Abstract：
:The antimalarial drug chloroquine is also used in the prevention of photodermatoses and in patients with inflammatory connective diseases. The drug binds strongly to melanin. Melanocytic activity can be studied by analysis of the urinary markers of eumelanin (6-hydroxy-5-methoxyindole-2-carboxylic acid, 6H5MI-2-C) and phaeomelanin (5-S-cysteinyl-dopa, 5-S-CD). To determine whether chloroquine interacts with this activity, we measured the urinary excretion of the two metabolites in 16 patients with either systemic or discoid lupus erythematosus, polymorphic light eruption or rheumatoid arthritis, during a period with and without treatment with chloroquine phosphate. Two control groups consisting of 7 untreated patients and 10 healthy subjects were also included in the study. During medication, there was a significant increase in 5-S-CD excretion, while the excretion of 6H5MI-2-C was not significantly affected. No significant changes in the excretion of any of the two urinary markers were found in the untreated patients, while a non-significant increase in 5-S-CD excretion was seen in the healthy controls at the follow-up.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Sjölin-Forsberg G,Hansson C,Kågedal B,Gannedahl EL,Berne Bdoi
10.2340/0001555575287289subject
Has Abstractpub_date
1995-07-01 00:00:00pages
287-9issue
4eissn
0001-5555issn
1651-2057journal_volume
75pub_type
杂志文章abstract：:Eight out of 30 consecutive patients with AIDS and cryptococcal meningoencephalitis (26,7%) presented cutaneous involvement, in the form of papulo-nodular lesions in 3 patients, molluscum contagiosum-like lesions in 3 patients, and pustular-ulcerative lesions in 2 patients. Skin localization represented an untoward pr...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555767274
更新日期：1996-01-01 00:00:00
abstract：:We present a young male patient referred to our hospital with leg ulcers on both legs that were more than 3 years refractory to standard treatment with compression therapy. By thrombophilia screening factor V Leiden mutation, hyperhomocysteinemia and evidence for impaired fibrinolysis were found. Treatment with folic ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155502753600902
更新日期：2002-01-01 00:00:00
abstract：:Eye colour, hair colour and skin colour are important risk factors for malignant melanoma and non-melanoma skin cancers. There are few studies in which the distribution of these pigmentary factors in risk populations has been assessed. The purpose of this study was to investigate the prevalence of the major eye and ha...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155598441567
更新日期：1998-05-01 00:00:00
abstract：:In a patient affected with acrodermatitis continua Hallopeau, acitretin (Ro 10-1670) monotherapy resulted in a complete clearance of pustulation at a dosage of 45 mg per day. At this dosage the leukotriene B4-induced intraepidermal accumulation of polymorphonuclear leukocytes was markedly inhibited. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Suction blisters were raised in lesions and normal appearing skin of patients with psoriasis. The blister roof which contains the epidermis separated at the dermal-epidermal junction was stained with ATPase, OKT-6 and anti-HLA-DR monoclonal antibodies. The technique permits the counting of the Langerhans' cells per mm...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Anorexia nervosa and bulimia nervosa are common yet occult eating disorders which each affect between 1 and 2% of young adult women in the UK (1). Cutaneous signs may provide valuable clues allowing earlier diagnosis. Eating disorders may both imitate (Table I) and complicate other medical illnesses, resulting in unne...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555746869
更新日期：1994-01-01 00:00:00
abstract：:Patients with rheumatoid arthritis were investigated for contact allergy to gold in connection with treatment with gold preparations. There were 57 patients with rheumatoid arthritis previously treated with gold, with or without cutaneous side-effects, as well as 20 patients intended for such treatment; all were expos...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章
doi：10.2340/0001555577370373
更新日期：1997-09-01 00:00:00
abstract：:The naevus profile was examined in a Swedish cohort of 8-9-year-old children; 524/545 individuals (96%) were examined (279 boys and 245 girls). There was a wide variation in the total number of naevi (0-79) and boys had more naevi than girls (median 9 and 7, respectively, p<0.01). No dysplastic naevi were found. Overa...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550410025903
更新日期：2004-01-01 00:00:00
abstract：:Sympathetic dysfunction and skin microvascular arteriovenous shunting with insufficient nutritive perfusion and tissue hypoxia have been reported in patients with erythromelalgia. The objective of this study was to determine whether iloprost, a synthetic prostacyclin analogue--primarily a vasodilator and inhibitor of ...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1080/00015550310015031
更新日期：2003-01-01 00:00:00
abstract：:Fusarium spp. are emergent opportunistic moulds capable of producing life-threatening diseases, usually in immunocompromised hosts. When they infect immunocompetent patients, they usually cause localized diseases. We describe here a case of cutaneous fusariosis in a patient with a medical history of diabetes mellitus ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0276
更新日期：2007-01-01 00:00:00
abstract：:A 10-year follow-up of patients with juvenile plantar dermatosis and gluteo-femoral eczema disclosed a worse prognosis than previously assumed, with a course in some cases protracted into adult age. The presence of atopy was established with a clinical point score system. It was found that 52% of the patients with juv...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Calcium and 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) are promoters of epithelial cell functions; however their effects on sebaceous glands are unknown. In this study, morphology, ultrastructure, cell numbers, lipid synthesis and apoptosis of SZ95 sebocytes were assessed in vitro under different concentrations of extrace...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2525
更新日期：2017-03-10 00:00:00
abstract：:Twenty-one patients with Behçet's disease were typed for HLA antigens. The controls were 50 subjects randomly chosen from a local population and 24 apparently healthy subjects of the same ethnic groupings as those of the patients. The study revealed significant differences in the frequencies of various antigens in the...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Significant cutaneous vascular IgA deposits are common in Henoch-Schönlein purpura but not in other vasculitides. The specificity for IgA vascular deposits for Henoch-Schönlein purpura is not well defined. To examine the specificity of IgA vascular deposits for this disease, we compared clinicopathologic features of 9...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555575125129
