Microbial challenge of a blood cell separator outside-seal bowl system.

abstract：BACKGROUND:Liberal transfusion strategy increases the risk of acute lung injury (ALI), but specific transfusion-related factors have not been characterized. We tested the hypotheses that storage age and specific type of blood products are associated with increased risk of ALI in mechanically ventilated patients. STUDY...

journal_title：Transfusion

authors： Gajic O,Rana R,Mendez JL,Rickman OB,Lymp JF,Hubmayr RD,Moore SB

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Screening blood units for hepatitis C virus (HCV) with nucleic acid testing (NAT) reduces the risk associated with the long "window period" (8-9 weeks) after HCV infection. The feasibility of adding the HCV core antigen assay in pools to the existing anti-HCV individual screening was examined as an alternati...

journal_title：Transfusion

authors： Beer N,Shinar E,Novack L,Safi J,Soliman H,Yaari A,Goldman-Levi R,Yahalom V,Bolotin A,Sarov B

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:A system has been developed to inactivate a wide spectrum of blood-borne pathogens in red blood cells (RBCs) before transfusion. The system utilizes S-303 to target nucleic acids of pathogens and white blood cells. The safety of pathogen inactivated RBC was assessed using S-303-treated RBCs (S-303 RBCs) and ...

journal_title：Transfusion

authors： North A,Ciaravino V,Mufti N,Corash L

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:TT virus (TTV), a novel DNA virus, was originally thought to be transmitted by transfusion. However, nonparenteral transmission is recently suspected to be a major mode of transmission. To investigate the possibility of reinfection with TTV in multiply transfused patients and to evaluate the significance of ...

journal_title：Transfusion

authors： Toyoda H,Fukuda Y,Nakano I,Katano Y,Yokozaki S,Hayashi K,Ito Y,Suzuki K,Nakano H,Saito H,Takamatsu J

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Retrospective studies suggested that storage age of RBCs is associated with inflammation and thromboembolism. The Red Cell Storage Duration Study (RECESS) trial randomized subjects undergoing complex cardiac surgery to receive RBCs stored for shorter versus longer periods, and no difference was seen in the p...

journal_title：Transfusion

authors： Spinella PC,Sniecinski RM,Trachtenberg F,Inglis HC,Ranganathan G,Heitman JW,Szlam F,Danesh A,Stone M,Keating SM,Levy JH,Assmann SF,Steiner ME,Doctor A,Norris PJ

更新日期：2019-04-01 00:00:00

abstract：:A polyolefin plastic (PL 732) bag formulated without liquid plasticizer allows storage of platelets for 5 and, now, up to 7 days. In order to assess the leaching of compounds from this new plastic, extracts of the supernatant from platelet concentrates stored in these bags were analyzed by high-performance liquid chro...

journal_title：Transfusion

authors： Labow RS,Tocchi M,Rock G

更新日期：1986-07-01 00:00:00

abstract：:White cells (WBCs) constitute a significant contaminant of platelet concentrates (PCs). Various technologies, including apheresis and filtration, are currently being developed to minimize the carryover of WBCs into platelets. The aim is to reduce contamination of less than 10(8) WBCs per platelet unit. As part of qual...

journal_title：Transfusion

authors： Marx G,Blankenfeld A,Gorodetsky R,BarShany S

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:A 28-year-old woman of Lebanese origin experienced two stillbirths. At the time, serology typed her red blood cells as being group A D- and found an anti-D in her serum sample. Molecular biology analysis, however, showed that she was in fact RHD+. STUDY DESIGN AND METHODS:To better characterize this case, a...

journal_title：Transfusion

authors： Richard M,Perreault J,Constanzo-Yanez J,Khalifé S,St-Louis M

更新日期：2007-05-01 00:00:00

abstract：:The potassium load of transfused blood must be minimized. We have compared the total plasma potassium content of units of CPD-preserved stored whole blood (SWB), stored packed cells (SPC), and packed cells prepared from stored whole blood (WB-PC). Plasma potassium concentrations, unit weights, and hematocrits of 20 un...

journal_title：Transfusion

authors： Michael JM,Dorner I,Bruns D,Ladenson JH,Sherman LA

更新日期：1975-03-01 00:00:00

abstract：BACKGROUND:Phthalocyanines are useful sensitizers for photodynamic sterilization of red cell concentrates. Various lipid-enveloped viruses can be inactivated with only limited red cell damage. Because white cells are involved in the immunomodulatory effects of blood transfusions, the study of the effect of photodynamic...

