Urinary 5-S-cysteinyldopa in Parkinsonism after DOPA and carbidopa.

Abstract:

:The effect of anti-Parkinson therapy on the urinary excretion of 5-S-cysteinyldopa (5SCD), a catechol metabolite of dihydroxyphenylalanine (DOPA) and marker for the melanocyte, was studied by means of high performance liquid chromatography. 5SCD was normal in Parkinson patients treated with anticholinergics. DOPA administration increased 5SCD excretion. Carbidopa and DOPA together elevated 5SCD markedly in a dose-dependent manner to values higher than seen in some patients with metastatic malignant melanoma. The effect of anti-Parkinson therapy should be considered when using 5SCD as a tumor marker or when a Parkinson patient has a melanoma.

journal_name

Acta Derm Venereol

authors

Stewart RM,Miller S,Gunder M

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

97-101

issue

2

eissn

0001-5555

issn

1651-2057

journal_volume

63

pub_type

杂志文章
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  • Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo.

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    更新日期:1992-11-01 00:00:00

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    journal_title:Acta dermato-venereologica

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    doi:

    authors: Kauppinen K,Stubb S

    更新日期:1984-01-01 00:00:00

  • Verapamil is Less Effective than Triamcinolone for Prevention of Keloid Scar Recurrence After Excision in a Randomized Controlled Trial.

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    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章,随机对照试验

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  • Genital psoriasis: A systematic literature review on this hidden skin disease.

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    pub_type: 杂志文章,评审

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    更新日期:2011-01-01 00:00:00

  • Gestational pemphigoid: placental morphology and function.

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