Current challenges for CAR T-cell therapy of acute myeloid leukemia.

Abstract:

:KEY IDEAS Chimeric antigen receptor (CAR) T-cell therapy has the potential to improve the dismal outcome of patients diagnosed with acute myeloid leukemia (AML). A major challenge for CAR T-cell therapy of AML patients is identifying leukemia-specific target antigens. Immune escape through down-regulation of target antigens and/or a suppressive tumor microenvironment jeopardizes the success of CAR T-cell therapy.

journal_name

Transfusion

journal_title

Transfusion

authors

Sauer T,Rooney CM

doi

10.1111/trf.15199

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

1171-1173

issue

4

eissn

0041-1132

issn

1537-2995

journal_volume

59

pub_type

杂志文章,评审
  • Genotyping of RHD by multiplex polymerase chain reaction analysis of six RHD-specific exons.

    abstract:BACKGROUND:Qualitative RHD variants are the result of the replacement of RHD exons by their RHCE counterparts or of point mutations in RHD causing amino acid substitutions. For RHD typing, the use of at least two RHD typing polymerase chain reaction (PCR) assays directed at different regions of RHD is advised to preven...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38111299056309.x

    authors: Maaskant-van Wijk PA,Faas BH,de Ruijter JA,Overbeeke MA,von dem Borne AE,van Rhenen DJ,van der Schoot CE

    更新日期:1998-11-01 00:00:00

  • The effect of hydroxyethyl starch on in vitro platelet and granulocyte function.

    abstract::The effect of hydroxyethyl starch (HES) on granulocyte and platelet functions was assessed. No alteration of granulocyte viability, morphology, phagocytic ability, or bactericidal capacity was detected after incubation with 6 per cent HES at 25 C for two hours. Platelet morphology, size distribution, aggregation, nucl...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1975.15576082223.x

    authors: Schiffer CA,Aisner J,Schmukler M,Whitaker CL,Wolff JH

    更新日期:1975-09-01 00:00:00

  • Inactivation of Japanese encephalitis virus in plasma by methylene blue combined with visible light and in platelet concentrates by ultraviolet C light.

    abstract::Japanese encephalitis virus (JEV) is endemic to tropical areas in Asia and the Western Pacific. It can cause fatal encephalitis, although most infected individuals are asymptomatic. JEV is mainly transmitted to humans through the bite of an infected mosquito, but can also be transmitted through blood transfusion. To m...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16021

    authors: Rustanti L,Hobson-Peters J,Colmant AMG,Hall RA,Young PR,Reichenberg S,Tolksdorf F,Sumian C,Gravemann U,Seltsam A,Marks DC,Faddy HM

    更新日期:2020-11-01 00:00:00

  • Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells.

    abstract:BACKGROUND:The relationship between length of storage of red blood cell (RBC) units and biochemical changes has been well studied, but little is known about the progression of cellular immunomodulative properties in blood recipients. This study aims to quantify in vitro T-cell activation and cytokine release by white b...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02319.x

    authors: Karam O,Tucci M,Toledano BJ,Robitaille N,Cousineau J,Thibault L,Lacroix J,Le Deist F

    更新日期:2009-11-01 00:00:00

  • Barriers to blood donation in African communities in Australia: the role of home and host country culture and experience.

    abstract:BACKGROUND:An influx of African migrants and refugees can strain a host country's blood services, because often migrants have unique blood needs that cannot be sourced from local donors. To increase blood donation by the new migrants, host country blood services need to understand how blood and blood donations are view...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.03053.x

    authors: Polonsky MJ,Renzaho AM,Brijnath B

    更新日期:2011-08-01 00:00:00

  • Red blood cell alloimmunization in transfused patients with bone marrow failure syndromes.

    abstract:BACKGROUND:Red blood cell (RBC) alloimmunization is a concern for patients who receive multiple or chronic transfusions. Alloimmunization prevalence in transfused patients with bone marrow failure syndrome (BMFS) is unknown. This study aimed to determine physician practice for RBC antigen matching, immunization rates, ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13608

    authors: Cohen D,Hartung H,Evans P,Friedman DF,Chou ST

    更新日期:2016-06-01 00:00:00

  • Implementation of a blood irradiation program at a community cancer center.

    abstract:BACKGROUND:Blood component irradiation is an accepted method of preventing transfusion-associated GVHD. Previous publications have largely focused on the technical aspects of the irradiation process itself, but relatively little attention has been paid to the details associated with the implementation of a blood irradi...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41121610.x

    authors: Patton GA,Skowronski MG

    更新日期:2001-12-01 00:00:00

  • Transfusion-associated Serratia marcescens infection: studies of the mechanism of action.

