Remission of ordinary psoriasis following a short clearance course of cyclosporin.

Abstract:

:We set out to show that the assumption is incorrect that continuous treatment with cyclosporin is necessary in psoriasis, as this tenet forms a basis for current recommended treatment regimens. Sixty patients with mild to moderate plaque psoriasis were allocated at random to treatment with oral cyclosporin 5 mg/kg/day (30 patients) or topical dithranol and ultraviolet B therapy (30 patients) for up to 16 weeks until clear (median time 6 weeks cyclosporin and 8 dithranol), and the times to relapse compared. The patients were seen monthly for up to 8 months, and the severity and the extent of psoriasis were assessed. Relapse, defined as return of psoriasis to 50% of the area at the start of the trial or patient demand for further treatment, was not significantly different between the groups (hazard ratio 1.11, 95% CI 0.55-2.32). No patients suffered a rebound of severe disease and none relapsed in the first 8 weeks after stopping treatment. The relapse rate was higher following cyclosporin from 8 to 28 weeks after treatment and following dithranol from 28 to 34 weeks. The patients with arthritis had a higher median joint severity score at relapse than prior to treatment with cyclosporin. At the end of 8 months, 5 patients treated with dithranol and 8 patients with cyclosporin remained clear, 75% and 67% having relapsed. We conclude that rapid relapse does not occur after clearance of mild to moderate plaque psoriasis with cyclosporin and the relapse rate was no different from dithranol treatment.

journal_name

Acta Derm Venereol

authors

Levell NJ,Shuster S,Munro CS,Friedmann PS

doi

10.2340/00015555756569

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

65-9

issue

1

eissn

0001-5555

issn

1651-2057

journal_volume

75

pub_type

临床试验,杂志文章,随机对照试验
  • The cutaneous signs of eating disorders.

    abstract::Anorexia nervosa and bulimia nervosa are common yet occult eating disorders which each affect between 1 and 2% of young adult women in the UK (1). Cutaneous signs may provide valuable clues allowing earlier diagnosis. Eating disorders may both imitate (Table I) and complicate other medical illnesses, resulting in unne...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555746869

    authors: Siddiqui A,Ramsay B,Leonard J

    更新日期:1994-01-01 00:00:00

  • Neurosyphilis is unlikely in patients with late latent syphilis and a negative blood VDRL-test.

    abstract::Patients with latent syphilis or syphilis of unknown duration should be evaluated for tertiary disease and neurosyphilis. The aim of this retrospective study was to determine relevant serological parameters for the identification of those individuals with syphilis who are most likely to have neurosyphilis and who ther...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-0092

    authors: Wöhrl S,Geusau A

    更新日期:2006-01-01 00:00:00

  • Thalidomide treatment of prurigo nodularis.

    abstract::Four patients with classic recalcitrant prurigo nodularis had symptomatic and physical responses to thalidomide with remissions. Three of the four patients had increased IgE levels that decreased during therapy. In two patients, short-term treatment (2 to 3 months) was not sufficient to produce remission, but retreatm...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Winkelmann RK,Connolly SM,Doyle JA,Padilha-Goncalves A

    更新日期:1984-01-01 00:00:00

  • Hyperkeratosis lenticularis perstans: report on three cases.

    abstract::Three women with hyperkeratosis lenticularis perstans (HLP) are described. The lesions developed after the age of 45 and there was no family history of this disease. The possible role of UV-light in the pathogenesis of this disease is discussed. ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Rosdahl I,Rosén K

    更新日期:1985-01-01 00:00:00

  • A two-step schedule for the treatment of actinomycotic mycetomas.

    abstract::Actinomycotic mycetomas usually respond slowly to treatment with antibiotics. In an attempt to hasten clinical resolution, we used a 2-step regimen consisting of an intensive phase of therapy with penicillin, gentamycin and co-trimoxazole for 5-7 weeks, followed by maintenance therapy with amoxicillin and co-trimoxazo...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/000155500459367

    authors: Ramam M,Garg T,D'Souza P,Verma KK,Khaitan BK,Singh MK,Banerjee U

    更新日期:2000-09-01 00:00:00

  • Psychosocial Aspects of Adult Acne: Data from 13 European Countries.

