Rao N,Issitt PD,Roy RB,Combs MR,Telen MJ

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:This study was designed to evaluate the potential yield of introducing nucleic acid amplification testing (NAT) in blood donation, according to the detection threshold and the pool size. STUDY DESIGN AND METHODS:A mathematical model of early HIV-1 population dynamics in blood has been developed and is used ...

journal_title：Transfusion

authors： Le Corfec E,Le Pont F,Tuckwell HC,Rouzioux C,Costagliola D

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:A new generation of assays for the detection of human T-lymphotropic virus types I and II (HTLV-I/II) antibodies has been released. These assays incorporate HTLV-I- and HTLV-II-specific antigens, and some are based on new assay principles. Comparative evaluation data that include these new as well as previou...

journal_title：Transfusion

authors： Andersson S,Thorstensson R,Ramirez KG,Krook A,von Sydow M,Dias F,Biberfeld G

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Chronic red blood cell exchanges (RBCXs) are frequently used to prevent complications in patients with sickle cell anemia, but the scarcity of matched red blood cell packs (RBCPs) is a serious concern. The main goal of this study was to compare the number of RBCPs used during RBCXs between the Spectra Optia ...

journal_title：Transfusion

authors： Hequet O,Poutrel S,Connes P,Revesz D,Chelghoum Y,Kebaili K,Cannas G,Gauthier A,Guironnet-Paquet A,Vocanson M,Nicolas JF,Renoux C,Raba M,Cognasse F,Bertrand Y,Hot A,Joly P

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Deferral for travel to malaria-endemic areas excludes many blood donors in the United States. Most transfusion-transmitted malaria is associated with lengthy residence in malaria-endemic areas rather than routine travel. This study compares the impact of existing deferral requirements to the risk that a pres...

journal_title：Transfusion

authors： Spencer B,Steele W,Custer B,Kleinman S,Cable R,Wilkinson S,Wright D

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Idarucizumab (IDA) is approved for emergency reversal of dabigatran; prothrombin complex concentrates (PCCs) are recommended in the absence of specific antidote. The combined effects of IDA and PCC in trauma-related bleeding are unknown. The efficacy and safety of combined IDA + PCC were assessed in a lethal...

journal_title：Transfusion

authors： Honickel M,Braunschweig T,Rossaint R,Schöchl H,Grottke O

更新日期：2019-04-01 00:00:00

abstract：:Mild-to-profound anemia, thrombocytopenia, and rarely neutropenia have been observed in patients with the acquired immune deficiency syndrome (AIDS). To investigate a possible immune mechanism, blood samples from 28 hospitalized AIDS patients, four asymptomatic homosexual men, four homosexual men with the AIDS-related...

journal_title：Transfusion

authors： McGinniss MH,Macher AM,Rook AH,Alter HJ

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:The Am phenotype has been characterized as a weak expression of the A antigen on red blood cells but the presence of a normal quantity of the A antigen in saliva. This study describes a molecular genetic analysis of members of an Am family. STUDY DESIGN AND METHODS:The eight exon regions of the ABO genes of...

journal_title：Transfusion

authors： Lin M,Hou MJ,Twu YC,Yu LC

更新日期：2005-01-01 00:00:00

abstract：:This study was designed to test the viability of two multiple request techniques of behavioral influence for recruiting blood donors by telephone. The first technique utilizes a small antecedent request to encourage behavioral involvement and favorable disposition toward the target activity of the critical request to ...

journal_title：Transfusion

authors： Hayes TJ,Dwyer FR,Greenwalt TJ,Coe NA

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Routine HCV NAT of blood donors to detect persons in the preseroconversion phase of acute infection was introduced in Canada in October 1999. The source of virus exposure was investigated in the first, and to date only, blood donor found to be HCV NAT positive, anti-HCV negative in Canada. He was a regular d...

journal_title：Transfusion

authors： Larke B,Hu YW,Krajden M,Scalia V,Byrne SK,Boychuk LR,Klein J

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Hemolysis of red blood cells (RBCs) during blood bank storage is the most obvious manifestation of RBC storage system failure. However, its analysis is made difficult because the largest source of interunit difference is donor specific. Availability of data from national blood systems on large numbers of RBC...

journal_title：Transfusion

authors： Hess JR,Sparrow RL,van der Meer PF,Acker JP,Cardigan RA,Devine DV

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Deferasirox (DFRA) is a new approved oral iron chelator. Its advantages are that it is convenient and better tolerated and adhered to due to "once-daily" oral dosage. However, its use in the field is limited and it is yet to be subjected to postmarketing surveillance. CASE REPORT:A 18.75-year-old male with ...

journal_title：Transfusion

authors： Wei HY,Yang CP,Cheng CH,Lo FS

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Most patients with severe aplastic anemia (sAA) respond to immunosuppression, but a significant number relapse or develop clonal abnormalities such as paroxysmal nocturnal hemoglobinuria, myelodysplasia, or leukemia. In principle, patients without matched sibling donors and older patients might benefit from ...

journal_title：Transfusion

authors： Sloand EM,Read EJ,Scheinberg P,Tang Y,More K,Leitman SF,Maciejewski J,Young NS

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Although a recent study reported shorter survivals in human immunodeficiency virus type 1 (HIV-1)-infected patients who received transfusions, no study has analyzed the relationship in such patients between the frequency of opportunistic infection and transfusion. STUDY DESIGN AND METHODS:Records of 196 HIV...

journal_title：Transfusion

authors： Sloand E,Kumar P,Klein HG,Merritt S,Sacher R

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Routine quantification of platelet-derived extracellular vesicles (PL-EVs) may be useful in the quality control (QC) of platelet concentrates (PCs). The aim of this multicenter study was to establish and validate a consensus protocol for the standardized PL-EV quantification using conventional flow cytometer...

journal_title：Transfusion

authors： Black A,Orsó E,Kelsch R,Pereira M,Kamhieh-Milz J,Salama A,Fischer MB,Meyer E,Frey BM,Schmitz G

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Whole blood donors are at risk of becoming iron deficient. To monitor iron stores, Sanquin implemented a new deferral policy based on ferritin levels, in addition to the traditional hemoglobin measurements. METHODS:Ferritin levels are determined in every fifth donation, as well as in all first-time donors. ...

journal_title：Transfusion

authors： Vinkenoog M,van den Hurk K,van Kraaij M,van Leeuwen M,Janssen MP

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Recruitment of young donors is critical to expand the donor base and sustain the blood supply. Nevertheless, there is concern that younger blood donors may have a higher risk profile than their older counterparts. STUDY DESIGN AND METHODS:The prevalence of behavioral risks associated with transfusion-transm...

journal_title：Transfusion

authors： Damesyn MA,Glynn SA,Schreiber GB,Ownby HE,Bethel J,Fridey J,McMullen Q,Garratty G,Busch MP,NHLBI Retrovirus Epidemiology Donor Study.

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Red blood cell (RBC) alloimmunization is common in transfused patients. Most studies report on the rate of alloimmunization in chronically transfused patients, which can be as high as 60 percent. Less is known on the incidence of clinically relevant antibodies in accidentally transfused patients. Because the...

journal_title：Transfusion

authors： Schonewille H,van de Watering LM,Brand A

更新日期：2006-04-01 00:00:00