Functional antibodies to Haemophilus influenzae type B, Neisseria meningitidis, and Streptococcus pneumoniae contained in intravenous immunoglobulin products.

Abstract:

BACKGROUND:Intravenous immunoglobulin G (IVIG) replacement therapy is used to prevent invasive infections in patients with primary antibody deficiency (PAD). However, few studies have functionally evaluated specific antibodies against encapsulated bacteria that cause invasive infection in patients with PAD. In this study, functional antibodies against Haemophilus influenzae type b (Hib), Streptococcus pneumoniae (pneumococci), and Neisseria meningitidis (meningococci) in IVIG therapy were evaluated. STUDY DESIGN AND METHODS:Sixteen lots of IVIG products prepared by two Korean manufacturers (Products A and B) were evaluated. The functional antibodies were measured by serum bactericidal assay for Hib and four meningococcal serogroups and by multiplexed opsonophagocytic assay for 26 pneumococcal serotypes. The estimated trough levels of antibodies against Hib, pneumococcus, and meningococcus were calculated to determine whether the usual IVIG dose is appropriate for protecting patients with PAD. RESULTS:The functional antibody levels for Hib were similar in all of the IVIG products. In contrast, serum bacterial indices of meningococcal serogroups A and Y showed significant differences between products A and B. Opsonic indices to pneumococci varied depending on the serotype in each IVIG product. The estimated trough levels of antibodies against Hib, pneumococcus, and meningococcus exceeded the protective levels in most of the IVIG products except for the antibodies against two pneumococcal serotypes. CONCLUSION:Most of the tested commercial IVIG products had sufficient functional antibodies against Hib, pneumococcus, and meningococcus to protect patients with PAD receiving IVIG treatment. Regular and continuous evaluation of IVIG products is necessary to maintain an optimal therapeutic effect.

journal_name

Transfusion

journal_title

Transfusion

authors

Lee S,Kim HW,Kim KH

doi

10.1111/trf.13869

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

157-165

issue

1

eissn

0041-1132

issn

1537-2995

journal_volume

57

pub_type

杂志文章
  • Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.

    abstract:BACKGROUND:Pulmonary transfusion reactions are important complications of blood transfusion, yet differentiating these clinical syndromes is diagnostically challenging. We hypothesized that biologic markers of inflammation could be used in conjunction with clinical predictors to distinguish transfusion-related acute lu...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13021

    authors: Roubinian NH,Looney MR,Kor DJ,Lowell CA,Gajic O,Hubmayr RD,Gropper MA,Koenigsberg M,Wilson GA,Matthay MA,Toy P,Murphy EL,TRALI Study Group.

    更新日期:2015-08-01 00:00:00

  • Safety and impact of donor-type red blood cell transfusion before allogeneic peripheral blood progenitor cell transplantation with major ABO mismatch.

    abstract:BACKGROUND:Changes within the ABO system are regularly observed phenomena in allogeneic bone marrow transplantation (BMT) and peripheral blood progenitor cell transplantation (PBPCT). Major ABO mismatch can lead to different clinical problems including acute hemolysis after infusion of the allograft, delay of red blood...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/j.1537-2995.2005.00578.x

    authors: Scholl S,Klink A,Mügge LO,Schilling K,Höffken K,Sayer HG

    更新日期:2005-10-01 00:00:00

  • The RADAR repository: a resource for studies of infectious agents and their transmissibility by transfusion.

    abstract:BACKGROUND:An ongoing issue in transfusion medicine is whether newly identified or emerging pathogens can be transmitted by transfusion. One method to study this question is through the use of a contemporary linked donor-recipient repository. STUDY DESIGN AND METHODS:The Retrovirus Epidemiology Donor Study Allogeneic ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00171.x

    authors: Kleinman SH,Glynn SA,Higgins MJ,Triulzi DJ,Smith JW,Nass CC,Garratty G,Murphy EL,LeParc GF,Schreiber GB,King MR,Chamberland ME,Nemo GJ

