Effects of granulocyte-colony-stimulating factor on Monosomy 7 aneuploidy in healthy hematopoietic stem cell and granulocyte donors.

Abstract:

BACKGROUND:Reports of Monosomy 7 in patients receiving granulocyte-colony-stimulating factor (G-CSF) have raised concerns that this cytokine may promote genomic instability. However, there are no studies addressing whether repeated administration of G-CSF produces Monosomy 7 aneuploidy in healthy donors. STUDY DESIGN AND METHODS:We examined Chromosomes 7 and 8 by fluorescent in situ hybridization (FISH) in CD34+ cells from 35 healthy hematopoietic stem cell transplant (HSCT) donors after G-CSF administration for 5 days and by spectral karyotyping analysis (SKY) in four individuals to assess chromosomal integrity. We also studied 38 granulocyte donors who received up to 42 doses of G-CSF and dexamethasone (Dex) using FISH for Chromosomes 7 and 8. RESULTS:We found no abnormalities in Chromosomes 7 and 8 in G-CSF-mobilized CD34+ cells when assessed by FISH or SKY, nor did we detect aneuploidy in G-CSF- and Dex-treated donors. CONCLUSION:G-CSF does not promote clinically detectable Monosomy 7 or Trisomy 8 aneuploidy in HSCT or granulocyte donors. These findings should be reassuring to healthy HSCT and granulocyte donors.

journal_name

Transfusion

journal_title

Transfusion

authors

Olnes MJ,Poon A,Miranda SJ,Pfannes L,Tucker Z,Loeliger K,Padilla-Nash H,Yau YY,Ried T,Leitman SF,Young NS,Sloand EM

doi

10.1111/j.1537-2995.2011.03313.x

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

537-41

issue

3

eissn

0041-1132

issn

1537-2995

journal_volume

52

pub_type

杂志文章
  • Granulocyte transfusion kinetics measured by chemiluminescence, nitroblue tetrazolium reduction, and recovery of indium-111-labeled granulocytes.

    abstract::A 20-year-old man with chronic granulomatous disease (CGD) and who was receiving granulocyte transfusions for a refractory liver abscess was studied to compare the kinetics of 111In-labeled granulocytes with those of two functional granulocyte assays, nitroblue tetrazolium reduction and chemiluminescence. Transfused g...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27187121467.x

    authors: Elliott GR,Clay ME,Mills EL,Abramson JS,McCullough J,Quie PG

    更新日期:1987-01-01 00:00:00

  • Blood screening nucleic acid amplification tests for human immunodeficiency virus Type 1 may require two different amplification targets.

    abstract:BACKGROUND:Five cases of human immunodeficiency virus Type 1 (HIV-1) RNA-positive blood donations are described that escaped detection by three different CE-marked nucleic acid amplification technique (NAT) screening assays. These events were associated with two HIV-1 transmissions to recipients of blood components. Th...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03281.x

    authors: Chudy M,Weber-Schehl M,Pichl L,Jork C,Kress J,Heiden M,Funk MB,Nübling CM

    更新日期:2012-02-01 00:00:00

  • Chemically modified and unmodified anti-D (Rho) reagents in the micro Du procedure.

    abstract::The ability of anti-D (Rho) reagents containing chemically modified and unmodified IgG molecules to detect fetal-maternal hemorrhages was compared using mixtures of Rh negative adult red blood cells and Rh positive cord red blood cells. No significant differences among reagents were observed in this small study. These...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22182154226.x

    authors: Treacy M,Hall SJ,Duerr JM,Kebles D,Olekna DJ

    更新日期:1982-01-01 00:00:00

  • Inactivation of lipid-enveloped and non-lipid-enveloped model viruses in normal human plasma by crosslinked starch-iodine.

    abstract:BACKGROUND:The purpose of this study was to evaluate an iodine-based method of activating potentially harmful viruses that might be found in normal human plasma. STUDY DESIGN AND METHODS:A procedure has been developed for inactivating lipid-enveloped and non-lipid-enveloped model viruses in normal human plasma by usin...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1994.34494233580.x

    authors: Highsmith FA,Xue H,Caple M,Walthall B,Drohan WN,Shanbrom E

    更新日期:1994-04-01 00:00:00

  • Red cell alloantibodies in thalassemia major. Results of an Italian cooperative study.

    abstract::Clinical and serological data on 1435 Italian thalassemia major patients were collected during a cooperative study involving 19 centers in 10 regions. The main findings were as follows: 18 percent of the patients were under 6 years of age, 63 percent between 6 and 15, and 19 percent over 15. Forty-one percent had unde...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25285169198.x

    authors: Sirchia G,Zanella A,Parravicini A,Morelati F,Rebulla P,Masera G

    更新日期:1985-03-01 00:00:00

  • Intraoperative cell salvage in obstetrics: is it a real therapeutic option?