journal_title：Transfusion

authors： Moor AC,van der Veen A,Dubbelman TM,VanSteveninck J,Brand A

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Low-titer group O whole blood (LTOWB) is increasingly being used in the civilian trauma setting, although there is a risk of hemolysis. This study evaluated the impact on hemolytic markers following the transfusion of 4 or more units of uncrossmatched LTOWB. METHODS:Civilian adult trauma patients who receiv...

journal_title：Transfusion

authors： Harrold IM,Seheult JN,Alarcon LH,Corcos A,Sperry JL,Triulzi DJ,Yazer MH

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Alloimmunization against human platelet antigens (HPAs) during pregnancy is rare but can lead to severe bleeding disorders, such as fetal and neonatal alloimmune thrombocytopenia. STUDY DESIGN AND METHODS:In a cohort of 241 uncomplicated pregnancies, we investigated the immunogenicity of HPA mismatches and ...

journal_title：Transfusion

authors： Reiher VSA,Hönger G,Infanti L,Passweg JR,Hösli I,Frey BM,Gassner C,Meyer S,Buser AS,Holbro A,Schaub S

更新日期：2017-05-01 00:00:00

abstract：:A family is described in which two members of the second generation are of the phenotype LW3. In the course of the investigation the mother of the LW3 propositus was at first believed to be phenotypically LW3 as well. Eventually, it was shown that she is, in fact, phenotypically LW2 but that her R-1 (no D), LWlw, geno...

journal_title：Transfusion

authors： Behzad O,Pothiawala M,Rolih SD,Issitt PD,Lee CL

更新日期：1978-07-01 00:00:00

abstract：:The platelets used in this study were collected by serial centrifugation, and within four hours of collection were frozen with 5% dimethylsulfoxide (DMSO) at an overall rate of 2 to 3 C per minute by storage in a mechanical refrigerator at -80 C. The frozen platelets were stored for four to ten weeks before thawing an...

journal_title：Transfusion

authors： Zaroulis CG,Spector JI,Emerson CP,Valeri CR

更新日期：1979-07-01 00:00:00

abstract：:A simple method for preparing relatively pure C3c fragment from serum-reacted zymosan is described. Although hyperimmunization studies indicate contamination of the "C3c" product by C3d and immunoglobulin antigenic materials, these are present in such small amounts that they do not impair the effectiveness of the prod...

journal_title：Transfusion

authors： Chaplin H Jr,Hoffmann NL,Monroe MC

更新日期：1980-05-01 00:00:00

abstract：:The present study describes the use of a new polyacrolein microsphere (acrobead) protein A column. This method enables immunomodulation by the perfusion of whole blood. The efficacy of the column and its adverse effects following perfusion of blood of patients with immune thrombocytopenic purpura (ITP) or malignancies...

journal_title：Transfusion

authors： Dvilansky A,Aharon M,Riesenfeld G,Nathan I

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:RBCs modified with cyanuric chloride activated methoxy-PEG (CmPEG; 5000 Da) are less immunogenic than untreated RBCs, and their use thus may reduce the risk of alloimmunization in chronically transfused patients. STUDY DESIGN AND METHODS:To further examine the potential utility of CmPEG-RBCs, the effects of...

journal_title：Transfusion

authors： Bradley AJ,Test ST,Murad KL,Mitsuyoshi J,Scott MD

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:We reported previously that the incidence of breakage was 34.2 percent when human RBCs were frozen with 40-percent wt/vol glycerol in polyolefin plastic bags stored in aluminum containers at -80 degrees C and subjected to transportation. When human RBCs were frozen with 40-percent wt/vol glycerol at -80 degr...

journal_title：Transfusion

authors： Valeri CR,Lane JP,Srey R,Ragno G

更新日期：2003-03-01 00:00:00

abstract：:A technique of platelet concentrate preparation and storage is presented which permits the maximum number of viable and functional platelets to be preserved for periods of 72 hours. Although the storage conditions must be followed precisely, the method is nevertheless simple to perform and does not require specialized...