    更新日期:2005-07-01 00:00:00

  • Multicenter performance evaluation of a transcription-mediated amplification assay for screening of human immunodeficiency virus-1 RNA, hepatitis C virus RNA, and hepatitis B virus DNA in blood donations.

    abstract:BACKGROUND:The performance of the recently launched Procleix Ultrio (Chiron/Gen-Probe) human immunodeficiency virus-1 (HIV-1), hepatitis C virus (HCV), and hepatitis B virus (HBV) blood screening assay was evaluated in a European multicenter study. STUDY DESIGN AND METHODS:Serial dilutions of reference materials were ...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1537-2995.2005.00197.x

    authors: Koppelman MH,Assal A,Chudy M,Torres P,de Villaescusa RG,Reesink HW,Lelie PN,Cuypers HT

    更新日期:2005-08-01 00:00:00

  • Intravenous administration of tranexamic acid effectively reduces blood loss in primary total knee arthroplasty in a 610-patient consecutive case series.

    abstract:BACKGROUND:Tranexamic acid (TXA) has been reported to demonstrate efficacy in reducing blood loss during arthroplasty procedures. STUDY DESIGN AND METHODS:This study examines the effectiveness of TXA as a central element of a patient blood management program (PBMP) by evaluating blood loss and transfusion of red blood...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13354

    authors: Pitta M,Zawadsky M,Verstraete R,Rubinstein A

    更新日期:2016-02-01 00:00:00

  • Routine bacterial screening of apheresis platelets on Day 4 using a rapid test: a 4-year single-center experience.

    abstract:BACKGROUND:The platelet (PLT) Pan Genera Detection test (PGD) is a rapid bacterial detection system used to screen PLTs for bacterial contamination. We report a single center 46-month experience with secondary screening of apheresis PLTs by PGD testing. STUDY DESIGN AND METHODS:Existing testing records of apheresis PL...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12083

    authors: Dunbar NM,Kreuter JD,Marx-Wood CR,Dumont LJ,Szczepiorkowski ZM

    更新日期:2013-10-01 00:00:00

  • Clinical investigation of posttransfusion Kidd blood group typing using a rapid normalized quantitative polymerase chain reaction.

    abstract:BACKGROUND:Accurate typing of a patient's RBCs in the setting of prior transfusion or a hemolytic transfusion reaction is crucial in the selection of compatible blood but is time consuming, technically difficult, and sometimes impossible. To address this problem, a simple, rapid, and inexpensive quantitative PCR method...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.03303.x

    authors: Montalvo L,Walker P,Wen L,Lim W,Reed W,Busch MP,Lee TH

    更新日期:2004-05-01 00:00:00

  • Efficacy and safety of the drugs used to reverse direct oral anticoagulants: a systematic review and meta-analysis.

    abstract:BACKGROUND:Direct oral anticoagulants (DOACs) are effective and safe for prophylaxis and treatment of thromboembolic phenomena. However, managing DOACs during bleeding emergencies is challenging. A systematic review and meta-analysis was conducted on studies addressing efficacy and safety of the drugs used for reversal...

    journal_title:Transfusion

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/trf.14096

    authors: da Luz LT,Marchand M,Nascimento B,Tien H,Nathens A,Shah P

    更新日期:2017-07-01 00:00:00

  • Clinical outcomes and transfusion management following intracranial hemorrhage in patients with acute leukemia.

    abstract:BACKGROUND:There is little evidence to guide management of patients with acute leukemia and intracranial hemorrhage (ICH). Predictors of long-term outcome following ICH are unknown. STUDY DESIGN AND METHODS:This study included adult patients with acute leukemia and ICH over an 8-year period. The primary outcome was da...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15621

    authors: Nixon S,Lieberman L,Atenafu EG,Doherty M,Murray C,Wolfe A,Brandys D,Rowland S,Kwan BY,Yu E,Lechner B,Maze D

    更新日期:2020-02-01 00:00:00

  • Anti-PP1Pk and early abortion.

