Abstract:
:Gestational pemphigoid (PG), a very rare pregnancy-associated bullous dermatosis, is associated with adverse pregnancy outcome (miscarriage, preterm delivery, foetal growth restriction). The major antigen in PG is collagen XVII (BP180). PG autoantibodies cross-react with collagen XVII in the skin and have been suggested to cause placental failure. On this basis, we evaluated clinical outcome and morphological and functional placental data of 12 PG pregnancies in Finland during 2002 to 2011. The placental-to-birth weight ratio was abnormal in half of the pregnancies. Ultrastructural analysis of PG placentas showed detachment of basement membranes and undeveloped hemidesmosomes. Ultrasound evaluations of placental function prior to delivery were normal in all but one pregnancy. Three (25%) neonates were delivered preterm after 35 gestational weeks and one pregnancy was complicated by preeclampsia and severe foetal growth restriction. Neonatal outcome was uneventful in every case. In conclusion, in pregnancies complicated by PG, slight alteration in ultrastructural morphology of the placental basement membrane was detected, but umbilical artery Doppler evaluation indicated no functional placental changes.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Huilaja L,Mäkikallio K,Sormunen R,Lohi J,Hurskainen T,Tasanen Kdoi
10.2340/00015555-1370subject
Has Abstractpub_date
2013-01-01 00:00:00pages
33-8issue
1eissn
0001-5555issn
1651-2057journal_volume
93pub_type
杂志文章abstract::Halo naevi are considered benign. They occur in children and adolescents. Eruptive multiple halo naevi are infrequently seen in adults. The first patient in this case series had previously had melanoma. Positron emission tomography-computed tomography (PET-CT) showed a papillary thyroid carcinoma. Subsequent adult pat...
journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
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pub_type: 杂志文章,多中心研究
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
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更新日期:1976-01-01 00:00:00
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
doi:10.2340/00015555734145
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pub_type: 杂志文章
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journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Acta dermato-venereologica
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journal_title:Acta dermato-venereologica
pub_type: 杂志文章
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abstract::Adequate sun protection is often neglected during occupational outdoor work. To investigate the acceptance and usability of sunscreens during outdoor work a single-blind, randomized-controlled, cross-over trial was performed in 40 subjects. Two sunscreen formulations were used daily on working days for 4 weeks at a ti...
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pub_type: 杂志文章,随机对照试验
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