当前位置： SCI文献检索 > MAGNETIC RESONANCE IMAGING期刊下所有文献 > AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging.

AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging.

Abstract：

:Dynamic contrast-enhanced MRI (DCE-MRI) was used to noninvasively evaluate the effects of AG-03736, a novel inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases, on tumor microvasculature in a breast cancer model. First, a dose response study was undertaken to determine the responsiveness of the BT474 human breast cancer xenograft to AG-013736. Then, DCE-MRI was used to study the effects of a 7-day treatment regimen on tumor growth and microvasculature. Two DCE-MRI protocols were evaluated: (1) a high molecular weight (MW) contrast agent (albumin-(GdDTPA)(30)) with pharmacokinetic analysis of the contrast uptake curve and (2) a low MW contrast agent (GdDTPA) with a clinically utilized empirical parametric analysis of the contrast uptake curve, the signal enhancement ratio (SER). AG-013736 significantly inhibited growth of breast tumors in vivo at all doses studied (10-100 mg/kg) and disrupted tumor microvasculature as assessed by DCE-MRI. Tumor endothelial transfer constant (K(ps)) measured with albumin-(GdDTPA)(30) decreased from 0.034+/-0.005 to 0.003+/-0.001 ml min(-1) 100 ml(-1) tissue (P<.0022) posttreatment. No treatment-related change in tumor fractional plasma volume (fPV) was detected. Similarly, in the group of mice studied with GdDTPA DCE-MRI, AG-013736-induced decreases in tumor SER measures were observed. Additionally, our data suggest that 3D MRI-based volume measurements are more sensitive than caliper measurements for detecting small changes in tumor volume. Histological staining revealed decreases in tumor cellularity and microvessel density with treatment. These data demonstrate that both high and low MW DCE-MRI protocols can detect AG-013736-induced changes in tumor microvasculature. Furthermore, the correlative relationship between microvasculature changes and tumor growth inhibition supports DCE-MRI methods as a biomarker of VEGF receptor target inhibition with potential clinical utility.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Wilmes LJ,Pallavicini MG,Fleming LM,Gibbs J,Wang D,Li KL,Partridge SC,Henry RG,Shalinsky DR,Hu-Lowe D,Park JW,McShane TM,Lu Y,Brasch RC,Hylton NM

doi

10.1016/j.mri.2006.09.041

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

319-27

issue

3

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(06)00307-9

journal_volume

25

pub_type

杂志文章

相关文献

MAGNETIC RESONANCE IMAGING文献大全
  • Magnetization transfer and T2 quantitation in normal appearing cortical gray matter and white matter adjacent to focal abnormality in patients with traumatic brain injury.

    abstract：:Traumatic brain injury (TBI) is one of the commonest causes of morbidity and mortality in the developed countries with posttraumatic epilepsy and functional disability being its major sequelae. The purpose of this study was to test the hypothesis whether the normal appearing adjacent gray and white matter regions on T...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(03)00189-9

    authors： Kumar R,Gupta RK,Rao SB,Chawla S,Husain M,Rathore RK

    更新日期：2003-10-01 00:00:00

  • A data augmentation approach to train fully convolutional networks for left ventricle segmentation.

    abstract：:Left ventricle (LV) segmentation plays an important role in the diagnosis of cardiovascular diseases. The cardiac contractile function can be quantified by measuring the segmentation results of LVs. Fully convolutional networks (FCNs) have been proven to be able to segment images. However, a large number of annotated ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2019.08.004

    authors： Lin A,Wu J,Yang X

    更新日期：2020-02-01 00:00:00

  • A non-invasive technique for 3-dimensional assessment of articular cartilage thickness based on MRI. Part 1: Development of a computational method.