    abstract::Anti-PP1Pk is found in the serum of individuals of phenotype p. Recurrent first trimester miscarriages have been reported in nearly 50 percent of mothers with the p phenotype. A comparative serologic study of three p phenotype mothers is reported. The proposita had three miscarriages while her two identical twin siste...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1983.23483276877.x

    authors: Cantin G,Lyonnais J

    更新日期:1983-07-01 00:00:00

  • Meropenem-induced immune thrombocytopenia and the diagnostic process of laboratory testing.

    abstract:BACKGROUND:Drug-induced immune thrombocytopenia (DITP) is a serious, life-threatening clinical syndrome, the diagnosis of which is consistently difficult. In this report, we present a case of DITP caused by meropenem that was confirmed by laboratory tests. CASE REPORT:A 59-year-old male patient developed severe thromb...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.14267

    authors: Huang R,Cai GQ,Zhang JH,Liu FX,Ma JQ,Liu H,Nie XM,Gui R

    更新日期:2017-11-01 00:00:00

  • Trend in ABO-incompatible RBC transfusion-related fatalities reported to the FDA, 2000-2019.

    abstract:BACKGROUND:ABO-incompatible red blood cell (RBC) transfusions and acute hemolytic reactions occur infrequently, yet resultant fatalities are reported to the US Food and Drug Administration (FDA) every year. We describe a 20-year retrospective study of reported mistransfusion cases to identify temporal trends, common ca...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16121

    authors: Storch EK,Rogerson B,Eder AF

    更新日期:2020-12-01 00:00:00

  • Comparison of plateletapheresis with two continuous-flow cell separators using identical donors.

    abstract::Each of 20 donors underwent plateletapheresis on both the CS-3000 (Fenwal) and the 2997 (IBM) blood cell separators. The same operator performed both procedures and conducted all product studies for each donor. Platelet collection efficiency was significantly greater with the 2997 (81%) than the CS-3000 (60%) (p less ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25485273811.x

    authors: Mintz PD

    更新日期:1985-07-01 00:00:00

  • The successful implementation of an automated institution-wide assessment of hemoglobin and ABO typing to dynamically estimate red blood cell inventory requirements.

    abstract:BACKGROUND:Blood bank inventories must balance adequate supply with minimal outdate rates. The day-to-day practice of ordering red blood cell (RBC) inventory usually involves manually comparing current inventory levels with predetermined thresholds calculated from historical usage and ordering the difference. To date, ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15272

    authors: Quinn J,Campbell C,Gomez A,Kumar-Misir A,Watson S,Liwski D,Covello T,Tennankore KK,Chisholm N,Sadek I,Cheng C

    更新日期:2019-07-01 00:00:00

  • Anti-Cob causing acute hemolytic transfusion reaction.

    abstract::An example of anti-Cob which caused an acute hemolytic transfusion reaction is reported. Immunohematologic studies showed this antibody to be an IgG immunoglobulin that weakly bound complement and reacted in the antiglobulin phase of the crossmatch. The unit of whole blood implicated in the hemolytic transfusion react...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1982.22282177127.x

    authors: Lee EL,Bennett C

    更新日期:1982-03-01 00:00:00

  • Glucose-6-phosphate dehydrogenase activity decreases during storage of leukoreduced red blood cells.

    abstract:BACKGROUND:During storage, the activity of the red blood cell (RBC) antioxidant system decreases. Glucose-6-phosphate dehydrogenase (G6PD) is essential for protection against oxidative stress by producing NADPH. G6PD function of RBC transfusion products is reported to remain stable during storage, but activity was meas...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13378

    authors: Peters AL,van Bruggen R,de Korte D,Van Noorden CJ,Vlaar AP

    更新日期:2016-02-01 00:00:00

  • Significance of the signal-to-cutoff ratios of anti-hepatitis C virus enzyme immunoassays in screening of Chinese blood donors.

