Abstract：
:Retinol and proguanil are metabolised by the same family of hepatic cytochrome P450, i.e. CYP2C. We used proguanil as a probe to study CYP2C activity, and by implication retinol metabolism, in psoriasis. In vitro studies showed that retinol competitively inhibited the hepatic metabolism of proguanil to cycloguanil. Proguanil metabolism was assessed in 82 patients with chronic plaque psoriasis. Following proguanil orally (200 mg), urine was analysed for proguanil and cycloguanil. A proguanil to cycloguanil ratio < 1 signified extensive metabolism and a ratio > 10 poor metabolism. A wider range of ratios was observed in psoriasis than previously reported for normal subjects. The proguanil to cycloguanil ratio was assessed in 10 cases each of know severe and mild psoriasis. Low CYP2C activity was associated with severe psoriasis, poor metaboliser status occurring in 50% of the severe group, but in none of the mild cases, p < 0.01. These findings may indicate differences in retinoid metabolism in psoriasis.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Helsby NA,Ward SA,Parslew RA,Friedmann PS,Rhodes LEdoi
10.1080/000155598433359subject
Has Abstractpub_date
1998-03-01 00:00:00pages
81-3issue
2eissn
0001-5555issn
1651-2057journal_volume
78pub_type
杂志文章abstract：:We evaluated the reproducibility of atopy patch test reactions and the quality and quantity of itch in 16 patients with atopic eczema and a history of a positive atopy patch test reaction, comparing three different application sites. The allergen was re-applied simultaneously on both forearms and the back. Intensity a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550410024418
更新日期：2005-01-01 00:00:00
abstract：:The urine of an albino woman contained small quantities of 5-S-cysteinyldopa; 6-hydroxy-5-methoxyindole-2-carboxylic acid, a melanin precursor metabolite, was lacking. The 5-S-cysteinyldopa excretion observed may reflect non-specific oxidation of dopa. Two other albino patients showed normal values for the excretion o...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The immunological activity in the cerebrospinal fluid (CSF) was studied in 47 patients with early syphilis. The immunoglobulin production within the central nervous system (CNS) was estimated by analysing immunoglobulin G and albumin in CSF and serum and constructing an IgG index according to Tibbling et al. and calcu...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:Given the long purported anecdotal association between rosacea and gastrointestinal disease, the discovery that Helicobacter pylori causes gastritis and duodenal ulcer disease has led to a hypothesized role for this organism in the aetiology of rosacea. We conducted a case-series study of 49 patients to assess the pot...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550310016544
更新日期：2003-01-01 00:00:00
abstract：:Cinnamic alcohol and cinnamic aldehyde are a cause of allergic contact dermatitis in man and give rise to similar rates of positive reactions in routine patch testing. However, data from animal models indicates that the aldehyde is the stronger sensitizer of the two. Circumstantial evidence has pointed to the conversi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555572264265
更新日期：1992-08-01 00:00:00
abstract：:Calcium and 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) are promoters of epithelial cell functions; however their effects on sebaceous glands are unknown. In this study, morphology, ultrastructure, cell numbers, lipid synthesis and apoptosis of SZ95 sebocytes were assessed in vitro under different concentrations of extrace...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2525
更新日期：2017-03-10 00:00:00
abstract：:Irritation and staining by dithranol and some 10-meso-substituted acyl analogues was studied with the chamber-testing technique in a series of 50 psoriasis patients. The test concentrations for dithranol, 10-acetyldithranol, 10-propionyldithranol and 10-butyryldithranol were 0.05 and 0.5%, for 10-valeryldithranol 5% a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The effect of a protective cream was tested in a new tandem repeated irritation test with tandem application of 0.5% sodium lauryl sulphate (SLS) and undiluted toluene. The irritants were applied twice daily for 30 min to the ventral forearms of 20 volunteers. Irritant cutaneous reactions were quantified by a visual s...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550252948103
更新日期：2002-01-01 00:00:00
abstract：:The association between itch and suicidal ideation has not been explored previously in the general population. The aim of the present study is to analyse the association between itch and suicidal ideation in adolescents, and to compare the findings with an expected association between pain and suicidal ideation in the...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-1251
更新日期：2012-09-01 00:00:00
abstract：:The distribution of Fc-receptors for IgG (FcR) on human epidermal cells (EC) was characterized in situ using monoclonal antibodies (MoAbs) by indirect immunofluorescence staining of cryosections. The results showed heterogeneity of FcR expression on Langerhans' cells (LC) and keratinocytes (KC). The MoAb IV.3 against ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：102340/0001555570385390
更新日期：1990-01-01 00:00:00
abstract：:Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated significant clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis where reported in a minority of patients. The present case series describe 10 patients treated...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3121
更新日期：2019-04-01 00:00:00
abstract：:Skin biopsies from a collodion baby, spontaneously healing at the end of the third month, were taken on the 1st and 15th day after delivery and examined by light and electron microscopy. The microscopical features observed were different from those known to occur in collodion babies evolving into lamellar ichthyosis a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Zinc therapies exert beneficial effects in several cutaneous pathologies through their antiinflammatory properties, but target cells and mechanisms of action are still uncertain. We wondered whether markers of the keratinocyte activation state, such as the expression of immune surface antigens (ICAM-1 and HLA-DR) and ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555751923
更新日期：1995-01-01 00:00:00