    abstract：:Articular cartilage thickness is of relevance in various fields in diagnostics and biomedical research. In view of recent improvements of MR cartilage imaging a computational method has been developed for three-dimensional determination of cartilage thickness from tomographic datasets. A correction algorithm that comp...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(97)00012-x

    authors： Lösch A,Eckstein F,Haubner M,Englmeier KH

    更新日期：1997-01-01 00:00:00

  • Three-dimensional magnetic resonance spectroscopic imaging of histologically confirmed brain tumors.

    abstract：:The goal of this study was to determine whether presurgical metabolite levels measured by 3D MR Spectroscopic Imaging (MRSI) can accurately detect viable cancer within human brain tumor masses. A total of 31 patients (33 exams, 39 pathology correlations) with brain tumors were studied prior to surgical biopsy and/or r...

    journal_title：Magnetic resonance imaging

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0730-725x(01)00225-9

    authors： Vigneron D,Bollen A,McDermott M,Wald L,Day M,Moyher-Noworolski S,Henry R,Chang S,Berger M,Dillon W,Nelson S

    更新日期：2001-01-01 00:00:00

  • Comparison of different methods for combining phase-contrast images obtained with multiple coils.

    abstract：:The ability to determine coil sensitivities implies that a method optimized in terms of maximized signal-to-noise ratio (SNR) can be applied to the combination of multiple coil images. An optimization of SNR subsequently results in a minimized variance in quantitative velocity measurements using phase-contrast imaging...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2005.06.002

    authors： Thunberg P,Karlsson M,Wigström L

    更新日期：2005-09-01 00:00:00

  • Balanced multi-image demons for non-rigid registration of magnetic resonance images.

    abstract：:A new approach is introduced for non-rigid registration of a pair of magnetic resonance images (MRI). It is a generalization of the demons algorithm with low computational cost, based on local information augmentation (by integrating multiple images) and balanced implementation. Specifically, a single deformation that...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2020.09.013

    authors： Mesin L

    更新日期：2020-12-01 00:00:00

  • Predictability of SNR and reader preference in clinical MR imaging.

    abstract：:Fifty-four independent scans were performed in two volunteers covering one anatomic region in each (the brain and knee) with the purpose of ascertaining the agreement between predicted and measured signal-to-noise ratios (SNR). Systematically varied parameters were number of excitations (NEX), field of view (FOV), sec...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(90)90009-q

    authors： Owen RS,Wehrli FW

    更新日期：1990-01-01 00:00:00

  • Investigation of molecular order and dynamics in liquid crystals confined in porous media using the dipolar-correlation effect on the stimulated echo.

    abstract：:A new application of the stimulated echo pulse sequence is presented that permits the elucidation of molecular order and dynamics in a time scale between about 100 microseconds and the spin-lattice relaxation time. The technique exploits the influence of dipolar coupling on the quotient of the stimulated and primary e...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(96)00172-5

    authors： Grinberg F,Kimmich R,Stapf S

    更新日期：1996-01-01 00:00:00

  • Transdermal water mobility in the presence of electrical fields using MR microscopy.

    abstract：:Magnetic resonance microscopy of skin from hairless rats under the influence of electrical fields was conducted for two cases: 1) low voltage constant electrical fields and 2) high-voltage short pulse, electrical fields. Under conditions of the low voltage and low current iontophoresis, i.e., 0 to 20 V, and 0 to 0.5 m...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(99)00067-3

    authors： Caban JB,Moerland TS,Gibbs SJ,McFadden L,Locke BR

    更新日期：1999-10-01 00:00:00

  • Study on the variations of the apparent diffusion coefficient in areas of solid tumor in high grade gliomas.

    abstract：:Present knowledge suggests that in glioblastoma multiforme the value of the apparent diffusion coefficient (ADC) is elevated in the solid part and hyperintense in T1, in spite of the elevated cellularity, and also in areas where peritumoral vasogenic edema is present. The purpose of our study has been to verify in viv...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(02)00594-5

    authors： Muti M,Aprile I,Principi M,Italiani M,Guiducci A,Giulianelli G,Ottaviano P