    abstract:BACKGROUND:The correlation between signal-to-cutoff (S/CO) ratios of a second-generation hepatitis C virus (HCV) enzyme immunoassay (EIA; Abbott) and a third-generation HCV enzyme-linked immunosorbent assay (ELISA; Ortho) and confirmed HCV infection has been reported. The utility of the values for the Chinese anti-HCV ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00611.x

    authors: Ren FR,Lv QS,Zhuang H,Li JJ,Gong XY,Gao GJ,Liu CL,Wang JX,Yao FZ,Zheng YR,Zhu FM,Tiemuer MH,Bai XH,Shan H

    更新日期:2005-11-01 00:00:00

  • A multicenter evaluation of reproducibility of swirling in platelet concentrates. Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society of Blood Transfusion.

    abstract:BACKGROUND:Eleven laboratories participated in a study investigating whether swirling can be used in monitoring platelet discoid morphology in platelet concentrates (PCs). STUDY DESIGN AND METHODS:In each laboratory, two readers observed the swirling pattern in 1- to 5-day-old PCs, in PCs containing spherical platelet...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1994.34994378282.x

    authors: Bertolini F,Murphy S

    更新日期:1994-09-01 00:00:00

  • Transfusion-related acute lung injury caused by an NB2 granulocyte-specific antibody in a patient with thrombotic thrombocytopenic purpura.

    abstract::HLA and granulocyte-specific antibodies have been implicated in the production of transfusion-related acute lung injury (TRALI). Reported here is a case that suggests that the patient's preexisting condition may play an important role in determining whether TRALI develops upon transfusion of blood products containing ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30190117629.x

    authors: Van Buren NL,Stroncek DF,Clay ME,McCullough J,Dalmasso AP

    更新日期:1990-01-01 00:00:00

  • Primary structure of human neutrophil antigens 1a and 1b.

    abstract:BACKGROUND:Neutrophil specific Fcγ receptor IIIb (CD16b) is a low-affinity IgG receptor. Its polymorphic variants are associated with human neutrophil antigens (HNA). HNA-1a and HNA-1b differ in four amino acids. Immunization can lead to the production of alloantibodies. The exact contribution of four amino acid exchan...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15707

    authors: Sachs UJ,Radke C,Bein G,Grabowski C,Simtong P,Bux J,Bayat B,Reil A

    更新日期:2020-04-01 00:00:00

  • An evaluation of several blood transfusion filters.

    abstract::Several blood transfusion filters designed to remove microemboli were evaluated for filtration and flow characteristics, as well as for hemolysis and for release of particulate debris from the filter. The Dacron wool filter, a depth filter, was superior at removing microemboli measured with an electronic particle size...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1977.17678075651.x

    authors: Kennedy PS,Solis RT,Scott MA,Wilson RK

    更新日期:1977-11-01 00:00:00

  • A national survey of transfusion-related acute lung injury risk reduction policies for platelets and plasma in the United States.

    abstract:BACKGROUND:Little information exists on the specific transfusion-related acute lung injury (TRALI) risk reduction practices used by multiple blood collecting institutions in the United States. STUDY DESIGN AND METHODS:An AABB-appointed TRALI working group designed a set of questions about TRALI risk reduction for plat...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02659.x

    authors: Kleinman S,Grossman B,Kopko P

    更新日期:2010-06-01 00:00:00

  • Recruitment of unrelated persons as bone marrow donors. A preliminary experience.

    abstract::Seven hundred and sixty-three blood donors previously typed for HLA-A and B antigens were asked to consider donating bone marrow to unrelated patients for whom no HLA-matched sibling was available. Eighty-eight percent (668) indicated willingness to donate marrow, and of these, 615 (81%) participated in testing and 53...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26486262736.x

    authors: McElligott MC,Menitove JE,Aster RH

    更新日期:1986-07-01 00:00:00

  • Hemotherapy bedside biovigilance involving vital sign values and characteristics of patients with suspected transfusion reactions associated with fluid challenges: can some cases of transfusion-associated circulatory overload have proinflammatory aspects?

