Effect of alpha 1-proteinase inhibitor and sulphated polysaccharides on the activity of m beta-acrosin.

abstract：:The addition of the chemotactic factor fMet-Leu-Phe to cell homogenates causes a decrease in the pertussis toxin catalyzed ADP-ribosylation of a 41 kDa protein. The fMet-Leu-Phe induced decrease is not abolished in homogenates prepared from phorbol 12-myristate 13-acetate treated neutrophils. This decreased ribosylati...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto T,Molski TF,Kanaho Y,Becker EL,Sha'afi RI

更新日期：1987-03-13 00:00:00

abstract：:The developing and the adult brain respond in similar ways to ischemia, but also display clear differences. For example, the relative contributions of necrosis and apoptosis to neuronal death may be different, such that apoptotic mechanisms would be more prevalent in the developing brain. During normal development, mo...

journal_title：Biochemical and biophysical research communications

authors： Blomgren K,Zhu C,Hallin U,Hagberg H

更新日期：2003-05-09 00:00:00

abstract：:Dystroglycan has recently been characterized in blood tissue cells, as part of the dystrophin glycoprotein complex but to date nothing is known of its role in the differentiation process of neutrophils. We have investigated the role of dystroglycan in the human promyelocytic leukemic cell line HL-60 differentiated to ...

journal_title：Biochemical and biophysical research communications

authors： Martínez-Zárate AD,Martínez-Vieyra I,Alonso-Rangel L,Cisneros B,Winder SJ,Cerecedo D

更新日期：2014-06-06 00:00:00

abstract：:Pancreatic carcinoma is characterized by a poor prognosis and lack of response to conventional therapy. The regulatory mechanisms for the rapid proliferation of pancreatic cancer cells and the particular aggressiveness of this cancer are still not fully understood. In mammalian cells, three MAPK families including ERK...

journal_title：Biochemical and biophysical research communications

authors： Ding XZ,Adrian TE

更新日期：2001-03-30 00:00:00

abstract：:Tyrosine kinase inhibitors (TKIs) exert potent therapeutic efficacy in non-small cell lung cancers (NSCLC) harboring epidermal growth factor receptor (EGFR) activating mutations. However, a major impediment for the effective treatment is the development of drug resistance. Some evidence supports a role for miRNAs in m...

journal_title：Biochemical and biophysical research communications

authors： Ping W,Gao Y,Fan X,Li W,Deng Y,Fu X

更新日期：2018-01-22 00:00:00

abstract：:The effect of eicosapentaenoic acid (EPA) on natural killer (NK) cell activity of human lymphocytes was examined. The addition of an emulsion of trieicosapentaenoyl-glycerol (EPA-TG) emulsified with purified phosphatidylcholine from krill to a cytotoxicity assay system resulted in a marked depression of NK activity. T...

journal_title：Biochemical and biophysical research communications

authors： Yamashita N,Yokoyama A,Hamazaki T,Yano S

更新日期：1986-08-14 00:00:00

abstract：:Six healthy subjects were given endothelin-1, intravenously in a dose of 4 pmol.kg-1.min-1 for 20 min. Blood samples were drawn from arterial, hepatic and renal vein catheters for determinations of splanchnic and renal blood flows and the extraction of endothelin-1 in these vascular beds. Intravenous infusion of endot...

journal_title：Biochemical and biophysical research communications

authors： Weitzberg E,Ahlborg G,Lundberg JM

更新日期：1991-11-14 00:00:00

abstract：:Isolated rat hepatocytes took up [3H]-aflatoxin B1 during incubation with fifty percent of the aflatoxin B1 covalantly bound to cellular macromolecules. The amount of bound-aflatoxin B1 was proportional to the medium concentration of aflatoxin B1. The specific radioactivity (pmole/mg) of aflatoxin B1 found in the DNA ...

journal_title：Biochemical and biophysical research communications

authors： Ch'ih JJ,Lin T,Devlin TM

更新日期：1983-01-27 00:00:00

abstract：:Osteoblasts mediate much of the hormonal responsiveness of osteoclasts. We and others have found that one mechanism through which this regulation is effected is by release of osteoclast resorption-stimulating activity (ORSA) into culture supernatants. However, although hormonal responsiveness is regularly observed in ...

journal_title：Biochemical and biophysical research communications

authors： Fuller K,Gallagher AC,Chambers TJ

更新日期：1991-11-27 00:00:00

abstract：:SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangol...

journal_title：Biochemical and biophysical research communications

authors： Luan J,Lu Y,Jin X,Zhang L

更新日期：2020-05-21 00:00:00

abstract：:Glucocorticoids are used as a treatment for a variety of conditions and hypertension is a well-recognized side effect of their use. The mechanism of glucocorticoid-induced hypertension is incompletely understood and has traditionally been attributed to promiscuous activation of the mineralocorticoid receptor by cortis...