    更新日期：2002-11-01 00:00:00

  • The effects of changing water content, relaxation times, and tissue contrast on tissue segmentation and measures of cortical anatomy in MR images.

    abstract：:Water content is the dominant chemical compound in the brain and it is the primary determinant of tissue contrast in magnetic resonance (MR) images. Water content varies greatly between individuals, and it changes dramatically over time from birth through senescence of the human life span. We hypothesize that the effe...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2013.07.017

    authors： Bansal R,Hao X,Liu F,Xu D,Liu J,Peterson BS

    更新日期：2013-12-01 00:00:00

  • In vivo measurement of diffusion and pseudo-diffusion in skeletal muscle at rest and after exercise.

    abstract：:To investigate whether diffusion-related compartmentalization could be observed in skeletal muscle and whether this compartmentalization was affected by exercising, attenuation curves of signal against diffusion weighting were obtained in skeletal muscle of nine healthy volunteers at rest and after an exercise. Fiftee...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(94)00096-l

    authors： Morvan D

    更新日期：1995-01-01 00:00:00

  • Assessment of the anomalous pulmonary circulation by dynamic contrast-enhanced MR angiography in under four seconds.

    abstract：:The purpose of this study was to demonstrate the initial results of the dynamic contrast-enhanced MRA in under four seconds in the assessment of anomalous pulmonary circulation. We performed dynamic contrast enhanced MRA on ten patients with a temporal resolution of 2-3 sec for each phase. Five patients had pulmonary ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(02)00634-3

    authors： Balci NC,Yalçin Y,Tunaci A,Balci Y

    更新日期：2003-01-01 00:00:00

  • A highly accurate symmetric optical flow based high-dimensional nonlinear spatial normalization of brain images.

    abstract：:Spatial normalization plays a key role in voxel-based analyses of brain images. We propose a highly accurate algorithm for high-dimensional spatial normalization of brain images based on the technique of symmetric optical flow. We first construct a three dimension optical model with the consistency assumption of inten...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2015.01.013

    authors： Wen Y,Hou L,He L,Peterson BS,Xu D

    更新日期：2015-05-01 00:00:00

  • Perfusion imaging by un-inverted flow-sensitive alternating inversion recovery (UNFAIR).

    abstract：:A new pulse sequence for estimating cerebral blood flow called UNFAIR, which uses a combination of sequential hyperbolic secant preparatory pulses, is introduced. This sequence is based on the same generalized conditions as previously introduced inversion recovery techniques except that the spins in the image slice of...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(96)00353-0

    authors： Helpern JA,Branch CA,Yongbi MN,Huang NC

    更新日期：1997-01-01 00:00:00

  • Test-retest reliability of cerebral blood flow in healthy individuals using arterial spin labeling: Findings from the EMBARC study.

    abstract：INTRODUCTION:Previous investigations of test-retest reliability of cerebral blood flow (CBF) at rest measured with pseudo-continuous Arterial Spin Labeling (pCASL) demonstrated good reliability, but are limited by the use of similar scanner platforms. In the present study we examined test-retest reliability of CBF in r...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2017.09.004

    authors： Almeida JRC,Greenberg T,Lu H,Chase HW,Fournier JC,Cooper CM,Deckersbach T,Adams P,Carmody T,Fava M,Kurian B,McGrath PJ,McInnis MG,Oquendo MA,Parsey R,Weissman M,Trivedi M,Phillips ML

    更新日期：2018-01-01 00:00:00

  • Trajectory correction for free-breathing radial cine MRI.

    abstract：:Radial acquisitions can suffer from trajectory errors leading to reduced image quality. Here we present a new method of trajectory correction that uses all spokes of a radial acquisition and compare it to an existing method that uses a two-spoke pre-scan calibration. For both methods, estimates of the necessary shifts...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2014.04.006

    authors： Buonincontri G,Methner C,Krieg T,Carpenter TA,Sawiak SJ

    更新日期：2014-09-01 00:00:00

  • Compensation of susceptibility-induced signal loss in echo-planar imaging for functional applications.