    abstract:BACKGROUND:Monitoring of patients' vital sign values (VSVs) during hemotherapy may have an important role in the recognition and mitigation of transfusion-associated circulatory overload (TACO). Knowledge regarding VSVs and other patient characteristics in bedside-reported TACO or fluid challenge-suspected transfusion ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03595.x

    authors: Andrzejewski C Jr,Popovsky MA,Stec TC,Provencher J,O'Hearn L,Visintainer P,Steingrub J

    更新日期:2012-11-01 00:00:00

  • Enhanced detection of hepatitis B virus in Hong Kong blood donors after introduction of a more sensitive transcription-mediated amplification assay.

    abstract:BACKGROUND:A total of 517,072 and 399,326 consecutive donations were screened for hepatitis B virus (HBV) by individual-donation nucleic acid testing (ID-NAT) using Ultrio and Ultrio Plus assays (Novartis Diagnostics), respectively. The impact of more sensitive HBV detection by the latter assay version was established ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12165

    authors: Tsoi WC,Lelie N,Lin CK

    更新日期:2013-10-01 00:00:00

  • Genomic coordinates and continental distribution of 120 blood group variants reported by the 1000 Genomes Project.

    abstract:BACKGROUND:The 1000 Genomes Project provides a database of genomic variants from whole genome sequencing of 2504 individuals across five continental superpopulations. This database can enrich our background knowledge of worldwide blood group variant geographic distribution and identify novel variants of potential clini...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14953

    authors: Montemayor-Garcia C,Karagianni P,Stiles DA,Reese EM,Smellie DA,Loy DA,Levy KY,Nwokocha M,Bueno MU,Miller JL,Klein HG

    更新日期:2018-11-01 00:00:00

  • Dynamics of shape recovery by stored red blood cells during washing at the single cell level.

    abstract:BACKGROUND:Hypothermic storage transforms red blood cells (RBC) from smooth biconcave discocytes into increasingly spherical spiculated echinocytes and, ultimately, fragile spherocytes (S). Individual cells undergo this transformation at different rates, producing a heterogeneous mixture of RBCs at all stages of echino...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15979

    authors: Lu M,Shevkoplyas SS

    更新日期:2020-08-04 00:00:00

  • Transfusion support in COVID-19 patients: Impact on hospital blood component supply during the outbreak.

    abstract:BACKGROUND:During the COVID-19 outbreak, most hospitals deferred elective surgical procedures to allow space for the overwhelming number of COVID-19 patient admissions, expecting a decrease in routine blood component requirements. However, because transfusion support needs of COVID-19 patients are not well known, its i...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16171

    authors: Velázquez-Kennedy K,Luna A,Sánchez-Tornero A,Jiménez-Chillón C,Jiménez-Martín A,Vallés Carboneras A,Tenorio M,García García I,López-Jiménez FJ,Moreno-Jiménez G

    更新日期:2020-11-04 00:00:00

  • Four-year survival of transfusion recipients identified by hepatitis C lookback.

    abstract:BACKGROUND:Information on the probability of survival of transfused patients is needed for policy making, but there is a paucity of empirical research into this question. A Swedish population-based study reported that the 40-month posttransfusion probability of survival was 51 percent in all patients and 41 percent in ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00109.x

    authors: Vamvakas EC,Goldstein R

    更新日期:2002-06-01 00:00:00

  • A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions.

    abstract:BACKGROUND:Acetaminophen and diphenhydramine are commonly used as pretransfusion medications to prevent transfusion reactions. The purpose of this study was to prospectively compare the risk of transfusion reactions in hematology/oncology patients who receive acetaminophen with diphenhydramine or placebo before transfu...

    journal_title:Transfusion

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1537-2995.2008.01858.x

    authors: Kennedy LD,Case LD,Hurd DD,Cruz JM,Pomper GJ

    更新日期:2008-11-01 00:00:00