journal_title：Biochemical and biophysical research communications

authors： Goodwin JE,Zhang J,Velazquez H,Geller DS

更新日期：2010-04-02 00:00:00

abstract：:To investigate pathophysiological roles of endothelin-1 (ET-1) in collagen remodeling in pulmonary hypertension, we measured: (a) mRNA expression, concentration, localization of ET-1; (b) changes in types and content of collagen in the lung; (c) and confirmed direct effects of ET-1 on type V collagen metabolism in vas...

journal_title：Biochemical and biophysical research communications

authors： Mansoor AM,Honda M,Saida K,Ishinaga Y,Kuramochi T,Maeda A,Takabatake T,Mitsui Y

更新日期：1995-10-24 00:00:00

abstract：:Carbon monoxide (CO) and nitric oxide (NO) are two gas molecules which have cytoprotective functions against oxidative stress and inflammatory responses in many cell types. Currently, it is known that NO produced by nitric oxide synthase (NOS) induces heme oxygenase 1 (HO1) expression and CO produced by the HO1 inhibi...

journal_title：Biochemical and biophysical research communications

authors： Lee BS,Heo J,Kim YM,Shim SM,Pae HO,Kim YM,Chung HT

更新日期：2006-05-12 00:00:00

abstract：:Full activation of different T cell populations via the TcR/CD3 complex leads to transient expression of lymphokine mRNA and to transient and specific down-modulation of TcR, CD4, CD8 and p56lck mRNA (Multi-Receptor Complex or MRC mRNA). This transient down-modulation is due to both a decrease in transcription and sta...

journal_title：Biochemical and biophysical research communications

authors： Paillard F,Sterkers G,Vaquero C

更新日期：1992-07-31 00:00:00

abstract：:Hepatocytes from human bone marrow-derived mesenchymal stem cells (hBM-MSCs) are expected to be a useful source for cell transplantation. However, relatively low efficiency and repeatability of hepatic differentiation of human BM-MSCs remains an obstacle for clinical translation. Hepatocyte nuclear factor 4 alpha (HNF...

journal_title：Biochemical and biophysical research communications

authors： Hu X,Xie P,Li W,Li Z,Shan H

更新日期：2016-09-16 00:00:00

abstract：:BRCA1-associated protein 1 (BAP1) has been implicated in diverse biological functions, including tumor suppression. However, its regulation via glycosylation and its role in embryonic stem (ES) cells are poorly defined. BAP1 was recently reported to interact with O-linked N-acetylglucosamine (O-GlcNAc) transferase (OG...

journal_title：Biochemical and biophysical research communications

authors： Moon S,Lee YK,Lee SW,Um SJ

更新日期：2017-10-07 00:00:00

abstract：:Isolation of pure acinar cells of the rat pancreas was achieved employing counterflow sedimentation filtration technique (CSFT). The preparation of purified acinar cells contained an occasional red blood cell (RBC, 200:1) with total absence of endocrine and duct cells. A significant stimulation of amylase secretion fr...

journal_title：Biochemical and biophysical research communications

authors： Bandisode MS,Singh M

更新日期：1985-05-31 00:00:00

abstract：:The Ca(2+)-binding S100A1 protein displays a specific and high expression level in the human myocardium and is considered to be an important regulator of heart contractility. Diminished protein levels detected in dilated cardiomyopathy possibly contribute to impaired Ca(2+) handling and contractility in heart failure....

journal_title：Biochemical and biophysical research communications

authors： Kiewitz R,Acklin C,Schäfer BW,Maco B,Uhrík B,Wuytack F,Erne P,Heizmann CW

更新日期：2003-06-27 00:00:00

abstract：:A 24h pretreatment of the human hepatoma cell line HepG2 with dibutyryl cyclic AMP in the presence of theophylline induced a dose dependent decrease in low density lipoprotein binding, uptake and degradation. This effect is most likely due to a reduction of the LDL receptor number. Sterol synthesis from sodium acetate...

journal_title：Biochemical and biophysical research communications

authors： Maziere C,Maziere JC,Salmon S,Auclair M,Mora L,Moreau M,Polonovski J

更新日期：1988-10-14 00:00:00

abstract：:Galanin is a neuroendocrine peptide that modulates many different normal physiological effects including memory, weight, and pain perception. To better understand galanin receptor function, we cloned and characterized the galanin-1 receptor (GALN1R) gene isolated from a human P1 library. We determined that this gene c...