    abstract::The link between acne and psychiatric morbidities has been demonstrated in many studies; however, large scale studies aiming to reveal the psychosocial impact of acne are rare. The aim of this study was to assess the psychological burden of adult acne patients. This analysis was based on a multicenter study including ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章,多中心研究

    doi:10.2340/00015555-3409

    authors: Altunay IK,Özkur E,Dalgard FJ,Gieler U,Tomas Aragones L,Lien L,Poot F,Jemec GB,Misery L,Szabó C,Linder D,Sampogna F,Evers AWM,Halvorsen JA,Balieva F,Szepietowski JC,Romanov DV,Marron SE,Finlay AY,Salek S,Kupfer J

    更新日期:2020-02-05 00:00:00

  • Cutaneous infection with Mycobacterium fortuitum after localized microinjections (mesotherapy) treated successfully with a triple drug regimen.

    abstract::Mesotherapy is a treatment method devised for controlling pain syndromes or diseases by subcutaneous microinjections given at or around the involved areas at short intervals of time. Different adverse effects have been described due to this modality of treatment. This report describes 3 patients with cutaneous infecti...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/00015550152572967

    authors: Nagore E,Ramos P,Botella-Estrada R,Ramos-Níguez JA,Sanmartín O,Castejón P

    更新日期:2001-08-01 00:00:00

  • Kinetics of phototoxicity in trioxysalen bath psoralen plus ultraviolet A photochemotherapy.

    abstract::A trioxysalen bath is a safe alternative to systemic 8-methoxypsoralen in long-term psoralen plus ultraviolet A (PUVA) treatment. The kinetics of its main side-effect, the strong phototoxicity, has not been thoroughly studied. This study determined the degree and persistence of phototoxicity after a single 10 min bath...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/000155501750376230

    authors: Snellman E,Rantanen T

    更新日期:2001-06-01 00:00:00

  • The Wasserman, Kline and VDRL reactions in routine syphilis serodiagnosis.

    abstract::The WR, Kline and VDRL reactions were compared in 496 cases of syphilis. The VDRL was significantly more sensitive than both WR and Kline. ...

    journal_title:Acta dermato-venereologica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Berntsson E,Larsson P

    更新日期:1980-01-01 00:00:00

  • Expression of blood group antigens by cultured human epidermal cells used as allografts.

    abstract::The expression of blood-group antigens was studied on human epidermal cultures used as allografts in 13 non-immunosuppressed patients treated for leg ulcers. The study was carried out using monoclonal antibodies to A and B antigens by an indirect immunofluorescence technique. Blood-group antigens are weakly expressed ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Mauduit G,Ohrt C,Faure M,Kanitakis J,Demidem A,Thivolet J

    更新日期:1987-01-01 00:00:00

  • The Rombo syndrome: a familial disorder with vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis.

    abstract::This hitherto unknown and dominantly inherited disorder is characterized by vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis. It has been present in the family reported for at least four generations. The lesions become visible in late c...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Michaëlsson G,Olsson E,Westermark P

    更新日期:1981-01-01 00:00:00

  • Loss of hyaluronan in the basement membrane zone of the skin correlates to the degree of stiff hands in diabetic patients.

    abstract::Glycosaminoglycans are important components of all extracellular matrices. One of the glycosaminoglycans is hyaluronan, which is ubiquitously distributed throughout the connective tissue. Hyaluronan is especially abundant in the skin, in which it is of both structural and functional importance. This study describes th...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/000155502320624041

    authors: Bertheim U,Engström-Laurent A,Hofer PA,Hallgren P,Asplund J,Hellström S

    更新日期:2002-01-01 00:00:00

  • Atopic dermatitis may be a genetically determined dysmaturation of ectodermal tissue, resulting in disturbed T-lymphocyte maturation. A hypothesis.

    abstract::Although atopic dermatitis is a skin disorder, it includes immune deviations such as T-cell accumulation and activation in the skin, resulting in chronic, relapsing eczema. The T-lymphocyte activation in the skin is not accompanied by specific allergies in up to two thirds of the patients. It has been shown that T-cel...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555577020021

    authors: Thestrup-Pedersen K,Ellingsen AR,Olesen AB,Lund M,Kaltoft K

    更新日期:1997-01-01 00:00:00

  • Comparison of Foxp3+ regulatory T cells and CD163+ macrophages in invasive and non-invasive extramammary Paget's disease.

    abstract::Regulatory T cells (Tregs), identified by the expression of CD4, CD25 and Foxp3, together with immunosuppressive macrophages, such as CD163+ M2 macrophages, are involved in maintaining peripheral tolerance. The aim of this study was to elucidate the involvement of Tregs and CD163+ macrophages in invasive and non-invas...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-1453

    authors: Fujimura T,Kambayashi Y,Hidaka T,Hashimoto A,Haga T,Aiba S

    更新日期:2012-11-01 00:00:00

  • Deposition of fibrinogen (FR-antigen) in skin diseases. II. Pustulosis palmaris et plantaris (with special reference to heparin-precipitable fraction).