abstract：:Biopsies for electron microscopy were obtained from syphilitic chancres of 7 patients, 6 males and one female. In 4 of the patients, Treponemata pallida were seen gathering around peripheral nerves and invading the spaces between Schwann cells and their basal lamina. No definite degenerative changes were seen in the a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Age and sex have been identified as predictors of outcome in malignant melanoma (MM). This aim of this multicentre, cross-sectional study was to analyse the role of age and sex as explanatory variables for the diagnosis of thin MM. A total of 2430 patients with MM were recruited. Cases of in situ-T1 MM were more frequ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,多中心研究
doi：10.2340/00015555-2115
更新日期：2015-11-01 00:00:00
abstract：:The proactive use of topical anti-inflammatory (TAI) therapy to address subclinical inflammation is an effective, contemporary clinical strategy for the management of atopic dermatitis (AD). The interaction of a proactive TAI dose with the subclinical epidermal barrier defect in AD is yet to be determined. A randomise...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,随机对照试验
doi：10.2340/00015555-2048
更新日期：2015-07-01 00:00:00
abstract：:Immunotherapy with wasp allergen leads to a variety of specific immunological changes. It is unknown, however, whether unspecific effects also occur, and which parameter shifts might indicate treatment success. Therefore, data of patients who had completed immunotherapy with wasp venom were analysed retrospectively fo...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0690
更新日期：2009-01-01 00:00:00
abstract：:Patients with psoriasis who are being treated with biologics require intensive monitoring. However, the monitoring tool teledermatology is not commonly used. We investigated the applicability of a mobile phone based teledermatological system for monitoring psoriasis patients on biologic therapy. Nineteen patients were...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-1148
更新日期：2011-10-01 00:00:00
abstract：:Patients with palpebral cellulitis may turn in the first place to a skin clinic. The clinical picture and the course of disease are illustrated here by four case histories. The importance of differentiating between collateral orbital edema, palpebral cellulitis and orbital cellulitis is stressed. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Terfenadine is a safe non-sedative H1-receptor antagonist. This study aimed to quantify the relative reduction in weal and flare area, thickness and erythema at 4, 8, 12 and 24 h following a single but variable oral dose of terfenadine compared with pre-treatment measurements, in order to compare the dose-effect relat...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-01-01 00:00:00
abstract：:The link between acne and psychiatric morbidities has been demonstrated in many studies; however, large scale studies aiming to reveal the psychosocial impact of acne are rare. The aim of this study was to assess the psychological burden of adult acne patients. This analysis was based on a multicenter study including ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,多中心研究
doi：10.2340/00015555-3409
更新日期：2020-02-05 00:00:00
abstract：:The introduction of biologics has changed treatment patterns as well as costs in patients with psoriasis. This study was performed to estimate direct and indirect costs of the psoriasis population in Sweden, and to analyse changes in costs between 2006 and 2009. The study population was identified in national register...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-1895
更新日期：2015-02-01 00:00:00
abstract：:Neuromediators may influence the immune response. To investigate their potential immunomodulating role in established allergic contact dermatitis in man, the following neuromediators were tested: vasoactive intestinal polypeptide (VIP), serotonin, and the serotonin antagonists ketanserin, methiotepine and ICS-205-930....
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555576102106
更新日期：1996-03-01 00:00:00
abstract：:Systemic contact dermatitis may occur in contact-sensitized individuals when they are exposed to haptens orally, transcutaneously, intravenously or by inhalation. We report the case of a woman developing a diffuse skin eruption after the topical use of Rhus toxicodendron alcoholic extract and the oral introduction of ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550410023293
更新日期：2004-01-01 00:00:00
abstract：:In a prospective study of 63 patients with long-lasting hand eczema, a diagnosis of atopic dermatitis could be established in 49%. Comparison between patients with atopic dermatitis and those without atopic dermatitis showed that the hand eczema pattern differed very little between the groups. Hyperlinearity was signi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Cutaneous leishmaniasis poses a therapeutic challenge in the paediatric population. The aim of this study was to assess the efficacy and safety of miltefosine treatment for Old World cutaneous leishmaniasis in paediatric patients. A multicentre retrospective review of 10 children (≤ 18 years of age) with cutaneous lei...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3669
更新日期：2020-10-19 00:00:00
abstract：:Mesotherapy is a treatment method devised for controlling pain syndromes or diseases by subcutaneous microinjections given at or around the involved areas at short intervals of time. Different adverse effects have been described due to this modality of treatment. This report describes 3 patients with cutaneous infecti...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550152572967
更新日期：2001-08-01 00:00:00
abstract：:Keratinocyte growth in vitro and DNA synthesis by epidermal cells in vivo are inhibited by therapeutic doses of cyclosporin A (CsA). This effect may be potentialized by topical treatment with ketoconazole, since this drug has been shown to inhibit CsA metabolism. Normal human skin grafts on nude mice receiving intrape...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555574257259
更新日期：1994-07-01 00:00:00
abstract：:Health-related quality of life (HRQOL) has become an important patient reported outcome in health service research. The dermatology life quality index (DLQI) is the most commonly used instrument in dermatology. In recent years, the psychometric properties of the DLQI have been a subject of debate as requirements of mo...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-1842
更新日期：2014-11-01 00:00:00
abstract：:A case of POEMS syndrome and Castleman's multicentric disease is reported. Multiple long-standing cutaneous lesions, histologically similar to histiocytomas, were the initial manifestation of POEMS syndrome. A high incidence of angiomatous lesions associated with POEMS syndrome has already been established. To our kno...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555574388390
更新日期：1994-09-01 00:00:00
