Abstract:
:KEY IDEAS Chimeric antigen receptor (CAR) T-cell therapy has the potential to improve the dismal outcome of patients diagnosed with acute myeloid leukemia (AML). A major challenge for CAR T-cell therapy of AML patients is identifying leukemia-specific target antigens. Immune escape through down-regulation of target antigens and/or a suppressive tumor microenvironment jeopardizes the success of CAR T-cell therapy.
journal_name
Transfusionjournal_title
Transfusionauthors
Sauer T,Rooney CMdoi
10.1111/trf.15199subject
Has Abstractpub_date
2019-04-01 00:00:00pages
1171-1173issue
4eissn
0041-1132issn
1537-2995journal_volume
59pub_type
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