    abstract::Obstetric hemorrhage is a leading cause of maternal and perinatal mortality worldwide. Intraoperative blood salvage is common practice in many surgical specialties but its safety in obstetrics is questioned for concerns on the risks of contamination of recovered blood with amniotic fluid (AF) and of maternal-fetal all...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2011.03116.x

    authors: Liumbruno GM,Liumbruno C,Rafanelli D

    更新日期:2011-10-01 00:00:00

  • Survival of red blood cells after transfusion: a comparison between red cells concentrates of different storage periods.

    abstract:BACKGROUND:The use of fresh red blood cells (RBCs) is recommended for critically ill patients and patients undergoing surgery, although there is no conclusive evidence that this is beneficial. In this follow-up study, the short-term and the long-term recovery of irradiated, leukoreduced RBCs transfused after either a s...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.01734.x

    authors: Luten M,Roerdinkholder-Stoelwinder B,Schaap NP,de Grip WJ,Bos HJ,Bosman GJ

    更新日期:2008-07-01 00:00:00

  • Functional antibodies to Haemophilus influenzae type B, Neisseria meningitidis, and Streptococcus pneumoniae contained in intravenous immunoglobulin products.

    abstract:BACKGROUND:Intravenous immunoglobulin G (IVIG) replacement therapy is used to prevent invasive infections in patients with primary antibody deficiency (PAD). However, few studies have functionally evaluated specific antibodies against encapsulated bacteria that cause invasive infection in patients with PAD. In this stu...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13869

    authors: Lee S,Kim HW,Kim KH

    更新日期:2017-01-01 00:00:00

  • Accuracy of hepatitis C virus core antigen testing in pools among seroconverters.

    abstract:BACKGROUND:Screening blood units for hepatitis C virus (HCV) with nucleic acid testing (NAT) reduces the risk associated with the long "window period" (8-9 weeks) after HCV infection. The feasibility of adding the HCV core antigen assay in pools to the existing anti-HCV individual screening was examined as an alternati...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00972.x

    authors: Beer N,Shinar E,Novack L,Safi J,Soliman H,Yaari A,Goldman-Levi R,Yahalom V,Bolotin A,Sarov B

    更新日期:2006-10-01 00:00:00

  • Evidence of an anti-A1 inhibited by EDTA.

    abstract::EDTA is added to some commercial A and B cells as a means of preventing hemolysis in serum testing. Unexpected results in serum testing have been reported with EDTA-dependent agglutinins, but not with agglutinins inhibited by EDTA. A serum sample was found to contain an anti-A1 undetected by serum testing, but resulti...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28288179026.x

    authors: Tedrow HE,Zeigler ZR

    更新日期:1988-03-01 00:00:00

  • Plasma ectonucleotidases prevent desensitization of purinergic receptors in stored platelets: importance for platelet activity during thrombus formation.

    abstract:BACKGROUND:Platelets (PLTs) contain purinergic receptors for ATP (P2X1) and ADP (P2Y1 and P2Y12) that rapidly desensitize upon stimulation with these nucleotides. In vivo, this is antagonized by ectonucleotidases on the surface of endothelial cells and white blood cells (WBCs). The receptor desensitization of ATP- and ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00837.x

    authors: Cauwenberghs S,Feijge MA,Hageman G,Hoylaerts M,Akkerman JW,Curvers J,Heemskerk JW

    更新日期:2006-06-01 00:00:00

  • Platelet storage. Effects of leachable materials on morphology and function.

    abstract::A polyolefin plastic (PL 732) bag formulated without liquid plasticizer allows storage of platelets for 5 and, now, up to 7 days. In order to assess the leaching of compounds from this new plastic, extracts of the supernatant from platelet concentrates stored in these bags were analyzed by high-performance liquid chro...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26486262743.x

    authors: Labow RS,Tocchi M,Rock G

    更新日期:1986-07-01 00:00:00

  • Preparation of commercial quantities of a hyperimmune human intravenous immunoglobulin preparation against an emerging infectious disease: the example of pandemic H1N1 influenza.

    abstract:BACKGROUND:The recent H1N1 pandemic provided an opportunity to conceptually assess the possibility of rapidly providing a "hyperimmune" human immunoglobulin (H-IVIG) to an emerging infectious disease, in useful quantities with respect to public health. Commercial-scale H-IVIG production from plasma collected from donor...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03347.x

    authors: Kreil TR,Mc Vey JK,Lei LS,Camacho L,Wodal W,Kerschbaum A,Segura E,Vandamme E,Gavit P,Ehrlich HJ,Barrett PN,Baker DA