    abstract::Ten out-patients with pustulosis palmaris et plantaris were examined with direct immunofluorescence (IF) technique for deposition of fibrinogen, fibrin or its degradation products (FR-antigen) in affected and unaffected skin, together with heparin-precipitable fraction (HPF), cryoglobulin and total plasma fibrinogen i...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Fyrand O,Mellbye OJ,Larsen TE

    更新日期:1975-01-01 00:00:00

  • Topical indomethacin aggravates the weal and flare response in chronic dermographic urticaria: evidence for a new class of histamine receptors.

    abstract::The effect of topical indomethacin on the weal and flare response was measured in 9 patients with chronic dermographic urticaria. An augmentation of dermographic wealing by topical indomethacin was shown with lowering of the weal threshold from 22.3 +/- 4.7 g/mm2 (mean +/- SEM, n = 9) to 16.4 +/- 3.8 (p < 0.005), but ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/000155557379

    authors: Sharpe GR,Shuster S

    更新日期:1993-02-01 00:00:00

  • Pustular Psoriasis: The Dawn of a New Era.

    abstract::Pustular psoriasis is a clinically heterogeneous entity of different, orphan disease subtypes, among which the most clearly defined are generalized pustular psoriasis, palmoplantar psoriasis, and acrodermatitis continua of Hallopeau. Although phenotypically and genetically distinct from psoriasis vulgaris, these subty...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章,评审

    doi:10.2340/00015555-3388

    authors: Bachelez H

    更新日期:2020-01-30 00:00:00

  • Red lunulae in severe alopecia areata.

    abstract::The development of red nail lunulae has been extremely rarely described in alopecia areata. We observed 2 patients, a 30-year-old woman and a 61-year-old man, both suffering from severe alopecia areata, and having red lunulae. The colour changes, which developed a few weeks after the acute onset of hair loss, disappea...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/0001555572203205

    authors: Bergner T,Donhauser G,Ruzicka T

    更新日期:1992-01-01 00:00:00

  • Nail--patella syndrome associated with renal failure requiring transplantation.

    abstract::The nail--patella syndrome is a rare, inheritable disease of the connective tissue in which multiple osseous abnormalities are associated with dysplasia of the nails. Renal dysfunction is found in 25--42% of cases and varies from asymptomatic proteinuria to renal failure. This paper describes a patient with nail--pate...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Verdich J

    更新日期:1980-01-01 00:00:00

  • Electron spin resonance studies on phaeomelanins.

    abstract::ESR spectra of synthetic melanins formed from dopa and from 5-S-cysteinyldopa and of melanins isolated from human melanomas were studied. Alkali-soluble melanin synthesized from cysteinyldopa showed a signal similar to that of insoluble melanin synthesized from dopa, but also a simple fine structure. Trichochromes C a...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Hansson C,Agrup G,Rorsman H,Rosengren AM,Rosengren E

    更新日期:1979-01-01 00:00:00

  • Cutaneous adverse reaction to ciprofloxacin: demonstration of specific lymphocyte proliferation and cross-reactivity to ofloxacin in vitro.

    abstract::Ciprofloxacin (CPFX) is a widely used fluoroquinolone antibiotic, inducing cutaneous adverse drug reactions in about 1 to 2% of the treated patients. Conclusive diagnosis of drug allergy, however, still remains a major problem in daily clinical practice. Here, we present 2 patients with drug allergy to CPFX. In both c...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555577285288

    authors: Rönnau AC,Sachs B,von Schmiedeberg S,Hunzelmann N,Ruzicka T,Gleichmann E,Schuppe HC

    更新日期:1997-07-01 00:00:00

  • Quantitative description of echographic images of morphea plaques as assessed by computerized image analysis on 20 MHz B-scan recordings.

    abstract::In order to find image descriptors enabling the characterization of sclerotic skin of morphea plaques and their objective differentiation from normal skin, we studied 52 lesions in 35 patients affected by plaque type morphea. Echographic evaluations were carried out using a 20 MHz B-scanner, providing cross-sectional ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555575442445

    authors: Seidenari S,Conti A,Pepe P,Giannetti A

    更新日期:1995-11-01 00:00:00

  • Subclinical joint involvement in psoriasis: magnetic resonance imaging and X-ray findings.

