Acnegenicity testing in rabbits. An objective quantification method.

Abstract:

:An objective method for the quantification of follicular hyperkeratosis is proposed for the rabbit ear assay of acnegenicity. The area (area%) of hyperkeratinized follicles, covering a stereomicroscopic photo of the epidermis, is proposed for the quantification of the response. The uniformity of two observers' quantification was evaluated in six tested formulations. The quantification of the response in area% was found to be a suitable and objective alternative to visual scoring on a graded scale. The median relative difference between two observers' area%-quantification was found to be 26%, and there was no statistically significant difference between the two observers' quantification (p greater than 0.10). An area% of 2, 7, and 15 is preliminarily suggested to be equivalent to the lower limit for scores 1, 2 and 3 respectively.

journal_name

Acta Derm Venereol

authors

Bechgaard E

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

282-6

issue

4

eissn

0001-5555

issn

1651-2057

journal_volume

65

pub_type

杂志文章
  • Efficacy and skeletal side effects of two years' acitretin treatment.

    abstract::In this prospective study, 51 patients suffering from psoriasis and ichthyosis were treated with acitretin for 2 years. The average dose was 0.5 mg/kg/day. We have evaluated the efficacy and side effects, focusing on skeletal side effects. X-ray examinations were done before treatment and after 1 and 2 years. Forty-fi...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/0001555572445448

    authors: Mørk NJ,Kolbenstvedt A,Austad J

    更新日期:1992-11-01 00:00:00

  • Development of gastric dysfunction in dermatitis herpetiformis.

    abstract::In order to study the development of atrophic gastritis, gastric secretory function was examined by a standard pentagastrin test 24 to 78 months after a previous examination (Ex I). The study included 12 patients with dermatitis herpetiformis (DH), 6 patients with functional signs of atrophic gastritis previously, and...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Stockbrügger R,Kastrup W,Lundqvist G,Mobacken H

    更新日期:1978-01-01 00:00:00

  • Comparative nuclear morphometric analysis of aggressive and non-aggressive squamous cell carcinomas of the skin.

    abstract::Squamous cell carcinomas (SCC) are the most frequent tumours complicating organ transplantation. Whereas most SCC can be successfully treated with conventional surgery, other lesions show an aggressive course with recurrence and metastases. We assessed the value of nuclear morphometry in detecting tumours with an ab i...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555577115117

    authors: Narvaez D,Kanitakis J,Euvrard S,Schmitt D,Faure M,Claudy A

    更新日期:1997-03-01 00:00:00

  • Bestatin therapy of patients with atopic dermatitis.

    abstract::Ten adult patients with severe atopic dermatitis were treated for three months with estatin, which is a metabolite of Streptomyces olivoreticuli. Bestatin has been shown to increase tumor resistance in mice, augment a variety of immune responses and to reduce the level of IgE in non-atopic healthy persons. During best...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Thestrup-Pedersen K,Cramers M,Kongsholm H,Zachariae H

    更新日期:1983-01-01 00:00:00

  • Erythema nodosum and erythema multiforme associated with milker's nodules.

    abstract::An epidemic of 44 cases of milker's nodules was recorded in the Tampere Central Hospital catchment area in Finland during the autumn of 1974. Exanthema or erythema multiforme-like secondary eruptions were seen in 10 cases. One female patient is reported in detail because of the simultaneous occurrence of erythema nodo...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Kuokkanen K,Launis J,Mörttinen A

    更新日期:1976-01-01 00:00:00

  • Neutrophil Extracellular Traps are Present in Immune-complex-mediated Cutaneous Small Vessel Vasculitis and Correlate with the Production of Reactive Oxygen Species and the Severity of Vessel Damage.

    abstract::Formation of neutrophil extracellular traps has been implicated in autoimmunity. However, the presence and clinical relevance of neutrophil extracellular traps in immune-complex-mediated cutaneous small and medium vessel vasculitides has not been investigated. This study retrospectively analysed 72 patients with histo...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-3363

    authors: Bergqvist C,Safi R,El Hasbani G,Abbas O,Kibbi A,Nassar D

    更新日期:2020-10-06 00:00:00

  • Genital and extra-genital screening for gonorrhoea using the BD Probetec ET system with an in-house PCR method targeting the porA pseudogene as confirmatory test.