    abstract::The growth of two strains of Serratia marcescens in blood components was tested in this study. One of the strains had been implicated in the epidemic of transfusion-associated sepsis experienced in Denmark and Sweden in 1991. In whole blood with a final concentration of 100 colony-forming units per mL of S. marcescens...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1993.331094054615.x

    authors: Gong J,Högman CF,Hambraeus A,Johansson CS,Eriksson L

    更新日期:1993-10-01 00:00:00

  • Red cell use during cesarean delivery.

    abstract::The transfusion of red cells (RBCs) was analyzed over a 4-year period (1984-1987), during which 9596 cesarean deliveries were performed. A total of 336 patients were identified as receiving RBC transfusions during or after cesarean delivery; 747 units of RBCs were administered. The overall incidence of transfusion in ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1991.31191096177.x

    authors: Camann WR,Datta S

    更新日期:1991-01-01 00:00:00

  • Etoricoxib-induced immune hemolytic anemia: first case presenting acute kidney failure.

    abstract:BACKGROUND:Etoricoxib is a selective inhibitor of cyclooxygenase 2 used mainly to treat osteoarticular pain. Here, we report the case of a patient who developed acute kidney failure and immune hemolytic anemia after the use of etoricoxib. STUDY DESIGN AND METHODS:An 83-year-old female patient developed immune hemolyti...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.15226

    authors: Burgos Pratx L,Santoro D,Coca Mogro B,Valiente VL,Camino P,Scordo W,Salamone H

    更新日期:2019-05-01 00:00:00

  • First transmission of human immunodeficiency virus Type 1 by a cellular blood product after mandatory nucleic acid screening in Germany.

    abstract:BACKGROUND:In February 2007, a 63-year-old man underwent surgery. Retrospective testing with nucleic acid testing (NAT) showed that the patient was human immunodeficiency virus Type 1 (HIV-1) positive 10 days after transfusion. The transfusion-transmitted infection had been identified by a donor-related lookback starte...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02203.x

    authors: Schmidt M,Korn K,Nübling CM,Chudy M,Kress J,Horst HA,Geusendam G,Hennig H,Sireis W,Rabenau HF,Doerr HW,Berger A,Hourfar MK,Gubbe K,Karl A,Fickenscher H,Tischer BK,Babiel R,Seifried E,Gürtler L

    更新日期:2009-09-01 00:00:00

  • Obtaining an accepted Investigational New Drug application to operate an umbilical cord blood bank.

    abstract:BACKGROUND:The residual blood left in the placenta, previously considered a biologic waste, contains sufficient hematopoietic stem and progenitor cells to consistently engraft at least a small recipient. Over the past several years, more than 500 HLA-matched, related and unrelated, allogeneic cord blood transplants hav...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1999.39499235666.x

    authors: Reems JA,Fujita D,Tyler T,Moldwin R,Smith SD

    更新日期:1999-04-01 00:00:00

  • Reducing reactions to blood donation with applied muscle tension: a randomized controlled trial.

    abstract:BACKGROUND:Unpleasant blood donation-related symptoms may discourage otherwise healthy, altruistic individuals from becoming repeat donors. This study examined a behavioral technique called applied muscle tension (AMT) that might reduce reactions. STUDY DESIGN AND METHODS:A total of 605 donors at mobile clinics were a...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1537-2995.2003.00488.x

    authors: Ditto B,France CR,Lavoie P,Roussos M,Adler PS

    更新日期:2003-09-01 00:00:00

  • Collection and immunoselection of CD34+ cells: the impact of age, sex, and diabetes in patients with chronic heart failure.

    abstract:BACKGROUND:Mobilized peripheral blood is the most common source of CD34+ cells intended for transplantations. The collection and enrichment of CD34+ cells could be affected by various factors and there are some controversies regarding the effects of patient-related factors. The aim of this study was to assess the impac...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/trf.13646

    authors: Kresnik PK,Krasna M,Rozman P,Vrtovec B,Malicev E

    更新日期:2016-07-01 00:00:00

  • Managing a tissue recall in a large academic hospital.

    abstract:BACKGROUND:In October 2005, a recall of human tissue for implantation was initiated because one recovery center obtained tissues from donors who were not screened properly for infectious diseases. The Food and Drug Administration (FDA) and Centers for Disease Control (CDC) recommended notifying affected patients and of...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01211.x

    authors: Steelman VM,Schlueter AJ

    更新日期:2007-05-01 00:00:00

  • A large number of mature and functional dendritic cells can be efficiently generated from umbilical cord blood-derived mononuclear cells by a simple two-step culture method.