    abstract::Previous studies have shown that magnetic resonance imaging is more sensitive in assessing soft tissue and bone involvement in inflammatory arthritis than conventional radiography. Therefore the main objects of this study were to evaluate the frequency of hand involvement in psoriatic patients free from arthritic symp...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.1080/000155598442809

    authors: Offidani A,Cellini A,Valeri G,Giovagnoni A

    更新日期:1998-11-01 00:00:00

  • Gestational pemphigoid: placental morphology and function.

    abstract::Gestational pemphigoid (PG), a very rare pregnancy-associated bullous dermatosis, is associated with adverse pregnancy outcome (miscarriage, preterm delivery, foetal growth restriction). The major antigen in PG is collagen XVII (BP180). PG autoantibodies cross-react with collagen XVII in the skin and have been suggest...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-1370

    authors: Huilaja L,Mäkikallio K,Sormunen R,Lohi J,Hurskainen T,Tasanen K

    更新日期:2013-01-01 00:00:00

  • Impairment of the postural venoarteriolar reflex in aged individuals.

    abstract::The venoarteriolar vasoconstriction reflex plays a major role in the prevention of leg oedema in the upright position in man. We studied the venoarteriolar vasoconstriction reflex with laser Doppler flowmetry in young (21 subjects, age 17-27) and very old (20 subjects, age 75-100) healthy volunteers. In the group of y...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/0001555574194196

    authors: Gniadecka M,Gniadecki R,Serup J,Søndergaard J

    更新日期:1994-05-01 00:00:00

  • Clinical Management of Atopic Dermatitis in Adults: Mapping of Expert Opinion in 4 Nordic Countries using a Modified Delphi Process.

    abstract::Similarities and differences in the everyday clinical management of moderate-to-severe atopic dermatitis in Nordic countries are unknown. Using a modified Delphi approach, 15 dermatologists from Denmark, Finland, Norway and Sweden completed face-to-face and online questionnaires and participated in summary discussions...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章,多中心研究

    doi:10.2340/00015555-3369

    authors: Thyssen JP,Berents T,Bradley M,Deleuran M,Grimstad Ø,Korhonen L,Langeland T,Särnhult T,Thomsen SF,Thune T,Wahlgren CF,Vestergaard C,Kobyletzki LB,Remitz A

    更新日期:2020-01-07 00:00:00

  • Irritation and staining by dithranol (anthralin) and related compounds: II. Structure-activity relationships among 10-meso-substituted acyl analogues.

    abstract::Irritation and staining by dithranol and some 10-meso-substituted acyl analogues was studied with the chamber-testing technique in a series of 50 psoriasis patients. The test concentrations for dithranol, 10-acetyldithranol, 10-propionyldithranol and 10-butyryldithranol were 0.05 and 0.5%, for 10-valeryldithranol 5% a...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:

    authors: Mustakallio KK

    更新日期:1980-01-01 00:00:00

  • The effect of UV-light on pityrosporum yeasts: ultrastructural changes and inhibition of growth.

    abstract::The effect of UV-light on Pityrosporum yeasts (P.) was studied: P. yeasts cultured from the skin were spread on Dixon plates and irradiated with different UVB-and UVA-light dosages and read after three days, controls were not irradiated. Also P. yeasts, immediately after irradiation, were isolated from the plates and ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:102340/00015555706971

    authors: Wikler JR,Janssen N,Bruynzeel DP,Nieboer C

    更新日期:1990-01-01 00:00:00

  • Alexithymia, Illness Perception and Self-management Competency in Psoriasis.

    abstract::Alexithymia, defined as difficulty in describing or recognizing emotions, has been shown to be connected with psoriasis, but its relationship with self-management of psoriasis has not been explored. The aim of this study was to assess the frequency of alexithymia and its relationship with self-management and illness p...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章,随机对照试验

    doi:10.2340/00015555-2707

    authors: Larsen MH,Krogstad AL,Wahl AK

    更新日期:2017-08-31 00:00:00

  • Single Dose of Azithromycin for Treatment of Patients with Asymptomatic Rectal Chlamydia trachomatis.

    abstract::is missing (Short communication). ...

    journal_title:Acta dermato-venereologica

    pub_type: 杂志文章

    doi:10.2340/00015555-3675

    authors: Macaux L,Zemali N,Jaubert J,Koumar Y,Manaquin R,Poubeau P,Camuset G,Gérardin P,Bertolotti A

    更新日期:2020-11-04 00:00:00