    abstract::Diagnosing gonorrhoea from extra-genital as well as genital sites is important in managing this sexually transmitted disease. In this study we evaluated a screening procedure for Neisseria gonorrhoeae (GC) from all sample sites in a low-prevalence setting. A total of 69,252 specimens submitted for Chlamydia trachomati...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-1192

    authors: Skovgaard S,Larsen HK,Sand C,Friis-Møller A,Schønning K,Jensen JS,Westh H

    更新日期:2012-01-01 00:00:00

  • Contact thermography for assessment of skin damage due to experimental irritants.

    abstract::Irritant dermatitis after application of experimental irritants was studied by means of contact thermography. Sixteen healthy persons were patch-tested, using the following irritants: Sodium lauryl sulphate, benzalkonium chloride, nonanoic acid, hydrochloric acid, croton oil, sapo kalinus and sodium hydroxide. A main ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Agner T,Serup J

    更新日期:1988-01-01 00:00:00

  • Chlamydia trachomatis urethritis in men attending a venereal disease clinic: a culture and therapeutic study.

    abstract::Urethral specimens from 459 male patients attending a venereal disease clinic were studied for presence of Chlamydia trachomatis and Neisseria gonorrhoeae. Of the 459 patients, 362 had symptoms suggestive of urethritis. In these 362, gonorrhoea was diagnosed in 78 (22%), while 88 (24%) harboured C. trachomatis; 15 har...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Ripa KT,Mårdh PA,Thelin I

    更新日期:1978-01-01 00:00:00

  • Urinary glycosaminoglycans excretion in Graves' disease.

    abstract::Urinary excretion of glycosaminoglycans was measured in 10 patients with pretibial myxoedema, 7 of whom also had thyroid-associated ophthalmopathy, and in 3 additional patients with ophthalmopathy but no skin changes. Total uronic acid excretion was raised above control levels in only 2 patients, who had both eye and ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555576368370

    authors: Priestley GC,Aldridge RD,Hurel S

    更新日期:1996-09-01 00:00:00

  • Expression of transglutaminase I in human anagen hair follicles.

    abstract::The expression of the transglutaminase I in human anagen hair follicles was studied by an immunohistochemical staining. In the bulbar and suprabulbar portions of anagen hair follicles, transglutaminase I was detected on the hair cuticle and the three layers of the inner root sheath. Subsequently, the positive staining...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555575190192

    authors: Tamada Y,Takama H,Kitamura T,Ikeya T,Yokochi T

    更新日期:1995-05-01 00:00:00

  • Protective effect of zinc on keratinocyte activation markers induced by interferon or nickel.

    abstract::Zinc therapies exert beneficial effects in several cutaneous pathologies through their antiinflammatory properties, but target cells and mechanisms of action are still uncertain. We wondered whether markers of the keratinocyte activation state, such as the expression of immune surface antigens (ICAM-1 and HLA-DR) and ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555751923

    authors: Guéniche A,Viac J,Lizard G,Charveron M,Schmitt D

    更新日期:1995-01-01 00:00:00

  • Palmoplantar lesions in psoriasis: a study of 3065 patients.

    abstract::Although palmoplantar psoriasis can be severely disabling, there are very few large clinico-epidemiological studies on this condition. Our purpose was to study the morphology and pattern of lesions in Indian patients with palmoplantar psoriasis and to elucidate the role of occupation in the incidence/localization of t...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/00015550260132488

    authors: Kumar B,Saraswat A,Kaur I

    更新日期:2002-01-01 00:00:00

  • Ultrastructure of murine dermis following topical application of the vitamin D3 analogue KH-1060.

    abstract::The aim of this study, was to observe the effects of KH-1060, a new vitamin D3 analogue, on the dermis of hairless mice by electron microscopy. KH-1060 (0.2 micrograms/ml in isopropanol) or KH-1060 following betamethasone 17-valerate (2 mg/ml in isopropanol) was applied topically to the backs of hairless mice for 4 we...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555577198202

    authors: Kobayasi T

    更新日期:1997-05-01 00:00:00

  • Five novel mutations of RNA-specific adenosine deaminase gene with dyschromatosis symmetrica hereditaria.