    abstract：:Functional magnetic resonance imaging favors the use of multi-slice gradient-recalled echo-planar imaging due to its short image acquisition times, whole brain coverage and sensitivity to BOLD contrast. However, despite its advantages, gradient-recalled echo-planar imaging also is sensitive to static magnetic field gr...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(00)00199-5

    authors： Cordes D,Turski PA,Sorenson JA

    更新日期：2000-11-01 00:00:00

  • Lesion load measurements in multiple sclerosis: the effect of incorporating magnetization transfer contrast in fast-FLAIR sequence.

    abstract：:We compared the ability and reproducibility of a fast fluid-attenuated inversion recovery (fast-FLAIR) sequence with and without a magnetization transfer (MT) pulse for detecting and measuring multiple sclerosis (MS)-related abnormalities on magnetic resonance imaging (MRI) scans from 20 patients. The Contrast-to-Nois...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(98)00182-9

    authors： Filippi M,Rocca MA,Mastronardo G,Comi G

    更新日期：1999-04-01 00:00:00

  • Effect of vasodilator hydralazine on tumor microvascular random flow and blood volume as measured by intravoxel incoherent motion (IVIM) weighted MRI in conjunction with Gd-DTPA-Albumin enhanced MRI.

    abstract：:We studied the effect of hydralazine on tumor blood volume fraction and microvascular random flow velocity magnitude by IVIM weighted MRI in conjunction with dynamic Gd-DTPA-Albumin enhanced MRI. Blood volume fraction maps were obtained from the dynamic Gd-DTPA-Albumin enhanced MRI measurements. The average blood volu...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(01)00431-3

    authors： Wang Z,Su MY,Najafi A,Nalcioglu O

    更新日期：2001-10-01 00:00:00

  • Paradoxical parasellar high signals resembling shunt diseases on routine 3D time-of-flight MR angiography of the brain: mechanism for the signals and differential diagnosis from shunt diseases.

    abstract：BACKGROUND AND PURPOSE:We occasionally encounter phenomena in which venous flow signals of the cavernous sinus (CS) and/or inferior petrosal sinus (IPS) are visualized paradoxically in patients without arteriovenous shunt in 3D time-of-flight magnetic resonance angiography (3D-TOF MRA) of the brain. The aims of this st...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2004.08.004

    authors： Sakamoto M,Taoka T,Iwasaki S,Nakagawa H,Fukusumi A,Takayama K,Wada T,Kichikawa K

    更新日期：2004-11-01 00:00:00

  • Magnetic resonance T2* measurements of the normal human lung in vivo with ultra-short echo times.

    abstract：:The objective of this study was to measure T2* values of the normal human lung in vivo during breathhold using a rapid gradient-echo sequence with ultra-short echo times (TE). A sagittal slice of the right lung was imaged in six volunteers with various TE ranging from 0.5 ms to 5 ms using a clinical 1.5 Tesla MR scann...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(99)00047-8

    authors： Stock KW,Chen Q,Hatabu H,Edelman RR

    更新日期：1999-09-01 00:00:00

  • The lever-coil: a simple, inexpensive sensor for respiratory and cardiac motion in MRI experiments.

    abstract：:Thoracic and abdominal magnetic resonance imaging studies generally require some type of compensation for respiratory and cardiac motions in order to yield artifact-free images with good signal-to-noise ratio. Most techniques for respiratory compensation require the use of a non-NMR sensing device to monitor the subje...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(01)00403-9

    authors： Fishbein KW,McConville P,Spencer RG

    更新日期：2001-07-01 00:00:00

  • Dual-acquisition phase-sensitive fat-water separation using balanced steady-state free precession.

