Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate.

Abstract:

:p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38β/δ-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced skin inflammation model and compared with wild-type mice. The inflammatory response was determined by ear thickness, myeloperoxidase activity and histology. mRNA and protein expression of interleukin (IL)-1β and IL-6 was determined by quantitative real-time reverse transcription PCR and enzyme-linked immunoassay. In both groups application of TPA resulted in a significant increase in inflammation, and pretreatment with the p38α/β inhibitor, SB202190 resulted in a significant inhibition. A significantly slower onset but prolonged duration of the response was seen in p38β/δ knockout mice. This was paralleled by a significant, but transient, lower IL-1β and IL-6 protein expression in p38β/δ knockout mice. Although the p38α isoform is important, our data also demonstrate an important role of the p38β and/or δ isoforms in the regulation of TPA-induced skin inflammation.

journal_name

Acta Derm Venereol

authors

Lilleholt LL,Johansen C,Arthur JS,Funding A,Bibby BM,Kragballe K,Iversen L

doi

10.2340/00015555-1046

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

271-8

issue

3

eissn

0001-5555

issn

1651-2057

journal_volume

91

pub_type

杂志文章
  • Local photochemotherapy in nodular prurigo.

    abstract::Fifteen patients with nodular prurigo were treated with a trioxsalen bath (50 mg/150 l of water) and UVA given in an ordinary PUVA cabin. Good results were observed in 8 and moderate in 7 patients in the initial phase. The result was good or excellent in 13 of the 15 patients during maintenance treatment. The good res...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Väätäinen N,Hannuksela M,Karvonen J

    更新日期:1979-01-01 00:00:00

  • 5-year recurrence rates of Mohs micrographic surgery for aggressive and recurrent facial basal cell carcinoma.

    abstract::Mohs micrographic surgery allows for complete microscopic examination of the surgical margin when treating aggressive and recurrent facial basal cell carcinomas. This leads to the highest cure rates and maximal preservation of healthy tissue. The 5-year recurrence rates of 587 aggressive and/or recurrent facial basal ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-1134

    authors: Paoli J,Daryoni S,Wennberg AM,Mölne L,Gillstedt M,Miocic M,Stenquist B

    更新日期:2011-10-01 00:00:00

  • The distribution of Fc gamma RI, Fc gamma RII and Fc gamma R III on Langerhans' cells and keratinocytes in normal skin.

    abstract::The distribution of Fc-receptors for IgG (FcR) on human epidermal cells (EC) was characterized in situ using monoclonal antibodies (MoAbs) by indirect immunofluorescence staining of cryosections. The results showed heterogeneity of FcR expression on Langerhans' cells (LC) and keratinocytes (KC). The MoAb IV.3 against ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/0001555570385390

    authors: Tigalonowa M,Bjerke JR,Livden JK,Matre R

    更新日期:1990-01-01 00:00:00

  • The Wiskott-Aldrich syndrome gene as a candidate gene for atopic dermatitis.

    abstract::Atopic dermatitis is a multifactorial disorder probably caused by environmental factors in combination with susceptibility genes. The clinical similarity between atopic dermatitis and the eczema manifestation in patients with Wiskott-Aldrich syndrome made the previously identified WAS gene in chromosome sub-band Xpl 1...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/000155501317140043

    authors: Bradley M,Söderhäll C,Wahlgren CF,Luthman H,Nordenskjöld M,Kockum I

    更新日期:2001-10-01 00:00:00

  • Circulating immune complexes in a patient with prolonged gonococcal septicemia.

    abstract::A case of prolonged gonococcal speticemia is presented. Lack of genital symptoms, of demonstrable gonococcal antibodies in whole serum, and initially also of skin lesions contributed to a delayed diagnosis that was finally confirmed by positive blood culture. Evidence of circulating immune complexes was obtained by th...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Danielsson D,Norberg R,Svanbom M

    更新日期:1975-01-01 00:00:00

  • The role of vascular surgery in chronic leg ulcers: report from a specialized ulcer clinic.