    abstract::Dyschromatosis symmetrica hereditaria (OMIM127400) is a rare autosomal dominant pigmentary genodermatosis caused by mutations in the RNA-specific adenosine deaminase (ADAR) gene. This study investigated 5 families and 3 sporadic patients with dyschromatosis symmetrica hereditaria in the Chinese Han population from Anh...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-0168

    authors: Hou Y,Chen J,Gao M,Zhou F,Du W,Shen Y,Yang S,Zhang XJ

    更新日期:2007-01-01 00:00:00

  • Intralesional interferon alpha-2b therapy for Buschke-Loewenstein tumour.

    abstract::A patient with a Buschke-Loewenstein tumour associated with human papillomavirus type 6/11 is reported. He was intralesionally treated with human recombinant alpha-2b interferon (9 x 10(6) IU/day) three times weekly. The tumour completely disappeared within 5 months of continuous treatment which was well tolerated. Si...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555574457459

    authors: Tsambaos D,Monastirli A,Kapranos N,Georgiou S,Pasmatzi E,Berger H

    更新日期:1994-11-01 00:00:00

  • Remission of ordinary psoriasis following a short clearance course of cyclosporin.

    abstract::We set out to show that the assumption is incorrect that continuous treatment with cyclosporin is necessary in psoriasis, as this tenet forms a basis for current recommended treatment regimens. Sixty patients with mild to moderate plaque psoriasis were allocated at random to treatment with oral cyclosporin 5 mg/kg/day...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2340/00015555756569

    authors: Levell NJ,Shuster S,Munro CS,Friedmann PS

    更新日期:1995-01-01 00:00:00

  • Ultrastructural features of oral discoid lupus erythematosus.

    abstract::Tissue from buccal and labial mucosal lesions of discoid lupus erythematosus (DLE) was studied in the electron microscope. The material comprised 10 patients, 7 of whom presented skin lesions as well. The epithelium showed a change in differentiation pattern from nonkeratinizing to keratinizing epithelium. Civatte bod...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Schiødt M,Andersen L

    更新日期:1980-01-01 00:00:00

  • Comparison of dithranol and butantrone in short contact therapy of psoriasis.

    abstract::Thirty psoriatic out-patients were treated as a right-left comparison with dithranol (0.1, 0.5, 1, 2%) and butantrone (0.66, 1.3, 2.7, 3.9%) short contact therapy, both in white petrolatum. Fifteen of the treated patients cleared well and no obvious differences between the treated sides were clinically observed. Six p...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Göransson A

    更新日期:1987-01-01 00:00:00

  • Itch in Psoriasis: A New Look at Well-known Subject.

    abstract::Psoriasis is a chronic inflammatory dermatosis, frequently presenting with chronic itch. This study investigated the prevalence and detailed clinical characteristics of chronic itch in 143 psoriatic patients, with regard to different age groups, comorbidities and pharmacotherapy. Chronic itch was reported by 72% of su...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-3147

    authors: Reszke R,Białynicki-Birula R,Szepietowski JC

    更新日期:2019-04-01 00:00:00

  • Clinical Management of Atopic Dermatitis in Adults: Mapping of Expert Opinion in 4 Nordic Countries using a Modified Delphi Process.

    abstract::Similarities and differences in the everyday clinical management of moderate-to-severe atopic dermatitis in Nordic countries are unknown. Using a modified Delphi approach, 15 dermatologists from Denmark, Finland, Norway and Sweden completed face-to-face and online questionnaires and participated in summary discussions...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章,多中心研究

    doi:10.2340/00015555-3369

    authors: Thyssen JP,Berents T,Bradley M,Deleuran M,Grimstad Ø,Korhonen L,Langeland T,Särnhult T,Thomsen SF,Thune T,Wahlgren CF,Vestergaard C,Kobyletzki LB,Remitz A

    更新日期:2020-01-07 00:00:00

  • Multiple keratoacanthomas, giant keratoacanthoma and keratoacanthoma centrifugum marginatum: development in a single patient and treatment with oral isotretinoin.

    abstract::A 78-year-old man is described, who over 18 years developed three different types of keratoacanthoma: multiple keratoacanthomas, keratoacanthoma centrifugum marginatum and giant keratoacanthoma. Histological examination of the different neoplasms showed similar changes, all typical of a keratoacanthoma. In situ hybrid...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555764042

    authors: Schaller M,Korting HC,Wolff H,Schirren CG,Burgdorf W

    更新日期:1996-01-01 00:00:00

  • Ultrastructural changes of zinc deficient rat epidermis: an electron microscopic study.