    更新日期:2012-04-01 00:00:00

  • How to verify patient identity and blood product compatibility using an electronic bedside transfusion system.

    abstract::Transfusion of an incorrect blood component is an important avoidable serious hazard of transfusion resulting from process errors. Our group and others have taken advantage of new technology and developed electronic transfusion systems for safe transfusion practice in a previous studies. They allow the clinical staff ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16028

    authors: Staples S,O'Callaghan C,Pavord S,Staves J,Murphy MF

    更新日期:2020-09-01 00:00:00

  • The effect of storage on degranulation by human neutrophils.

    abstract::We investigated the possibility that the functional impairment in neutrophil (PMN) chemotaxis which occurs during granulocyte concentrate storage might be due to autotoxicity from the release of neutrophil granule contents during storage. Preliminary experiments confirmed that the exposure of fresh PMNs to the intrace...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25285169211.x

    authors: Lane TA,Lamkin GE

    更新日期:1985-03-01 00:00:00

  • A new radioimmunoassay for the detection of small amounts of white cells and platelets in red cell concentrates: implications for blood transfusion.

    abstract::In the procedure for quality control of red cell concentrates, made white cell (WBC)-poor by filtration, the particle-counting technique was found to be insufficiently sensitive in detecting the remaining WBCs and platelets. Therefore, direct radioimmunoassays were developed using murine monoclonal antibodies specific...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30290162896.x

    authors: Webster MR,Prins HK,Huisman JG

    更新日期:1990-02-01 00:00:00

  • Microbial challenge of a blood cell separator outside-seal bowl system.

    abstract::The ability to store platelets beyond 24 hours requires a functionally closed system. This study tested the ability of a cell separator bowl seal system to resist penetration of microbial contamination under normal running conditions and under extreme environmental stress. Three test organisms, Micrococcus luteus, Ser...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30290162901.x

    authors: Jacobson MS,Kevy SV,Thorne GM,Goldmann DA,Blasetti L,Smith JW,Schaefer H

    更新日期:1990-02-01 00:00:00

  • Safe fetal platelet genotyping: new developments.

    abstract:BACKGROUND:Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is due to maternal alloimmunization against fetal platelet (PLT) antigens. Antenatal management strategies have been developed to avoid complications such as intracranial hemorrhage. The aim of this study was to set up two reliable, noninvasive fetal gen...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03954.x

    authors: Le Toriellec E,Chenet C,Kaplan C

    更新日期:2013-08-01 00:00:00

  • Genomic coordinates and continental distribution of 120 blood group variants reported by the 1000 Genomes Project.

    abstract:BACKGROUND:The 1000 Genomes Project provides a database of genomic variants from whole genome sequencing of 2504 individuals across five continental superpopulations. This database can enrich our background knowledge of worldwide blood group variant geographic distribution and identify novel variants of potential clini...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14953

    authors: Montemayor-Garcia C,Karagianni P,Stiles DA,Reese EM,Smellie DA,Loy DA,Levy KY,Nwokocha M,Bueno MU,Miller JL,Klein HG

    更新日期:2018-11-01 00:00:00

  • Ultrastructural localization of glycoprotein IIIa (GPIIIa, beta 3 integrin) on placental syncytiotrophoblast microvilli: implications for platelet alloimmunization during pregnancy.

    abstract:BACKGROUND:Fetal and neonatal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-1a more commonly occurs in first pregnancies, unlike hemolytic disease of the newborn. Anti-D is produced after D+ fetomaternal hemorrhage; this usually occurs at parturition. Anti-HPA-1a could develop during pregnancy if...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2008.01832.x

    authors: Kumpel BM,Sibley K,Jackson DJ,White G,Soothill PW

    更新日期:2008-10-01 00:00:00

  • Will clinical studies elucidate the connection between the length of storage of transfused red blood cells and clinical outcomes? An analysis based on the simulation of randomized controlled trials.

    abstract:BACKGROUND:The temporal pattern of the biologic mechanism linking red blood cell (RBC) storage duration with clinical outcomes is yet unknown. This study investigates how such a temporal pattern can affect the power of randomized controlled trials (RCT) to detect a relevant clinical outcome mediated by the transfusion ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03656.x

    authors: Pereira A

    更新日期:2013-01-01 00:00:00

  • Another potential source of error in Rh-hr typing.

