Immunohistochemical examination of P-cadherin in bullous and acantholytic skin diseases.

Abstract:

:Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-dependent cell-cell adhesion molecules which play an important role in the cellular connection between normal cells. P-cadherin is involved in the selective adhesion of epidermal cells, and is expressed only on the surfaces of the two basal layers. We examined the expression of P-cadherin in some autoimmune bullous skin diseases and Darier's disease using immunohistochemistry and found P-cadherin to be strongly upregulated. We believe the upregulation is compensatory to the primary pathophysiological events in the various bullous dermatoses.

journal_name

Acta Derm Venereol

authors

Kovács A,Schmidt E,Bégány A,Hunyadi J,Szegedi A

doi

10.1080/00015550310006842

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

116-9

issue

2

eissn

0001-5555

issn

1651-2057

journal_volume

84

pub_type

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