Efficacy and skeletal side effects of two years' acitretin treatment.

Abstract:

:In this prospective study, 51 patients suffering from psoriasis and ichthyosis were treated with acitretin for 2 years. The average dose was 0.5 mg/kg/day. We have evaluated the efficacy and side effects, focusing on skeletal side effects. X-ray examinations were done before treatment and after 1 and 2 years. Forty-five patients completed the study. Acitretin had a good clinical effect, with 75% improvement in 35 of the patients. Apart from the well-known side effects affecting the mucous membranes, one patient developed biopsy- proven toxic hepatitis. In 2 patients we observed unusual skeletal calcifications located in the forearms and in the hip. These were considered to be caused by the drug. In this study, which included patients up to 71 years, only radiographs of the pelvis and the forearms were of value as routine follow-up films.

journal_name

Acta Derm Venereol

authors

Mørk NJ,Kolbenstvedt A,Austad J

doi

102340/0001555572445448

subject

Has Abstract

pub_date

1992-11-01 00:00:00

pages

445-8

issue

6

eissn

0001-5555

issn

1651-2057

journal_volume

72

pub_type

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