journal_title：Biochemical and biophysical research communications

authors： Lorimer DD,Matkowskj K,Benya RV

更新日期：1997-12-18 00:00:00

abstract：:Cytokines represent a multi-diverse family of polypeptide regulators; they are of relatively low molecular weight, pharmacologically active proteins that are secreted by one cell for the purpose of altering either its own functions (autocrine effect) or those of adjacent cells (paracrine effect). Cytokines are small, ...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2002-10-04 00:00:00

abstract：:In order to evaluate the receptor subtypes of arginine vasopressin (AVP) in early proximal tubule (S1), outer medullary thick ascending limb of Henle's loop (MTAL) and collecting tubule (OMCT), the effect of AVP on intracellular free calcium ([Ca++]i) was determined using the fluorescence indicator Fura-2. Physiologic...

journal_title：Biochemical and biophysical research communications

authors： Jung KY,Endou H

更新日期：1991-10-15 00:00:00

abstract：:The cis-acting element of the granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter, CLE0, is required for stimulation dependent expression of the GM-CSF gene by phorbol ester (PMA) and calcium ionophore (A23187) in T cells. We recently obtained evidence that NF-CLE0 gamma, one of the CLE0-binding factors...

journal_title：Biochemical and biophysical research communications

authors： Tokumitsu H,Masuda ES,Tsuboi A,Arai K,Arai N

更新日期：1993-10-29 00:00:00

abstract：:Lateral diffusion coefficients (D) of two surface differentiation antigens (sIgM and Bp35) were determined on interferon-sensitive (-IFs) or resistant (-IFr) Daudi cells by fluorescence photobleaching, using monospecific FITC-anti-IgM or PE-anti-Leu 16 probes. For untreated Daudi -IFs, mean (D) were 5.8 and 5.3 (x10(-...

journal_title：Biochemical and biophysical research communications

authors： Balint E,Aszalos A,Grimley PM

更新日期：1988-12-15 00:00:00

abstract：:A soluble protein that binds malonyl-CoA without requiring cofactors has been purified from rat liver. Until saturated, it competes with fatty acid synthetase for free malonyl-CoA, temporarily reducing the rate of fatty acid synthesis at low levels of malonyl-CoA, as in fatty acid synthetase--coupled assays for acetyl...

journal_title：Biochemical and biophysical research communications

authors： Dugan RE,Osterlund BR,Drong RF,Swenson TL

更新日期：1987-08-31 00:00:00

abstract：:Barnacles are notorious marine fouling organisms. Their successful attachment to a substrate requires that they search for an appropriate habitat during their cyprid stage. A chemical cue called SIPC (Settlement-Inducing Protein Complex) has been shown to play a key role in the induction of cyprid gregarious settlemen...

journal_title：Biochemical and biophysical research communications

authors： Zhang X,Liang C,Song J,Ye Z,Wu W,Hu B

更新日期：2020-05-14 00:00:00

abstract：:The marked impairment of hepatic drug metabolism during inflammation and infections has been known for many years and shown to result from down-regulation of cytochrome P450s (CYP) by cytokines. However, the mechanism of this repression is unknown. Using primary cultures of human hepatocytes, we show here that interle...

journal_title：Biochemical and biophysical research communications

authors： Pascussi JM,Gerbal-Chaloin S,Pichard-Garcia L,Daujat M,Fabre JM,Maurel P,Vilarem MJ

更新日期：2000-08-11 00:00:00

abstract：:In this study the sea bass (Dicentrarchus labrax) pepsinogen C gene was isolated. The nucleotide sequences of all exons are presented. The organization of the gene is compatible with that of other aspartic proteinases. The predicted 388-residue amino acid (aa) sequence of sea bass pepsinogen C consists of a signal seq...

journal_title：Biochemical and biophysical research communications

authors： Terova G,Rimoldi S,Larghi S,Bernardini G,Gornati R,Saroglia M

更新日期：2007-11-23 00:00:00

abstract：:Reoxidation of the reduced insulin A and B chains in 8 M urea leads to a recovery of native insulin of 2-7% whereas in 6 M guanidine or 0.5 mM dodecylsulfate very little, if any, resynthesis of insulin could be detected. Considering all the possibilities of different oligomeric forms containing one or both of the chai...

journal_title：Biochemical and biophysical research communications

authors： Qian YQ,Tsou CL

更新日期：1987-07-31 00:00:00

abstract：:Membrane-type 1 matrix metalloproteinase (MT1-MMP) localized on the plasma membrane plays a central role in various normal biological responses including tissue remodeling, wound heeling, and angiogenesis and in cancer cell invasion and metastasis, by functioning as a collagenase and activating other matrix metallopro...

journal_title：Biochemical and biophysical research communications

authors： Miyata T,Ohnishi H,Suzuki J,Yoshikumi Y,Ohno H,Mashima H,Yasuda H,Ishijima T,Osawa H,Satoh K,Sunada K,Kita H,Yamamoto H,Sugano K

更新日期：2004-10-08 00:00:00