    abstract:BACKGROUND:Advances in the past two decades in dendritic cell (DC) biology paved the way to exploit them as a promising tool in cancer immunotherapy. The prerequisite for DC vaccine preparations is large-scale in vitro generations of homogeneous, mature, and functional DCs. Frequent improvements are being made in the e...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02706.x

    authors: Balan S,Kale VP,Limaye LS

    更新日期:2010-11-01 00:00:00

  • The impact of e-mail in acquiring and retaining whole-blood donors: a comparative analysis of the Puget Sound Blood Center donor e-mail communication program.

    abstract:BACKGROUND:With the emergence of e-mail as a common form of communication, it is important to understand the role and impact e-mail can have on acquiring and retaining whole-blood donors. STUDY DESIGN AND METHODS:Whole-blood donors who opted in to receive e-mail communications (n = 43,232) from the Puget Sound Blood C...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00642.x

    authors: Geyer ME

    更新日期:2005-12-01 00:00:00

  • Spleen enlargement in healthy donors during G-CSF mobilization of PBPCs.

    abstract:BACKGROUND:Recombinant human G-CSF is widely used to mobilize PBPCs in healthy donors for allogeneic transplantation. There have been concerns about donor safety because of splenic ruptures during G-CSF application. To address this problem, changes in splenic size in 91 healthy donors during G-CSF mobilization of allog...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41020184.x

    authors: Platzbecker U,Prange-Krex G,Bornhäuser M,Koch R,Soucek S,Aikele P,Haack A,Haag C,Schuler U,Berndt A,Rutt C,Ehninger G,Hölig K

    更新日期:2001-02-01 00:00:00

  • Efficacy of single-dose pegfilgrastim after chemotherapy for the mobilization of autologous peripheral blood stem cells in patients with malignant lymphoma or multiple myeloma.

    abstract:BACKGROUND:A single injection of pegfilgrastim has been shown to be equivalent to daily filgrastim in enhancing neutrophil recovery after chemotherapy, whereas the experiences with pegfilgrastim in mobilization of peripheral blood progenitor cells (PBPCs) are limited. STUDY DESIGN AND METHODS:Forty unselected patients...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2006.00911.x

    authors: Kroschinsky F,Hölig K,Platzbecker U,Poppe-Thiede K,Ordemann R,Blechschmidt M,Oelschlaegel U,Schaich M,Hänel M,Bornhäuser M,Ehninger G

    更新日期:2006-08-01 00:00:00

  • Different growth kinetics in blood components and genetic analysis of Lactococcus garvieae isolated from platelet concentrates.

    abstract:BACKGROUND:In 2014, we experienced the first isolation of Lactococcus garvieae from a platelet concentrate (PC). Thereafter, L. garvieae contamination of PCs occurred in two more cases in Japan. It is rare that bacterial contamination with uncommon strains like this species occurs frequently within a short period. Ther...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15836

    authors: Kozakai M,Matsumoto C,Matsumoto M,Takakura A,Matsubayashi K,Satake M

    更新日期:2020-07-01 00:00:00

  • Trend in ABO-incompatible RBC transfusion-related fatalities reported to the FDA, 2000-2019.

    abstract:BACKGROUND:ABO-incompatible red blood cell (RBC) transfusions and acute hemolytic reactions occur infrequently, yet resultant fatalities are reported to the US Food and Drug Administration (FDA) every year. We describe a 20-year retrospective study of reported mistransfusion cases to identify temporal trends, common ca...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16121

    authors: Storch EK,Rogerson B,Eder AF

    更新日期:2020-12-01 00:00:00

  • The value of 10-minute posttransfusion platelet counts.

    abstract::Monitoring of platelet counts 1 hour after transfusion has become standard practice in most centers. In this study, platelet counts obtained 10 and 60 minutes after 48 platelet transfusions were compared. There was a close, linear relationship (r = 0.98) between these values over a wide range of posttransfusion counts...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28188127957.x

    authors: O'Connell B,Lee EJ,Schiffer CA

    更新日期:1988-01-01 00:00:00

  • A statistical model for estimating donor postdonation platelet counts after plateletpheresis.