更新日期：1995-03-01 00:00:00
abstract：:The effect on dermographic wealing of an H1 and H2 receptor antagonist was studied separately and in combination. a double-blind protocol was used and dermographism was measured as the diameter of weal response to a measured force. Both H1 and H2 antagonists had a small but non-significant effect, but the combination ...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1983-01-01 00:00:00
abstract：:The effect of anti-Parkinson therapy on the urinary excretion of 5-S-cysteinyldopa (5SCD), a catechol metabolite of dihydroxyphenylalanine (DOPA) and marker for the melanocyte, was studied by means of high performance liquid chromatography. 5SCD was normal in Parkinson patients treated with anticholinergics. DOPA admi...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：:We report the clinical variations and the duration of prodromal symptoms in 20 patients with bullous pemphigoid. Nearly two-thirds of the patients had prodromal symptoms. THe duration of the prodromal eruptions was up to 6 weeks if papular and/or urticarial and up to 2 years if eczematous, before the blisters appeared...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Similarities and differences in the everyday clinical management of moderate-to-severe atopic dermatitis in Nordic countries are unknown. Using a modified Delphi approach, 15 dermatologists from Denmark, Finland, Norway and Sweden completed face-to-face and online questionnaires and participated in summary discussions...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,多中心研究
doi：10.2340/00015555-3369
更新日期：2020-01-07 00:00:00
abstract：:An objective method for the quantification of follicular hyperkeratosis is proposed for the rabbit ear assay of acnegenicity. The area (area%) of hyperkeratinized follicles, covering a stereomicroscopic photo of the epidermis, is proposed for the quantification of the response. The uniformity of two observers' quantif...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:A patient with the Klippel Trenaunay Weber syndrome presented with prolonged bleeding from the finger tips during strenuous exercise. Tissue fibrinolysis studies showed increased fibrinolytic activity suggesting that the blood vessels in the affected limb may be functionally as well as anatomically abnormal. ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Two patients with multiple angiokeratomas on genitalia and thighs, one with Fabry's disease and one with Fordyce's disease, were treated with copper vapour laser light of 578 nm wavelength. The result was desirable, with destruction and disappearance of the lesions and minimal scarring and posttreatment hyper- or hypo...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555573133135
更新日期：1993-04-01 00:00:00
abstract：:BRAF and NRAS genetic analyses are time-consuming and can delay treatment choices in patients with metastatic melanomas presenting with acute deterioration. We compared the rapid, real-time, fully automated molecular diagnosis platform Idylla™ with next-generation sequencing (NGS) and immunohistochemistry for detectio...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2738
更新日期：2018-01-12 00:00:00
abstract：:Given the long purported anecdotal association between rosacea and gastrointestinal disease, the discovery that Helicobacter pylori causes gastritis and duodenal ulcer disease has led to a hypothesized role for this organism in the aetiology of rosacea. We conducted a case-series study of 49 patients to assess the pot...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550310016544
更新日期：2003-01-01 00:00:00
abstract：:Endoglin is a glycoprotein which is predominantly expressed on endothelial cells. It is upregulated under inflammatory conditions as well as in skin lesions where endothelial cell proliferation occurs. Endoglin has the capacity to bind transforming growth factor beta (TGF-beta) and can reduce the bioavailability of TG...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015559850135760
更新日期：1998-01-01 00:00:00
abstract：:Four patients with classic recalcitrant prurigo nodularis had symptomatic and physical responses to thalidomide with remissions. Three of the four patients had increased IgE levels that decreased during therapy. In two patients, short-term treatment (2 to 3 months) was not sufficient to produce remission, but retreatm...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Itch is known to be associated with psychological factors in adults, but has not been explored among adolescents. A cross-sectional, questionnaire-based population study involving adolescents born mostly in 1986 was carried out in 2004. A total of 4744 individuals were invited and the participation rate was 80%. The H...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0554
更新日期：2009-01-01 00:00:00
abstract：:Infection can be a trigger and an aggravating factor in psoriasis. Antibacterial and/or antifungal agents are commonly used in the treatment of intertriginous psoriasis, because it is believed that flexures in psoriasis are often colonized by Candida species and Staphylococcus aureus. Bacterial and fungal cultures wer...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550310007463
更新日期：2003-01-01 00:00:00
abstract：:Eighty-two cases of nodular panniculitis of the legs were examined clinically, histologically and immunohistologically. Clinically the cases could be divided into four groups: typical erythema nodosum (ENty) (35 cases), erythema nodosum migrans (ENmi) (11 cases), erythema induratum (EI) (11 cases) and the remaining 25...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Patients with clinical features of dorsal macular amyloidosis but without subepidermal amyloid deposits were followed for 2-11 years. The clinical appearance was fairly stable during this period of time, with little tendency of healing. Only 2 of the patients developed typical macular amyloidosis during the follow-up....
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555576302304
更新日期：1996-07-01 00:00:00
abstract：:Vulvar vestibulitis is a major cause of entry dyspareunia in young women. The aim of this study was to evaluate a self-reported history of bacterial vaginosis, candidiasis, use of oral contraception and nulli-pregnancy as risk factors for vestibulitis. A retrospective examination of medical records was performed for 4...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0250
更新日期：2007-01-01 00:00:00