    abstract::Experience gained from cooperation between dermatologists and vascular surgeons in 177 patients evaluated at a joint leg ulcer clinic is reported. Patients were divided into two subgroups: (i) 86 patients with healed ulcers and (ii) 91 patients with ongoing therapy-resistant ulcers. Venous insufficiency was the most c...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/000155502320323225

    authors: Bjellerup M,Akesson H

    更新日期:2002-01-01 00:00:00

  • The Cockayne-Touraine type of dominant dystrophic epidermolysis bullosa--ultrastructural similarities to the Pasini variant.

    abstract::Biopsies from the uninvolved skin of 5 patients with the Cockayne-Touraine (CT) type of dystrophic epidermolysis bullosa (DEB) were studied with the electron microscope. Dermal fibrillar bodies were noted in 2 patients and 3 showed basal lamina (BL) duplication or splitting. Discontinuity of the BL with herniation of ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Oakley CA,Gawkrodger DJ,Ross JA,Hunter JA

    更新日期:1984-01-01 00:00:00

  • In vivo and in vitro immune responses to trichophytin in dermatophytosis.

    abstract::Cell-mediated immunity in patients with verified dermatophytosis was investigated by means of skin test and lymphocyte stimulation test (LST) using purified trichophytin, prepared by the ethylene glycol method, and commercially available trichophytin. The purified trichophytin seemed to be more specific and sensitive ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Kaaman T,Petrini B,Wasserman J

    更新日期:1979-01-01 00:00:00

  • Subclinical joint involvement in psoriasis: magnetic resonance imaging and X-ray findings.

    abstract::Previous studies have shown that magnetic resonance imaging is more sensitive in assessing soft tissue and bone involvement in inflammatory arthritis than conventional radiography. Therefore the main objects of this study were to evaluate the frequency of hand involvement in psoriatic patients free from arthritic symp...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/000155598442809

    authors: Offidani A,Cellini A,Valeri G,Giovagnoni A

    更新日期:1998-11-01 00:00:00

  • Phylogenetic studies with pemphigus and pemphigoid antibodies.

    abstract::Indirect immunofluorescence (IF) studies were performed on skin from a variety of vertebrate specimens and IgG fractions from pemphigoid and pemphigus sera. Pemphigoid antigen was present in fish, amphibian, reptilian, avian and mammalian skin, whereas pemphigus antigen was observed in avian and mammalian skin only. ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Diaz LA,Weiss HJ,Calvanico NJ

    更新日期:1978-01-01 00:00:00

  • Long-term follow-up of photochemotherapy in pityriasis lichenoides.

    abstract::Five patients with a histopathologically confirmed diagnosis of pityriasis lichenoides were treated with PUVA or irradiated with a light source emitting UVB and UVA, without prior intake of psoralens. All patients showed a good response to treatment. Long-term follow up showed that patients remained free of lesions du...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Boelen RE,Faber WR,Lambers JC,Cormane RH

    更新日期:1982-01-01 00:00:00

  • Generalized morphea with vascular involvement. A case report and disaccharide analysis of the skin glycosaminoglycans.

    abstract::We report a 69-year-old man with severe generalized morphea, who showed over 80% of skin involvement, while the internal organs were not affected. We performed histological examinations and analysis of skin disaccharides constituting chondroitinase-digestible glycosaminoglycans in the center and periphery of the scler...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555576141143

    authors: Akimoto S,Ishikawa O,Yokoyama Y,Amano H,Miyachi Y

    更新日期:1996-03-01 00:00:00

  • Evaluation of port wine stain perfusion by laser Doppler imaging and thermography before and after argon laser treatment.

    abstract::Thirteen patients with port wine stains (PWS) were treated with argon laser therapy. Before and at different points in time following treatment, skin blood perfusion and temperature were mapped with laser Doppler imaging and thermography. In nine patients no elevation in blood perfusion was observed in the PWS in comp...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/0001555572610

    authors: Troilius A,Wårdell K,Bornmyr S,Nilsson GE,Ljunggren B

    更新日期:1992-01-01 00:00:00

  • Single Dose of Azithromycin for Treatment of Patients with Asymptomatic Rectal Chlamydia trachomatis.

    abstract::is missing (Short communication). ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-3675

    authors: Macaux L,Zemali N,Jaubert J,Koumar Y,Manaquin R,Poubeau P,Camuset G,Gérardin P,Bertolotti A

