Abstract：
:Zinc deficiency was produced in rats by feeding them a diet containing 0.5 mg zinc per kg. After 2 weeks the zinc-deficient rats showed markedly stunted growth as compared with control rats receiving an identical diet supplemented with 50 mg zinc per kg. After about 3 weeks all rats in the zinc-deficient group developed a greasy, coarse and scaly coat with dispersed, denuded, eczematous patches. After 32 days the animals were sacrificed and skin specimens were obtained from the abdominal area. Electron microscopy showed two different patterns of epidermal changes: (A) edematous cell bodies and cell organelles, degenerate nuclei, while desmosomes were well preserved: (B) parakeratotic and dyskeratotic cells with sparse keratohyalin granules, abnormal keratinosomes, poorly developed desmosomes, and disintegrated mitochondria in the upper part of the epidermis. In the lower part, keratinocytes contained numerous ribosomes and thick chromatin aggregates in the nuclei. Dendritic cells were disintegrated in pattern A, while they appeared normal in pattern B. In both patterns mitochondria showed vacuoles and a lack of DNA granules. A transient form of type A and B changes was also observed.
journal_name
Acta Derm Venereoljournal_title
Acta dermato-venereologicaauthors
Weismann K,Christophersen J,Kobayasi Tsubject
Has Abstractpub_date
1980-01-01 00:00:00pages
197-202issue
3eissn
0001-5555issn
1651-2057journal_volume
60pub_type
杂志文章abstract：:Previous immunofluorescence studies on pyoderma gangrenosum (PG) proved negative. Biopsies from the ulcer edge of 8 patients with PG were examined by immunofluorescence microscopy. Deposits of complement C3 were seen in the vessel walls of all samples, IgM in three and IgA in one. Granular deposits of C3 were seen at ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555562340341
更新日期：1982-01-01 00:00:00
abstract：:5-S-Cysteinyldopa (5-S-CD), a pheomelanin precursor, has been used as a biochemical marker of melanoma metastasis. Recently, 5-hydroxy-6-methoxyindole-2-carboxylic acid (5H6MI2C), a eumelanin-related metabolite, was shown to reflect well the degree of skin pigmentation. We measured the urinary excretion of 5H6MI2C and...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Oral terbinafine is licensed for use in onychomycosis after positive confirmation of infection. We describe five cases of subacute cutaneous lupus erythematosus associated with terbinafine therapy. All cases had positive antibodies to extractable nuclear antigens, predominantly anti-Ro, and several had a history of pr...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550410018361
更新日期：2004-01-01 00:00:00
abstract：:Skin biopsies from a collodion baby, spontaneously healing at the end of the third month, were taken on the 1st and 15th day after delivery and examined by light and electron microscopy. The microscopical features observed were different from those known to occur in collodion babies evolving into lamellar ichthyosis a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:A 39-year-old man presented with multiple basaloid follicular hamartomas involving the right side of his body in a systematized pattern following Blaschko's lines. His right leg was 22.5 cm shorter than the left, and rudimentary pre-axial polydactyly was noted on the left hand and the right foot. The teeth of the righ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0495
更新日期：2008-01-01 00:00:00
abstract：:Lymphocytotoxic autoantibody (LCTA) was studied in 9 patients with active pemphigus and 19 patients with active systemic lupus erythematosus (SLE). All patients with SLE showed high titres of LCTA but only one patient with pemphigus had LCTA. In this paper we discuss the immunological significance of LCTA and the diff...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:There are conflicting opinions concerning the epidermal immunofluorescence pattern in primary Sjögren's syndrome. In a prospective study of 12 patients we found a characteristic pattern of epidermal nuclear/cytoplasmic IgG deposits in 8 (67%). This pattern was associated with the presence of antibodies against SSA/Ro ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Actinomycotic mycetomas usually respond slowly to treatment with antibiotics. In an attempt to hasten clinical resolution, we used a 2-step regimen consisting of an intensive phase of therapy with penicillin, gentamycin and co-trimoxazole for 5-7 weeks, followed by maintenance therapy with amoxicillin and co-trimoxazo...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155500459367
更新日期：2000-09-01 00:00:00
abstract：:Although pemphigus has recently been linked to psoriasis, the risk of emergence of pemphigus during the course of psoriasis is yet to be delineated. The aim of this study was to evaluate the risk of developing pemphigus during the course of psoriasis. A large-scale population-based longitudinal retrospective cohort st...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3607
更新日期：2020-10-20 00:00:00
abstract：:Dermal cells maintained in cultured human skin explants for up to 10 weeks were studied by electron microscopy. Common findings in the cell organelles were: 1) altered nuclear shapes and numerous nuclear bodies; 2) reduced rough endoplasmic reticulum; 3) a prominent Golgi complex; and 4) an increasing number of free r...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:The Thomsen-Friedenreich (T) antigen is the core disaccharide of cancer-associated carbohydrates, whose expression allegedly correlates with the prognosis of some carcinomas. We studied the expression of the T antigen and its precursor (Tn) with monoclonal antibodies in formalin-fixed specimens of normal skin and vari...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/000155598441468
更新日期：1998-05-01 00:00:00
abstract：:The effect on dermographic wealing of an H1 and H2 receptor antagonist was studied separately and in combination. a double-blind protocol was used and dermographism was measured as the diameter of weal response to a measured force. Both H1 and H2 antagonists had a small but non-significant effect, but the combination ...