journal_title：Transfusion

authors： Slichter SJ,Harker LA

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:According to Landsteiner's law, alloantibodies are prevalent and autoantibodies are absent in the ABO blood group system. However, one study (Spalter et al., Blood 1999;93:4418-24) has suggested that low-affinity ABO autoantibodies, mitigated by anti-idiotypic immunoglobulins are also prevalent, while anothe...

journal_title：Transfusion

authors： Obukhova P,Korchagina E,Henry S,Bovin N

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Determination of the white cell (WBC) count in WBC-reduced platelet components requires methods that have a detection limit in the range of approximately 5.0 x 10(2) to 5.0 x 10(4) per mL. STUDY DESIGN AND METHODS:With a 50-microL Nageotte hemocytometer and bright-field microscopy (200x magnification), stud...

journal_title：Transfusion

authors： Moroff G,Eich J,Dabay M

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:All studied photosensitizers for virus inactivation impair RBCs. To reduce damage to the RBCs without affecting virucidal activity, selective protection of the RBCs is necessary. The ability of the band 3 ligand, dipyridamole, to react with singlet oxygen and to increase the selectivity of photosterilization...

journal_title：Transfusion

authors： vanSteveninck J,Trannoy LL,Besselink GA,Dubbelman TM,Brand A,de Korte D,Verhoeven AJ,Lagerberg JW

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Effective risk communication in transfusion medicine is important for health-care consumers, but understanding the numerical magnitude of risks can be difficult. The objective of this study was to determine the effect of a visual risk communication tool on the knowledge and perception of transfusion risk. S...

journal_title：Transfusion

authors： Lee DH,Mehta MD

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Recent retrospective studies indicate that D- recipients of D+ apheresis platelets (PLTs) are not alloimmunized to D. Our hospital policy is to offer RhIG to D- women of childbearing age who received D+ apheresis PLTs but not to other D- recipients of D+ apheresis PLTs. We instituted prospective surveillance...

journal_title：Transfusion

authors： Weinstein R,Simard A,Ferschke J,Vauthrin M,Bailey JA,Greene M

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Diclofenac has frequently been implicated as the cause of immune hemolytic anemias and less frequently of immune thrombocytopenia. The presence of the causative antibodies has only been demonstrated in patients with immune hemolytic anemia, but not yet in patients with thrombocytopenia. The cases of two pati...

journal_title：Transfusion

authors： Meyer O,Hoffmann T,Aslan T,Ahrens N,Kiesewetter H,Salama A

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Pigs are a potential source of red blood cells (RBCs) for transfusion into humans, but the presence of galactose-alpha1,3-galactose (Gal) epitopes on their surface, against which humans have anti-Gal, has been perceived as a major barrier. alpha1,3-Galactosyltransferase gene-knockout pigs, which do not expre...

journal_title：Transfusion

authors： Rouhani FJ,Dor FJ,Cooper DK

更新日期：2004-07-01 00:00:00

abstract：:We investigated the possibility that the functional impairment in neutrophil (PMN) chemotaxis which occurs during granulocyte concentrate storage might be due to autotoxicity from the release of neutrophil granule contents during storage. Preliminary experiments confirmed that the exposure of fresh PMNs to the intrace...

journal_title：Transfusion

authors： Lane TA,Lamkin GE

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:The Mirasol pathogen reduction technology (PRT) system for plasma is based on a riboflavin (vitamin B(2)) and ultraviolet (UV) light treatment process resulting in pathogen inactivation due to irreversible photo-oxidative damage of nucleic acids. The purpose of this study was to evaluate the in vitro protein...

journal_title：Transfusion

authors： Smith J,Rock G

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:With the emergence of e-mail as a common form of communication, it is important to understand the role and impact e-mail can have on acquiring and retaining whole-blood donors. STUDY DESIGN AND METHODS:Whole-blood donors who opted in to receive e-mail communications (n = 43,232) from the Puget Sound Blood C...

journal_title：Transfusion

authors： Geyer ME

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:There is controversy regarding the application of transfusion triggers in cardiac surgery. The goal of this study was to determine if lowering the hemoglobin threshold for red cell (RBC) transfusion to 8 g per dL after coronary artery bypass graft surgery would reduce blood use without adversely affecting pa...

journal_title：Transfusion

authors： Bracey AW,Radovancevic R,Riggs SA,Houston S,Cozart H,Vaughn WK,Radovancevic B,McAllister HA Jr,Cooley DA

更新日期：1999-10-01 00:00:00