    abstract::Zinc deficiency was produced in rats by feeding them a diet containing 0.5 mg zinc per kg. After 2 weeks the zinc-deficient rats showed markedly stunted growth as compared with control rats receiving an identical diet supplemented with 50 mg zinc per kg. After about 3 weeks all rats in the zinc-deficient group develop...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Weismann K,Christophersen J,Kobayasi T

    更新日期:1980-01-01 00:00:00

  • Response of intractable skin ulcers in recessive dystrophic epidermolysis bullosa patients to an allogeneic cultured dermal substitute.

    abstract::Recessive dystrophic epidermolysis bullosa (RDEB) is an inherited skin disorder caused by mutations in the COL7A1 gene, which encodes collagen VII (COL7). Skin ulcers in RDEB patients are sometimes slow to heal. We describe here the therapeutic response of intractable skin ulcers in two patients with generalized RDEB ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-0776

    authors: Natsuga K,Sawamura D,Goto M,Homma E,Goto-Ohguchi Y,Aoyagi S,Akiyama M,Kuroyanagi Y,Shimizu H

    更新日期:2010-03-01 00:00:00

  • A spontaneously healing collodion baby: a light and electron microscopical study.

    abstract::Skin biopsies from a collodion baby, spontaneously healing at the end of the third month, were taken on the 1st and 15th day after delivery and examined by light and electron microscopy. The microscopical features observed were different from those known to occur in collodion babies evolving into lamellar ichthyosis a...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Frenk E

    更新日期:1981-01-01 00:00:00

  • Itch, stress and self-efficacy among 18-year-old boys and girls: a Norwegian population-based cross-sectional study.

    abstract::Itch is the most common dermatological symptom and worsens with stress. The general belief of a person in their own ability to cope in stressful situations, known as self-efficacy, is relevant in the management of chronic diseases other than skin diseases. The aim of this study was to explore the association between p...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-1309

    authors: Dalgard F,Stern R,Lien L,Hauser S

    更新日期:2012-09-01 00:00:00

  • Generalized normolipemic plane xanthomatosis associated with relapsing polychondritis.

    abstract::Generalized normolipemic plane xanthomatosis is a rare cutaneous disorder, frequently associated with reticuloendothelial diseases and some disorders with inflammation. Relapsing polychondritis is also a rare disease that shows an association with various immune-mediated diseases. We report a case of generalized normo...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555574221223

    authors: Yoshimura T,Aiba S,Tadaki T,Tagami H

    更新日期:1994-05-01 00:00:00

  • Skin reactions to primary irritants in men and women.

    abstract::The skin reactions to skin provocation tests with 11 primary irritants were compared in 21 pairs of men and women with hand eczema, matched for age, and in 21 pairs of non-eczematous subjects. With a few exceptions, no statistically significant differences were demonstrated in the intensities of the skin reactions bet...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/0001555555191194

    authors: Björnberg A

    更新日期:1975-01-01 00:00:00

  • Effect of psoriasis heliotherapy on epidermal urocanic acid isomer concentrations.

    abstract::A noninvasive Finn Chamber sampling method and HPLC analysis were used to determine epidermal urocanic acid (UCA) concentrations of psoriasis patients during 4 weeks of heliotherapy on the Spanish Canary Islands and a follow-up period of 8 weeks. During heliotherapy the epidermal cis-UCA concentration increased from a...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/000155555571231233

    authors: Snellman E,Koulu L,Pasanen P,Lammintausta K,Neuvonen K,Ayräs P,Jansén CT

    更新日期:1992-01-01 00:00:00

  • Extraskeletal osteochondroma in the finger. Mimicking the fourth phalangeal bone.

    abstract::A 36-year-old Japanese woman with an extraskeletal osteochondroma in the left thumb is reported. A roentgenogram showed a calcified tumor, located at the distal portion of the left distal phalanx, which mimicked the fourth phalangeal bone. The pathogenesis might in this case be hamartomatous. ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/0001555572287288

    authors: Nogita T,Kawakami M

    更新日期:1992-08-01 00:00:00