    abstract::Three cases are presented in which the presence of sodium caprylate dependent albumin auto-agglutinins in the patients' sera resulted in erroneous Rh-hr phenotyping of their erythrocytes. In the initial testing, the albumin control was negative in each case. Since one of the cases was an Rh0(D) negative individual who...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1975.15576082226.x

    authors: Reid ME,Ellisor SS,Frank BA

    更新日期:1975-09-01 00:00:00

  • Routine bacterial screening of apheresis platelets on Day 4 using a rapid test: a 4-year single-center experience.

    abstract:BACKGROUND:The platelet (PLT) Pan Genera Detection test (PGD) is a rapid bacterial detection system used to screen PLTs for bacterial contamination. We report a single center 46-month experience with secondary screening of apheresis PLTs by PGD testing. STUDY DESIGN AND METHODS:Existing testing records of apheresis PL...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12083

    authors: Dunbar NM,Kreuter JD,Marx-Wood CR,Dumont LJ,Szczepiorkowski ZM

    更新日期:2013-10-01 00:00:00

  • Center error reduction by recheck of blood type.

    abstract::Our computer system currently stores donor blood types for seven years and checks typing of all repeat donors against these files. In a recent three-month period (42,500 units), five discrepancies were found--two representing current error. Retrospective analysis of 18 errors made over the last three years showed that...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1981.21281178157.x

    authors: Grindon AJ,Liles BA

    更新日期:1981-03-01 00:00:00

  • Effect of delayed blood processing on the yield of factor VIII in cryoprecipitate and factor VIII concentrate.

    abstract::Current standards for the preparation of factor VIII (FVIII) concentrates from human plasma recommend separation of plasma from red cells (RBCs) within 6 hours of blood donation, thereby reducing the volume of plasma from donated whole blood available for processing to FVIII concentrate. The decay of FVIII clotting ac...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28689059033.x

    authors: Hughes C,Thomas KB,Schiff P,Herrington RW,Polacsek EE,McGrath KM

    更新日期:1988-11-01 00:00:00

  • Compatibility testing without a centrifuge: the slide Polybrene method.

    abstract:BACKGROUND:A simple and rapid slide Polybrene method (SP) for pretransfusion compatibility testing is described. SP is particularly suitable for use in developing countries where, due to limited resources, centrifuges and biologic reagents may not be readily available. STUDY DESIGN AND METHODS:The original manual Poly...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.00659.x

    authors: Lin M

    更新日期:2004-03-01 00:00:00

  • A simplified procedure for deglycerolizing red blood cells frozen in a high glycerol concentration.

    abstract::Although the high (40 to 50 per cent) glycerol method of freezing red blood cells has many advantages, no feasible procedure for deglycerolizing with only a clinical centrifuge has been available. Thus this method has been restricted to blood centers that distribute a sufficient number of frozen cells to warrant the i...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1977.17578014580.x

    authors: Meryman HT,Hornblower M

    更新日期:1977-09-01 00:00:00

  • Administrative and research policies required to bring cellular therapies from the research laboratory to the patient's bedside.

    abstract::The research process is a balance between the inherent risks of new discoveries and the risks of research participant safety. Conflicts of interest, inherent to the research process, as well as those introduced by emerging cellular therapies, have the potential to compromise safety. The relationship of trust between t...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2005.00616.x

    authors: Yim R

    更新日期:2005-10-01 00:00:00

  • Differential induction of P-selectin expression on platelets by two cell separators during plateletpheresis and the effect of gender on the release of soluble P-selectin.

    abstract:BACKGROUND:Though a number of studies have elegantly characterized platelet activation during storage, less attention has been paid to the initial activation caused by different collection procedures. STUDY DESIGN AND METHODS:The effects of two blood cell separators on the initial activation of platelets were measured...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1537-2995.1998.38198141494.x

    authors: Stohlawetz P,Hergovich N,Stiegler G,Eichler HG,Höcker P,Kapiotis S,Jilma B

    更新日期:1998-01-01 00:00:00

  • Degenerate polymerase chain reaction strategy with DNA microarray for detection of multiple and various subtypes of virus during blood screening.

    abstract:BACKGROUND:The risk of transferring blood-borne infections during transfusion is continually increasing because of newly emerging and reemerging viruses. Development of a rapid screening method for emerging viruses that might be transmitted by transfusion is required to eliminate such pathogens during blood donor scree...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12193

    authors: Takizawa K,Nakashima T,Mizukami T,Kuramitsu M,Endoh D,Kawauchi S,Sasaki K,Momose H,Kiba Y,Mizutani T,Furuta RA,Yamaguchi K,Hamaguchi I

    更新日期:2013-10-01 00:00:00