    更新日期:2020-11-04 00:00:00

  • Epidermal hydration and skin mechanics. The relationship between electrical capacitance and the mechanical properties of human skin in vivo.

    abstract::The possible relationship between skin capacitance and the mechanical properties of the skin was studied using non-invasive techniques. Skin hydration was changed by soaking skin with tap water. Hydration of the skin increased the capacitance significantly (p less than 0.01) and hysteresis (creeping phenomenon) (p les...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/0001555570245247

    authors: Jemec GB,Serup J

    更新日期:1990-01-01 00:00:00

  • Clinical and immunological studies in chronic dermatophytosis caused by Trichophyton rubrum.

    abstract::Twenty-six patients with chronic dermatophytosis (CD) by Trichophyton rubrum (TR) through one year were included in a double-blind clinical trial with Levamisole/Placebo. All patients were treated with griseofulvin concomitantly. Before, during and after the trial, studies of the cellular and humoral immune response w...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Svejgaard E,Christiansen AH,Stahl D,Thomsen K

    更新日期:1984-01-01 00:00:00

  • 5-S-cysteinyldopa as a substrate for tyrosinase.

    abstract::Oxidation of 5-S-cysteinyldopa by mushroom tyrosinase was studied by measuring 5-S-cysteinyldopa consumption with HPLC. 5-S-cysteinyldopa was found to be a substrate for tyrosinase, but our results suggests that a self-catalysed oxidation induced by enzymatically formed 5-S-cysteinyl dopaquinone also takes place. Dopa...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Hansson C,Rorsman H,Rosengren E

    更新日期:1980-01-01 00:00:00

  • Two siblings with epidermodysplasia verruciformis with large clear cells in the epidermis: electron microscope and immunological findings.

    abstract::In two Arab brothers presenting the characteristic clinical picture of epidermodysplasia verruciformis (EV), histological examination revealed large clear cells in the granular layer and uppermost part of the prickle cell layer of the epidermis. The report of this histological picture in two cases by other authors in ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Feuerman EJ,Sandbank M,David M

    更新日期:1979-01-01 00:00:00

  • Teledermatological monitoring of psoriasis patients on biologic therapy.

    abstract::Patients with psoriasis who are being treated with biologics require intensive monitoring. However, the monitoring tool teledermatology is not commonly used. We investigated the applicability of a mobile phone based teledermatological system for monitoring psoriasis patients on biologic therapy. Nineteen patients were...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-1148

    authors: Koller S,Hofmann-Wellenhof R,Hayn D,Weger W,Kastner P,Schreier G,Salmhofer W

    更新日期:2011-10-01 00:00:00

  • Meclosorb, a new topical antibiotic agent in the treatment of acne vulgaris: a double-blind clinical study.

    abstract::The clinical effect on acne vulgaris of topical treatment with meclocycline sulfosalicylate and systemic treatment with peroral tetracycline (500 mg daily) was compared in a double-blind study of 60 patients treated for 8 weeks. The reducing effect of Meclosorb cream and tetracycline tablets on the number of closed co...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Hjorth N,Schmidt H,Thomsen K,Dela K

    更新日期:1984-01-01 00:00:00

  • Congenital reticular ichthyosiform erythroderma--ichthyosis variegata: a case report and review of the literature.

    abstract::We present a 32-year-old white patient with congenital reticular ichthyosiform erythroderma, also known as ichthyosis variegata. The patient had typical clinical features with areas of normal appearing skin surrounded by erythematous hyperkeratotic patches. The smaller "confetti-like" patches were mostly present on th...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章,评审

    doi:10.1080/00015550310002684

    authors: Krunic AL,Palcesky D,Busbey S,Medenica M

    更新日期:2003-01-01 00:00:00

  • Presence of Epstein-Barr virus in cutaneous lesions of mycosis fungoides and Sézary syndrome.

    abstract::It has been suggested that prolonged antigenic stimulation contributes to the development of epidermotropic cutaneous T cell lymphoma (CTCL), mycosis fungoides and Sézary syndrome, characterized by a cutaneous infiltration of proliferating helper T cells. Since Epstein-Barr virus (EBV) antibodies were increased in CTC...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555574355357

    authors: Dreno B,Celerier P,Fleischmann M,Bureau B,Litoux P

    更新日期:1994-09-01 00:00:00

  • Investigation on biovars and genotypes of Ureaplasma urealyticum in the cervix in a Chinese gynecologic check-up population and sex workers.