    abstract:BACKGROUND:To avoid the need, in serial apheresis donors, either to delay plateletpheresis until a predonation platelet count is completed or to obtain a postdonation count after each procedure, a statistical model has been developed to predict the postdonation platelet count from the donor predonation platelet count, ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1994.34194098605.x

    authors: Cabezudo I,Winegarden DK,Randels MJ,Strauss RG

    更新日期:1994-01-01 00:00:00

  • Large scale preparation of leukocyte concentrates and further purification of lymphocytes and granulocytes with the IBM 2991 cell processor.

    abstract::A procedure is described for the large-scale production of pure suspensions of human lymphocytes and granulocytes. Platelet-poor buffy-coats, obtained by centrifugation of six units of ABO-compatible ACD blood, were pooled and centrifuged again, resulting in a crude leukocyte concentrate containing approximately 60 pe...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1977.17578014593.x

    authors: de la Rivière AB,Verhoef-Karssen PR,de Wit JJ,Loos JA,Prins HK

    更新日期:1977-09-01 00:00:00

  • Plasma ectonucleotidases prevent desensitization of purinergic receptors in stored platelets: importance for platelet activity during thrombus formation.

    abstract:BACKGROUND:Platelets (PLTs) contain purinergic receptors for ATP (P2X1) and ADP (P2Y1 and P2Y12) that rapidly desensitize upon stimulation with these nucleotides. In vivo, this is antagonized by ectonucleotidases on the surface of endothelial cells and white blood cells (WBCs). The receptor desensitization of ATP- and ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00837.x

    authors: Cauwenberghs S,Feijge MA,Hageman G,Hoylaerts M,Akkerman JW,Curvers J,Heemskerk JW

    更新日期:2006-06-01 00:00:00

  • Blood supply safety in Afghanistan: a national assessment of high-volume facilities.

    abstract:BACKGROUND:Little information is available regarding blood supply safety in Afghanistan. The purpose of this study was to assess blood safety through serologic and observational measures in Afghanistan. STUDY DESIGN AND METHODS:This cross-sectional assessment included the 40 highest-volume facilities collecting and tr...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12005

    authors: Mansoor GF,Rahmani AM,Kakar MA,Hashimy P,Abrahimi P,Scott PT,Peel SA,Rentas FJ,Todd CS

    更新日期:2013-09-01 00:00:00

  • In vivo red cell destruction by anti-Lu6.

    abstract::An example is presented of an IgG1, anti-Lu6, that reacted by indirect antiglobulin test and was capable of destroying antigen-positive red cells in vivo. Two methods for the measurement of red cell survival, 51Cr labeling and flow cytometry, gave the same result: 20 percent of the test dose of Lu:6 red cells was dest...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30390194349.x

    authors: Issitt PD,Valinsky JE,Marsh WL,DiNapoli J,Gutgsell NS

    更新日期:1990-03-01 00:00:00

  • Molecular analysis of inactive and active RHD alleles in native Congolese cohorts.

    abstract:BACKGROUND:In Africa, RHD alleles have not been fully characterized. The purpose of this study was to identify inactive and active RHD alleles at the molecular level in Congolese cohorts. STUDY DESIGN AND METHODS:Blood samples were collected from people living in central Congo populated by Teke ethnic group. A total o...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02161.x

    authors: Touinssi M,Chapel-Fernandes S,Granier T,Bokilo A,Bailly P,Chiaroni J

    更新日期:2009-07-01 00:00:00

  • Hematology patterns after hemoglobin-based oxygen carrier resuscitation from severe controlled hemorrhage with prolonged delayed definitive care.

    abstract:BACKGROUND:The hemoglobin-based oxygen carrier (HBOC-201) resuscitation fluid improves outcome in hemorrhagic shock swine models with minimal coagulopathy. Herein, coagulation parameters were evaluated after resuscitation with HBOC-201 after severe bleeding and prolonged delay to definitive care. STUDY DESIGN AND METH...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01435.x

    authors: Arnaud F,Fasipe D,Philbin N,Rice J,Flournoy WS,Ahlers S,McCarron R,Freilich D

    更新日期:2007-11-01 00:00:00

  • Erythrocytapheresis for chronic transfusion therapy in sickle cell disease: survey of current practices and review of the literature.

    abstract:BACKGROUND:Chronic red blood cell (RBC) transfusion therapy (CTT) is an integral component of the management of severe sickle cell disease (SCD) and can prevent complications, such as stroke. RBC units can be administered via simple transfusion or exchange transfusion, and erythrocytapheresis (automated RBC exchange tr...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.13800

    authors: Kelly S,Quirolo K,Marsh A,Neumayr L,Garcia A,Custer B

    更新日期:2016-11-01 00:00:00