journal_title：Acta dermato-venereologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1983-01-01 00:00:00
abstract：:Previously we observed that systemic CyA induces hair growth in an experimental model of human scalp skin graft transplanted onto nude mice. In the present study we investigated the role of topical CyA in the murine transplantation model, using human split-thickness skin grafts (HSTSG). Ten mice grafted with 1-mm-thic...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:We describe a case of gingival hyperplasia in a 36-year-old renal transplantation recipient treated with nifedipine for severe arterial hypertension. The appearance of the gingival disorder was probably related to nifedipine intake. Histologically, in addition to the findings of acanthosis, papillomatosis and connecti...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-d...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.1080/00015550310006842
更新日期：2004-01-01 00:00:00
abstract：:The aim of this study was to assess quality of life in patients with scalp dermatitis using the Italian version of the Scalpdex, and to validate the instrument in Italian. The survey was conducted in outpatients with psoriasis, seborrhoeic dermatitis, alopecia, or follicular lichen. Data were completed on 194 patients...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,多中心研究
doi：10.2340/00015555-1731
更新日期：2014-07-01 00:00:00
abstract：:The effect of occlusion on epidermal morphology was studied at electron microscopic resolution. the morphological changes recorded were relatively mild, though conspicuous, and consisted in dilatation of the intercellular space, appearance of cytoplasmic vacuoles and an oedematous change in the dermis. Stereological a...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Although recent therapeutic developments raise hope, melanoma remains a devastating disease with a need for new treatment targets. In other tumours prohormone convertases have been shown to be pro-tumourigenic as they are involved in processing preforms of matrix-metalloproteinases, growth factors and adhesion molecul...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-3525
更新日期：2020-05-28 00:00:00
abstract：:Patients with mood depression have been found to have a higher prevalence of seborrheic dermatitis (SD), possibly related to their tendency to live indoors. The prevalence of outpatients with SD has now been found to be directly related to the number of gloomy days in the area. Since UV light might not be the only rea...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The biosynthesis of prostaglandins by human inflamed skin was studied in 8 patients with primary irritant dermatitis induced by benzalconium-chloride. Inflamed skin from these patients evidenced an increased ability to synthesize prostaglandins. In the presence of exogenous arachidonic acid in the incubation medium, t...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:Eosinophilic pustular folliculitis is a rare dermatosis. Recently, in addition to oral indomethacin, other treatments have been applied for eosinophilic pustular folliculitis. The aim of this study was to assess the effectiveness of various therapies encompassing conventional to newly applied drugs for eosinophilic pu...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-0578
更新日期：2009-01-01 00:00:00
abstract：:32 women complaining of diffuse alopecia were assessed by a psychiatrist, and daily hair loss and root counts were measured and compared with control women. Seven of the 32 women had severe marital difficulties, and 2 of these were overtly depressed. In these 7 women, daily hair loss and telogen counts did not differ ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Melanoma tissues produce not only 5-S-cysteinyldopa (5-S-CD), a pheomelanin precursor, but also 5,6-dihydroxyindoles, eumelanin precursors. We compared 5-S-CD and eumelanin-related metabolites regarding the correlation of their production in melanoma and excretion in urine, versus the weight of B16 mouse melanoma. It ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Generalized normolipemic plane xanthomatosis is a rare cutaneous disorder, frequently associated with reticuloendothelial diseases and some disorders with inflammation. Relapsing polychondritis is also a rare disease that shows an association with various immune-mediated diseases. We report a case of generalized normo...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555574221223
更新日期：1994-05-01 00:00:00
abstract：:The venoarteriolar vasoconstriction reflex plays a major role in the prevention of leg oedema in the upright position in man. We studied the venoarteriolar vasoconstriction reflex with laser Doppler flowmetry in young (21 subjects, age 17-27) and very old (20 subjects, age 75-100) healthy volunteers. In the group of y...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555574194196
更新日期：1994-05-01 00:00:00
abstract：:A 15-month-old boy with pachyonychia congenita is described. The patient also had follicular keratosis, leukokeratosis of the tongue, and blisters on the soles. Histopathological examination of the follicular keratosis showed hyperkeratosis and acanthosis. Horny plugs were located in sweat pores. By electron microscop...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:We present a 32-year-old white patient with congenital reticular ichthyosiform erythroderma, also known as ichthyosis variegata. The patient had typical clinical features with areas of normal appearing skin surrounded by erythematous hyperkeratotic patches. The smaller "confetti-like" patches were mostly present on th...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章,评审
doi：10.1080/00015550310002684
更新日期：2003-01-01 00:00:00
abstract：:The hair root status (trichogram) was studied in eleven patients with primary and eight with secondary syphilis. Variables studied in addition to the hair roots were absence or presence of hair root sheaths, deformities and hair roots with angulations exceeding 20 degrees. A decrease in the number of anagen hair roots...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Most dermatologists are aware of the benefits of dermoscopy, and a few are familiar with laser-scanning confocal microscopy. Beyond confocal, there are fully 11 different categories of optical techniques that have been applied to clinical dermatology. This article first provides a comprehensive tabular overview of all...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/00015555-2717
更新日期：2017-01-01 00:00:00
abstract：:Patients with X-linked recessive ichthyosis (RXLI) were studied as a model of the effect of disturbed epidermal lipid composition on skin barrier function. Thirteen patients with RXLI and 15 age- and sex-matched controls were patch-tested with sodium lauryl sulphate (SLS) 0.5% for 24 h. Basal skin properties and skin ...
journal_title：Acta dermato-venereologica
pub_type： 杂志文章
doi：10.2340/0001555575198201
更新日期：1995-05-01 00:00:00