    abstract::Ureaplasma urealyticum is a causative agent of non-gonococcal urethritis and is implicated in the pathogenesis of several other diseases. However, U. urealyticum is also frequently found in the normal genitourinary tract. To characterize the distribution pattern of biovars and genotypes in normal physical check-up wom...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/00015550310007157

    authors: Ren Y,Zhu X

    更新日期:2003-01-01 00:00:00

  • Health-related quality of life in psoriasis: important role of personal resources.

    abstract::Many patients with psoriasis demonstrate psychological disturbances, including decreased health-related quality of life (HRQoL). The aim of this study was to evaluate selected personal resources and HRQoL in 168 in-patients with psoriasis vulgaris. The following questionnaires were used: Skindex-29, General Health Que...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-1530

    authors: Miniszewska J,Juczyński Z,Ograczyk A,Zalewska A

    更新日期:2013-09-04 00:00:00

  • A retrospective analysis of skin bacterial colonisation, susceptibility and resistance in atopic dermatitis and impetigo patients.

    abstract::Atopic dermatitis (AD) and impetigo are skin conditions where bacterial colonisation and infection, especially with Staphylococcus aureus play an important role. We compared skin bacterial population, resistance patterns and choice of antimicrobial agents in patients diagnosed with AD and impetigo during 2005 and 2011...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-1996

    authors: Salah LA,Faergemann J

    更新日期:2015-05-01 00:00:00

  • Effect of acupuncture on experimentally induced itch.

    abstract::We evaluated the effect of acupuncture on histamine-induced itch and flare in healthy volunteers (n = 25) and compared it with the effect of a pseudo-acupuncture procedure and of no-intervention in a single-blind randomized cross-over study. A cumulative itch index is defined and was found to be smaller with acupunctu...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Belgrade MJ,Solomon LM,Lichter EA

    更新日期:1984-01-01 00:00:00

  • 'Dry' skin in atopic dermatitis. II. A surface profilometry study.

    abstract::In patients with atopic dermatitis, the skin is often 'dry' on non-eczematous areas, and feels rough to the touch. In the scanning electron microscope (SEM) this roughness corresponds to a change in the skin surface, from regular major and minor furrows into a coarse and irregular pattern. In the present study the top...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Linde YW,Bengtsson A,Lodén M

    更新日期:1989-01-01 00:00:00

  • Dendrocytoclasis in Henoch-Schönlein purpura.

    abstract::We studied by immunohistochemistry the fate of factor XIIIa-positive dermal dendrocytes in Henoch-Schönlein purpura. We have observed apoptosis affecting most of the perivascular dendrocytes. Such an aspect of dendrocytoclasis has never previously been reported in inflammatory disorders in the absence of vasculitis. ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Estrada JA,Goffin F,Cornil F,Pierard-Franchimont C,Pierard GE

    更新日期:1991-01-01 00:00:00

  • Comparative multi-center study with TRUE Test and Finn Chamber Patch Test methods in eight Swedish hospitals.

    abstract::292 individuals were patch tested with twelve allergens, using a new patch test technique, TRUE Test (TT). As controls, the same allergens in standard concentrations in petrolatum were applied using the Finn Chamber technique (FC). The allergen doses used in TT were chosen according to results from a previous serial d...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Ruhnek-Forsbeck M,Fischer T,Meding B,Pettersson L,Stenberg B,Strand A,Sundberg K,Svensson L,Wahlberg JE,Widström L

    更新日期:1988-01-01 00:00:00

  • Interferon alpha-2b treatment of symptomatic chronic vulvodynia associated with koilocytosis.

    abstract::In an open study with identical criteria for diagnosis, 16 female patients with typical symptoms of chronic vulvodynia associated with acetowhitening of the vestibular epithelium and koilocytosis in biopsy specimens received recombinant interferon alpha-2b 5 MIU intralesionally 3 times weekly for 3 weeks or subcutaneo...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章

    doi:10.2340/0001555573385387

    authors: Larsen J,Peters K,Petersen CS,Damkjaer K,Albrectsen J,Weismann K

    更新日期:1993-10-01 00:00:00