    abstract：:Balanced steady-state free precession (SSFP) sequences use fully re-focussed gradient waveforms to achieve a high signal and useful image contrast in short scan times. Despite these strengths, the clinical feasibility of balanced SSFP is still limited both by bright fat signal and by the signal voids that result from ...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2005.10.013

    authors： Hargreaves BA,Bangerter NK,Shimakawa A,Vasanawala SS,Brittain JH,Nishimura DG

    更新日期：2006-02-01 00:00:00

  • A novel in silico platform for a fully automatic personalized brain tumor growth.

    abstract：:Glioblastoma Multiforme is the most common and most aggressive type of brain tumors. Although accurate prediction of Glioblastoma borders and shape is absolutely essential for neurosurgeons, there are not many in silico platforms that can make such predictions. In the current study, an automatic patient-specific simul...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2019.12.012

    authors： Hajishamsaei M,Pishevar A,Bavi O,Soltani M

    更新日期：2020-05-01 00:00:00

  • esfMRI of the upper STS: further evidence for the lack of electrically induced polysynaptic propagation of activity in the neocortex.

    abstract：:Combining electrical stimulation with fMRI (esfMRI) has proven to be an important tool to study the global effects of electrical stimulation on neural networks in the brain. Here we extend our previous studies to stimulating the upper superior temporal sulcus (STS) in the anesthetized monkey. Our results show that sti...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2011.04.005

    authors： Sultan F,Augath M,Murayama Y,Tolias AS,Logothetis N

    更新日期：2011-12-01 00:00:00

  • Dielectric resonances and B(1) field inhomogeneity in UHFMRI: computational analysis and experimental findings.

    abstract：:B(1) Field inhomogeneity and the relative effects of dielectric resonances are analyzed within the context of ultra high field MRI. This is accomplished by calculating the electromagnetic fields inside spherical phantoms and within a human head model in the presence and absence of an RF coil. These calculations are th...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(01)00300-9

    authors： Ibrahim TS,Lee R,Abduljalil AM,Baertlein BA,Robitaille PM

    更新日期：2001-02-01 00:00:00

  • Management of branch-duct intraductal papillary mucinous neoplasms of the pancreas: observation with MR imaging.

    abstract：PURPOSE:To evaluate the clinical outcomes of conservative management by observation with MRI of patients with branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs). MATERIALS AND METHODS:Twenty-three consecutive patients, who were followed up by MRI with magnetic resonance cholangiopancreatography (MRCP) ove...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/j.mri.2010.06.026

    authors： Shin SS,Armao DM,Shah M,Kim YH,Lee CH,Rubinas T,Brubaker LM,Semelka RC

    更新日期：2010-12-01 00:00:00

  • Relationship between cancellous bone induced magnetic field and ultrastructure in a rat ovariectomy model.

    abstract：:The site-dependent variations in trabecular bone morphology were studied in the rat tibia by magnitude and phase difference three-dimensional nuclear magnetic resonance microscopy and image processing, and the implications of ovariectomy were evaluated. Specimens excised from the proximal tibial metaphysis in ovariect...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/s0730-725x(99)00107-1

    authors： Takahashi M,Wehrli FW,Hwang SN,Wehrli SL

    更新日期：2000-01-01 00:00:00

  • Fast T2-mapping with snapshot flash imaging.

    abstract：:It has been shown recently that quantitative T2-maps may be measured by acquisition of a series of at least eight T2-weighted SNAPSHOT FLASH images. These measurements require a relaxation delay of 10-15 s after each T2-weighted image for the complete relaxation of the spin system. This results in long measuring times...

    journal_title：Magnetic resonance imaging

    pub_type： 杂志文章

    doi：10.1016/0730-725x(95)00004-z

    authors： Deichmann R,Adolf H,Nöth U,Morrissey S,Schwarzbauer C,Haase A

    更新日期：1995-01-01 00:00:00